Cheap flights from LAX to FLO (Los Angeles Intl. to Florence Regional)

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Cheap Flights from LAX to FLO starting at $289 One Way, $531 Round Trip

Prices starting at $531 for return flights and $289 for one-way flights to Florence Regional were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Oct 30 - Mon, Nov 2
LAX
Los Angeles
FLO
Florence
$531 Roundtrip, found 3 days ago
$531
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Oct 30 from Los Angeles to Florence, returning Mon, Nov 2, priced at $531 found 3 days ago
Fri, Oct 30 - Mon, Nov 2
LAX
Los Angeles
FLO
Florence
$580 Roundtrip, found 3 days ago
$580
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Oct 30 from Los Angeles to Florence, returning Mon, Nov 2, priced at $580 found 3 days ago
Fri, Oct 30 - Mon, Nov 2
LAX
Los Angeles
FLO
Florence
$597 Roundtrip, found 3 days ago
$597
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Oct 30 from Los Angeles to Florence, returning Mon, Nov 2, priced at $597 found 3 days ago
Fri, Oct 30 - Mon, Nov 2
LAX
Los Angeles
FLO
Florence
$611 Roundtrip, found 3 days ago
$611
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Oct 30 from Los Angeles to Florence, returning Mon, Nov 2, priced at $611 found 3 days ago
Fri, Oct 30 - Mon, Nov 2
LAX
Los Angeles
FLO
Florence
$628 Roundtrip, found 3 days ago
$628
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Oct 30 from Los Angeles to Florence, returning Mon, Nov 2, priced at $628 found 3 days ago

Hotel Ideas near Florence Regional

Airport Hotels near Florence Regional

Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence Florence SC
$114 nightly
The price is $128 total per night from Aug 17 to Aug 18
$128 total
Aug 17 - Aug 18
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
9/10 Wonderful! (1,012 reviews)
"It's a nice hotel. Good restaurants nearby and staff are very friendly."

Reviewed on Aug 10, 2026

Hyatt Place Florence Downtown
Hotel Florence, Tapestry Collection by Hilton

Hotel Florence, Tapestry Collection by Hilton

3 out of 5
126 W Evans St Florence SC
$139 nightly
The price is $155 total per night from Aug 16 to Aug 17
$155 total
Aug 16 - Aug 17
Total with taxes and fees
Book a stay at this spa hotel in Florence. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (649 reviews)
"Amazing location and Monica at the front desk is a doll!"

Reviewed on Jul 29, 2026

Hotel Florence, Tapestry Collection by Hilton
Cozy & Inviting

Cozy & Inviting

Florence SC
Stay at this apartment in Florence. Enjoy air conditioning. Popular attractions Drs Bruce and Lee Foundation Library and War Between the States Museum are located ...
Get rates
Cozy & Inviting
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Florence

Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

2.5 out of 5
150 Dunbarton Dr Florence SC
$88 nightly
The price is $99 total per night from Aug 16 to Aug 17
$99 total
Aug 16 - Aug 17
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (318 reviews)
"The curtains were small for the windows. Coverage at night was not good"

Reviewed on Aug 10, 2026

Quality Inn & Suites Florence Civic Center
Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road Florence SC
$71 nightly
The price is $80 total per night from Sep 7 to Sep 8
$80 total
Sep 7 - Sep 8
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
Park Inn by Radisson Florence, SC
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
$64 nightly
The price is $72 total per night from Sep 8 to Sep 9
$72 total
Sep 8 - Sep 9
Total with taxes and fees
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,704 reviews)
"Great room for travel. Room was clean and breakfast was good well worth it for the price"

Reviewed on Aug 10, 2026

Howard Johnson by Wyndham Florence
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Florence Hotels

Red Roof Inn Florence - Civic Center

Red Roof Inn Florence - Civic Center

2 out of 5
2690 David H McLeod Boulevard Florence SC
$56 nightly
The price is $63 total per night from Sep 1 to Sep 2
$63 total
Sep 1 - Sep 2
Total with taxes and fees
Stay at this hotel in Florence. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
Red Roof Inn Florence - Civic Center
Budget Inn Timmonsville

Budget Inn Timmonsville

2 out of 5
2200 Cale Yarborough Highway Timmonsville SC
$61 nightly
The price is $68 total per night from Aug 11 to Aug 12
$68 total
Aug 11 - Aug 12
Total with taxes and fees
Stay at this motel in Timmonsville. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attraction Florence Motor Speedway is located nearby.
7/10 Good! (348 reviews)
"I booked to crash for the night and keep getting to my destination. But there is no reception, everything is through the window. Entire reception is filled with boxes, mentioned complimentary breakfast, but when I checked in, I understood nothing will be as I expected. TV, Microwave, Fridge didnt ..."

Reviewed on Aug 7, 2026

Budget Inn Timmonsville
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
$65 nightly
The price is $73 total per night from Aug 19 to Aug 20
$73 total
Aug 19 - Aug 20
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,006 reviews)
"I had to change my room twice . First room the covers on the bed was dirty and had a whole in the bathroom door . The second room it was mold all over the ceiling and on the lamp covers. Third one was ok . Not the best ."

Reviewed on Aug 10, 2026

Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Florence

Home2 Suites by Hilton Florence, SC

Home2 Suites by Hilton Florence, SC

3 out of 5
900 Woody Jones Blvd Florence SC
$108 nightly
The price is $121 total per night from Sep 1 to Sep 2
$121 total
Sep 1 - Sep 2
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (1,003 reviews)
"The floors, walls, and bathroom were all dirty. The shower drain had hair all over it. The towels had hair stuck in the fibers. The tiled areas were sticky & carpet was poorly kept. Nothing felt clean in the room and had we not been so tired from our drive leading up to our stay we would have left ..."

Reviewed on Aug 10, 2026

Home2 Suites by Hilton Florence, SC
Spark by Hilton Florence North I-95, SC

Spark by Hilton Florence North I-95, SC

2.5 out of 5
1739 Mandeville Rd Florence SC
$93 nightly
The price is $104 total per night from Aug 17 to Aug 18
$104 total
Aug 17 - Aug 18
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Spark by Hilton Florence North I-95, SC
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
$65 nightly
The price is $73 total per night from Aug 19 to Aug 20
$73 total
Aug 19 - Aug 20
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,006 reviews)
"I had to change my room twice . First room the covers on the bed was dirty and had a whole in the bathroom door . The second room it was mold all over the ceiling and on the lamp covers. Third one was ok . Not the best ."

Reviewed on Aug 10, 2026

Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

LAX to FLO Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
LAX Address & GPS
Address:
One World Way
Los Angeles CA, 90045-5803
United States
IATA Code:
LAX
Longitude:
-118.408279
Latitude:
33.943399
Time Zone:
America/Los_Angeles
FLO Address & GPS
Address:
2100 Terminal Drive
Florence SC, 29501
United States
IATA Code:
FLO
Longitude:
-79.724444
Latitude:
34.188889
Time Zone:
America/New_York

Frequently asked questions

What is the shortest flight from LAX to FLO?
Take the opportunity to kick back and unwind on the flight from Los Angeles to Florence. The quickest flight time from LAX to FLO is 5 hours and 36 minutes, which gives you lots of time to indulge in a tipple or get engrossed in a book.
How many hours flight from LAX to Florence Regional Airport (FLO)?
The flight from LAX to FLO takes an average of 5 hours and 47 minutes. A couple of movies, a gripping novel and a nice snooze will make the time zip by.
What airlines have the most flights from LAX to FLO?
For now, there aren't any direct flights from LAX to FLO. However, you will be able to book a flight with at least one stop. Look on the positive side — use the time to stretch your travel-weary legs or go in search of a nice meal!

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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