Cheap flights from DSM to SAN (Des Moines Intl. to San Diego Intl.)

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Cheap Flights from DSM to SAN starting at $134 One Way, $264 Round Trip

Prices starting at $264 for return flights and $134 for one-way flights to San Diego Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Jun 24 - Wed, Jul 1
DSM
Des Moines
SAN
San Diego
$264 Roundtrip, found 4 days ago
$264
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Wed, Jun 24 from Des Moines to San Diego, returning Wed, Jul 1, priced at $264 found 4 days ago
Wed, Aug 12 - Wed, Aug 19
DSM
Des Moines
SAN
San Diego
$270 Roundtrip, found 2 days ago
$270
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Wed, Aug 12 from Des Moines to San Diego, returning Wed, Aug 19, priced at $270 found 2 days ago
Wed, Jul 8 - Mon, Jul 13
DSM
Des Moines
SAN
San Diego
$275 Roundtrip, found 3 days ago
$275
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Wed, Jul 8 from Des Moines to San Diego, returning Mon, Jul 13, priced at $275 found 3 days ago
Wed, Jun 17 - Wed, Jun 24
DSM
Des Moines
SAN
San Diego
$276 Roundtrip, found 4 days ago
$276
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Wed, Jun 17 from Des Moines to San Diego, returning Wed, Jun 24, priced at $276 found 4 days ago
Thu, Sep 24 - Wed, Sep 30
DSM
Des Moines
SAN
San Diego
$289 Roundtrip, found 2 hours ago
$289
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Thu, Sep 24 from Des Moines to San Diego, returning Wed, Sep 30, priced at $289 found 2 hours ago

Hotel Ideas near San Diego Intl.

Airport Hotels near San Diego Intl.

Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
The price is $245 total per night from Jun 28 to Jun 29
$245 total
per night
Jun 28 - Jun 29
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (3,554 reviews)
"The welcoming staff were amazing. We're senior citizens, using canes to walk around. Both upon arrival, departure there were a number of staff that helped us out of the car, unloaded/loaded our luggage. When we left the property for tours, the same cheerful staff helped us to our Uber cars in both ..."

Reviewed on May 29, 2026

Sheraton San Diego Resort
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
The price is $211 total per night from Jun 1 to Jun 2
$211 total
per night
Jun 1 - Jun 2
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,179 reviews)
"Only good thing is the hotel is near the Bay."

Reviewed on May 30, 2026

Wyndham San Diego Bayside
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
150 W Broadway San Diego CA
The price is $223 total per night from Jun 29 to Jun 30
$223 total
per night
Jun 29 - Jun 30
Book a stay at this historic hotel in San Diego. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (2,137 reviews)
"It was a cool hotel, lots of history"

Reviewed on May 30, 2026

The Sofia Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In San Diego

The Sofia Hotel

The Sofia Hotel

3.5 out of 5
150 W Broadway San Diego CA
The price is $223 total per night from Jun 29 to Jun 30
$223 total
per night
Jun 29 - Jun 30
Book a stay at this historic hotel in San Diego. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (2,137 reviews)
"It was a cool hotel, lots of history"

Reviewed on May 30, 2026

The Sofia Hotel
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
The price is $320 total per night from Jun 5 to Jun 6
$320 total
per night
Jun 5 - Jun 6
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the helpful staff ...
9/10 Wonderful! (2,826 reviews)
"Stayed in a newly renovated room and it was great!"

Reviewed on May 29, 2026

Manchester Grand Hyatt San Diego
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
The price is $246 total per night from Jun 7 to Jun 8
$246 total
per night
Jun 7 - Jun 8
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
9/10 Wonderful! (3,749 reviews)
"Good place"

Reviewed on May 29, 2026

Hard Rock Hotel San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

San Diego Hotels With Airport Transportation

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
The price is $211 total per night from Jun 1 to Jun 2
$211 total
per night
Jun 1 - Jun 2
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,179 reviews)
"Only good thing is the hotel is near the Bay."

Reviewed on May 30, 2026

Wyndham San Diego Bayside
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
The price is $245 total per night from Jun 28 to Jun 29
$245 total
per night
Jun 28 - Jun 29
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (3,554 reviews)
"The welcoming staff were amazing. We're senior citizens, using canes to walk around. Both upon arrival, departure there were a number of staff that helped us out of the car, unloaded/loaded our luggage. When we left the property for tours, the same cheerful staff helped us to our Uber cars in both ..."

Reviewed on May 29, 2026

Sheraton San Diego Resort
Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG

2.5 out of 5
1955 San Diego Ave San Diego CA
The price is $166 total per night from Jun 7 to Jun 8
$166 total
per night
Jun 7 - Jun 8
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and the ...
9.2/10 Wonderful! (1,063 reviews)
"Charger for electric cars was free! Huge advantage for us. Staff was so helpful and they have a shuttle to Old Town. Only downside was being so close to the freeway we could hear all night. Had to download a fan app to drown out the noise."

Reviewed on May 28, 2026

Holiday Inn Express San Diego Airport - Old Town by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced San Diego Hotels

Pleasant Inn

Pleasant Inn

2.5 out of 5
5550 Clairemont Mesa Blvd San Diego CA
The price is $117 total per night from Jun 1 to Jun 2
$117 total
per night
Jun 1 - Jun 2
Stay at this hotel in San Diego. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the convenient parking in our ...
8.6/10 Excellent! (1,417 reviews)
"Affordable stay in San Diego area."

Reviewed on May 29, 2026

Pleasant Inn
E-Z 8 Motel Old Town

E-Z 8 Motel Old Town

2.5 out of 5
4747 Pacific Highway San Diego CA
The price is $97 total per night from May 31 to Jun 1
$97 total
per night
May 31 - Jun 1
Book a stay at this business-friendly hotel in San Diego. Enjoy free parking, WiFi (surcharge), and a 24-hour front desk. Our guests praise the helpful staff ...
6.6/10 (2,125 reviews)
"I highly recommend that you DO NOT book a stay at Easy 8 Motel. If you are considering staying here, spend the extra money and book somewhere safer, cleaner, and more professional. For Memorial Day weekend,I booked a room through Expedia. Shortly after booking, I was told my reservation had been ..."

Reviewed on May 29, 2026

E-Z 8 Motel Old Town
Kings Inn San Diego

Kings Inn San Diego

2.5 out of 5
1333 Hotel Cir S San Diego CA
The price is $106 total per night from Jun 1 to Jun 2
$106 total
per night
Jun 1 - Jun 2
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the breakfast and the pool in our reviews. Popular ...
8.8/10 Excellent! (3,717 reviews)
"Clean room. Great staff."

Reviewed on May 29, 2026

Kings Inn San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in San Diego

Bahia Resort Hotel

Bahia Resort Hotel

3.5 out of 5
998 W Mission Bay Dr San Diego CA
The price is $287 total per night from Jun 7 to Jun 8
$287 total
per night
Jun 7 - Jun 8
Book a stay at this beach resort in San Diego. Enjoy a beach locale, breakfast (surcharge), and 24-hour room service. Our guests praise the pool and the restaurant ...
8.8/10 Excellent! (2,103 reviews)
"We were in the back of the resort that backs up to Gleason Road. There were many people living in their cars on that side of the bay. We had no issues but I think it's important to let quests know that there is homeless people living that close to the resort. Especially for the price we are paying ..."

Reviewed on May 30, 2026

Bahia Resort Hotel
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
The price is $246 total per night from May 31 to Jun 1
$246 total
per night
May 31 - Jun 1
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
9/10 Wonderful! (4,364 reviews)
"Our room was right next to the staff supply room (many rooms are near these supply rooms) which means we heard banging, doors slamming, power washers and other loud machinery throughout the day. The adjoining wall with the staff supply room had loud banging audible until 11pm. My husband works from ..."

Reviewed on May 30, 2026

The Dana on Mission Bay
Catamaran Resort and Spa

Catamaran Resort and Spa

4 out of 5
3999 Mission Boulevard San Diego CA
The price is $282 total per night from May 31 to Jun 1
$282 total
per night
May 31 - Jun 1
Book a stay at this beach resort in San Diego. Enjoy free WiFi, a full-service spa, and a beach locale. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (1,260 reviews)

Families like: Outdoor pool, game room, on the beach, bicycle rentals

Travelers say...
"Great location, super nice staff and perfect room"

Reviewed on May 26, 2026

Catamaran Resort and Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

DSM to SAN Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
DSM Address & GPS
Address:
5800 Fleur Drive, Suite 201
Des Moines IA, 50321-2854
United States
IATA Code:
DSM
Longitude:
-93.648087
Latitude:
41.532434
Time Zone:
America/Chicago
SAN Address & GPS
Address:
Airport Drive
San Diego CA, 92101
United States
IATA Code:
SAN
Longitude:
-117.197312
Latitude:
32.731938
Time Zone:
America/Los_Angeles

Frequently asked questions

Are there non-stop flights from DSM to San Diego Intl. Airport (SAN)?
You'll have to switch planes if you want to get from Des Moines Intl. Airport (DSM) to SAN. A number of companies service this route with just one stopover, including American Airlines, Southwest Airlines and United Airlines.
What is the shortest flight from Des Moines Intl. Airport (DSM) to San Diego Intl. Airport (SAN)?
Grab a glass of vino and get comfortable in your seat with a riveting movie or novel. With the journey from Des Moines to San Diego taking 5 hours and 50 minutes, there's plenty of time to enjoy the flying experience.
How many hours flight from DSM to San Diego Intl. Airport (SAN)?
On a normal day, the trip from DSM to San Diego Intl. Airport (SAN) takes 5 hours and 57 minutes. If you're eager to be as comfortable as possible, contemplate upgrading your seat using miles or cash.
What airlines have the most flights from DSM to San Diego Intl. Airport (SAN)?
Currently, no airlines fly direct between Des Moines Intl. Airport (DSM) and San Diego Airport. But never fear. There are loads of single or multi-stop flights available.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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