Cheap flights from LGA to FLO (LaGuardia to Florence Regional)

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Cheap Flights from LGA to FLO starting at $151 One Way, $669 Round Trip

Prices starting at $669 for return flights and $151 for one-way flights to Florence Regional were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Jul 17 - Sun, Jul 19
LGA
New York
FLO
Florence
$669 Roundtrip, found 2 days ago
$669
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, Jul 17 from New York to Florence, returning Sun, Jul 19, priced at $669 found 2 days ago
Fri, Jul 17 - Sun, Jul 19
LGA
New York
FLO
Florence
$787 Roundtrip, found 2 days ago
$787
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, Jul 17 from New York to Florence, returning Sun, Jul 19, priced at $787 found 2 days ago
Fri, Jul 17 - Sun, Jul 19
LGA
New York
FLO
Florence
$824 Roundtrip, found 2 days ago
$824
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, Jul 17 from New York to Florence, returning Sun, Jul 19, priced at $824 found 2 days ago
Fri, Jul 17 - Sun, Jul 19
LGA
New York
FLO
Florence
$867 Roundtrip, found 2 days ago
$867
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, Jul 17 from New York to Florence, returning Sun, Jul 19, priced at $867 found 2 days ago
Fri, Jul 17 - Sun, Jul 19
LGA
New York
FLO
Florence
$928 Roundtrip, found 2 days ago
$928
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, Jul 17 from New York to Florence, returning Sun, Jul 19, priced at $928 found 2 days ago

Hotel Ideas near Florence Regional

Airport Hotels near Florence Regional

Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence Florence SC
$122 nightly
The price is $137 total per night from Apr 26 to Apr 27
$137 total
Apr 26 - Apr 27
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
9/10 Wonderful! (1,009 reviews)
Excellent hotel so clean, friendy staff

Reviewed on Apr 13, 2026

Hyatt Place Florence Downtown
Hotel Florence, Tapestry Collection by Hilton

Hotel Florence, Tapestry Collection by Hilton

3 out of 5
126 W Evans St Florence SC
$130 nightly
The price is $146 total per night from May 3 to May 4
$146 total
May 3 - May 4
Total with taxes and fees
Book a stay at this spa hotel in Florence. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (625 reviews)
I called ahead to request a pack and play for our small child in our suite for when we arrived since it was going to be late, they said no problem. We asked the front desk if the pack and play is in the room already, they said yes. We got in the room.. and the pack and play was not there. The TV ...

Reviewed on Apr 4, 2026

Hotel Florence, Tapestry Collection by Hilton
Rodeway Inn Florence Downtown

Rodeway Inn Florence Downtown

2 out of 5
415 S. IRBY ST Florence SC
$56 nightly
The price is $63 total per night from Apr 15 to Apr 16
$63 total
Apr 15 - Apr 16
Total with taxes and fees
Stay at this hotel in Florence. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Drs Bruce and Lee Foundation Library and Florence ...
4.6/10 (4 reviews)
Looks like the owners are doing a lot of work on the property however, cleanliness is doable but not done. Our room was supposed to have 2 beds in it but the first room we got looked like someone was still in it. Unmade bed, clothes on chair and a huge fan in the middle of the room. Second room, ...

Reviewed on Mar 11, 2026

Rodeway Inn Florence Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Florence

Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
$67 nightly
The price is $75 total per night from Apr 26 to Apr 27
$75 total
Apr 26 - Apr 27
Total with taxes and fees
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,632 reviews)
I appreciated the vintage charm and keeping with the history of the Howard Johnson. That made it fun. The room was a good size and pretty clean but it was missing some of the finishes that are nice to have; the sheets were kind of scratchy, the tub was shiny clean but had some bubbling of the coating ...

Reviewed on Apr 13, 2026

Howard Johnson by Wyndham Florence
Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road Florence SC
$89 nightly
The price is $100 total per night from Apr 19 to Apr 20
$100 total
Apr 19 - Apr 20
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (2,266 reviews)
Everything was excellent from front desk to housekeeping

Reviewed on Apr 12, 2026

Park Inn by Radisson Florence, SC
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

2.5 out of 5
527 Woody Jones Blvd Florence SC
$101 nightly
The price is $113 total per night from May 10 to May 11
$113 total
May 10 - May 11
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,268 reviews)
Bol de glaces très très salé. Climatisation bruyante. Manque de pression dans la douche

Reviewed on Apr 13, 2026

Comfort Inn & Suites Florence Center Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Florence Hotels

Red Roof Inn Florence - Civic Center

Red Roof Inn Florence - Civic Center

2 out of 5
2690 David H McLeod Boulevard Florence SC
$56 nightly
The price is $63 total per night from May 3 to May 4
$63 total
May 3 - May 4
Total with taxes and fees
Stay at this hotel in Florence. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
6.8/10 (1,004 reviews)
It does the job. Clean bed and bathroom.

Reviewed on Apr 10, 2026

Red Roof Inn Florence - Civic Center
Budget Inn Timmonsville

Budget Inn Timmonsville

2 out of 5
2200 Cale Yarborough Highway Timmonsville SC
$61 nightly
The price is $68 total per night from Apr 15 to Apr 16
$68 total
Apr 15 - Apr 16
Total with taxes and fees
Stay at this motel in Timmonsville. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attraction Florence Motor Speedway is located nearby.
7/10 Good! (336 reviews)
yes

Reviewed on Apr 13, 2026

Budget Inn Timmonsville
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
$66 nightly
The price is $74 total per night from Apr 19 to Apr 20
$74 total
Apr 19 - Apr 20
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7/10 Good! (1,008 reviews)
I booked this room for what I was hoping to be a nice quiet weekend get away for my elderly mother and it was not!! First, this property is very dated. Upon arrival there were people sitting in their car in the parking lot across from my mother’s room and I felt a little unsafe. When we got inside ...

Reviewed on Apr 13, 2026

Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Florence

Home2 Suites by Hilton Florence, SC

Home2 Suites by Hilton Florence, SC

3 out of 5
900 Woody Jones Blvd Florence SC
$129 nightly
The price is $144 total per night from Apr 26 to Apr 27
$144 total
Apr 26 - Apr 27
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,007 reviews)
We love staying here! Great staff and huge rooms- super conveniently located for the hockey crowd; can walk to the arena :)

Reviewed on Apr 11, 2026

Home2 Suites by Hilton Florence, SC
Spark by Hilton Florence North I-95, SC

Spark by Hilton Florence North I-95, SC

2.5 out of 5
1739 Mandeville Rd Florence SC
$93 nightly
The price is $104 total per night from Apr 20 to Apr 21
$104 total
Apr 20 - Apr 21
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (67 reviews)
The hotel was comfortable. The bed was very comfortable. The breakfast, however, was a little sparse. The coffee was terrible.

Reviewed on Apr 13, 2026

Spark by Hilton Florence North I-95, SC
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
$66 nightly
The price is $74 total per night from Apr 19 to Apr 20
$74 total
Apr 19 - Apr 20
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7/10 Good! (1,008 reviews)
I booked this room for what I was hoping to be a nice quiet weekend get away for my elderly mother and it was not!! First, this property is very dated. Upon arrival there were people sitting in their car in the parking lot across from my mother’s room and I felt a little unsafe. When we got inside ...

Reviewed on Apr 13, 2026

Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

LGA to FLO Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date

Frequently asked questions

What is the shortest flight from LaGuardia Airport (LGA) to Florence Regional Airport?
The quickest flight from LaGuardia Airport (LGA) to FLO is 3 hours and 1 minute. Grab your favorite tipple from the drink cart, get stuck into your travel journal or read a few magazines — you'll have plenty of time on this medium-haul journey.
How many hours flight from LaGuardia Airport (LGA) to FLO?
The journey from LaGuardia Airport (LGA) to FLO takes an average of 3 hours and 18 minutes. A few good movies, a gripping novel and a decent snooze will help make time fly by.
What airlines have the most flights from LaGuardia Airport to FLO?
You won't find any airlines that fly direct between LaGuardia Airport (LGA) and FLO. Be organized and secure a multi-stop or one-stop plane ticket.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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