Cheap flights from LGA to FLO (LaGuardia to Florence Regional)

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Cheap Flights from LGA to FLO starting at $407 One Way, Round Trip

Prices starting at for return flights and $407 for one-way flights to Florence Regional were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Hotel Ideas near Florence Regional

Airport Hotels near Florence Regional

Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence Florence SC
$110 nightly
The price is $123 total per night from Oct 1 to Oct 2
$123 total
Oct 1 - Oct 2
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
9/10 Wonderful! (1,005 reviews)
"Very clean, nice staff and good breakfast"

Reviewed on Sep 21, 2026

Hyatt Place Florence Downtown
Hotel Florence, Tapestry Collection by Hilton

Hotel Florence, Tapestry Collection by Hilton

3 out of 5
126 W Evans St Florence SC
$127 nightly
The price is $142 total per night from Oct 19 to Oct 20
$142 total
Oct 19 - Oct 20
Total with taxes and fees
Book a stay at this spa hotel in Florence. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (655 reviews)
"Beautiful boutique like hotel. Will definitely stay there again!"

Reviewed on Sep 18, 2026

Hotel Florence, Tapestry Collection by Hilton
The Urban Flats

The Urban Flats

4 out of 5
135 N Dargan St Florence SC
$406 nightly
The price is $454 total per night from Sep 29 to Sep 30
$454 total
Sep 29 - Sep 30
Total with taxes and fees
Book a stay at this business-friendly aparthotel in Florence. Enjoy free WiFi, free parking, and laundry facilities. Popular attractions Florence County Museum ...
The Urban Flats
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Florence

Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road Florence SC
$89 nightly
The price is $100 total per night from Oct 4 to Oct 5
$100 total
Oct 4 - Oct 5
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
Park Inn by Radisson Florence, SC
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
$65 nightly
The price is $72 total per night from Sep 23 to Sep 24
$72 total
Sep 23 - Sep 24
Total with taxes and fees
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Howard Johnson by Wyndham Florence
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

2.5 out of 5
150 Dunbarton Dr Florence SC
$89 nightly
The price is $100 total per night from Oct 4 to Oct 5
$100 total
Oct 4 - Oct 5
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (376 reviews)
"The room and bathroom were clean. Bed was comfy and the room had everything needed. I didn't realize that room access was from the outside but I didn't pay attention when I booked the room so that's on me. Breakfast was good and everything was neat and clean . The AC in my room only worked correctly ..."

Reviewed on Sep 19, 2026

Quality Inn & Suites Florence Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Florence Hotels

Red Roof Inn Florence - Civic Center

Red Roof Inn Florence - Civic Center

2 out of 5
2690 David H McLeod Boulevard Florence SC
$61 nightly
The price is $68 total per night from Sep 27 to Sep 28
$68 total
Sep 27 - Sep 28
Total with taxes and fees
Stay at this hotel in Florence. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
Red Roof Inn Florence - Civic Center
Budget Inn Timmonsville

Budget Inn Timmonsville

2 out of 5
2200 Cale Yarborough Highway Timmonsville SC
$61 nightly
The price is $68 total per night from Sep 23 to Sep 24
$68 total
Sep 23 - Sep 24
Total with taxes and fees
Stay at this motel in Timmonsville. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attraction Florence Motor Speedway is located nearby.
7/10 Good! (351 reviews)
"Room not clean had to get towels and light bulbs. I think a lot of people live there.."

Reviewed on Sep 19, 2026

Budget Inn Timmonsville
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
$69 nightly
The price is $77 total per night from Sep 23 to Sep 24
$77 total
Sep 23 - Sep 24
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Florence

Home2 Suites by Hilton Florence, SC

Home2 Suites by Hilton Florence, SC

3 out of 5
900 Woody Jones Blvd Florence SC
$111 nightly
The price is $124 total per night from Sep 29 to Sep 30
$124 total
Sep 29 - Sep 30
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (1,001 reviews)
"Clean hotel, easy parking, good breakfast, friendly staff"

Reviewed on Sep 19, 2026

Home2 Suites by Hilton Florence, SC
Spark by Hilton Florence North I-95, SC

Spark by Hilton Florence North I-95, SC

2.5 out of 5
1739 Mandeville Rd Florence SC
$85 nightly
The price is $95 total per night from Oct 18 to Oct 19
$95 total
Oct 18 - Oct 19
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (300 reviews)
"The bathroom had zero soap in the containers and the shampoo wasn’t even in the bathroom. The breakfast was very poor- there was hardly anything the worst breakfast layout I have ever been too."

Reviewed on Sep 21, 2026

Spark by Hilton Florence North I-95, SC
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
$69 nightly
The price is $77 total per night from Sep 23 to Sep 24
$77 total
Sep 23 - Sep 24
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

LGA to FLO Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date

Frequently asked questions

What is the shortest flight from LaGuardia Airport (LGA) to Florence Regional Airport?
The quickest flight from LaGuardia Airport (LGA) to FLO is 3 hours and 1 minute. Grab your favorite tipple from the drink cart, get stuck into your travel journal or read a few magazines — you'll have plenty of time on this medium-haul journey.
How many hours flight from LaGuardia Airport (LGA) to FLO?
The journey from LaGuardia Airport (LGA) to FLO takes an average of 3 hours and 18 minutes. A few good movies, a gripping novel and a decent snooze will help make time fly by.
What airlines have the most flights from LaGuardia Airport to FLO?
You won't find any airlines that fly direct between LaGuardia Airport (LGA) and FLO. Be organized and secure a multi-stop or one-stop plane ticket.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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