Cheap flights from STL to TYS (Lambert-St. Louis Intl. to McGhee Tyson)
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Cheap Flights from STL to TYS starting at $149 One Way, $280 Round Trip
Prices starting at $280 for return flights and $149 for one-way flights to McGhee Tyson were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
STL
St. Louis
TYS
Knoxville
$280 Roundtrip, found 4 days ago
$280
Roundtrip
found 4 days ago
STL
St. Louis
TYS
Knoxville
$284 Roundtrip, found 4 days ago
$284
Roundtrip
found 4 days ago
STL
St. Louis
TYS
Knoxville
$290 Roundtrip, found 4 days ago
$290
Roundtrip
found 4 days ago
STL
St. Louis
TYS
Knoxville
$294 Roundtrip, found 2 days ago
$294
Roundtrip
found 2 days ago
STL
St. Louis
TYS
Knoxville
$296 Roundtrip, found 4 days ago
$296
Roundtrip
found 4 days ago
Hotel Ideas near McGhee Tyson
Airport Hotels near McGhee Tyson
La Quinta Inn & Suites by Wyndham Knoxville Airport
126 Cusick Road Alcoa TN
$74 nightly
The price is $88 total per night from Jun 14 to Jun 15
$88 total
Jun 14 - Jun 15
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,895 reviews)
"Room had odor, just wasn’t bad enough to move rooms. The AC also slightly louder than preferred. Conveniently located to airport. Nice shuttle service. Give it average rating."
Reviewed on May 26, 2026
Hilton Knoxville Airport
2001 Alcoa Hwy Alcoa TN
$141 nightly
The price is $162 total per night from Jun 21 to Jun 22
$162 total
Jun 21 - Jun 22
Total with taxes and fees
Book a stay at this family-friendly hotel in Alcoa. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (1,007 reviews)
"The room was hot. You take the covers off and you are cold and then you put it back on and you’re hot. My husband said the same thing it was absolutely miserable."
Reviewed on May 26, 2026
Candlewood Suites Knoxville Airport-Alcoa by IHG
176 Cusick Road Alcoa TN
$76 nightly
The price is $90 total per night from May 31 to Jun 1
$90 total
May 31 - Jun 1
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free WiFi, an outdoor pool, and a free airport shuttle. Popular attractions Meigs Falls and Palace ...
8.4/10 Very Good! (664 reviews)
"Todo ok cerca de la zona del aeropuerto"
Reviewed on May 26, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels In Knoxville
La Quinta Inn & Suites by Wyndham Knoxville Airport
126 Cusick Road Alcoa TN
$74 nightly
The price is $88 total per night from Jun 14 to Jun 15
$88 total
Jun 14 - Jun 15
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,895 reviews)
"Room had odor, just wasn’t bad enough to move rooms. The AC also slightly louder than preferred. Conveniently located to airport. Nice shuttle service. Give it average rating."
Reviewed on May 26, 2026
Hilton Knoxville Airport
2001 Alcoa Hwy Alcoa TN
$141 nightly
The price is $162 total per night from Jun 21 to Jun 22
$162 total
Jun 21 - Jun 22
Total with taxes and fees
Book a stay at this family-friendly hotel in Alcoa. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (1,007 reviews)
"The room was hot. You take the covers off and you are cold and then you put it back on and you’re hot. My husband said the same thing it was absolutely miserable."
Reviewed on May 26, 2026
Mainstay Suites Knoxville Airport
361 Fountain View Cir Alcoa TN
$89 nightly
The price is $106 total per night from May 31 to Jun 1
$106 total
May 31 - Jun 1
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
7.8/10 Good! (752 reviews)
"The hotel had a very odd smell to it when you first walked in. It wasn’t super alarming just odd. Once we got into our room this horrible stench was stuck to all the furniture. We had to open a window just to breathe comfortably. My husband and I came to the hotel very late at night from travel so ..."
Reviewed on May 25, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Knoxville Hotels With Airport Transportation
La Quinta Inn & Suites by Wyndham Knoxville Airport
126 Cusick Road Alcoa TN
$74 nightly
The price is $88 total per night from Jun 14 to Jun 15
$88 total
Jun 14 - Jun 15
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,895 reviews)
"Room had odor, just wasn’t bad enough to move rooms. The AC also slightly louder than preferred. Conveniently located to airport. Nice shuttle service. Give it average rating."
Reviewed on May 26, 2026
USA Inn
Alcoa Hwy, 2962 Alcoa TN
$59 nightly
The price is $71 total per night from May 28 to May 29
$71 total
May 28 - May 29
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Meigs Falls and Fort Loudoun ...
Best Western Knoxville Airport/Alcoa
162 Cusick Rd Alcoa TN
$73 nightly
The price is $87 total per night from Jun 14 to Jun 15
$87 total
Jun 14 - Jun 15
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (1,003 reviews)
"My flight was cancelled. I arrived after 10 pm slept for a few hours and departed early the next morning. The two staff members I interacted with were very pleasant and friendly. The room was clean and comfortable. I left too early to have breakfast. Overall a good stay."
Reviewed on May 26, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Low Priced Knoxville Hotels
USA Inn
Alcoa Hwy, 2962 Alcoa TN
$59 nightly
The price is $71 total per night from May 28 to May 29
$71 total
May 28 - May 29
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Meigs Falls and Fort Loudoun ...
Candlewood Suites Knoxville Airport-Alcoa by IHG
176 Cusick Road Alcoa TN
$76 nightly
The price is $90 total per night from May 31 to Jun 1
$90 total
May 31 - Jun 1
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free WiFi, an outdoor pool, and a free airport shuttle. Popular attractions Meigs Falls and Palace ...
8.4/10 Very Good! (664 reviews)
"Todo ok cerca de la zona del aeropuerto"
Reviewed on May 26, 2026
Best Western Knoxville Airport/Alcoa
162 Cusick Rd Alcoa TN
$73 nightly
The price is $87 total per night from Jun 14 to Jun 15
$87 total
Jun 14 - Jun 15
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (1,003 reviews)
"My flight was cancelled. I arrived after 10 pm slept for a few hours and departed early the next morning. The two staff members I interacted with were very pleasant and friendly. The room was clean and comfortable. I left too early to have breakfast. Overall a good stay."
Reviewed on May 26, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Family Friendly Hotels in Knoxville
Comfort Suites Knoxville Airport
140 Cusick Rd Alcoa TN
$81 nightly
The price is $97 total per night from May 31 to Jun 1
$97 total
May 31 - Jun 1
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.8/10 Good! (799 reviews)
"Very family feel to the staff. Excellent customer service."
Reviewed on May 24, 2026
Best Western Knoxville Airport/Alcoa
162 Cusick Rd Alcoa TN
$73 nightly
The price is $87 total per night from Jun 14 to Jun 15
$87 total
Jun 14 - Jun 15
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (1,003 reviews)
"My flight was cancelled. I arrived after 10 pm slept for a few hours and departed early the next morning. The two staff members I interacted with were very pleasant and friendly. The room was clean and comfortable. I left too early to have breakfast. Overall a good stay."
Reviewed on May 26, 2026
La Quinta Inn & Suites by Wyndham Knoxville Airport
126 Cusick Road Alcoa TN
$74 nightly
The price is $88 total per night from Jun 14 to Jun 15
$88 total
Jun 14 - Jun 15
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,895 reviews)
"Room had odor, just wasn’t bad enough to move rooms. The AC also slightly louder than preferred. Conveniently located to airport. Nice shuttle service. Give it average rating."
Reviewed on May 26, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
STL to TYS Route Info
Origin Airport | |
|---|---|
Destination Airport | |
Number Of Airlines Serving | |
Distance | |
Shortest Flight Departure Time | |
Shortest Flight Departure Date |
- Airport Locations
- More Popular Flights
- Top Trending
- Flights from Other Cities
- Flights From Other Airports
- Great Travel Ideas
STL Address & GPS
Address:
10701 Lambert International Blvd.
Saint Louis MO, 63145
United States
IATA Code:
STL
Longitude:
-90.379002
Latitude:
38.748707
Time Zone:
America/Chicago
TYS Address & GPS
Address:
2055 Alcoa Highway
Knoxville TN, 37701
United States
IATA Code:
TYS
Longitude:
-83.989729
Latitude:
35.80565
Time Zone:
America/New_York
Other Flights from Lambert-St. Louis Intl. Airport (STL)
Other Flights to McGhee Tyson Airport (TYS)
- Abraham Lincoln Capital Airport (SPI)
- Quincy Regional-Baldwin Field Airport (UIN)
- Columbia Regional Airport (COU)
- Veterans Airport of Southern Illinois Airport (MWA)
- Decatur Airport (DEC)
- Cape Girardeau Municipal Airport (CGI)
- St. Robert Regional Airport (TBN)
- Cairo Regional Airport (CIR)
- Greater Peoria Regional Airport (PIA)
- Central Illinois Regional Airport (BMI)
Top Trending
Flights
- DFW to SAN
- BOS to MCO
- ORD to DFW
- DCA to DFW
- JFK to LAS
- FLL to LGA
- LGA to FLL
- SNA to SEA
- LAX to DFW
- IAD to DFW
- PDX to SAN
- SEA to SAN
- JFK to FLL
- BWI to DFW
- SEA to SNA
- SAN to PHX
- ORD to LAS
- SNA to LAS
- MSP to SAN
- BWI to FLL
- DFW to LGA
- PHL to MCO
- BOS to DCA
- DFW to CDG
- SNA to DFW
- FLL to JFK
- RDU to PHL
- DCA to FLL
- DFW to ORD
- DCA to BOS
Frequently asked questions
Map To Nearby Hotels
Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.
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