Cheap flights from LAX to FLO (Los Angeles Intl. to Florence Regional)

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Cheap Flights from LAX to FLO starting at $329 One Way, Round Trip

Prices starting at for return flights and $329 for one-way flights to Florence Regional were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Hotel Ideas near Florence Regional

Airport Hotels near Florence Regional

Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence Florence SC
$119 nightly
The price is $133 total per night from Mar 31 to Apr 1
$133 total
Mar 31 - Apr 1
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
9/10 Wonderful! (1,003 reviews)
This is a very nice hotel. The room was very clean & the bed extremely comfortable. We loved almost everything about the hotel. The first thing we found that we did not like was the person who checked us in, they were so soft-spoken that you could not hear them. Very nice & friendly just kept having ...

Reviewed on Mar 24, 2026

Hyatt Place Florence Downtown
Hotel Florence, Tapestry Collection by Hilton

Hotel Florence, Tapestry Collection by Hilton

3 out of 5
126 W Evans St Florence SC
$130 nightly
The price is $146 total per night from Apr 5 to Apr 6
$146 total
Apr 5 - Apr 6
Total with taxes and fees
Book a stay at this spa hotel in Florence. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (622 reviews)
This was a nice hotel. The room didn’t have a fridge or freezer. I was disappointed with this because I had some food to keep cool. It was close to train tracks so you can hear the train throughout the night. Bring ear plugs!

Reviewed on Mar 17, 2026

Hotel Florence, Tapestry Collection by Hilton
Rodeway Inn Florence Downtown

Rodeway Inn Florence Downtown

2 out of 5
415 S. IRBY ST Florence SC
$57 nightly
The price is $63 total per night from Apr 23 to Apr 24
$63 total
Apr 23 - Apr 24
Total with taxes and fees
Stay at this hotel in Florence. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Drs Bruce and Lee Foundation Library and Florence ...
4.8/10 (3 reviews)
Looks like the owners are doing a lot of work on the property however, cleanliness is doable but not done. Our room was supposed to have 2 beds in it but the first room we got looked like someone was still in it. Unmade bed, clothes on chair and a huge fan in the middle of the room. Second room, ...

Reviewed on Mar 11, 2026

Rodeway Inn Florence Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Florence

Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

2.5 out of 5
527 Woody Jones Blvd Florence SC
$100 nightly
The price is $112 total per night from Apr 19 to Apr 20
$112 total
Apr 19 - Apr 20
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,240 reviews)
Pleasant staff and very clean room. Comfortable sleeping quarters and very close to a variety of restaurants and shopping. Great location!

Reviewed on Mar 25, 2026

Comfort Inn & Suites Florence Center Area
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
$67 nightly
The price is $75 total per night from Mar 29 to Mar 30
$75 total
Mar 29 - Mar 30
Total with taxes and fees
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,589 reviews)
The room wasn't as clean as my last stay there in the of last year.

Reviewed on Mar 24, 2026

Howard Johnson by Wyndham Florence
Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence Florence SC
$119 nightly
The price is $133 total per night from Mar 31 to Apr 1
$133 total
Mar 31 - Apr 1
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
9/10 Wonderful! (1,003 reviews)
This is a very nice hotel. The room was very clean & the bed extremely comfortable. We loved almost everything about the hotel. The first thing we found that we did not like was the person who checked us in, they were so soft-spoken that you could not hear them. Very nice & friendly just kept having ...

Reviewed on Mar 24, 2026

Hyatt Place Florence Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Florence Hotels

Red Roof Inn Florence - Civic Center

Red Roof Inn Florence - Civic Center

2 out of 5
2690 David H McLeod Boulevard Florence SC
$61 nightly
The price is $68 total per night from Mar 29 to Mar 30
$68 total
Mar 29 - Mar 30
Total with taxes and fees
Stay at this hotel in Florence. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
6.8/10 (1,003 reviews)
The health department should pay them a visit. Not sure how Florence provides them with a buisness license every year. Disgusting place.

Reviewed on Mar 22, 2026

Red Roof Inn Florence - Civic Center
Budget Inn Timmonsville

Budget Inn Timmonsville

2 out of 5
2200 Cale Yarborough Highway Timmonsville SC
$61 nightly
The price is $68 total per night from Mar 26 to Mar 27
$68 total
Mar 26 - Mar 27
Total with taxes and fees
Stay at this motel in Timmonsville. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attraction Florence Motor Speedway is located nearby.
7/10 Good! (331 reviews)
Check in was easy. Parking was easy. The room was clean. For a $72 room, I didn't mind that the microwave or fridge had cosmetic issues (I didn't need to use them). I work in hotels and found that everything was standard for a roadside motel. The one issue I had was my tub didn't have a drain. Not ...

Reviewed on Mar 23, 2026

Budget Inn Timmonsville
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
$67 nightly
The price is $75 total per night from Mar 30 to Mar 31
$75 total
Mar 30 - Mar 31
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7/10 Good! (1,000 reviews)
I recently stayed at a Wyndham property and, unfortunately, my experience was disappointing. Upon entering my room, I was greeted by an unpleasant odor that lingered throughout my stay, making it uncomfortable to relax. The overall condition of the room was subpar, with peeling paint on the walls ...

Reviewed on Mar 21, 2026

Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Florence

Home2 Suites by Hilton Florence, SC

Home2 Suites by Hilton Florence, SC

3 out of 5
900 Woody Jones Blvd Florence SC
$111 nightly
The price is $125 total per night from Apr 6 to Apr 7
$125 total
Apr 6 - Apr 7
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,004 reviews)
Staff was very nice and accommodating

Reviewed on Mar 20, 2026

Home2 Suites by Hilton Florence, SC
Spark by Hilton Florence North I-95, SC

Spark by Hilton Florence North I-95, SC

2.5 out of 5
1739 Mandeville Rd Florence SC
$95 nightly
The price is $106 total per night from Apr 21 to Apr 22
$106 total
Apr 21 - Apr 22
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.8/10 Good! (56 reviews)
Rooms were clean. The Staff was very nice.

Reviewed on Mar 22, 2026

Spark by Hilton Florence North I-95, SC
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
$67 nightly
The price is $75 total per night from Mar 30 to Mar 31
$75 total
Mar 30 - Mar 31
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7/10 Good! (1,000 reviews)
I recently stayed at a Wyndham property and, unfortunately, my experience was disappointing. Upon entering my room, I was greeted by an unpleasant odor that lingered throughout my stay, making it uncomfortable to relax. The overall condition of the room was subpar, with peeling paint on the walls ...

Reviewed on Mar 21, 2026

Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

LAX to FLO Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
LAX Address & GPS
Address:
One World Way
Los Angeles CA, 90045-5803
United States
IATA Code:
LAX
Longitude:
-118.408279
Latitude:
33.943399
Time Zone:
America/Los_Angeles
FLO Address & GPS
Address:
2100 Terminal Drive
Florence SC, 29501
United States
IATA Code:
FLO
Longitude:
-79.724444
Latitude:
34.188889
Time Zone:
America/New_York

Frequently asked questions

What is the shortest flight from LAX to FLO?
Take the opportunity to kick back and unwind on the flight from Los Angeles to Florence. The quickest flight time from LAX to FLO is 5 hours and 36 minutes, which gives you lots of time to indulge in a tipple or get engrossed in a book.
How many hours flight from LAX to Florence Regional Airport (FLO)?
The flight from LAX to FLO takes an average of 5 hours and 47 minutes. A couple of movies, a gripping novel and a nice snooze will make the time zip by.
What airlines have the most flights from LAX to FLO?
For now, there aren't any direct flights from LAX to FLO. However, you will be able to book a flight with at least one stop. Look on the positive side — use the time to stretch your travel-weary legs or go in search of a nice meal!

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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