Cheap flights from VPS to CLE (Northwest Florida Regional to Hopkins Intl.)

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Cheap Flights from VPS to CLE starting at $165 One Way, $405 Round Trip

Prices starting at $405 for return flights and $165 for one-way flights to Hopkins Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Hotel Ideas near Hopkins Intl.

Airport Hotels near Hopkins Intl.

The Orbit Hotel, Trademark Collection by Wyndham

The Orbit Hotel, Trademark Collection by Wyndham

2.5 out of 5
21500 Brookpark Rd Fairview Park OH
$112 nightly
The price is $131 total per night from Apr 26 to Apr 27
$131 total
Apr 26 - Apr 27
Total with taxes and fees
Book a stay at this business-friendly hotel in Fairview Park. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and ...
9.2/10 Wonderful! (1,734 reviews)
The rook is good and good size

Reviewed on Apr 21, 2026

The Orbit Hotel, Trademark Collection by Wyndham
Hilton Garden Inn Cleveland Airport

Hilton Garden Inn Cleveland Airport

3 out of 5
4900 Emerald Court SW Cleveland OH
$107 nightly
The price is $126 total per night from May 3 to May 4
$126 total
May 3 - May 4
Total with taxes and fees
Book a stay at this business-friendly hotel in Cleveland. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
8.6/10 Excellent! (1,006 reviews)
Place was fine. A little dated and with all such properties, the carpets had that old smell. Room amenities were fine.

Reviewed on Apr 17, 2026

Hilton Garden Inn Cleveland Airport
Best Western Airport Inn & Suites Cleveland

Best Western Airport Inn & Suites Cleveland

2.5 out of 5
16501 Snow Rd Brook Park OH
$81 nightly
The price is $95 total per night from Apr 29 to Apr 30
$95 total
Apr 29 - Apr 30
Total with taxes and fees
Book a stay at this business-friendly hotel in Brook Park. Enjoy free breakfast, free parking, and a free airport shuttle. Our guests praise the breakfast and ...
8/10 Very Good! (1,246 reviews)
The property was very clean. I found the cleaning products they used to have a very strong odor. That was my only issue

Reviewed on Apr 21, 2026

Best Western Airport Inn & Suites Cleveland
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Cleveland

The Westin Cleveland Downtown

The Westin Cleveland Downtown

4 out of 5
777 Saint Clair Ave Ne Cleveland OH
$129 nightly
The price is $152 total per night from May 24 to May 25
$152 total
May 24 - May 25
Total with taxes and fees
Book a stay at this business-friendly hotel in Cleveland. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
8.6/10 Excellent! (2,146 reviews)
Did not eat there.

Reviewed on Apr 20, 2026

The Westin Cleveland Downtown
Holiday Inn Cleveland Clinic by IHG

Holiday Inn Cleveland Clinic by IHG

3 out of 5
8650 Euclid Ave Cleveland OH
$135 nightly
The price is $159 total per night from May 2 to May 3
$159 total
May 2 - May 3
Total with taxes and fees
Book a stay at this business-friendly hotel in Cleveland. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,323 reviews)
My check-in was not geat. But,, it was not due to the Hotel staff. There wasa disgruntled costomer checking out and he was arguing about some charge on his bill. He was very ignorant to the lady and very disruptive for folks trying to check-in.

Reviewed on Apr 20, 2026

Holiday Inn Cleveland Clinic by IHG
Hotel Indigo Cleveland Downtown by IHG

Hotel Indigo Cleveland Downtown by IHG

3.5 out of 5
651 Huron Rd E Cleveland OH
$100 nightly
The price is $118 total per night from May 3 to May 4
$118 total
May 3 - May 4
Total with taxes and fees
Book a stay at this business-friendly hotel in Cleveland. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
8.4/10 Very Good! (1,630 reviews)
The place was relatively fine. The room was nice maybe could have been clleaner and they do have a restaurant attached to the hotel.

Reviewed on Apr 22, 2026

Hotel Indigo Cleveland Downtown by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cleveland Hotels With Airport Transportation

Comfort Inn Cleveland Airport

Comfort Inn Cleveland Airport

2.5 out of 5
17550 Rosbough Blvd Middleburg Heights OH
$66 nightly
The price is $77 total per night from Apr 26 to Apr 27
$77 total
Apr 26 - Apr 27
Total with taxes and fees
Book a stay at this business-friendly hotel in Middleburg Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and ...
6.8/10 (612 reviews)
I use this hotel for one night stay only as a transitional hotel when I was awaiting my flight the following day. The staff was not helpful, the hallways and the room and overall the hotel was dirty. They were broken elements within the breakfast that didn’t allow for some breakfast items. As a transitional ...

Reviewed on Apr 19, 2026

Comfort Inn Cleveland Airport
Crowne Plaza Cleveland Airport by IHG

Crowne Plaza Cleveland Airport by IHG

3.5 out of 5
7230 Engle Rd Middleburg Heights OH
$93 nightly
The price is $109 total per night from May 3 to May 4
$109 total
May 3 - May 4
Total with taxes and fees
Book a stay at this business-friendly hotel in Middleburg Heights. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff ...
6.8/10 (1,000 reviews)
Airport shuttle ran on time. Check-in was good. Staff were friendly and helpful. Rooms are dated but quiet and clean.

Reviewed on Apr 20, 2026

Crowne Plaza Cleveland Airport by IHG
Best Western Airport Inn & Suites Cleveland

Best Western Airport Inn & Suites Cleveland

2.5 out of 5
16501 Snow Rd Brook Park OH
$81 nightly
The price is $95 total per night from Apr 29 to Apr 30
$95 total
Apr 29 - Apr 30
Total with taxes and fees
Book a stay at this business-friendly hotel in Brook Park. Enjoy free breakfast, free parking, and a free airport shuttle. Our guests praise the breakfast and ...
8/10 Very Good! (1,246 reviews)
The property was very clean. I found the cleaning products they used to have a very strong odor. That was my only issue

Reviewed on Apr 21, 2026

Best Western Airport Inn & Suites Cleveland
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Cleveland Hotels

Red Roof Inn Cleveland Airport-Middleburg Heights

Red Roof Inn Cleveland Airport-Middleburg Heights

2 out of 5
17555 Bagley Rd Middleburg Heights OH
$52 nightly
The price is $61 total per night from Apr 29 to Apr 30
$61 total
Apr 29 - Apr 30
Total with taxes and fees
Stay at this hotel in Middleburg Heights. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular ...
6.6/10 (1,002 reviews)
The room was not clean, there were paw print stains on the bed as well as a lot of mysterious crumbs, asked them to change the sheets and they insisted the bed was not dirty, just stained (despite the crumbs) and then changed the top blanket for us. on top of that there were several bugs I found ...

Reviewed on Apr 19, 2026

Red Roof Inn Cleveland Airport-Middleburg Heights
University Hotel & Suites

University Hotel & Suites

2 out of 5
3614 Euclid Ave Cleveland OH
Stay at this hotel in Cleveland. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Progressive Field and Rocket Arena are located ...
4.6/10 (999 reviews)
Do Not Stay Here
This hotel is not a good place to stay. The staff was polite, and the three gentlemen that manned the door were very helpful. But the condition is run down and it looked it. It is NOT handicap accessible. The showers were dirty (we had 2 rooms), the mattresses were wrapped in plastic (bedbugs? I ...

Reviewed on Dec 7, 2020

University Hotel & Suites
SkyLight Inn Cleveland - Willoughby

SkyLight Inn Cleveland - Willoughby

2.5 out of 5
34600 Maplegrove Rd Willoughby OH
$61 nightly
The price is $70 total per night from Apr 29 to Apr 30
$70 total
Apr 29 - Apr 30
Total with taxes and fees
Stay at this motel in Willoughby. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
6.2/10 (1,001 reviews)
The sweet old man always looks out on cleaning the room and making sure we always had what we needed good rates as well

Reviewed on Apr 14, 2026

SkyLight Inn Cleveland - Willoughby
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Cleveland

Extended Stay America Premier Suites - Cleveland - Independence

Extended Stay America Premier Suites - Cleveland - Independence

2.5 out of 5
6025 Jefferson Dr Independence OH
$80 nightly
The price is $94 total per night from May 17 to May 18
$94 total
May 17 - May 18
Total with taxes and fees
Book a stay at this business-friendly hotel in Independence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,762 reviews)
The rooms are nice and clean. The entire property was well kept. Very nice staff as well.

Reviewed on Apr 21, 2026

Extended Stay America Premier Suites - Cleveland - Independence
Sonesta Simply Suites Cleveland Airport

Sonesta Simply Suites Cleveland Airport

3 out of 5
17525 Rosbough Dr Middleburg Heights OH
$72 nightly
The price is $85 total per night from May 22 to May 23
$85 total
May 22 - May 23
Total with taxes and fees
Stay at this hotel in Middleburg Heights. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff and the clean rooms in our ...
6.2/10 (1,006 reviews)
There were fake eyelashes still on the shelf above the dining table, all kinds of debris and a fortune cookie paper behind the bathroom door, the carpets were insultingly dirty, and the safety lock on the door wasn’t functional.

Reviewed on Apr 22, 2026

Sonesta Simply Suites Cleveland Airport
Sonesta Simply Suites Cleveland Westlake

Sonesta Simply Suites Cleveland Westlake

3 out of 5
30100 Clemens Rd Westlake OH
$84 nightly
The price is $99 total per night from Apr 28 to Apr 29
$99 total
Apr 28 - Apr 29
Total with taxes and fees
Stay at this hotel in Westlake. Enjoy free WiFi, free parking, and a 24-hour fitness center. Our guests praise the helpful staff in our reviews. Popular attractions ...
7.2/10 Good! (1,001 reviews)
Horriable

Reviewed on Apr 2, 2026

Sonesta Simply Suites Cleveland Westlake
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

VPS to CLE Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date

Frequently asked questions

Are there non-stop flights from Northwest Florida Regional Airport (VPS) to CLE?
If you're flying from VPS to CLE, be prepared to change planes. American Airlines, Delta Air Lines and Southwest Airlines are some airlines that operate on this route with just one stopover. Use the layover to give your legs a stretch and get a bite to eat.
What is the shortest flight from Destin–Fort Walton Beach Airport to Cleveland Hopkins Intl. Airport?
The shortest flight time from Northwest Florida Regional Airport (VPS) to CLE is around 3 hours and 49 minutes. Grab a refreshment from the drink cart, hone your travel itinerary or make friends with your seat mate — you'll have plenty of time on this medium-haul journey.
How many hours flight from Northwest Florida Regional Airport (VPS) to Cleveland Hopkins Intl. Airport?
On a normal day, the flight from Destin–Fort Walton Beach Airport to Hopkins Intl. Airport (CLE) takes 3 hours and 54 minutes. If you're looking to be as comfortable as possible, think about upgrading your seat using miles or cash.
What airlines have the most flights from VPS to CLE?
You'll need to make one or more stopovers if you need to get from Destin–Fort Walton Beach Airport to Cleveland Hopkins Intl. Airport. For now, there aren't any airlines that advertise direct flights on this route.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.