Cheap flights from LGA to FLO (LaGuardia to Florence Regional)

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Cheap Flights from LGA to FLO starting at $487 One Way, $619 Round Trip

Prices starting at $619 for return flights and $487 for one-way flights to Florence Regional were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Oct 22 - Mon, Nov 2
LGA
New York
FLO
Florence
$619 Roundtrip, found 3 days ago
$619
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Oct 22 from New York to Florence, returning Mon, Nov 2, priced at $619 found 3 days ago
Thu, Oct 22 - Mon, Nov 2
LGA
New York
FLO
Florence
$675 Roundtrip, found 3 days ago
$675
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Oct 22 from New York to Florence, returning Mon, Nov 2, priced at $675 found 3 days ago
Thu, Oct 22 - Mon, Nov 2
LGA
New York
FLO
Florence
$747 Roundtrip, found 3 days ago
$747
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Oct 22 from New York to Florence, returning Mon, Nov 2, priced at $747 found 3 days ago
Thu, Oct 22 - Mon, Nov 2
LGA
New York
FLO
Florence
$781 Roundtrip, found 3 days ago
$781
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Oct 22 from New York to Florence, returning Mon, Nov 2, priced at $781 found 3 days ago
Thu, Oct 22 - Mon, Nov 2
LGA
New York
FLO
Florence
$860 Roundtrip, found 5 days ago
$860
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Oct 22 from New York to Florence, returning Mon, Nov 2, priced at $860 found 5 days ago

Hotel Ideas near Florence Regional

Airport Hotels near Florence Regional

Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence Florence SC
$100 nightly
The price is $112 total per night from Nov 2 to Nov 3
$112 total
Nov 2 - Nov 3
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
Hyatt Place Florence Downtown
Hotel Florence, Tapestry Collection by Hilton

Hotel Florence, Tapestry Collection by Hilton

3 out of 5
126 W Evans St Florence SC
$120 nightly
The price is $135 total per night from Nov 1 to Nov 2
$135 total
Nov 1 - Nov 2
Total with taxes and fees
Book a stay at this spa hotel in Florence. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
Hotel Florence, Tapestry Collection by Hilton
The Urban Flats

The Urban Flats

4 out of 5
135 N Dargan St Florence SC
$383 nightly
The price is $429 total per night from Oct 14 to Oct 15
$429 total
Oct 14 - Oct 15
Total with taxes and fees
Book a stay at this business-friendly aparthotel in Florence. Enjoy free WiFi, free parking, and laundry facilities. Popular attractions Florence County Museum ...
The Urban Flats
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Florence

Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road Florence SC
$89 nightly
The price is $100 total per night from Oct 11 to Oct 12
$100 total
Oct 11 - Oct 12
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (2,459 reviews)
"Great location , staff and clea liness"

Reviewed on Oct 6, 2026

Park Inn by Radisson Florence, SC
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
$65 nightly
The price is $72 total per night from Oct 8 to Oct 9
$72 total
Oct 8 - Oct 9
Total with taxes and fees
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,733 reviews)
"La chambre est insaluble, draps très sales avec taches jaunes et noires (voir photos). Coquerelle vivante dans la toilette aperçue la nuit (voir photo). Nous sommes arrivés tardivement et étions fatigués alors nous nous sommes couchés habillés sans utiliser les draps. Le dejeuner est très ordinaire. ..."

Reviewed on Oct 6, 2026

Howard Johnson by Wyndham Florence
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

2.5 out of 5
527 Woody Jones Blvd Florence SC
$101 nightly
The price is $113 total per night from Oct 27 to Oct 28
$113 total
Oct 27 - Oct 28
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,372 reviews)
"It was ok"

Reviewed on Oct 5, 2026

Comfort Inn & Suites Florence Center Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Florence Hotels

Red Roof Inn Florence - Civic Center

Red Roof Inn Florence - Civic Center

2 out of 5
2690 David H McLeod Boulevard Florence SC
$61 nightly
The price is $68 total per night from Oct 11 to Oct 12
$68 total
Oct 11 - Oct 12
Total with taxes and fees
Stay at this hotel in Florence. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
Red Roof Inn Florence - Civic Center
Budget Inn Timmonsville

Budget Inn Timmonsville

2 out of 5
2200 Cale Yarborough Highway Timmonsville SC
$61 nightly
The price is $68 total per night from Oct 8 to Oct 9
$68 total
Oct 8 - Oct 9
Total with taxes and fees
Stay at this motel in Timmonsville. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attraction Florence Motor Speedway is located nearby.
7/10 Good! (351 reviews)
"Room was terrible. Stained sheets, stained tub ( as if it was burned. I read the reviews and thought it was a clean, good place to stay, NOT. Went to check out, rang the bell and when the lady came out, she told me quiet, sleeping. Really???!!!"

Reviewed on Oct 2, 2026

Budget Inn Timmonsville
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
$65 nightly
The price is $73 total per night from Oct 15 to Oct 16
$73 total
Oct 15 - Oct 16
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Florence

Home2 Suites by Hilton Florence, SC

Home2 Suites by Hilton Florence, SC

3 out of 5
900 Woody Jones Blvd Florence SC
$115 nightly
The price is $129 total per night from Oct 25 to Oct 26
$129 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Home2 Suites by Hilton Florence, SC
Spark by Hilton Florence North I-95, SC

Spark by Hilton Florence North I-95, SC

2.5 out of 5
1739 Mandeville Rd Florence SC
$88 nightly
The price is $98 total per night from Oct 25 to Oct 26
$98 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (312 reviews)
"C’est un très bel hôtel."

Reviewed on Oct 5, 2026

Spark by Hilton Florence North I-95, SC
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
$65 nightly
The price is $73 total per night from Oct 15 to Oct 16
$73 total
Oct 15 - Oct 16
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

LGA to FLO Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date

Frequently asked questions

What is the shortest flight from LaGuardia Airport (LGA) to Florence Regional Airport?
The quickest flight from LaGuardia Airport (LGA) to FLO is 3 hours and 1 minute. Grab your favorite tipple from the drink cart, get stuck into your travel journal or read a few magazines — you'll have plenty of time on this medium-haul journey.
How many hours flight from LaGuardia Airport (LGA) to FLO?
The journey from LaGuardia Airport (LGA) to FLO takes an average of 3 hours and 18 minutes. A few good movies, a gripping novel and a decent snooze will help make time fly by.
What airlines have the most flights from LaGuardia Airport to FLO?
You won't find any airlines that fly direct between LaGuardia Airport (LGA) and FLO. Be organized and secure a multi-stop or one-stop plane ticket.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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