Hotels in Depew
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Top Rated Depew Hotels

Buffalo Airport Hotel
4600 Genesee St Buffalo NY
Free Cancellation
Reserve now, pay when you stay
2.49 mi from city center
$119 nightly
The price is $135 total per night
$135 total
Dec 29 - Dec 30
Total with taxes and fees
Guests of Buffalo Airport Hotel enjoy a 24-hour gym, free WiFi in public areas, and meeting rooms. There's free parking, as well as a free airport shuttle (available 24 hours). Multilingual staff at the 24-hour front desk can assist with luggage storage, concierge services, and dry cleaning/laundry. Additional amenities include conference space, a 24-hour business center, and coffee/tea in a common area.
Free airport shuttle
Parking included

M Hotel Buffalo
2040 Walden Ave Buffalo NY
Free Cancellation
Reserve now, pay when you stay
2.88 mi from city center
$99 nightly
The price is $113 total per night
$113 total
Dec 29 - Dec 30
Total with taxes and fees
Guests of M Hotel Buffalo have access to an indoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking, along with a free airport shuttle (available 24 hours). The front desk is staffed 24 hours a day to help with securing valuables and luggage storage. Additional amenities include conference space, a 24-hour business center, and a computer station.
Pool
Breakfast included

Hyatt Regency Buffalo / Hotel and Conference Center
Two Fountain Plaza Buffalo NY
Free Cancellation
Reserve now, pay when you stay
8.62 mi from city center
$143 nightly
The price is $167 total per night
$167 total
Jan 8 - Jan 9, 2026
Total with taxes and fees
At Hyatt Regency Buffalo / Hotel and Conference Center, guests enjoy features like an indoor pool, a 24-hour gym, and free WiFi in public areas. Valet parking is offered for USD 29.50 per night. The front desk has multilingual staff on hand 24/7 to help with securing valuables, dry cleaning/laundry, and concierge services. Additional amenities include meeting rooms, a conference center, and a business center.
Pool
Pet friendly

Garden Place Hotel
6615 Transit Road Buffalo NY
Free Cancellation
Reserve now, pay when you stay
3.27 mi from city center
$99 nightly
The price is $113 total per night
$113 total
Dec 29 - Dec 30
Total with taxes and fees
Guests staying at Garden Place Hotel enjoy a 24-hour gym, a sauna, and free WiFi in public areas. You can take advantage of free parking, along with a free airport shuttle (available 24 hours). The front desk is staffed 24/7 to help with luggage storage, dry cleaning/laundry, and securing valuables. Additional amenities include a business center, a meeting room, and express check-out.
Free airport shuttle
Pet friendly

Sleep Inn & Suites Buffalo Airport
100 Holtz Dr Buffalo NY
Free Cancellation
2.62 mi from city center
$84 nightly
The price is $96 total per night
$96 total
Jan 15 - Jan 16, 2026
Total with taxes and fees
Sleep Inn & Suites Buffalo Airport features a gym, free WiFi in public areas, and a 24-hour business center. You can take advantage of free parking, along with a free airport shuttle (available 24 hours). The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Additional amenities include coffee/tea in a common area, a microwave in a common area, and a meeting room.
Breakfast included
Free airport shuttle

Holiday Inn Express Grand Island - Niagara Falls by IHG
2761 Long Road Grand Island NY
Free Cancellation
17.86 mi from city center
$87 nightly
The price is $99 total per night
$99 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Guests staying at Holiday Inn Express Grand Island - Niagara Falls by IHG enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. You can put free parking to good use if you drive. The 24-hour front desk has multilingual staff ready to assist with tours/tickets and luggage storage. Additional amenities include meeting rooms, a business center, and a terrace.
Pool
Breakfast included

Days Inn & Suites by Wyndham Niagara Falls/Buffalo
2821 Niagara Falls Blvd Niagara Falls NY
Free Cancellation
Reserve now, pay when you stay
16.1 mi from city center
$61 nightly
The price is $69 total per night
$69 total
Dec 29 - Dec 30
Total with taxes and fees
Guests of Days Inn & Suites by Wyndham Niagara Falls/Buffalo enjoy access to free WiFi in public areas, a business center, and a seasonal outdoor pool. You can put free parking to good use if you drive. The 24-hour front desk has staff standing by to help with tours/tickets and securing valuables. Additional amenities include free newspapers, laundry facilities, and a vending machine.
Pool
Breakfast included

Hampton Inn Buffalo - Amherst, NY
1601 Amherst Manor Drive Buffalo NY
Free Cancellation
Reserve now, pay when you stay
7.64 mi from city center
$106 nightly
The price is $120 total per night
$120 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
Guests staying at Hampton Inn Buffalo - Amherst, NY enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. You can take advantage of free parking if you drive. The 24-hour front desk has staff standing by to help with securing valuables, luggage storage, and dry cleaning/laundry. Additional amenities include meeting rooms, a 24-hour business center, and coffee/tea in a common area.
Pool
Breakfast included

Homewood Suites by Hilton Buffalo/Amherst
1138 Millersport Hwy Buffalo NY
Free Cancellation
Reserve now, pay when you stay
7.37 mi from city center
$130 nightly
The price is $148 total per night
$148 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
At Homewood Suites by Hilton Buffalo/Amherst, guests enjoy features like an indoor pool, a 24-hour gym, and free WiFi in public areas. You can put free parking to good use if you drive. The 24-hour front desk has staff standing by to help with dry cleaning/laundry, luggage storage, and securing valuables. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Additional amenities include a hot tub, conference space, and a 24-hour business center.
Pool
Hot Tub

La Quinta Inn by Wyndham Buffalo Airport
6619 Transit Rd Buffalo NY
Free Cancellation
Reserve now, pay when you stay
3.32 mi from city center
$76 nightly
The price is $86 total per night
$86 total
Jan 18 - Jan 19, 2026
Total with taxes and fees
Renovated in 2024, La Quinta Inn by Wyndham Buffalo Airport offers a gym, free WiFi in public areas, and a 24-hour business center. You can take advantage of free parking, along with a free airport shuttle (available 24 hours). Front-desk staff are standing by 24/7 to assist with any requests. Additional amenities include coffee/tea in a common area, express check-in, and express check-out.
Breakfast included
Free airport shuttle

The Richardson Hotel
444 Forest Avenue Buffalo NY
Free Cancellation
Reserve now, pay when you stay
9.17 mi from city center
$140 nightly
The price is $163 total per night
$163 total
Jan 8 - Jan 9, 2026
Total with taxes and fees
Guests of The Richardson Hotel enjoy a 24-hour gym, free WiFi in public areas, and a business center. If you drive, put free parking to good use. The front desk is staffed 24/7 to help with dry cleaning/laundry, securing valuables, and luggage storage. Additional amenities include coffee/tea in a common area, a garden, and a banquet hall.
Parking included
Free WiFi

Motel 6 Amherst, NY - Buffalo
4400 Maple Rd Buffalo NY
Free Cancellation
Reserve now, pay when you stay
7.94 mi from city center
$55 nightly
The price is $63 total per night
$63 total
Jan 16 - Jan 17, 2026
Total with taxes and fees
Guests staying at Motel 6 Amherst, NY - Buffalo enjoy free WiFi in public areas, laundry facilities, and a vending machine. If you decide to drive, there's free parking. The 24-hour front desk has staff always at the ready.
Pet friendly
Parking included
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
What's the best place for a stay in Depew?
What are some favorite hotels in downtown Depew?
These are some of our travelers' favorite hotels in downtown Depew:
- M Hotel Buffalo is hotel has free breakfast, free WiFi, and free parking.
- Garden Place Hotel is hotel has free parking, a 24-hour fitness center, and a free airport shuttle.
- Buffalo Airport Hotel is hotel has free WiFi, free parking, and a 24-hour fitness center.
Depew hotels essential information
Accommodation | 872 hotels |
|---|---|
Lowest Price | $63 |
Highest Price | $167 |
Popular hotels | Buffalo Airport Hotel, M Hotel Buffalo, Hyatt Regency Buffalo / Hotel and Conference Center, Garden Place Hotel, Sleep Inn & Suites Buffalo Airport, Holiday Inn Express Grand Island - Niagara Falls by IHG, Days Inn & Suites by Wyndham Niagara Falls/Buffalo, Hampton Inn Buffalo - Amherst, NY, Homewood Suites by Hilton Buffalo/Amherst, La Quinta Inn by Wyndham Buffalo Airport, The Richardson Hotel, Motel 6 Amherst, NY - Buffalo |
Recent Reviews

Buffalo Airport Hotel
5/5 Excellent
"My daughter in law got there six hours before me and they let her check in... Even before the 3 o'clock check in time which was greatly appreciated. The free shuttle picked her up. She felt very safe and secure. When I arrived self parking was easy. I'm grateful they allowed her to check in as when I pulled in there was a bus unloading. The hotel is much nicer than I was expecting for the price. The courtyard is beautiful. The bar menu had plenty of basics to choose from... Nothing fancy. Reasonably priced. The wait staff was wonderful. I would definitely book this hotel again. King size bed was comfy."
A verified traveler stayed at Buffalo Airport Hotel
Posted 1 day ago
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