Cheap flights from STL to TYS (Lambert-St. Louis Intl. to McGhee Tyson)

Cheap Flights from STL to TYS starting at $122 One Way, $243 Round Trip

Prices starting at $243 for return flights and $122 for one-way flights to McGhee Tyson were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Oct 19 - Tue, Oct 20
STL
St. Louis
TYS
Knoxville
$243 Roundtrip, found 3 days ago
$243
Roundtrip
found 3 days ago
Select Delta flight, departing Mon, Oct 19 from St. Louis to Knoxville, returning Tue, Oct 20, priced at $243 found 3 days ago
Tue, Oct 13 - Sat, Oct 17
STL
St. Louis
TYS
Knoxville
$246 Roundtrip, found 4 days ago
$246
Roundtrip
found 4 days ago
Select United flight, departing Tue, Oct 13 from St. Louis to Knoxville, returning Sat, Oct 17, priced at $246 found 4 days ago
Tue, Oct 13 - Sat, Oct 17
STL
St. Louis
TYS
Knoxville
$246 Roundtrip, found 4 days ago
$246
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Oct 13 from St. Louis to Knoxville, returning Sat, Oct 17, priced at $246 found 4 days ago
Fri, Nov 27 - Tue, Dec 1
STL
St. Louis
TYS
Knoxville
$254 Roundtrip, found 14 hours ago
$254
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Fri, Nov 27 from St. Louis to Knoxville, returning Tue, Dec 1, priced at $254 found 14 hours ago
Mon, Nov 9 - Fri, Nov 13
STL
St. Louis
TYS
Knoxville
$257 Roundtrip, found 4 days ago
$257
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Mon, Nov 9 from St. Louis to Knoxville, returning Fri, Nov 13, priced at $257 found 4 days ago

Hotel Ideas near McGhee Tyson

Airport Hotels near McGhee Tyson

Hilton Knoxville Airport

Hilton Knoxville Airport

3.5 out of 5
2001 Alcoa Hwy Alcoa TN
$139 nightly
The price is $160 total per night from Oct 11 to Oct 12
$160 total
Oct 11 - Oct 12
Total with taxes and fees
Book a stay at this family-friendly hotel in Alcoa. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
Hilton Knoxville Airport
La Quinta Inn & Suites by Wyndham Knoxville Airport

La Quinta Inn & Suites by Wyndham Knoxville Airport

3 out of 5
126 Cusick Road Alcoa TN
$77 nightly
The price is $91 total per night from Oct 26 to Oct 27
$91 total
Oct 26 - Oct 27
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (2,036 reviews)
"Very convenient location Accommodating staff Good selection of breakfast items Clean property inside & out"

Reviewed on Sep 26, 2026

La Quinta Inn & Suites by Wyndham Knoxville Airport
Best Western Knoxville Airport/Alcoa

Best Western Knoxville Airport/Alcoa

2.5 out of 5
162 Cusick Rd Alcoa TN
$73 nightly
The price is $87 total per night from Oct 27 to Oct 28
$87 total
Oct 27 - Oct 28
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Best Western Knoxville Airport/Alcoa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Knoxville

La Quinta Inn & Suites by Wyndham Knoxville Airport

La Quinta Inn & Suites by Wyndham Knoxville Airport

3 out of 5
126 Cusick Road Alcoa TN
$77 nightly
The price is $91 total per night from Oct 26 to Oct 27
$91 total
Oct 26 - Oct 27
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (2,036 reviews)
"Very convenient location Accommodating staff Good selection of breakfast items Clean property inside & out"

Reviewed on Sep 26, 2026

La Quinta Inn & Suites by Wyndham Knoxville Airport
Hilton Knoxville Airport

Hilton Knoxville Airport

3.5 out of 5
2001 Alcoa Hwy Alcoa TN
$139 nightly
The price is $160 total per night from Oct 11 to Oct 12
$160 total
Oct 11 - Oct 12
Total with taxes and fees
Book a stay at this family-friendly hotel in Alcoa. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
Hilton Knoxville Airport
Quality Inn Alcoa Knoxville

Quality Inn Alcoa Knoxville

2.5 out of 5
206 Corporate Pl Alcoa TN
$83 nightly
The price is $99 total per night from Oct 18 to Oct 19
$99 total
Oct 18 - Oct 19
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Quality Inn Alcoa Knoxville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Knoxville Hotels With Airport Transportation

La Quinta Inn & Suites by Wyndham Knoxville Airport

La Quinta Inn & Suites by Wyndham Knoxville Airport

3 out of 5
126 Cusick Road Alcoa TN
$77 nightly
The price is $91 total per night from Oct 26 to Oct 27
$91 total
Oct 26 - Oct 27
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (2,036 reviews)
"Very convenient location Accommodating staff Good selection of breakfast items Clean property inside & out"

Reviewed on Sep 26, 2026

La Quinta Inn & Suites by Wyndham Knoxville Airport
USA Inn

USA Inn

3 out of 5
Alcoa Hwy, 2962 Alcoa TN
$50 nightly
The price is $59 total per night from Sep 27 to Sep 28
$59 total
Sep 27 - Sep 28
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Meigs Falls and Fort Loudoun ...
5/10 (723 reviews)
"The price was the best in the Knoxville are and the location was near the airport. The staff was satisfactory. Bugs made the room almost unbearable."

Reviewed on Sep 23, 2026

USA Inn
Best Western Knoxville Airport/Alcoa

Best Western Knoxville Airport/Alcoa

2.5 out of 5
162 Cusick Rd Alcoa TN
$73 nightly
The price is $87 total per night from Oct 27 to Oct 28
$87 total
Oct 27 - Oct 28
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Best Western Knoxville Airport/Alcoa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Knoxville Hotels

USA Inn

USA Inn

3 out of 5
Alcoa Hwy, 2962 Alcoa TN
$50 nightly
The price is $59 total per night from Sep 27 to Sep 28
$59 total
Sep 27 - Sep 28
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Meigs Falls and Fort Loudoun ...
5/10 (723 reviews)
"The price was the best in the Knoxville are and the location was near the airport. The staff was satisfactory. Bugs made the room almost unbearable."

Reviewed on Sep 23, 2026

USA Inn
Candlewood Suites Knoxville Airport-Alcoa by IHG

Candlewood Suites Knoxville Airport-Alcoa by IHG

2.5 out of 5
176 Cusick Road Alcoa TN
$76 nightly
The price is $90 total per night from Oct 18 to Oct 19
$90 total
Oct 18 - Oct 19
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free WiFi, an outdoor pool, and a free airport shuttle. Popular attractions Meigs Falls and Palace ...
8.4/10 Very Good! (722 reviews)
"Bed bugs !!! I had to be switched rooms because i found bed bugs on the bed and also the chair and i emailed the office and got no response as of yet and no refund offered. The woman who worked at night was super helpful and genuinely felt bad and did what she could to help move me and said she would ..."

Reviewed on Sep 20, 2026

Candlewood Suites Knoxville Airport-Alcoa by IHG
Best Western Knoxville Airport/Alcoa

Best Western Knoxville Airport/Alcoa

2.5 out of 5
162 Cusick Rd Alcoa TN
$73 nightly
The price is $87 total per night from Oct 27 to Oct 28
$87 total
Oct 27 - Oct 28
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Best Western Knoxville Airport/Alcoa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Knoxville

Comfort Suites Knoxville Airport

Comfort Suites Knoxville Airport

2.5 out of 5
140 Cusick Rd Alcoa TN
$85 nightly
The price is $101 total per night from Oct 26 to Oct 27
$101 total
Oct 26 - Oct 27
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Comfort Suites Knoxville Airport
Best Western Knoxville Airport/Alcoa

Best Western Knoxville Airport/Alcoa

2.5 out of 5
162 Cusick Rd Alcoa TN
$73 nightly
The price is $87 total per night from Oct 27 to Oct 28
$87 total
Oct 27 - Oct 28
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Best Western Knoxville Airport/Alcoa
La Quinta Inn & Suites by Wyndham Knoxville Airport

La Quinta Inn & Suites by Wyndham Knoxville Airport

3 out of 5
126 Cusick Road Alcoa TN
$77 nightly
The price is $91 total per night from Oct 26 to Oct 27
$91 total
Oct 26 - Oct 27
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (2,036 reviews)
"Very convenient location Accommodating staff Good selection of breakfast items Clean property inside & out"

Reviewed on Sep 26, 2026

La Quinta Inn & Suites by Wyndham Knoxville Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

Are there non-stop flights from St. Louis Lambert International Airport to McGhee Tyson Airport (TYS)?
As you can't fly direct from Lambert Field to McGhee Tyson Airport (TYS) at the moment, a flight with a single stopover is your best bet. American Airlines, Delta Air Lines and United Airlines are respected airlines that service this route.
What is the shortest flight from St. Louis Lambert International Airport to Knoxville Airport?
The quickest flight time from St. Louis to Knoxville is 4 hours and 1 minute. Grab your favorite tipple from the cabin crew, hone your travel itinerary or finish that podcast — you'll have plenty of time on this medium-haul journey.
How many hours flight from St. Louis Lambert International Airport to TYS?
From STL to TYS, you'll be in your plane seat for approximately 4 hours and 9 minutes. Get comfy, order a wine and put on your noise-canceling earphones. It's time for a binge-watching session.
What airlines have the most flights from St. Louis Lambert International Airport to Knoxville Airport?
At the moment, you can't fly direct between STL and TYS. However, you can find flights with one or more stops. It's not all bad — use the break to stretch your travel-weary legs or grab a nice coffee!

Map To Nearby Hotels

More to Explore