Cheap flights from STL to EYW (Lambert-St. Louis Intl. to Key West Intl.)

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Cheap Flights from STL to EYW starting at $272 One Way, $349 Round Trip

Prices starting at $349 for return flights and $272 for one-way flights to Key West Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Feb 1 - Thu, Feb 11
STL
St. Louis
EYW
Key West
$349 Roundtrip, found 2 days ago
$349
Roundtrip
found 2 days ago
Select United flight, departing Mon, Feb 1 from St. Louis to Key West, returning Thu, Feb 11, priced at $349 found 2 days ago
Tue, Dec 15 - Tue, Dec 29
STL
St. Louis
EYW
Key West
$351 Roundtrip, found 6 days ago
$351
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Dec 15 from St. Louis to Key West, returning Tue, Dec 29, priced at $351 found 6 days ago
Mon, Feb 1 - Thu, Feb 11
STL
St. Louis
EYW
Key West
$354 Roundtrip, found 2 days ago
$354
Roundtrip
found 2 days ago
Select United flight, departing Mon, Feb 1 from St. Louis to Key West, returning Thu, Feb 11, priced at $354 found 2 days ago
Tue, Dec 15 - Tue, Dec 29
STL
St. Louis
EYW
Key West
$373 Roundtrip, found 6 days ago
$373
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Dec 15 from St. Louis to Key West, returning Tue, Dec 29, priced at $373 found 6 days ago
Tue, Jan 26 - Thu, Feb 18
STL
St. Louis
EYW
Key West
$392 Roundtrip, found 3 days ago
$392
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Jan 26 from St. Louis to Key West, returning Thu, Feb 18, priced at $392 found 3 days ago

Hotel Ideas near Key West Intl.

Airport Hotels near Key West Intl.

Hyatt Vacation Club at Windward Pointe, Key West

Hyatt Vacation Club at Windward Pointe, Key West

3.5 out of 5
3675 South Roosevelt Boulevard Key West FL
$208 nightly
The price is $234 total per night from Oct 4 to Oct 5
$234 total
Oct 4 - Oct 5
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free WiFi, free parking, and a snack bar/deli. Our guests praise the pool and the helpful staff in our reviews. Popular ...
Hyatt Vacation Club at Windward Pointe, Key West
Hampton Inn Key West FL

Hampton Inn Key West FL

2.5 out of 5
3755 S Roosevelt Blvd Key West FL
$135 nightly
The price is $152 total per night from Sep 29 to Sep 30
$152 total
Sep 29 - Sep 30
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
Hampton Inn Key West FL
DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West

4 out of 5
3990 S Roosevelt Blvd Key West FL
$133 nightly
The price is $150 total per night from Sep 29 to Sep 30
$150 total
Sep 29 - Sep 30
Total with taxes and fees
Book a stay at this business-friendly resort in Key West. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,104 reviews)
"Tyrone was extremely helpful with any need that came up. Even when it was not his responsibility, he made sure we were taken care of"

Reviewed on Sep 22, 2026

DoubleTree Resort by Hilton Grand Key - Key West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Key West

Blue Flamingo Resort Key West

Blue Flamingo Resort Key West

4 out of 5
3820 North Roosevelt Boulevard Key West FL
$168 nightly
The price is $189 total per night from Sep 24 to Sep 25
$189 total
Sep 24 - Sep 25
Total with taxes and fees
Book a stay at this family-friendly hotel in Key West. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
8.6/10 Excellent! (2,680 reviews)
"Friendly and helpful staff. Love the 2 pools. It's great that they have a complimentary shuttle to take you downtown."

Reviewed on Sep 22, 2026

Blue Flamingo Resort Key West
Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street Key West FL
$225 nightly
The price is $253 total per night from Sep 29 to Sep 30
$253 total
Sep 29 - Sep 30
Total with taxes and fees
Book a stay at this spa hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.6/10 Excellent! (3,610 reviews)
"Great place, great location. We would stay there again!"

Reviewed on Sep 23, 2026

Southernmost Beach Resort and Guesthouses
Margaritaville Beach House Key West

Margaritaville Beach House Key West

4 out of 5
2001 South Roosevelt Blvd Key West FL
$234 nightly
The price is $263 total per night from Oct 6 to Oct 7
$263 total
Oct 6 - Oct 7
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy breakfast (surcharge), a free airport shuttle, and room service. Our guests praise the pool and the restaurant ...
Margaritaville Beach House Key West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Key West Hotels With Airport Transportation

DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West

4 out of 5
3990 S Roosevelt Blvd Key West FL
$133 nightly
The price is $150 total per night from Sep 29 to Sep 30
$150 total
Sep 29 - Sep 30
Total with taxes and fees
Book a stay at this business-friendly resort in Key West. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,104 reviews)
"Tyrone was extremely helpful with any need that came up. Even when it was not his responsibility, he made sure we were taken care of"

Reviewed on Sep 22, 2026

DoubleTree Resort by Hilton Grand Key - Key West
Hampton Inn Key West FL

Hampton Inn Key West FL

2.5 out of 5
3755 S Roosevelt Blvd Key West FL
$135 nightly
The price is $152 total per night from Sep 29 to Sep 30
$152 total
Sep 29 - Sep 30
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
Hampton Inn Key West FL
Eden House

Eden House

4 out of 5
1015 Fleming St Key West FL
$142 nightly
The price is $160 total per night from Sep 28 to Sep 29
$160 total
Sep 28 - Sep 29
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free WiFi, in-room massages, and a 24-hour front desk. Our guests praise the pool and the helpful staff in our reviews. ...
Eden House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Key West Hotels

Southwinds Motel

Southwinds Motel

2 out of 5
1321 Simonton Street Key West FL
$155 nightly
The price is $174 total per night from Sep 24 to Sep 25
$174 total
Sep 24 - Sep 25
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8.6/10 Excellent! (1,382 reviews)
"The room was clean and the staff very helpful"

Reviewed on Sep 21, 2026

Southwinds Motel
Seashell Motel

Seashell Motel

1.5 out of 5
718 South Street Key West FL
$101 nightly
The price is $114 total per night from Sep 27 to Sep 28
$114 total
Sep 27 - Sep 28
Total with taxes and fees
Stay at this hostel in Key West. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
Seashell Motel
Duval House

Duval House

3 out of 5
815 Duval St Key West FL
$128 nightly
The price is $142 total per night from Oct 5 to Oct 6
$142 total
Oct 5 - Oct 6
Total with taxes and fees
Stay at this B&B in Key West. Enjoy parking (surcharge), daily housekeeping, and a garden. Our guests praise the breakfast and the pool in our reviews. Popular ...
9.6/10 Exceptional! (1,101 reviews)
"Loved the chilled pool!"

Reviewed on Sep 22, 2026

Duval House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Key West

Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street Key West FL
$225 nightly
The price is $253 total per night from Sep 29 to Sep 30
$253 total
Sep 29 - Sep 30
Total with taxes and fees
Book a stay at this spa hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.6/10 Excellent! (3,610 reviews)
"Great place, great location. We would stay there again!"

Reviewed on Sep 23, 2026

Southernmost Beach Resort and Guesthouses
Blue Flamingo Resort Key West

Blue Flamingo Resort Key West

4 out of 5
3820 North Roosevelt Boulevard Key West FL
$168 nightly
The price is $189 total per night from Sep 24 to Sep 25
$189 total
Sep 24 - Sep 25
Total with taxes and fees
Book a stay at this family-friendly hotel in Key West. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
8.6/10 Excellent! (2,680 reviews)

Families like: Outdoor pools, playground, miniature golf, game room

Travelers say...
"Friendly and helpful staff. Love the 2 pools. It's great that they have a complimentary shuttle to take you downtown."

Reviewed on Sep 22, 2026

Blue Flamingo Resort Key West
Hilton Key West Resort & Marina

Hilton Key West Resort & Marina

4 out of 5
5950 Peninsular Avenue Key West FL
$159 nightly
The price is $179 total per night from Sep 29 to Sep 30
$179 total
Sep 29 - Sep 30
Total with taxes and fees
Book a stay at this luxury hotel in Key West. Enjoy free WiFi, 6 outdoor pools, and a marina. Our guests praise the pool and the restaurant in our reviews. Popular ...
9/10 Wonderful! (1,811 reviews)
"Nice and comfortable"

Reviewed on Sep 20, 2026

Hilton Key West Resort & Marina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

STL to EYW Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
STL Address & GPS
Address:
10701 Lambert International Blvd.
Saint Louis MO, 63145
United States
IATA Code:
STL
Longitude:
-90.379002
Latitude:
38.748707
Time Zone:
America/Chicago
EYW Address & GPS
Address:
3491 South Roosevelt Boulevard
Key West FL, 33040-5260
United States
IATA Code:
EYW
Longitude:
-81.75501
Latitude:
24.553574
Time Zone:
America/New_York

Frequently asked questions

Are there non-stop flights from Lambert Field to Key West Intl. Airport?
You're going to need to switch planes if you're wanting to fly from STL to Key West Intl. Airport. A range of companies offer services on this route with only one stopover, including American Airlines, United Airlines and Delta Air Lines.
What is the shortest flight from St. Louis Lambert International Airport to Key West Intl. Airport (EYW)?
The shortest flight from STL to EYW is 5 hours and 10 minutes. Pack a few things in your carry-on to keep you amused, like a magazine or a crossword puzzle.
How many hours flight from St. Louis Lambert International Airport to EYW?
Typically, it takes 5 hours and 15 minutes to fly from STL to EYW. Get through this medium-haul journey by watching movies and getting stuck into a good book. Alternatively, squeeze in a bit of shut-eye.
What airlines have the most flights from St. Louis Lambert International Airport to EYW?
Do some people-watching, pick up a doughnut, get the blood pumping again .... Airport stopovers don't have to be something to dread! If you're traveling between St. Louis and Key West, you won't find any direct flights. Prepare to make a stop somewhere.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.