Cheap flights from STL to EYW (Lambert-St. Louis Intl. to Key West Intl.)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

Cheap Flights from STL to EYW starting at $210 One Way, $343 Round Trip

Prices starting at $343 for return flights and $210 for one-way flights to Key West Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Mar 3 - Wed, Mar 10
STL
St. Louis
EYW
Key West
$343 Roundtrip, found 6 days ago
$343
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Mar 3 from St. Louis to Key West, returning Wed, Mar 10, priced at $343 found 6 days ago
Fri, Nov 27 - Wed, Dec 2
STL
St. Louis
EYW
Key West
$356 Roundtrip, found 3 days ago
$356
Roundtrip
found 3 days ago
Select United flight, departing Fri, Nov 27 from St. Louis to Key West, returning Wed, Dec 2, priced at $356 found 3 days ago
Wed, Mar 3 - Wed, Mar 10
STL
St. Louis
EYW
Key West
$371 Roundtrip, found 6 days ago
$371
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, Mar 3 from St. Louis to Key West, returning Wed, Mar 10, priced at $371 found 6 days ago
Wed, Mar 3 - Wed, Mar 10
STL
St. Louis
EYW
Key West
$393 Roundtrip, found 6 days ago
$393
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Mar 3 from St. Louis to Key West, returning Wed, Mar 10, priced at $393 found 6 days ago
Wed, Mar 3 - Wed, Mar 10
STL
St. Louis
EYW
Key West
$399 Roundtrip, found 6 days ago
$399
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, Mar 3 from St. Louis to Key West, returning Wed, Mar 10, priced at $399 found 6 days ago

Hotel Ideas near Key West Intl.

Airport Hotels near Key West Intl.

Hyatt Vacation Club at Windward Pointe, Key West

Hyatt Vacation Club at Windward Pointe, Key West

3.5 out of 5
3675 South Roosevelt Boulevard Key West FL
$213 nightly
The price is $240 total per night from Nov 17 to Nov 18
$240 total
Nov 17 - Nov 18
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free WiFi, free parking, and a snack bar/deli. Our guests praise the pool and the helpful staff in our reviews. Popular ...
9.4/10 Exceptional! (1,337 reviews)
"The only negative about this lovely property is its proximity to the Key West Airport. The runway was directly behind our unit and quite loud. Luckily we didn’t use the front bedroom—who could sleep with that noise?"

Reviewed on Nov 5, 2026

Hyatt Vacation Club at Windward Pointe, Key West
Hampton Inn Key West FL

Hampton Inn Key West FL

2.5 out of 5
3755 S Roosevelt Blvd Key West FL
$188 nightly
The price is $212 total per night from Nov 30 to Dec 1
$212 total
Nov 30 - Dec 1
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (1,570 reviews)
"The shuttle to town is a plus ( don’t have look for parking) Be aware some pick up times can be premium. The continental breakfast was very good and organized. The staff very helpful and friendly."

Reviewed on Nov 4, 2026

Hampton Inn Key West FL
DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West

4 out of 5
3990 S Roosevelt Blvd Key West FL
$153 nightly
The price is $172 total per night from Nov 15 to Nov 16
$172 total
Nov 15 - Nov 16
Total with taxes and fees
Book a stay at this business-friendly resort in Key West. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,131 reviews)
"Awesome Trip!"

Reviewed on Nov 4, 2026

DoubleTree Resort by Hilton Grand Key - Key West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Key West

Margaritaville Beach House Key West

Margaritaville Beach House Key West

4 out of 5
2001 South Roosevelt Blvd Key West FL
$285 nightly
The price is $321 total per night from Nov 18 to Nov 19
$321 total
Nov 18 - Nov 19
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy breakfast (surcharge), a free airport shuttle, and room service. Our guests praise the pool and the restaurant ...
Margaritaville Beach House Key West
Havana Cabana at Key West

Havana Cabana at Key West

4 out of 5
3420 N. Roosevelt Blvd Key West FL
$200 nightly
The price is $225 total per night from Nov 29 to Nov 30
$225 total
Nov 29 - Nov 30
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the pool and the helpful ...
Havana Cabana at Key West
Blue Flamingo Resort Key West

Blue Flamingo Resort Key West

4 out of 5
3820 North Roosevelt Boulevard Key West FL
$175 nightly
The price is $197 total per night from Nov 15 to Nov 16
$197 total
Nov 15 - Nov 16
Total with taxes and fees
Book a stay at this family-friendly hotel in Key West. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
Blue Flamingo Resort Key West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Key West Hotels With Airport Transportation

DoubleTree Resort by Hilton Grand Key - Key West

DoubleTree Resort by Hilton Grand Key - Key West

4 out of 5
3990 S Roosevelt Blvd Key West FL
$153 nightly
The price is $172 total per night from Nov 15 to Nov 16
$172 total
Nov 15 - Nov 16
Total with taxes and fees
Book a stay at this business-friendly resort in Key West. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,131 reviews)
"Awesome Trip!"

Reviewed on Nov 4, 2026

DoubleTree Resort by Hilton Grand Key - Key West
Hampton Inn Key West FL

Hampton Inn Key West FL

2.5 out of 5
3755 S Roosevelt Blvd Key West FL
$188 nightly
The price is $212 total per night from Nov 30 to Dec 1
$212 total
Nov 30 - Dec 1
Total with taxes and fees
Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (1,570 reviews)
"The shuttle to town is a plus ( don’t have look for parking) Be aware some pick up times can be premium. The continental breakfast was very good and organized. The staff very helpful and friendly."

Reviewed on Nov 4, 2026

Hampton Inn Key West FL
Eden House

Eden House

4 out of 5
1015 Fleming St Key West FL
$196 nightly
The price is $220 total per night from Nov 11 to Nov 12
$220 total
Nov 11 - Nov 12
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free WiFi, in-room massages, and a 24-hour front desk. Our guests praise the pool and the helpful staff in our reviews. ...
Eden House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Key West Hotels

Southwinds Motel

Southwinds Motel

2 out of 5
1321 Simonton Street Key West FL
$184 nightly
The price is $207 total per night from Dec 1 to Dec 2
$207 total
Dec 1 - Dec 2
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
Southwinds Motel
Seashell Motel

Seashell Motel

1.5 out of 5
718 South Street Key West FL
$193 nightly
The price is $217 total per night from Nov 22 to Nov 23
$217 total
Nov 22 - Nov 23
Total with taxes and fees
Stay at this hostel in Key West. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
Seashell Motel
Duval House

Duval House

3 out of 5
815 Duval St Key West FL
$200 nightly
The price is $222 total per night from Nov 18 to Nov 19
$222 total
Nov 18 - Nov 19
Total with taxes and fees
Stay at this B&B in Key West. Enjoy parking (surcharge), daily housekeeping, and a garden. Our guests praise the breakfast and the pool in our reviews. Popular ...
9.6/10 Exceptional! (1,132 reviews)
"Duval House was an excellent stay. Very clean rooms and common areas, attentive staff, complimentary breakfast, fair pricing and unbeatable location."

Reviewed on Nov 6, 2026

Duval House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Key West

Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street Key West FL
$264 nightly
The price is $297 total per night from Nov 15 to Nov 16
$297 total
Nov 15 - Nov 16
Total with taxes and fees
Book a stay at this spa hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.6/10 Excellent! (3,648 reviews)
"I didn't like the fact that when I booked the trip, it didn't say that the room was 2 or 3 blocks from the original hotel that Iwas thinking I booked. We had to do the check in ourselves in the original hotel while others around us got it done by staff , we felt like we were discriminated . The staff ..."

Reviewed on Nov 5, 2026

Southernmost Beach Resort and Guesthouses
Blue Flamingo Resort Key West

Blue Flamingo Resort Key West

4 out of 5
3820 North Roosevelt Boulevard Key West FL
$175 nightly
The price is $197 total per night from Nov 15 to Nov 16
$197 total
Nov 15 - Nov 16
Total with taxes and fees
Book a stay at this family-friendly hotel in Key West. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
Blue Flamingo Resort Key West
Hilton Key West Resort & Marina

Hilton Key West Resort & Marina

4 out of 5
5950 Peninsular Avenue Key West FL
$178 nightly
The price is $201 total per night from Nov 15 to Nov 16
$201 total
Nov 15 - Nov 16
Total with taxes and fees
Book a stay at this luxury hotel in Key West. Enjoy free WiFi, 6 outdoor pools, and a marina. Our guests praise the pool and the restaurant in our reviews. Popular ...
9/10 Wonderful! (1,793 reviews)
"The property is beautiful and very clean. The shuttle driver was very courteous and helped us navigate the city and our plans. We had an outstanding experience."

Reviewed on Nov 5, 2026

Hilton Key West Resort & Marina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

STL to EYW Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
STL Address & GPS
Address:
10701 Lambert International Blvd.
Saint Louis MO, 63145
United States
IATA Code:
STL
Longitude:
-90.379002
Latitude:
38.748707
Time Zone:
America/Chicago
EYW Address & GPS
Address:
3491 South Roosevelt Boulevard
Key West FL, 33040-5260
United States
IATA Code:
EYW
Longitude:
-81.75501
Latitude:
24.553574
Time Zone:
America/New_York

Frequently asked questions

Are there non-stop flights from Lambert Field to Key West Intl. Airport?
You're going to need to switch planes if you're wanting to fly from STL to Key West Intl. Airport. A range of companies offer services on this route with only one stopover, including American Airlines, United Airlines and Delta Air Lines.
What is the shortest flight from St. Louis Lambert International Airport to Key West Intl. Airport (EYW)?
The shortest flight from STL to EYW is 5 hours and 10 minutes. Pack a few things in your carry-on to keep you amused, like a magazine or a crossword puzzle.
How many hours flight from St. Louis Lambert International Airport to EYW?
Typically, it takes 5 hours and 15 minutes to fly from STL to EYW. Get through this medium-haul journey by watching movies and getting stuck into a good book. Alternatively, squeeze in a bit of shut-eye.
What airlines have the most flights from St. Louis Lambert International Airport to EYW?
Do some people-watching, pick up a doughnut, get the blood pumping again .... Airport stopovers don't have to be something to dread! If you're traveling between St. Louis and Key West, you won't find any direct flights. Prepare to make a stop somewhere.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.