Cheap flights from ISP to SAN (MacArthur to San Diego Intl.)

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Cheap Flights from ISP to SAN starting at $204 One Way, $451 Round Trip

Prices starting at $451 for return flights and $204 for one-way flights to San Diego Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Jun 4 - Fri, Jun 5
ISP
Islip
SAN
San Diego
$451 Roundtrip, found 13 hours ago
$451
Roundtrip
found 13 hours ago
Select Southwest Airlines flight, departing Thu, Jun 4 from Islip to San Diego, returning Fri, Jun 5, priced at $451 found 13 hours ago
Thu, Jun 4 - Fri, Jun 5
ISP
Islip
SAN
San Diego
$461 Roundtrip, found 13 hours ago
$461
Roundtrip
found 13 hours ago
Select Southwest Airlines flight, departing Thu, Jun 4 from Islip to San Diego, returning Fri, Jun 5, priced at $461 found 13 hours ago
Mon, Aug 3 - Sun, Aug 9
ISP
Islip
SAN
San Diego
$467 Roundtrip, found 4 days ago
$467
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Mon, Aug 3 from Islip to San Diego, returning Sun, Aug 9, priced at $467 found 4 days ago
Sun, Aug 16 - Mon, Aug 24
ISP
Islip
SAN
San Diego
$480 Roundtrip, found 15 hours ago
$480
Roundtrip
found 15 hours ago
Select Southwest Airlines flight, departing Sun, Aug 16 from Islip to San Diego, returning Mon, Aug 24, priced at $480 found 15 hours ago
Sun, Aug 16 - Mon, Aug 24
ISP
Islip
SAN
San Diego
$485 Roundtrip, found 15 hours ago
$485
Roundtrip
found 15 hours ago
Select Southwest Airlines flight, departing Sun, Aug 16 from Islip to San Diego, returning Mon, Aug 24, priced at $485 found 15 hours ago

Hotel Ideas near San Diego Intl.

Airport Hotels near San Diego Intl.

Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
$163 nightly
The price is $188 total per night from Apr 1 to Apr 2
$188 total
Apr 1 - Apr 2
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (3,374 reviews)
Great rooms and staff

Reviewed on Mar 12, 2026

Sheraton San Diego Resort
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
$130 nightly
The price is $150 total per night from Apr 5 to Apr 6
$150 total
Apr 5 - Apr 6
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
9/10 Wonderful! (1,196 reviews)
We were assigned a room on the second floor that SMELLED like dirty feet. We sprayed it ourselves and couldn’t get rid of the stench. The room was dark and dreary. The window faced the parking lot and a set of stairs that led who know where. But day and night people would open the gate to the stairs ...

Reviewed on Mar 15, 2026

The DEXTRO Little Italy, BW Premier Collection
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Mar 19 to Mar 20
$211 total
Mar 19 - Mar 20
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,054 reviews)
Great location right in the heart of San Diego! Beautiful views. The front desk staff was very friendly and helpful.

Reviewed on Mar 14, 2026

Wyndham San Diego Bayside
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In San Diego

Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
$245 nightly
The price is $281 total per night from Apr 5 to Apr 6
$281 total
Apr 5 - Apr 6
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8.8/10 Excellent! (2,452 reviews)
The room was clean but mixed with some things new and other things old. Never had hot water for the shower however the shower was large. Our view was awesome loved watching all the sailboats, skiers, row boats, kayaks etc. We even seen a purpose. People with dogs let them poo without picking up not ...

Reviewed on Mar 12, 2026

Paradise Point Resort & Spa
Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
$73 nightly
The price is $84 total per night from Apr 1 to Apr 2
$84 total
Apr 1 - Apr 2
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ...
7.8/10 Good! (3,286 reviews)
When checking in on Thursday I asked for a late checkout on Saturday because I work Saturday morning and fly home that afternoon. Checkout was 11am. I get off work at 11am and work 10 minutes from this hotel. The person said to ask the morning of departure. Because I leave for work Saturday morning ...

Reviewed on Mar 14, 2026

Best Western Seven Seas
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
$237 nightly
The price is $274 total per night from Apr 5 to Apr 6
$274 total
Apr 5 - Apr 6
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
9/10 Wonderful! (3,417 reviews)
Perfect location for a fun time.

Reviewed on Mar 14, 2026

Hard Rock Hotel San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

San Diego Hotels With Airport Transportation

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Mar 19 to Mar 20
$211 total
Mar 19 - Mar 20
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,054 reviews)
Great location right in the heart of San Diego! Beautiful views. The front desk staff was very friendly and helpful.

Reviewed on Mar 14, 2026

Wyndham San Diego Bayside
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
$163 nightly
The price is $188 total per night from Apr 1 to Apr 2
$188 total
Apr 1 - Apr 2
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (3,374 reviews)
Great rooms and staff

Reviewed on Mar 12, 2026

Sheraton San Diego Resort
Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG

2.5 out of 5
1955 San Diego Ave San Diego CA
$136 nightly
The price is $156 total per night from Mar 22 to Mar 23
$156 total
Mar 22 - Mar 23
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and the ...
9.2/10 Wonderful! (1,062 reviews)
Great quick stay!

Reviewed on Mar 13, 2026

Holiday Inn Express San Diego Airport - Old Town by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced San Diego Hotels

Pleasant Inn

Pleasant Inn

2.5 out of 5
5550 Clairemont Mesa Blvd San Diego CA
$94 nightly
The price is $107 total per night from Mar 16 to Mar 17
$107 total
Mar 16 - Mar 17
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the convenient parking in our ...
8.4/10 Very Good! (1,339 reviews)
The staff were very helpful. The rooms were amazing the a/c worked well. The king sized beds were perfect for the price. This hotel was cost efficient for our quick 1 night trip. Will visit this hotel again! Rooms were clean. The only thing is the parking lot was not as big but reasonable.

Reviewed on Mar 15, 2026

Pleasant Inn
E-Z 8 Motel Old Town

E-Z 8 Motel Old Town

2.5 out of 5
4747 Pacific Highway San Diego CA
$70 nightly
The price is $81 total per night from Mar 16 to Mar 17
$81 total
Mar 16 - Mar 17
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free parking, WiFi (surcharge), and a 24-hour front desk. Our guests praise the helpful staff ...
6.6/10 (2,101 reviews)
Room is way to bright, sounds carries, staff woke us up at 7am because check in forgot to get a signature and NO wd could not fall back to sleep

Reviewed on Mar 10, 2026

E-Z 8 Motel Old Town
Kings Inn San Diego

Kings Inn San Diego

2.5 out of 5
1333 Hotel Cir S San Diego CA
$106 nightly
The price is $121 total per night from Apr 5 to Apr 6
$121 total
Apr 5 - Apr 6
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the breakfast and the pool in our reviews. Popular ...
8.8/10 Excellent! (3,637 reviews)
Clean room, smell good, clean beds. Clean outdoor pool. Everything was great. Need and elevators only

Reviewed on Mar 14, 2026

Kings Inn San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in San Diego

Bahia Resort Hotel

Bahia Resort Hotel

3.5 out of 5
998 W Mission Bay Dr San Diego CA
$215 nightly
The price is $248 total per night from Apr 15 to Apr 16
$248 total
Apr 15 - Apr 16
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy a beach locale, breakfast (surcharge), and 24-hour room service. Our guests praise the pool and the restaurant ...
8.6/10 Excellent! (1,915 reviews)
Good

Reviewed on Mar 15, 2026

Bahia Resort Hotel
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
$189 nightly
The price is $217 total per night from Apr 5 to Apr 6
$217 total
Apr 5 - Apr 6
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
9/10 Wonderful! (4,151 reviews)
The infinity pool is beautiful. We loved the pool and hot tub area. The staff are all very nice and helpful. Our room was nice and very clean. My only criticism is that the room is in need of a refurbish. The shower head was not great. Wish there was a handheld in shower would have been better. Our ...

Reviewed on Mar 14, 2026

The Dana on Mission Bay
Catamaran Resort and Spa

Catamaran Resort and Spa

4 out of 5
3999 Mission Boulevard San Diego CA
$309 nightly
The price is $356 total per night from Apr 13 to Apr 14
$356 total
Apr 13 - Apr 14
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, a full-service spa, and a beach locale. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (1,188 reviews)

Families like: Outdoor pool, game room, on the beach, bicycle rentals

Travelers say...
Before I comment on the property, I want to call out the staff. I was moving to the hotel from another property in La Jolla and hoped I could check in a little early. The day manager from Catamaran texted me at 8:30 am and asked when I was likely to arrive. I told them I planned to come early and ...

Reviewed on Mar 13, 2026

Catamaran Resort and Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

ISP to SAN Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
ISP Address & GPS
Address:
100 Arrivals Avenue
Islip NY, 11779
United States
IATA Code:
ISP
Longitude:
-73.097546
Latitude:
40.789314
Time Zone:
America/New_York
SAN Address & GPS
Address:
Airport Drive
San Diego CA, 92101
United States
IATA Code:
SAN
Longitude:
-117.197312
Latitude:
32.731938
Time Zone:
America/Los_Angeles

Frequently asked questions

Are there non-stop flights from ISP to San Diego Airport?
Traveling from MacArthur Airport to San Diego Intl. Airport (SAN) means you'll need to switch planes. But hey — there's no need to worry. Southwest Airlines, American Airlines and Breeze Airways offer flights with just one simple stopover.
What is the shortest flight from MacArthur Airport to San Diego Intl. Airport (SAN)?
Grab an in-flight wine or two and get cozy in your seat with an interesting book or movie. With the trip from Islip to San Diego taking 7 hours and 15 minutes, there's plenty of time to relax and enjoy the experience.
How many hours flight from MacArthur Airport (ISP) to SAN?
From ISP to SAN, you'll be cruising the skies for an average of 7 hours and 25 minutes. Sit back, grab a wine and take out your noise-canceling earphones. It's time for a movie marathon.
What airlines have the most flights from ISP to SAN?
You'll need to make one or more stopovers if you need to get from MacArthur Airport to San Diego Intl. Airport (SAN). For now, there aren't any airlines that advertise direct flights on this route.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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