Cheap flights from DSM to SAN (Des Moines Intl. to San Diego Intl.)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

Cheap Flights from DSM to SAN starting at $122 One Way, $228 Round Trip

Prices starting at $228 for return flights and $122 for one-way flights to San Diego Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Oct 15 - Wed, Oct 22
DSM
Des Moines
SAN
San Diego
$228 Roundtrip, found 2 days ago
$228
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Wed, Oct 15 from Des Moines to San Diego, returning Wed, Oct 22, priced at $228 found 2 days ago
Sun, Sep 28 - Wed, Oct 15
DSM
Des Moines
SAN
San Diego
$238 Roundtrip, found 1 day ago
$238
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sun, Sep 28 from Des Moines to San Diego, returning Wed, Oct 15, priced at $238 found 1 day ago
Thu, Aug 21 - Sat, Aug 30
DSM
Des Moines
SAN
San Diego
$242 Roundtrip, found 1 day ago
$242
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Aug 21 from Des Moines to San Diego, returning Sat, Aug 30, priced at $242 found 1 day ago
Fri, Aug 8 - Sat, Aug 23
DSM
Des Moines
SAN
San Diego
$243 Roundtrip, found 1 day ago
$243
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Fri, Aug 8 from Des Moines to San Diego, returning Sat, Aug 23, priced at $243 found 1 day ago
Wed, Nov 5 - Sat, Nov 8
DSM
Des Moines
SAN
San Diego
$287 Roundtrip, found 6 days ago
$287
Roundtrip
found 6 days ago
Select United flight, departing Wed, Nov 5 from Des Moines to San Diego, returning Sat, Nov 8, priced at $287 found 6 days ago

Hotel Ideas near San Diego Intl.

Airport Hotels near San Diego Intl.

Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr, San Diego, CA
$175 nightly
The price is $201 total per night from Aug 24 to Aug 25
$201 total
Aug 24 - Aug 25
Total includes taxes and fees
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8/10 Very Good! (2,869 reviews)
"Everyone was perfect"

Reviewed on Jul 26, 2025

Sheraton San Diego Resort
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
$177 nightly
The price is $205 total per night from Aug 3 to Aug 4
$205 total
Aug 3 - Aug 4
Total includes taxes and fees
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,756 reviews)
"I liked the accessibility of the gym and the location of the hotel"

Reviewed on Jul 29, 2025

Wyndham San Diego Bayside
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
$111 nightly
The price is $128 total per night from Aug 10 to Aug 11
$128 total
Aug 10 - Aug 11
Total includes taxes and fees
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the bar in our ...
8/10 Very Good! (1,919 reviews)
Exceptional Staff / Front Desk Experience
"This hotel experience was exceptional because of the staff (thanks Pamela!) and care they took to ensure our stay was the best possible. I was there for Comic-Con and through the chaos we had a shuttle that ran every 15-20 minutes, a room with comfortable pillows and a view of the pool, reasonable ..."

Reviewed on Jul 27, 2025

Handlery Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In San Diego

Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
$111 nightly
The price is $128 total per night from Aug 10 to Aug 11
$128 total
Aug 10 - Aug 11
Total includes taxes and fees
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the bar in our ...
8/10 Very Good! (1,919 reviews)
Exceptional Staff / Front Desk Experience
"This hotel experience was exceptional because of the staff (thanks Pamela!) and care they took to ensure our stay was the best possible. I was there for Comic-Con and through the chaos we had a shuttle that ran every 15-20 minutes, a room with comfortable pillows and a view of the pool, reasonable ..."

Reviewed on Jul 27, 2025

Handlery Hotel
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
$246 nightly
The price is $285 total per night from Aug 29 to Aug 30
$285 total
Aug 29 - Aug 30
Total includes taxes and fees
Stay at this 4-star eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
9/10 Wonderful! (2,807 reviews)
Would Stay Again
"Pleased with the overall stay. Close to the convention center. Staff were very friendly and helpful. My only critique would be the hand washing sink in our bathroom took forever to drain. Not sure it was a plumbing issue or a disign flaw seeing as how the sink looks flat. Other than that I would ..."

Reviewed on Jul 28, 2025

Manchester Grand Hyatt San Diego
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
$177 nightly
The price is $205 total per night from Aug 3 to Aug 4
$205 total
Aug 3 - Aug 4
Total includes taxes and fees
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,756 reviews)
"I liked the accessibility of the gym and the location of the hotel"

Reviewed on Jul 29, 2025

Wyndham San Diego Bayside
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

San Diego Hotels With Airport Transportation

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
$177 nightly
The price is $205 total per night from Aug 3 to Aug 4
$205 total
Aug 3 - Aug 4
Total includes taxes and fees
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,756 reviews)
"I liked the accessibility of the gym and the location of the hotel"

Reviewed on Jul 29, 2025

Wyndham San Diego Bayside
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr, San Diego, CA
$175 nightly
The price is $201 total per night from Aug 24 to Aug 25
$201 total
Aug 24 - Aug 25
Total includes taxes and fees
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8/10 Very Good! (2,869 reviews)
"Everyone was perfect"

Reviewed on Jul 26, 2025

Sheraton San Diego Resort
Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG

2.5 out of 5
1955 San Diego Ave, San Diego, CA
$153 nightly
The price is $176 total per night from Aug 10 to Aug 11
$176 total
Aug 10 - Aug 11
Total includes taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and the ...
8.8/10 Excellent! (1,008 reviews)
"This is a very well kept, clean and quiet Holiday Inn express. When I return to San Diego, this will be my primary choice to stay."

Reviewed on Jul 24, 2025

Holiday Inn Express San Diego Airport - Old Town by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced San Diego Hotels

Pleasant Inn

Pleasant Inn

2.5 out of 5
5550 Clairemont Mesa Blvd, San Diego, CA
$94 nightly
The price is $107 total per night from Aug 25 to Aug 26
$107 total
Aug 25 - Aug 26
Total includes taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the convenient parking in our ...
8.4/10 Very Good! (1,090 reviews)
"Rooms clean and quiet. Staff was wonderfully helpful, courteous and kind. I would stay here again for sure!"

Reviewed on Jul 24, 2025

Pleasant Inn
E-Z 8 Motel Old Town

E-Z 8 Motel Old Town

2.5 out of 5
4747 Pacific Highway, San Diego, CA
$67 nightly
The price is $77 total per night from Jul 31 to Aug 1
$77 total
Jul 31 - Aug 1
Total includes taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free parking, WiFi (surcharge), and a 24-hour front desk. Our guests praise the helpful staff ...
6.2/10 (2,143 reviews)
"Good stay"

Reviewed on Jul 26, 2025

E-Z 8 Motel Old Town
Kings Inn San Diego

Kings Inn San Diego

2.5 out of 5
1333 Hotel Cir S, San Diego, CA
$97 nightly
The price is $111 total per night from Aug 5 to Aug 6
$111 total
Aug 5 - Aug 6
Total includes taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the breakfast and the pool in our reviews. Popular ...
8.6/10 Excellent! (3,361 reviews)
"A group of us stayed at the Kings Inn for a wedding. The rooms were comfortable and always freshly cleaned each day. After each days' activities, it was nice to sit in the hot tub and soak and the pool is really clean. Very easy access both leaving and coming back on I-8 and from there to 5, 805, ..."

Reviewed on Jul 29, 2025

Kings Inn San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in San Diego

Bahia Resort Hotel

Bahia Resort Hotel

3.5 out of 5
998 W Mission Bay Dr, San Diego, CA
$215 nightly
The price is $248 total per night from Aug 28 to Aug 29
$248 total
Aug 28 - Aug 29
Total includes taxes and fees
Stay at this 3.5-star beach resort in San Diego. Enjoy a beach locale, breakfast (surcharge), and 24-hour room service. Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (1,640 reviews)
"Nice place to stay, very family oriented when it comes to activities, overall a good location, only a 15 minute walk to mission beach and all that comes along with it!"

Reviewed on Jul 28, 2025

Bahia Resort Hotel
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
$166 nightly
The price is $190 total per night from Aug 25 to Aug 26
$190 total
Aug 25 - Aug 26
Total includes taxes and fees
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in ...
8.8/10 Excellent! (3,617 reviews)
"Heated pool. Have their own kayak, jet ski and boat rentals on site"

Reviewed on Jul 30, 2025

The Dana on Mission Bay
Catamaran Resort and Spa

Catamaran Resort and Spa

4 out of 5
3999 Mission Boulevard, San Diego, CA
$251 nightly
The price is $288 total per night from Aug 17 to Aug 18
$288 total
Aug 17 - Aug 18
Total includes taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, a full-service spa, and a beach locale. Our guests praise the helpful staff and the clean rooms ...
8.2/10 Very Good! (1,008 reviews)

Families like: Outdoor pool, game room, on the beach, bicycle rentals

Travelers say...
"Loved being close to the beach in an area with good vibes all around. Our family really enjoyed the pool, hot tub and family game night. Stayed for a week and have nothing but positive things to say about this resort!"

Reviewed on Jul 30, 2025

Catamaran Resort and Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

DSM to SAN Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
DSM Address & GPS
Address:
5800 Fleur Drive, Suite 201
Des Moines IA, 50321-2854
United States
IATA Code:
DSM
Longitude:
-93.648087
Latitude:
41.532434
Time Zone:
America/Chicago
SAN Address & GPS
Address:
Airport Drive
San Diego CA, 92101
United States
IATA Code:
SAN
Longitude:
-117.197312
Latitude:
32.731938
Time Zone:
America/Los_Angeles

Frequently asked questions

Are there non-stop flights from DSM to San Diego Intl. Airport (SAN)?
You'll have to switch planes if you want to get from Des Moines Intl. Airport (DSM) to SAN. A number of companies service this route with just one stopover, including American Airlines, Southwest Airlines and United Airlines.
What is the shortest flight from Des Moines Intl. Airport (DSM) to San Diego Intl. Airport (SAN)?
Grab a glass of vino and get comfortable in your seat with a riveting movie or novel. With the journey from Des Moines to San Diego taking 5 hours and 50 minutes, there's plenty of time to enjoy the flying experience.
How many hours flight from DSM to San Diego Intl. Airport (SAN)?
On a normal day, the trip from DSM to San Diego Intl. Airport (SAN) takes 5 hours and 57 minutes. If you're eager to be as comfortable as possible, contemplate upgrading your seat using miles or cash.
What airlines have the most flights from DSM to San Diego Intl. Airport (SAN)?
Currently, no airlines fly direct between Des Moines Intl. Airport (DSM) and San Diego Airport. But never fear. There are loads of single or multi-stop flights available.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.