Book 5 Star Hotels in South Central Houston

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Featured South Central Houston 5 Stars Hotels

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St, Houston, TX
Free Cancellation
Reserve now, pay when you stay
2.72 mi from South Central Houston
$100 nightly
The price is $117 total per night
$117 total
Oct 5 - Oct 6
Total with taxes and fees
Guests staying at Hilton Houston Plaza/Medical Center enjoy an outdoor pool, a 24-hour gym, and free WiFi in public areas. Self parking is available for USD 20 per night. Multilingual staff at the front desk are standing by 24/7 to help with securing valuables, concierge services, and dry cleaning/laundry. Other amenities at this luxury hotel include meeting rooms, conference space, and a 24-hour business center.
Pool
Free WiFi
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street, Houston, TX
Free Cancellation
Reserve now, pay when you stay
1.69 mi from South Central Houston
$322 nightly
The price is $377 total per night
$377 total
Oct 2 - Oct 3
Total with taxes and fees
Hotel Zaza Houston Museum District features a full-service spa, an outdoor pool, and a 24-hour gym. Valet parking is available for USD 59 per night, and there's also a free area shuttle. Front-desk staff can answer questions 24/7, and assist with concierge services, dry cleaning/laundry, and securing valuables. Other amenities at this luxury aparthotel include a sauna, a rooftop terrace, and free WiFi in public areas.
Pool
Pet friendly
InterContinental Houston by IHG

InterContinental Houston by IHG

4 out of 5
6750 Main St, Houston, TX
Free Cancellation
2.89 mi from South Central Houston
$172 nightly
The price is $201 total per night
$201 total
Oct 5 - Oct 6
Total with taxes and fees
Guests of InterContinental Houston by IHG have access to an outdoor pool, a 24-hour gym, and free WiFi in public areas. Parking is available for USD 40 per day (USD 50 per day for valet parking), and there's also a free area shuttle. Front-desk staff can answer questions 24/7, and assist with luggage storage, concierge services, and dry cleaning/laundry. Additional amenities include conference space, a 24-hour business center, and express check-out.
Pool
Pet friendly
The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

4 out of 5
1709 DRYDEN ROAD, Houston, TX
Free Cancellation
Reserve now, pay when you stay
2.64 mi from South Central Houston
$181 nightly
The price is $212 total per night
$212 total
Oct 5 - Oct 6
Total with taxes and fees
At The Westin Houston Medical Center/Museum District, guests enjoy an outdoor pool, a 24-hour gym, and free WiFi in public areas. Valet parking is available for USD 52 per night. Multilingual staff at the front desk are standing by 24/7 to help with securing valuables, concierge services, and dry cleaning/laundry. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Additional amenities include conference space, a business center, and coffee/tea in a common area.
Pool
Pet friendly
Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District

4 out of 5
6580 Fannin Street, Houston, TX
Free Cancellation
Reserve now, pay when you stay
2.61 mi from South Central Houston
$183 nightly
The price is $214 total per night
$214 total
Oct 10 - Oct 11
Total with taxes and fees
Guests of Houston Marriott Medical Center/Museum District enjoy a 24-hour gym, free WiFi in public areas, and a conference center. Valet parking is available for USD 44 per day, and there's also a free area shuttle. The front desk is staffed 24/7 to help with luggage storage, securing valuables, and dry cleaning/laundry. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Additional amenities include a business center, express check-in, and express check-out.
Pet friendly
Free WiFi
DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites

4 out of 5
6800 Main Street, Houston, TX
Free Cancellation
Reserve now, pay when you stay
2.91 mi from South Central Houston
$137 nightly
The price is $160 total per night
$160 total
Oct 12 - Oct 13
Total with taxes and fees
At DoubleTree by Hilton Houston Medical Center Hotel & Suites, guests enjoy features like an outdoor pool, a 24-hour gym, and free WiFi in public areas. If you drive, self parking is USD 25.00 per night, and there's also a free area shuttle. The 24-hour front desk has multilingual staff ready to assist with luggage storage and securing valuables. Additional amenities include conference space, a 24-hour business center, and a computer station.
Pool
Pet friendly
Wanderstay Boutique Hotel

Wanderstay Boutique Hotel

2 out of 5
520 Sampson St, Houston, TX
Free Cancellation
1.85 mi from South Central Houston
$130 nightly
The price is $152 total per night
$152 total
Oct 5 - Oct 6
Total with taxes and fees
Guests of Wanderstay Boutique Hotel enjoy access to free WiFi in public areas, microwave in a common area, and refrigerator in a common area. If you drive, take advantage of free parking. Front-desk staff can help with luggage storage, and provide local restaurant recommendations. Additional amenities include a meeting room, express check-in, and express check-out.
Pet friendly
Parking included
Mint House Houston – Medical Center

Mint House Houston – Medical Center

4 out of 5
1911 Holcombe Boulevard, Houston, TX
2.18 mi from South Central Houston
At Mint House Houston – Medical Center, guests enjoy features like an outdoor pool, a 24-hour gym, and a rooftop terrace. Self parking is available for USD 30 per night. Additional amenities include free WiFi in public areas, a 24-hour business center, and a meeting room.
Pool
Kitchen
Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl

2.5 out of 5
1301 Braeswood Blvd, Houston, TX
Free Cancellation
Reserve now, pay when you stay
2.93 mi from South Central Houston
$84 nightly
The price is $98 total per night
$98 total
Oct 5 - Oct 6
Total with taxes and fees
Guests of Extended Stay America Suites Houston Med Ctr Braeswood Bl have access to an outdoor pool, a gym, and free WiFi in public areas. Free parking is available if you drive. The front desk is staffed 24 hours a day to help with securing valuables and luggage storage. Additional amenities include conference space, coffee/tea in a common area, and laundry facilities.
Pool
Breakfast included
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Best 5 star hotels in South Central Houston

Guarantee yourself a relaxing time when you book the best of the best: 5 star hotels in South Central Houston. After all, treating yourself to the finer things is what vacations are about. 

What are the criteria for a 5 star hotel?
5 star hotel requirements include distinctive services and amenities that surpass all others. These South Central Houston hotels bring an incomparable degree of quality and attention to detail, with guest satisfaction being top priority. Your 5 star hotel should be dressed to impress, with design details like marble surfaces and hi-tech fixtures.

What amenities can I expect at a 5 star hotel?
South Central Houston 5 star hotels and resorts typically offer luxury amenities such as:

  • Gourmet restaurant
  • Full-service fitness center with pool
  • Luxury spa 
  • Welcome gifts upon arrival
  • Top-of-the-line beds and linens 
  • Designer personal care products
  • Premium cable, free Wi-Fi and device docking stations

How do I find an amazing 5 star hotel?
Finding 5 star hotel deals in South Central Houston with Orbitz is as easy as your stay will be. For the top-shelf vacation you deserve, we’ll help you choose the right hotel in the right place: 

  • Search hotels by price, ranging from $98 to $377
  • Find the best-loved hotels through word-of-mouth advice when you check out over reviews by Orbitz travelers
  • Choose from 1,154 5 star hotels in South Central Houston!

South Central Houston hotels essential information

Accommodation
1,154 hotels
Lowest Price
$98
Highest Price
$377
Popular hotels
Hilton Houston Plaza/Medical Center, Hotel Zaza Houston Museum District, InterContinental Houston by IHG, The Westin Houston Medical Center/Museum District, Houston Marriott Medical Center/Museum District, DoubleTree by Hilton Houston Medical Center Hotel & Suites, Wanderstay Boutique Hotel, Mint House Houston – Medical Center, Extended Stay America Suites Houston Med Ctr Braeswood Bl

Recent Reviews

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

5/5 Excellent
"Best place I have stayed in decades."
A verified traveler stayed at Hotel Zaza Houston Museum District
Posted 23 hours ago
Hotel Zaza Houston Museum District

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