Cheap flights from SYR to SDF (Hancock Intl. to Louisville Intl.)

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Cheap Flights from SYR to SDF starting at $269 One Way, $304 Round Trip

Prices starting at $304 for return flights and $269 for one-way flights to Louisville Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Hotel Ideas near Louisville Intl.

Airport Hotels near Louisville Intl.

Crowne Plaza Louisville Airport Expo Ctr by IHG

Crowne Plaza Louisville Airport Expo Ctr by IHG

3.5 out of 5
830 Phillips Lane Louisville KY
$82 nightly
The price is $97 total per night from Jul 2 to Jul 3
$97 total
Jul 2 - Jul 3
Total with taxes and fees
Book a stay at this business-friendly hotel in Louisville. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the restaurant and the ...
8.8/10 Excellent! (1,494 reviews)
"Nice room, clean and comfortable. Shower was good with amenities available. Only thing that would make it a 5 star is if it had a free breakfast."

Reviewed on Jun 3, 2026

Crowne Plaza Louisville Airport Expo Ctr by IHG
Tru by Hilton Louisville Airport

Tru by Hilton Louisville Airport

2.5 out of 5
810 Phillips Lane Louisville KY
$77 nightly
The price is $91 total per night from Jun 10 to Jun 11
$91 total
Jun 10 - Jun 11
Total with taxes and fees
Stay at this hotel in Louisville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
9/10 Wonderful! (1,015 reviews)
"Parking was not sufficient for the amount of guests. We, along with countless other guests, had to park in the neighboring hotel lots and walk over. First hotel I've heard of with only one entrance, at least that is what I was told at check in. Staff was nice, room was clean and nice, breakfast was...well, ..."

Reviewed on Jun 3, 2026

Tru by Hilton Louisville Airport
Studio 6 Suites Louisville, KY – Airport/Expo Center

Studio 6 Suites Louisville, KY – Airport/Expo Center

2 out of 5
571 Phillips Ln Louisville KY
$59 nightly
The price is $69 total per night from Jun 7 to Jun 8
$69 total
Jun 7 - Jun 8
Total with taxes and fees
Stay at this hotel in Louisville. Enjoy free parking, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean rooms in ...
7.4/10 Good! (654 reviews)
"Yes"

Reviewed on Jun 3, 2026

Studio 6 Suites Louisville, KY – Airport/Expo Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Louisville

Crowne Plaza Louisville Airport Expo Ctr by IHG

Crowne Plaza Louisville Airport Expo Ctr by IHG

3.5 out of 5
830 Phillips Lane Louisville KY
$82 nightly
The price is $97 total per night from Jul 2 to Jul 3
$97 total
Jul 2 - Jul 3
Total with taxes and fees
Book a stay at this business-friendly hotel in Louisville. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the restaurant and the ...
8.8/10 Excellent! (1,494 reviews)
"Nice room, clean and comfortable. Shower was good with amenities available. Only thing that would make it a 5 star is if it had a free breakfast."

Reviewed on Jun 3, 2026

Crowne Plaza Louisville Airport Expo Ctr by IHG
Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

4 out of 5
140 North Fourth Street Louisville KY
$117 nightly
The price is $138 total per night from Jun 30 to Jul 1
$138 total
Jun 30 - Jul 1
Total with taxes and fees
Book a stay at this spa hotel in Louisville. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the restaurant and the helpful staff ...
9/10 Wonderful! (4,166 reviews)
"Super clean, awesome facility with very cool restaurants/bars, convenient to downtown and traveling."

Reviewed on Jun 3, 2026

Galt House Hotel Trademark Collection by Wyndham
Radisson Hotel Louisville North

Radisson Hotel Louisville North

3 out of 5
505 Marriott Drive Clarksville IN
$54 nightly
The price is $61 total per night from Jun 10 to Jun 11
$61 total
Jun 10 - Jun 11
Total with taxes and fees
Book a stay at this business-friendly hotel in Clarksville. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the clean rooms in our reviews. ...
7/10 Good! (3,122 reviews)
"I have a very hard time everytime I stay here either getting more towels, getting my room cleaned or even getting my trash picked up if I sit it outside my room. I have stayed here 5 weeks Jan row because I am a travel nurse waiting for my Vrbo to be available but it seems like the longer I stayed, ..."

Reviewed on Jun 3, 2026

Radisson Hotel Louisville North
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Louisville Hotels With Airport Transportation

The Brown Hotel

The Brown Hotel

4.5 out of 5
335 W Broadway Louisville KY
$163 nightly
The price is $192 total per night from Jun 28 to Jun 29
$192 total
Jun 28 - Jun 29
Total with taxes and fees
Book a stay at this luxury hotel in Louisville. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff and the ...
9.4/10 Exceptional! (1,240 reviews)
"Our room was comfortable. The only thing to me that lacked was that the TV was too small. It had a nice shower and comfortable bed. I did love the historic atmosphere of the hotel—almost like stepping back in time! It was also convenient to several nice restaurants. Great breakfast we had at the ..."

Reviewed on Jun 3, 2026

The Brown Hotel
Holiday Inn Express Louisville Airport Expo Center by IHG

Holiday Inn Express Louisville Airport Expo Center by IHG

2.5 out of 5
1921 Bishop Ln Louisville KY
$86 nightly
The price is $102 total per night from Jun 8 to Jun 9
$102 total
Jun 8 - Jun 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Louisville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,002 reviews)
"I enjoyed my stay."

Reviewed on Jun 2, 2026

Holiday Inn Express Louisville Airport Expo Center by IHG
Fairfield Inn & Suites by Marriott Louisville Airport

Fairfield Inn & Suites by Marriott Louisville Airport

3 out of 5
653 Phillips Lane Louisville KY
$93 nightly
The price is $110 total per night from Jun 6 to Jun 7
$110 total
Jun 6 - Jun 7
Total with taxes and fees
Book a stay at this business-friendly hotel in Louisville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (727 reviews)
"It was nice and very friendly staff. We enjoyed our stay."

Reviewed on Jun 2, 2026

Fairfield Inn & Suites by Marriott Louisville Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Louisville Hotels

Econo Lodge Louisville Downtown

Econo Lodge Louisville Downtown

2 out of 5
401 S 2nd St Louisville KY
$62 nightly
The price is $73 total per night from Jul 1 to Jul 2
$73 total
Jul 1 - Jul 2
Total with taxes and fees
Book a stay at this business-friendly motel in Louisville. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the ...
7.2/10 Good! (1,008 reviews)
"Good stay and location. Easy access to my destinations."

Reviewed on May 28, 2026

Econo Lodge Louisville Downtown
Red Roof Inn Louisville Fair and Expo

Red Roof Inn Louisville Fair and Expo

2 out of 5
3322 Red Roof Inn Pl Louisville KY
$60 nightly
The price is $70 total per night from Jun 10 to Jun 11
$70 total
Jun 10 - Jun 11
Total with taxes and fees
Stay at this hotel in Louisville. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.6/10 Good! (1,003 reviews)
"This is a newly remodeled Red Roof Inn. We were pleasantly surprised as to how nice it was. It also has an elevator which a lot of the Red Roof Inns don't."

Reviewed on Jun 1, 2026

Red Roof Inn Louisville Fair and Expo
Super 8 by Wyndham Louisville Airport

Super 8 by Wyndham Louisville Airport

2.5 out of 5
4800 Preston Hwy Louisville KY
$60 nightly
The price is $71 total per night from Jun 7 to Jun 8
$71 total
Jun 7 - Jun 8
Total with taxes and fees
Book a stay at this business-friendly motel in Louisville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
4.8/10 (1,000 reviews)
"The staff was very friendly and helpful. The entrance/ramp was awful and very difficult getting the luggage cart in and through the doorway. Open butter dish in the breakfast area with a shared butter knife was unacceptable. Sometimes a shared bottle of jam was there also. The building is in need ..."

Reviewed on May 11, 2026

Super 8 by Wyndham Louisville Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Louisville

Drury Inn & Suites Louisville North

Drury Inn & Suites Louisville North

3 out of 5
9597 Brownsboro Road Louisville KY
$100 nightly
The price is $118 total per night from Jun 21 to Jun 22
$118 total
Jun 21 - Jun 22
Total with taxes and fees
Book a stay at this business-friendly hotel in Louisville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,000 reviews)
"The staff was consistently kind and helpful, the room was spacious, comfortable, and well appointed, and the breakfast was outstanding!"

Reviewed on Jun 1, 2026

Drury Inn & Suites Louisville North
Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

4 out of 5
140 North Fourth Street Louisville KY
$117 nightly
The price is $138 total per night from Jun 30 to Jul 1
$138 total
Jun 30 - Jul 1
Total with taxes and fees
Book a stay at this spa hotel in Louisville. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the restaurant and the helpful staff ...
9/10 Wonderful! (4,166 reviews)
"Super clean, awesome facility with very cool restaurants/bars, convenient to downtown and traveling."

Reviewed on Jun 3, 2026

Galt House Hotel Trademark Collection by Wyndham
Country Inn & Suites by Radisson, Louisville South, KY

Country Inn & Suites by Radisson, Louisville South, KY

2 out of 5
400 Paroquet Springs Drive Shepherdsville KY
$98 nightly
The price is $109 total per night from Jun 30 to Jul 1
$109 total
Jun 30 - Jul 1
Total with taxes and fees
Book a stay at this business-friendly hotel in Shepherdsville. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff ...
7.8/10 Good! (1,004 reviews)
"I was SO upset to find that even though I had reserved an ADA room, they did not give us one. Insult to injury - they put us at the very end of the hall & my husband cannot walk very far. He was not able to shower the next morning without the walk-in shower... When you reserve an accessible room ..."

Reviewed on Jun 1, 2026

Country Inn & Suites by Radisson, Louisville South, KY
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

SYR to SDF Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date

Frequently asked questions

Are there non-stop flights from Hancock Intl. Airport (SYR) to Louisville Intl. Airport (SDF)?
While you can't fly nonstop from SYR to Louisville Intl. Airport (SDF), there are a number of carriers that operate on this route with only one stopover. Why not find out if the dates and times available with American Airlines or Delta Air Lines fit with your travel plans? If not, there's always United Airlines.
What is the shortest flight from Hancock Intl. Airport (SYR) to SDF?
Grab an in-flight wine or two and get comfortable in your seat with a fascinating movie or book. With the journey from SYR to Louisville Muhammad Ali Intl. Airport taking 4 hours and 14 minutes, you'll have enough time to relax and enjoy the experience.
How many hours flight from SYR to Louisville Muhammad Ali Intl. Airport?
It usually takes about 4 hours and 21 minutes to go from SYR to SDF. Breeze through this medium-haul journey by watching a few movies and getting stuck into a good book. Alternatively, why not catch up on some sleep?
What airlines have the most flights from SYR to Louisville Muhammad Ali Intl. Airport?
If you're hoping to find an airline that operates direct flights from SYR to Louisville Muhammad Ali Intl. Airport, you won't have much luck. You'll need to make at least one stop to get to your destination.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.