Cheap flights from LAX to FLO (Los Angeles Intl. to Florence Regional)

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Cheap Flights from LAX to FLO starting at $478 One Way, $686 Round Trip

Prices starting at $686 for return flights and $478 for one-way flights to Florence Regional were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Jan 5 - Fri, Jan 9
LAX
Los Angeles
FLO
Florence
$686 Roundtrip, found 6 days ago
$686
Roundtrip
found 6 days ago
Select American Airlines flight, departing Mon, Jan 5 from Los Angeles to Florence, returning Fri, Jan 9, priced at $686 found 6 days ago
Mon, Jan 5 - Sun, Jan 11
LAX
Los Angeles
FLO
Florence
$696 Roundtrip, found 6 days ago
$696
Roundtrip
found 6 days ago
Select American Airlines flight, departing Mon, Jan 5 from Los Angeles to Florence, returning Sun, Jan 11, priced at $696 found 6 days ago
Sat, Jan 3 - Tue, Jan 6
LAX
Los Angeles
FLO
Florence
$737 Roundtrip, found 6 days ago
$737
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, Jan 3 from Los Angeles to Florence, returning Tue, Jan 6, priced at $737 found 6 days ago
Sat, Jan 3 - Sun, Jan 11
LAX
Los Angeles
FLO
Florence
$785 Roundtrip, found 6 days ago
$785
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, Jan 3 from Los Angeles to Florence, returning Sun, Jan 11, priced at $785 found 6 days ago
Fri, Jan 2 - Tue, Jan 6
LAX
Los Angeles
FLO
Florence
$809 Roundtrip, found 6 days ago
$809
Roundtrip
found 6 days ago
Select American Airlines flight, departing Fri, Jan 2 from Los Angeles to Florence, returning Tue, Jan 6, priced at $809 found 6 days ago

Hotel Ideas near Florence Regional

Airport Hotels near Florence Regional

Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence Florence SC
$100 nightly
The price is $112 total per night from Jan 5 to Jan 6
$112 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
8.8/10 Excellent! (1,007 reviews)
Great experience in a nice hotel in downtown.

Reviewed on Dec 20, 2025

Hyatt Place Florence Downtown
Hotel Florence, Tapestry Collection by Hilton

Hotel Florence, Tapestry Collection by Hilton

3 out of 5
126 W Evans St Florence SC
$130 nightly
The price is $146 total per night from Jan 1 to Jan 2
$146 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
Book a stay at this spa hotel in Florence. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (603 reviews)
Room spotless. Staff courteous. 👍

Reviewed on Dec 14, 2025

Hotel Florence, Tapestry Collection by Hilton
Walking distance from one of South Carolina's top Medical centers.

Walking distance from one of South Carolina's top Medical centers.

Florence SC
$208 nightly
The price is $233 total per night from Jan 6 to Jan 7
$233 total
Jan 6 - Jan 7, 2026
Total with taxes and fees
Stay at this vacation home in Florence. Enjoy free WiFi, a garden, and laundry facilities. Popular attractions Old Greenwood Athletic Park and Drs Bruce and ...
9.8/10 Exceptional! (41 reviews)
Everything was great!

Reviewed on Nov 10, 2025

Walking distance from one of South Carolina's top Medical centers.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Florence

Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
$62 nightly
The price is $70 total per night from Dec 25 to Dec 26
$70 total
Dec 25 - Dec 26
Total with taxes and fees
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,506 reviews)
Clean, safe room

Reviewed on Dec 20, 2025

Howard Johnson by Wyndham Florence
Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road Florence SC
$85 nightly
The price is $95 total per night from Jan 11 to Jan 12
$95 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
8.8/10 Excellent! (2,200 reviews)
Bathroom not so clean, but it was good for the rest.

Reviewed on Dec 21, 2025

Park Inn by Radisson Florence, SC
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

2.5 out of 5
527 Woody Jones Blvd Florence SC
$97 nightly
The price is $109 total per night from Jan 11 to Jan 12
$109 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,171 reviews)
Friendly and accommodating staff greeted me during my 4:15 arrival time! When I got to my room, I noticed that it (and the bathroom) looked very clean!

Reviewed on Dec 18, 2025

Comfort Inn & Suites Florence Center Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Florence Hotels

Red Roof Inn Florence - Civic Center

Red Roof Inn Florence - Civic Center

2 out of 5
2690 David H McLeod Boulevard Florence SC
$56 nightly
The price is $63 total per night from Dec 28 to Dec 29
$63 total
Dec 28 - Dec 29
Total with taxes and fees
Stay at this hotel in Florence. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
6.6/10 (1,002 reviews)
room was decent

Reviewed on Nov 23, 2025

Red Roof Inn Florence - Civic Center
Budget Inn Timmonsville

Budget Inn Timmonsville

2 out of 5
2200 Cale Yarborough Highway Timmonsville SC
$61 nightly
The price is $68 total per night from Dec 25 to Dec 26
$68 total
Dec 25 - Dec 26
Total with taxes and fees
Stay at this motel in Timmonsville. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attraction Florence Motor Speedway is located nearby.
7/10 Good! (321 reviews)
very clean

Reviewed on Oct 16, 2025

Budget Inn Timmonsville
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
$64 nightly
The price is $72 total per night from Dec 25 to Dec 26
$72 total
Dec 25 - Dec 26
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.8/10 (1,006 reviews)
Great service besides kids hanging round doors it was alright experience.

Reviewed on Dec 19, 2025

Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Florence

Home2 Suites by Hilton Florence, SC

Home2 Suites by Hilton Florence, SC

3 out of 5
900 Woody Jones Blvd Florence SC
$106 nightly
The price is $119 total per night from Jan 11 to Jan 12
$119 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,003 reviews)
The only downfall to our stay was the noise. Above us and our floors doors slamming. Luckily for us it stopped around 10 so we got to sleep

Reviewed on Dec 19, 2025

Home2 Suites by Hilton Florence, SC
Spark by Hilton Florence North I-95, SC

Spark by Hilton Florence North I-95, SC

2.5 out of 5
1739 Mandeville Rd Florence SC
$96 nightly
The price is $108 total per night from Dec 31 to Jan 1
$108 total
Dec 31 - Jan 1, 2026
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.8/10 Good! (27 reviews)
The former company at least supplied some bacon, eggs, sausage, potatoes, gravy, and other options such as waffles. Sparks offered stale, rock hard bagels, mini muffins, some cereals and that was about it. Very disappointing compared to the former company last year.

Reviewed on Dec 14, 2025

Spark by Hilton Florence North I-95, SC
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
$64 nightly
The price is $72 total per night from Dec 25 to Dec 26
$72 total
Dec 25 - Dec 26
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.8/10 (1,006 reviews)
Great service besides kids hanging round doors it was alright experience.

Reviewed on Dec 19, 2025

Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

LAX to FLO Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
LAX Address & GPS
Address:
One World Way
Los Angeles CA, 90045-5803
United States
IATA Code:
LAX
Longitude:
-118.408279
Latitude:
33.943399
Time Zone:
America/Los_Angeles
FLO Address & GPS
Address:
2100 Terminal Drive
Florence SC, 29501
United States
IATA Code:
FLO
Longitude:
-79.724444
Latitude:
34.188889
Time Zone:
America/New_York

Frequently asked questions

What is the shortest flight from LAX to FLO?
Take the opportunity to kick back and unwind on the flight from Los Angeles to Florence. The quickest flight time from LAX to FLO is 5 hours and 36 minutes, which gives you lots of time to indulge in a tipple or get engrossed in a book.
How many hours flight from LAX to Florence Regional Airport (FLO)?
The flight from LAX to FLO takes an average of 5 hours and 47 minutes. A couple of movies, a gripping novel and a nice snooze will make the time zip by.
What airlines have the most flights from LAX to FLO?
For now, there aren't any direct flights from LAX to FLO. However, you will be able to book a flight with at least one stop. Look on the positive side — use the time to stretch your travel-weary legs or go in search of a nice meal!

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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