Cheap flights from STL to TYS (Lambert-St. Louis Intl. to McGhee Tyson)

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Cheap Flights from STL to TYS starting at $129 One Way, $274 Round Trip

Prices starting at $274 for return flights and $129 for one-way flights to McGhee Tyson were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Sep 15 - Sun, Sep 20
STL
St. Louis
TYS
Knoxville
$274 Roundtrip, found 5 days ago
$274
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Tue, Sep 15 from St. Louis to Knoxville, returning Sun, Sep 20, priced at $274 found 5 days ago
Tue, Sep 15 - Sun, Sep 20
STL
St. Louis
TYS
Knoxville
$279 Roundtrip, found 5 days ago
$279
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Tue, Sep 15 from St. Louis to Knoxville, returning Sun, Sep 20, priced at $279 found 5 days ago
Tue, Sep 15 - Sun, Sep 20
STL
St. Louis
TYS
Knoxville
$284 Roundtrip, found 5 days ago
$284
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Tue, Sep 15 from St. Louis to Knoxville, returning Sun, Sep 20, priced at $284 found 5 days ago
Tue, Sep 15 - Sun, Sep 20
STL
St. Louis
TYS
Knoxville
$287 Roundtrip, found 5 days ago
$287
Roundtrip
found 5 days ago
Select Delta flight, departing Tue, Sep 15 from St. Louis to Knoxville, returning Sun, Sep 20, priced at $287 found 5 days ago
Sat, Aug 1 - Thu, Aug 6
STL
St. Louis
TYS
Knoxville
$290 Roundtrip, found 6 days ago
$290
Roundtrip
found 6 days ago
Select United flight, departing Sat, Aug 1 from St. Louis to Knoxville, returning Thu, Aug 6, priced at $290 found 6 days ago

Hotel Ideas near McGhee Tyson

Airport Hotels near McGhee Tyson

Hilton Knoxville Airport

Hilton Knoxville Airport

3.5 out of 5
2001 Alcoa Hwy Alcoa TN
$149 nightly
The price is $171 total per night from Jun 14 to Jun 15
$171 total
Jun 14 - Jun 15
Total with taxes and fees
Book a stay at this family-friendly hotel in Alcoa. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (1,003 reviews)
"Bathrooms were dirty requested towels never came room was hot and cold and hot and cold"

Reviewed on Jun 1, 2026

Hilton Knoxville Airport
La Quinta Inn & Suites by Wyndham Knoxville Airport

La Quinta Inn & Suites by Wyndham Knoxville Airport

3 out of 5
126 Cusick Road Alcoa TN
$74 nightly
The price is $88 total per night from Jun 14 to Jun 15
$88 total
Jun 14 - Jun 15
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,910 reviews)
"This place was very nice. Front desk associate was friendly and helpful. The only thing not so good was I found the bed to be a little less comfortable than other hotels I've stayed. Not as soft."

Reviewed on Jun 2, 2026

La Quinta Inn & Suites by Wyndham Knoxville Airport
Candlewood Suites Knoxville Airport-Alcoa by IHG

Candlewood Suites Knoxville Airport-Alcoa by IHG

2.5 out of 5
176 Cusick Road Alcoa TN
$76 nightly
The price is $90 total per night from Jun 28 to Jun 29
$90 total
Jun 28 - Jun 29
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free WiFi, an outdoor pool, and a free airport shuttle. Popular attractions Meigs Falls and Palace ...
8.4/10 Very Good! (671 reviews)
"We stayed two nights and specifically chose this hotel for the kitchenette. The ice maker didn't work, and since all the units have ice makers there is no where else to get ice. The 2 burner cooktop did not work at all. No lights, no heat. For us this, other than having a larger refrigerator than ..."

Reviewed on Jun 2, 2026

Candlewood Suites Knoxville Airport-Alcoa by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Knoxville

Hilton Knoxville Airport

Hilton Knoxville Airport

3.5 out of 5
2001 Alcoa Hwy Alcoa TN
$149 nightly
The price is $171 total per night from Jun 14 to Jun 15
$171 total
Jun 14 - Jun 15
Total with taxes and fees
Book a stay at this family-friendly hotel in Alcoa. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (1,003 reviews)
"Bathrooms were dirty requested towels never came room was hot and cold and hot and cold"

Reviewed on Jun 1, 2026

Hilton Knoxville Airport
La Quinta Inn & Suites by Wyndham Knoxville Airport

La Quinta Inn & Suites by Wyndham Knoxville Airport

3 out of 5
126 Cusick Road Alcoa TN
$74 nightly
The price is $88 total per night from Jun 14 to Jun 15
$88 total
Jun 14 - Jun 15
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,910 reviews)
"This place was very nice. Front desk associate was friendly and helpful. The only thing not so good was I found the bed to be a little less comfortable than other hotels I've stayed. Not as soft."

Reviewed on Jun 2, 2026

La Quinta Inn & Suites by Wyndham Knoxville Airport
Mainstay Suites Knoxville Airport

Mainstay Suites Knoxville Airport

2.5 out of 5
361 Fountain View Cir Alcoa TN
$85 nightly
The price is $100 total per night from Jun 4 to Jun 5
$100 total
Jun 4 - Jun 5
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
7.8/10 Good! (759 reviews)
"Staff was great, room and hotel was clean. Solid on most things. Very good value price for the experience overall."

Reviewed on Jun 2, 2026

Mainstay Suites Knoxville Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Knoxville Hotels With Airport Transportation

La Quinta Inn & Suites by Wyndham Knoxville Airport

La Quinta Inn & Suites by Wyndham Knoxville Airport

3 out of 5
126 Cusick Road Alcoa TN
$74 nightly
The price is $88 total per night from Jun 14 to Jun 15
$88 total
Jun 14 - Jun 15
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,910 reviews)
"This place was very nice. Front desk associate was friendly and helpful. The only thing not so good was I found the bed to be a little less comfortable than other hotels I've stayed. Not as soft."

Reviewed on Jun 2, 2026

La Quinta Inn & Suites by Wyndham Knoxville Airport
USA Inn

USA Inn

3 out of 5
Alcoa Hwy, 2962 Alcoa TN
$56 nightly
The price is $66 total per night from Jun 4 to Jun 5
$66 total
Jun 4 - Jun 5
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Meigs Falls and Fort Loudoun ...
5/10 (719 reviews)
"I didnt like the smell in the lobby or the strip lights in the room. The bathroom looked like the bathtub had been refinished poorly and not cleaned behind the bathroom door. The pool looked like it hadn't been open for years. There were bricks in the bottom with no water. We arrived about 1:00 and ..."

Reviewed on May 29, 2026

USA Inn
Best Western Knoxville Airport/Alcoa

Best Western Knoxville Airport/Alcoa

2.5 out of 5
162 Cusick Rd Alcoa TN
$73 nightly
The price is $87 total per night from Jun 14 to Jun 15
$87 total
Jun 14 - Jun 15
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (1,005 reviews)
"Very clean hotel. Loved it."

Reviewed on Jun 3, 2026

Best Western Knoxville Airport/Alcoa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Knoxville Hotels

USA Inn

USA Inn

3 out of 5
Alcoa Hwy, 2962 Alcoa TN
$56 nightly
The price is $66 total per night from Jun 4 to Jun 5
$66 total
Jun 4 - Jun 5
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Meigs Falls and Fort Loudoun ...
5/10 (719 reviews)
"I didnt like the smell in the lobby or the strip lights in the room. The bathroom looked like the bathtub had been refinished poorly and not cleaned behind the bathroom door. The pool looked like it hadn't been open for years. There were bricks in the bottom with no water. We arrived about 1:00 and ..."

Reviewed on May 29, 2026

USA Inn
Candlewood Suites Knoxville Airport-Alcoa by IHG

Candlewood Suites Knoxville Airport-Alcoa by IHG

2.5 out of 5
176 Cusick Road Alcoa TN
$76 nightly
The price is $90 total per night from Jun 28 to Jun 29
$90 total
Jun 28 - Jun 29
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free WiFi, an outdoor pool, and a free airport shuttle. Popular attractions Meigs Falls and Palace ...
8.4/10 Very Good! (671 reviews)
"We stayed two nights and specifically chose this hotel for the kitchenette. The ice maker didn't work, and since all the units have ice makers there is no where else to get ice. The 2 burner cooktop did not work at all. No lights, no heat. For us this, other than having a larger refrigerator than ..."

Reviewed on Jun 2, 2026

Candlewood Suites Knoxville Airport-Alcoa by IHG
Best Western Knoxville Airport/Alcoa

Best Western Knoxville Airport/Alcoa

2.5 out of 5
162 Cusick Rd Alcoa TN
$73 nightly
The price is $87 total per night from Jun 14 to Jun 15
$87 total
Jun 14 - Jun 15
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (1,005 reviews)
"Very clean hotel. Loved it."

Reviewed on Jun 3, 2026

Best Western Knoxville Airport/Alcoa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Knoxville

Comfort Suites Knoxville Airport

Comfort Suites Knoxville Airport

2.5 out of 5
140 Cusick Rd Alcoa TN
$82 nightly
The price is $97 total per night from Jun 29 to Jun 30
$97 total
Jun 29 - Jun 30
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.8/10 Good! (803 reviews)
"Enjoyed our stay. Very quiet."

Reviewed on Jun 2, 2026

Comfort Suites Knoxville Airport
Best Western Knoxville Airport/Alcoa

Best Western Knoxville Airport/Alcoa

2.5 out of 5
162 Cusick Rd Alcoa TN
$73 nightly
The price is $87 total per night from Jun 14 to Jun 15
$87 total
Jun 14 - Jun 15
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (1,005 reviews)
"Very clean hotel. Loved it."

Reviewed on Jun 3, 2026

Best Western Knoxville Airport/Alcoa
La Quinta Inn & Suites by Wyndham Knoxville Airport

La Quinta Inn & Suites by Wyndham Knoxville Airport

3 out of 5
126 Cusick Road Alcoa TN
$74 nightly
The price is $88 total per night from Jun 14 to Jun 15
$88 total
Jun 14 - Jun 15
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,910 reviews)
"This place was very nice. Front desk associate was friendly and helpful. The only thing not so good was I found the bed to be a little less comfortable than other hotels I've stayed. Not as soft."

Reviewed on Jun 2, 2026

La Quinta Inn & Suites by Wyndham Knoxville Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

STL to TYS Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
STL Address & GPS
Address:
10701 Lambert International Blvd.
Saint Louis MO, 63145
United States
IATA Code:
STL
Longitude:
-90.379002
Latitude:
38.748707
Time Zone:
America/Chicago
TYS Address & GPS
Address:
2055 Alcoa Highway
Knoxville TN, 37701
United States
IATA Code:
TYS
Longitude:
-83.989729
Latitude:
35.80565
Time Zone:
America/New_York

Frequently asked questions

Are there non-stop flights from St. Louis Lambert International Airport to McGhee Tyson Airport (TYS)?
As you can't fly direct from Lambert Field to McGhee Tyson Airport (TYS) at the moment, a flight with a single stopover is your best bet. American Airlines, Delta Air Lines and United Airlines are respected airlines that service this route.
What is the shortest flight from St. Louis Lambert International Airport to Knoxville Airport?
The quickest flight time from St. Louis to Knoxville is 4 hours and 1 minute. Grab your favorite tipple from the cabin crew, hone your travel itinerary or finish that podcast — you'll have plenty of time on this medium-haul journey.
How many hours flight from St. Louis Lambert International Airport to TYS?
From STL to TYS, you'll be in your plane seat for approximately 4 hours and 9 minutes. Get comfy, order a wine and put on your noise-canceling earphones. It's time for a binge-watching session.
What airlines have the most flights from St. Louis Lambert International Airport to Knoxville Airport?
At the moment, you can't fly direct between STL and TYS. However, you can find flights with one or more stops. It's not all bad — use the break to stretch your travel-weary legs or grab a nice coffee!

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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