Cheap flights from TRI to SAN (Tri-Cities Regional to San Diego Intl.)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

Cheap Flights from TRI to SAN starting at $399 One Way, $406 Round Trip

Prices starting at $406 for return flights and $399 for one-way flights to San Diego Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Dec 3 - Mon, Dec 7
TRI
Tri-Cities
SAN
San Diego
$406 Roundtrip, found 2 days ago
$406
Roundtrip
found 2 days ago
Select Delta flight, departing Thu, Dec 3 from Tri-Cities to San Diego, returning Mon, Dec 7, priced at $406 found 2 days ago
Thu, Dec 3 - Mon, Dec 7
TRI
Tri-Cities
SAN
San Diego
$406 Roundtrip, found 2 days ago
$406
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Dec 3 from Tri-Cities to San Diego, returning Mon, Dec 7, priced at $406 found 2 days ago
Thu, Dec 3 - Mon, Dec 7
TRI
Tri-Cities
SAN
San Diego
$437 Roundtrip, found 2 days ago
$437
Roundtrip
found 2 days ago
Select Delta flight, departing Thu, Dec 3 from Tri-Cities to San Diego, returning Mon, Dec 7, priced at $437 found 2 days ago
Wed, Nov 4 - Wed, Nov 11
TRI
Tri-Cities
SAN
San Diego
$443 Roundtrip, found 13 hours ago
$443
Roundtrip
found 13 hours ago
Select Delta flight, departing Wed, Nov 4 from Tri-Cities to San Diego, returning Wed, Nov 11, priced at $443 found 13 hours ago
Thu, Dec 3 - Mon, Dec 7
TRI
Tri-Cities
SAN
San Diego
$478 Roundtrip, found 2 days ago
$478
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Dec 3 from Tri-Cities to San Diego, returning Mon, Dec 7, priced at $478 found 2 days ago

Hotel Ideas near San Diego Intl.

Airport Hotels near San Diego Intl.

Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
The price is $184 total per night from Nov 22 to Nov 23
$184 total
per night
Nov 22 - Nov 23
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
Sheraton San Diego Resort
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
The price is $211 total per night from Oct 25 to Oct 26
$211 total
per night
Oct 25 - Oct 26
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Wyndham San Diego Bayside
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr San Diego CA
The price is $194 total per night from Oct 26 to Oct 27
$194 total
per night
Oct 26 - Oct 27
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a marina, and a health club. Our guests praise the breakfast and the restaurant in ...
9.2/10 Wonderful! (4,027 reviews)
"Beautiful spot"

Reviewed on Oct 21, 2026

Bay Club Hotel & Marina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In San Diego

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
The price is $211 total per night from Oct 25 to Oct 26
$211 total
per night
Oct 25 - Oct 26
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Wyndham San Diego Bayside
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr San Diego CA
The price is $194 total per night from Oct 26 to Oct 27
$194 total
per night
Oct 26 - Oct 27
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a marina, and a health club. Our guests praise the breakfast and the restaurant in ...
9.2/10 Wonderful! (4,027 reviews)
"Beautiful spot"

Reviewed on Oct 21, 2026

Bay Club Hotel & Marina
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
The price is $303 total per night from Oct 23 to Oct 24
$303 total
per night
Oct 23 - Oct 24
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
Paradise Point Resort & Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

San Diego Hotels With Airport Transportation

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
The price is $211 total per night from Oct 25 to Oct 26
$211 total
per night
Oct 25 - Oct 26
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Wyndham San Diego Bayside
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
The price is $184 total per night from Nov 22 to Nov 23
$184 total
per night
Nov 22 - Nov 23
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
Sheraton San Diego Resort
Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG

2.5 out of 5
1955 San Diego Ave San Diego CA
The price is $171 total per night from Oct 27 to Oct 28
$171 total
per night
Oct 27 - Oct 28
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and the ...
Holiday Inn Express San Diego Airport - Old Town by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced San Diego Hotels

Pleasant Inn

Pleasant Inn

2.5 out of 5
5550 Clairemont Mesa Blvd San Diego CA
The price is $89 total per night from Nov 22 to Nov 23
$89 total
per night
Nov 22 - Nov 23
Stay at this hotel in San Diego. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the convenient parking in our ...
Pleasant Inn
E-Z 8 Motel Old Town

E-Z 8 Motel Old Town

2.5 out of 5
4747 Pacific Highway San Diego CA
The price is $71 total per night from Oct 25 to Oct 26
$71 total
per night
Oct 25 - Oct 26
Book a stay at this business-friendly hotel in San Diego. Enjoy free parking, WiFi (surcharge), and a 24-hour front desk. Our guests praise the helpful staff ...
6.6/10 (2,201 reviews)
"I love this place"

Reviewed on Oct 21, 2026

E-Z 8 Motel Old Town
Kings Inn San Diego

Kings Inn San Diego

2.5 out of 5
1333 Hotel Cir S San Diego CA
The price is $95 total per night from Nov 22 to Nov 23
$95 total
per night
Nov 22 - Nov 23
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the breakfast and the pool in our reviews. Popular ...
Kings Inn San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in San Diego

Bahia Resort Hotel

Bahia Resort Hotel

3.5 out of 5
998 W Mission Bay Dr San Diego CA
The price is $264 total per night from Nov 22 to Nov 23
$264 total
per night
Nov 22 - Nov 23
Book a stay at this beach resort in San Diego. Enjoy free parking, a private beach, and a marina. Our guests praise the pool and the restaurant in our reviews. ...
Bahia Resort Hotel
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
The price is $235 total per night from Nov 3 to Nov 4
$235 total
per night
Nov 3 - Nov 4
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
9/10 Wonderful! (4,490 reviews)
"Really good hotel !!!"

Reviewed on Oct 22, 2026

The Dana on Mission Bay
Catamaran Resort and Spa

Catamaran Resort and Spa

4 out of 5
3999 Mission Boulevard San Diego CA
The price is $264 total per night from Nov 22 to Nov 23
$264 total
per night
Nov 22 - Nov 23
Book a stay at this beach resort in San Diego. Enjoy free WiFi, a full-service spa, and a beach locale. Our guests praise the helpful staff and the clean rooms ...
Catamaran Resort and Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

TRI to SAN Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
TRI Address & GPS
Address:
2525 Tennessee 75
Bristol, VA/Johnson City/Kingsport TN, 37617
United States
IATA Code:
TRI
Longitude:
-82.407852
Latitude:
36.481109
Time Zone:
America/New_York
SAN Address & GPS
Address:
Airport Drive
San Diego CA, 92101
United States
IATA Code:
SAN
Longitude:
-117.197312
Latitude:
32.731938
Time Zone:
America/Los_Angeles

Frequently asked questions

What is the shortest flight from TRI to San Diego Intl. Airport (SAN)?
Use the opportunity to unwind on the flight from Blountville to San Diego. The shortest flight time from Tri-Cities Airport to SAN is 6 hours and 20 minutes, which gives you loads of time to indulge in a tipple or get engrossed in a book.
How many hours flight from TRI to SAN?
From Tri-Cities Airport to SAN, you'll be in your seat for roughly 6 hours and 26 minutes. Settle back, order a glass of bubbly and take out your noise-canceling headphones. It's time to rewatch your favorite TV shows.
What airlines have the most flights from Tri-Cities Airport to San Diego Intl. Airport (SAN)?
If you're hoping to book with an airline that flies direct from TRI to San Diego Intl. Airport (SAN), you won't have much luck. You'll have to make at least one stop to get to your destination.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

More to Explore