Book 5 Star Hotels in South Main

Start date: Check-in selected.
To Date
End date: Check-out

Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels

Save 10% or more on select hotels with Insider Prices

Book on the app to instantly earn 5% on 350,000+ hotels

Sep 29 - Sep 30
Tonight
Check prices in South Main for tonight, Sep 29 - Sep 30
Sep 30 - Oct 1
Tomorrow night
Check prices in South Main for tomorrow night, Sep 30 - Oct 1

Featured South Main 5 Stars Hotels

Blossom Hotel Houston

Blossom Hotel Houston

4 out of 5
7118 Bertner Ave, Houston, TX
Free Cancellation
Reserve now, pay when you stay
2.15 mi from South Main
$189 nightly
The price is $221 total per night
$221 total
Oct 2 - Oct 3
Total with taxes and fees
Blossom Hotel Houston features a full-service spa, an outdoor pool, and a 24-hour gym. Valet parking is available for USD 49 per night, and there's also limo/town car service. The 24-hour front desk has multilingual staff ready to assist with luggage storage and dry cleaning/laundry. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Other amenities at this spa hotel include a rooftop terrace, free WiFi in public areas, and meeting rooms.
Pool
Spa
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St, Houston, TX
Free Cancellation
Reserve now, pay when you stay
2.74 mi from South Main
$100 nightly
The price is $117 total per night
$117 total
Oct 5 - Oct 6
Total with taxes and fees
Guests staying at Hilton Houston Plaza/Medical Center enjoy an outdoor pool, a 24-hour gym, and free WiFi in public areas. Self parking is available for USD 20 per night. Multilingual staff at the front desk are standing by 24/7 to help with securing valuables, concierge services, and dry cleaning/laundry. Other amenities at this luxury hotel include meeting rooms, conference space, and a 24-hour business center.
Pool
Free WiFi
DoubleTree by Hilton Hotel Houston - Greenway Plaza

DoubleTree by Hilton Hotel Houston - Greenway Plaza

4 out of 5
Free Cancellation
Reserve now, pay when you stay
4.08 mi from South Main
$108 nightly
The price is $127 total per night
$127 total
Oct 19 - Oct 20
Total with taxes and fees
Guests staying at DoubleTree by Hilton Hotel Houston - Greenway Plaza enjoy an outdoor pool, a 24-hour gym, and free WiFi in public areas. Parking is available for USD 30 per day (USD 40 per day for valet parking), and there's also a free area shuttle. Front-desk staff can answer questions 24/7, and assist with securing valuables, dry cleaning/laundry, and concierge services. Additional amenities include meeting rooms, conference space, and express check-in.
Pool
Free WiFi
Hyatt Place Houston/Galleria

Hyatt Place Houston/Galleria

3 out of 5
5252 W. Alabama, Houston, TX
Free Cancellation
Reserve now, pay when you stay
5.39 mi from South Main
$108 nightly
The price is $126 total per night
$126 total
Sep 30 - Oct 1
Total with taxes and fees
Guests staying at Hyatt Place Houston/Galleria enjoy an outdoor pool, a gym, and free WiFi in public areas. Valet parking is offered for USD 33.00 per day. Front-desk staff can answer questions 24/7, and assist with dry cleaning/laundry, luggage storage, and securing valuables. Additional amenities include a business center, express check-out, and laundry facilities.
Pool
Breakfast included
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
5353 Westheimer Rd, Houston, TX
Free Cancellation
Reserve now, pay when you stay
5.5 mi from South Main
$150 nightly
The price is $175 total per night
$175 total
Oct 10 - Oct 11
Total with taxes and fees
At DoubleTree by Hilton Hotel & Suites Houston by the Galleria, guests enjoy features like an outdoor pool, a 24-hour gym, and WiFi in public areas. Parking is available for USD 32 per night (USD 46.00 per night for valet parking), and there's also a free area shuttle. The 24-hour front desk has multilingual staff ready to assist with luggage storage and dry cleaning/laundry. Additional amenities include conference space, a business center, and a seasonal outdoor pool.
Pool
Pet friendly
The Whitehall Houston

The Whitehall Houston

4 out of 5
1700 Smith St, Houston, TX
Free Cancellation
Reserve now, pay when you stay
6.2 mi from South Main
$143 nightly
The price is $167 total per night
$167 total
Oct 12 - Oct 13
Total with taxes and fees
At The Whitehall Houston, guests enjoy features like an outdoor pool, a 24-hour gym, and free WiFi in public areas. Valet parking is available for USD 45 per night, and there's also limo/town car service. The front desk has multilingual staff on hand 24/7 to help with concierge services, dry cleaning/laundry, and securing valuables. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Additional amenities include meeting rooms, a conference center, and a 24-hour business center.
Pool
Pet friendly
Hilton Americas-Houston

Hilton Americas-Houston

4 out of 5
1600 Lamar Street, Houston, TX
6.45 mi from South Main
$201 nightly
The price is $235 total per night
$235 total
Oct 24 - Oct 25
Total with taxes and fees
Hilton Americas-Houston features a full-service spa, an indoor pool, and a 24-hour gym. Valet parking is available for USD 65 per night. Multilingual staff at the front desk are standing by 24/7 to help with securing valuables, luggage storage, and dry cleaning/laundry. Other amenities at this spa hotel include a rooftop terrace, WiFi in public areas, and a hot tub.
Pool
Hot Tub
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4 out of 5
1085 Rusk Street, Houston, TX
Free Cancellation
Reserve now, pay when you stay
6.76 mi from South Main
$105 nightly
The price is $123 total per night
$123 total
Oct 2 - Oct 3
Total with taxes and fees
At Club Quarters Hotel Downtown, Houston, guests have access to a 24-hour gym, free WiFi in public areas, and meeting rooms. Valet parking is offered for USD 34 per day. Multilingual staff at the 24-hour front desk can assist with dry cleaning/laundry, securing valuables, and concierge services. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Additional amenities include a 24-hour business center, coffee/tea in a common area, and a computer station.
Pet friendly
Free WiFi
Magnolia Hotel Houston, A Tribute Portfolio Hotel

Magnolia Hotel Houston, A Tribute Portfolio Hotel

4 out of 5
1100 Texas St, Houston, TX
Free Cancellation
Reserve now, pay when you stay
6.87 mi from South Main
$149 nightly
The price is $174 total per night
$174 total
Oct 2 - Oct 3
Total with taxes and fees
Guests of Magnolia Hotel Houston, A Tribute Portfolio Hotel have access to an outdoor pool, a 24-hour gym, and a rooftop terrace. Valet parking is available for USD 54 per night, and there's also a free area shuttle. The front desk is staffed 24/7 to help with securing valuables, luggage storage, and dry cleaning/laundry. Additional amenities include free WiFi in public areas, a conference center, and a 24-hour business center.
Pool
Pet friendly
Don't see what you're looking for?
See all available properties in South Main
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Best 5 star hotels in South Main

Guarantee yourself a relaxing time when you book the best of the best: 5 star hotels in South Main. After all, treating yourself to the finer things is what vacations are about. 

What are the criteria for a 5 star hotel?
5 star hotel requirements include distinctive services and amenities that surpass all others. These South Main hotels bring an incomparable degree of quality and attention to detail, with guest satisfaction being top priority. Your 5 star hotel should be dressed to impress, with design details like marble surfaces and hi-tech fixtures.

What amenities can I expect at a 5 star hotel?
South Main 5 star hotels and resorts typically offer luxury amenities such as:

  • Gourmet restaurant
  • Full-service fitness center with pool
  • Luxury spa 
  • Welcome gifts upon arrival
  • Top-of-the-line beds and linens 
  • Designer personal care products
  • Premium cable, free Wi-Fi and device docking stations

How do I find an amazing 5 star hotel?
Finding 5 star hotel deals in South Main with Orbitz is as easy as your stay will be. For the top-shelf vacation you deserve, we’ll help you choose the right hotel in the right place: 

  • Search hotels by price, ranging from $117 to $235
  • Find the best-loved hotels through word-of-mouth advice when you check out over reviews by Orbitz travelers
  • Choose from 6,577 5 star hotels in South Main!

South Main hotels essential information

Accommodation
6,577 hotels
Lowest Price
$117
Highest Price
$235
Popular hotels
DoubleTree by Hilton Hotel & Suites Houston by the Galleria, Club Quarters Hotel Downtown, Houston, The Whitehall Houston, Hilton Houston Plaza/Medical Center, DoubleTree by Hilton Hotel Houston - Greenway Plaza, Blossom Hotel Houston, Magnolia Hotel Houston, A Tribute Portfolio Hotel, Hilton Americas-Houston, Hyatt Place Houston/Galleria

Recent Reviews

DoubleTree by Hilton Hotel Houston - Greenway Plaza

DoubleTree by Hilton Hotel Houston - Greenway Plaza

5/5 Excellent
"Stay was great"
A verified traveler stayed at DoubleTree by Hilton Hotel Houston - Greenway Plaza
Posted 4 days ago
DoubleTree by Hilton Hotel Houston - Greenway Plaza

More to Explore

More to Explore