Cheap flights from MHT to SFO (Manchester-Boston Regional to San Francisco Intl.)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

Cheap Flights from MHT to SFO starting at $167 One Way, $380 Round Trip

Prices starting at $380 for return flights and $167 for one-way flights to San Francisco Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Mar 16 - Tue, Mar 17
MHT
Manchester
SFO
San Francisco
$380 Roundtrip, found 3 days ago
$380
Roundtrip
found 3 days ago
Select JetBlue Airways flight, departing Mon, Mar 16 from Manchester to San Francisco, returning Tue, Mar 17, priced at $380 found 3 days ago
Tue, Feb 17 - Sat, Feb 21
MHT
Manchester
SFO
San Francisco
$387 Roundtrip, found 2 days ago
$387
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Tue, Feb 17 from Manchester to San Francisco, returning Sat, Feb 21, priced at $387 found 2 days ago
Tue, Feb 17 - Sat, Feb 21
MHT
Manchester
SFO
San Francisco
$387 Roundtrip, found 2 days ago
$387
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Feb 17 from Manchester to San Francisco, returning Sat, Feb 21, priced at $387 found 2 days ago
Mon, Feb 9 - Tue, Feb 10
MHT
Manchester
SFO
San Francisco
$394 Roundtrip, found 5 days ago
$394
Roundtrip
found 5 days ago
Select JetBlue Airways flight, departing Mon, Feb 9 from Manchester to San Francisco, returning Tue, Feb 10, priced at $394 found 5 days ago
Fri, Mar 13 - Wed, Mar 18
MHT
Manchester
SFO
San Francisco
$408 Roundtrip, found 3 days ago
$408
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Mar 13 from Manchester to San Francisco, returning Wed, Mar 18, priced at $408 found 3 days ago

Hotel Ideas near San Francisco Intl.

Airport Hotels near San Francisco Intl.

The Westin San Francisco Airport

The Westin San Francisco Airport

4 out of 5
1 Old Bayshore Hwy Millbrae CA
$152 nightly
The price is $176 total per night from Jan 30 to Jan 31
$176 total
Jan 30 - Jan 31
Total with taxes and fees
Book a stay at this business-friendly hotel in Millbrae. Enjoy breakfast (surcharge), a free airport shuttle, and a 24-hour fitness center. Our guests praise ...
8.8/10 Excellent! (1,993 reviews)
nice people at the reception

Reviewed on Jan 20, 2026

The Westin San Francisco Airport
SFO El Rancho Inn SureStay Collection by Best Western

SFO El Rancho Inn SureStay Collection by Best Western

3 out of 5
1100 El Camino Real Millbrae CA
$92 nightly
The price is $106 total per night from Jan 31 to Feb 1
$106 total
Jan 31 - Feb 1
Total with taxes and fees
Book a stay at this business-friendly hotel in Millbrae. Enjoy free breakfast, an outdoor pool, and a 24-hour fitness center. Our guests praise the breakfast ...
8.4/10 Very Good! (3,016 reviews)
Very well and good experience.

Reviewed on Jan 21, 2026

SFO El Rancho Inn SureStay Collection by Best Western
The Millwood - A Boutique Hotel

The Millwood - A Boutique Hotel

3 out of 5
1375 El Camino Real Millbrae CA
$142 nightly
The price is $163 total per night from Jan 31 to Feb 1
$163 total
Jan 31 - Feb 1
Total with taxes and fees
Book a stay at this business-friendly hotel in Millbrae. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9/10 Wonderful! (1,000 reviews)
Friendly receptionist at check in. Nice room, good breakfast and free easy parking. Would stay again!

Reviewed on Jan 18, 2026

The Millwood - A Boutique Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In San Francisco

Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

3.5 out of 5
1500 Van Ness Ave San Francisco CA
$127 nightly
The price is $149 total per night from Jan 26 to Jan 27
$149 total
Jan 26 - Jan 27
Total with taxes and fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the pool ...
8.8/10 Excellent! (5,170 reviews)
Yes

Reviewed on Jan 24, 2026

Holiday Inn Golden Gateway by IHG
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
$154 nightly
The price is $181 total per night from Feb 9 to Feb 10
$181 total
Feb 9 - Feb 10
Total with taxes and fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast ...
8.8/10 Excellent! (7,288 reviews)
Yes room was big nice and clean staff very friendly breakfast very good we will stay again close to everything

Reviewed on Jan 22, 2026

Hotel Riu Plaza Fisherman's Wharf
Hilton San Francisco Financial District

Hilton San Francisco Financial District

4 out of 5
750 Kearny St San Francisco CA
$106 nightly
The price is $124 total per night from Feb 1 to Feb 2
$124 total
Feb 1 - Feb 2
Total with taxes and fees
Book a stay at this business-friendly hotel in San Francisco. Enjoy breakfast (surcharge), a fitness center, and WiFi (surcharge). Our guests praise the helpful ...
8.6/10 Excellent! (2,326 reviews)
I was able to check-in at midnight! Their cutoff

Reviewed on Jan 24, 2026

Hilton San Francisco Financial District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

San Francisco Hotels With Airport Transportation

The Dylan at SFO

The Dylan at SFO

3 out of 5
110 S El Camino Real Millbrae CA
$105 nightly
The price is $126 total per night from Jan 31 to Feb 1
$126 total
Jan 31 - Feb 1
Total with taxes and fees
Book a stay at this business-friendly hotel in Millbrae. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,834 reviews)
Inexpensive place to stay very close to SFO. Great bedding very clean newly remodeled. Walking distance to many restaurants bars.

Reviewed on Jan 22, 2026

The Dylan at SFO
Hotel Skye SFO

Hotel Skye SFO

3 out of 5
421 El Camino Real San Bruno CA
$114 nightly
The price is $131 total per night from Jan 29 to Jan 30
$131 total
Jan 29 - Jan 30
Total with taxes and fees
Book a stay at this business-friendly hotel in San Bruno. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,628 reviews)
Very nice rooms /hotel, quiet area , affordable cost, close to shopping.

Reviewed on Jan 24, 2026

Hotel Skye SFO
SFO El Rancho Inn SureStay Collection by Best Western

SFO El Rancho Inn SureStay Collection by Best Western

3 out of 5
1100 El Camino Real Millbrae CA
$92 nightly
The price is $106 total per night from Jan 31 to Feb 1
$106 total
Jan 31 - Feb 1
Total with taxes and fees
Book a stay at this business-friendly hotel in Millbrae. Enjoy free breakfast, an outdoor pool, and a 24-hour fitness center. Our guests praise the breakfast ...
8.4/10 Very Good! (3,016 reviews)
Very well and good experience.

Reviewed on Jan 21, 2026

SFO El Rancho Inn SureStay Collection by Best Western
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced San Francisco Hotels

Travelodge by Wyndham San Francisco Airport North

Travelodge by Wyndham San Francisco Airport North

2 out of 5
326 S Airport Blvd South San Francisco CA
$61 nightly
The price is $73 total per night from Jan 30 to Jan 31
$73 total
Jan 30 - Jan 31
Total with taxes and fees
Book a stay at this business-friendly motel in South San Francisco. Enjoy free WiFi, a free airport shuttle, and parking (surcharge). Our guests praise the clean ...
5.8/10 (3,074 reviews)
Small room not clean

Reviewed on Jan 19, 2026

Travelodge by Wyndham San Francisco Airport North
Hotel North Beach

Hotel North Beach

2 out of 5
935 Kearny Street San Francisco CA
$55 nightly
The price is $65 total per night from Jan 26 to Jan 27
$65 total
Jan 26 - Jan 27
Total with taxes and fees
Stay at this hotel in San Francisco. Enjoy free WiFi, a 24-hour front desk, and laundry facilities. Our guests praise the helpful staff and the clean rooms in ...
7.2/10 Good! (1,003 reviews)
Great

Reviewed on Jan 17, 2026

Hotel North Beach
Hotel Skye SFO

Hotel Skye SFO

3 out of 5
421 El Camino Real San Bruno CA
$114 nightly
The price is $131 total per night from Jan 29 to Jan 30
$131 total
Jan 29 - Jan 30
Total with taxes and fees
Book a stay at this business-friendly hotel in San Bruno. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,628 reviews)
Very nice rooms /hotel, quiet area , affordable cost, close to shopping.

Reviewed on Jan 24, 2026

Hotel Skye SFO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in San Francisco

Hotel Zephyr San Francisco

Hotel Zephyr San Francisco

4 out of 5
250 Beach Street San Francisco CA
$160 nightly
The price is $189 total per night from Jan 28 to Jan 29
$189 total
Jan 28 - Jan 29
Total with taxes and fees
Book a stay at this boutique hotel in San Francisco. Enjoy a 24-hour fitness center, parking (surcharge), and a 24-hour front desk. Our guests praise the helpful ...
8.6/10 Excellent! (2,380 reviews)
Great location! Friendly Staff and fun hotel😎

Reviewed on Jan 19, 2026

Hotel Zephyr San Francisco
Embassy Suites by Hilton San Francisco Airport Waterfront

Embassy Suites by Hilton San Francisco Airport Waterfront

3.5 out of 5
150 Anza Blvd Burlingame CA
$130 nightly
The price is $148 total per night from Jan 31 to Feb 1
$148 total
Jan 31 - Feb 1
Total with taxes and fees
Book a stay at this business-friendly hotel in Burlingame. Enjoy free breakfast, WiFi (surcharge), and parking (surcharge). Our guests praise the breakfast and ...
8.4/10 Very Good! (1,909 reviews)
great location, lovely comfortable rooms, free convenient airport shuttle. laundry room, free breakfast with egg station, casual atmosphere, very family oriented, beautiful hotel design. Breakfast selection was not as big as Huntsville nor the staff as attentive. Housekeeping and front desk staff ...

Reviewed on Jan 20, 2026

Embassy Suites by Hilton San Francisco Airport Waterfront
Embassy Suites by Hilton San Francisco Airport Oyster Point

Embassy Suites by Hilton San Francisco Airport Oyster Point

3.5 out of 5
250 Gateway Blvd South San Francisco CA
$147 nightly
The price is $172 total per night from Jan 31 to Feb 1
$172 total
Jan 31 - Feb 1
Total with taxes and fees
Book a stay at this business-friendly hotel in South San Francisco. Enjoy free breakfast, a 24-hour fitness center, and parking (surcharge). Our guests praise ...
8.4/10 Very Good! (1,268 reviews)
The room was clean. The staff was friendly and helpful. I will 100% return.

Reviewed on Jan 16, 2026

Embassy Suites by Hilton San Francisco Airport Oyster Point
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

MHT to SFO Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date

Frequently asked questions

Are there non-stop flights from MHT to San Francisco Intl. Airport (SFO)?
You'll need to switch planes if you're planning to get from Manchester Airport to SFO. Numerous airlines offer services on this route with just one stopover, including United Airlines, American Airlines and JetBlue Airways.
What is the shortest flight from Manchester Airport to San Francisco Airport?
Flying from Manchester Airport to SFO takes at least 8 hours and 23 minutes. Indulge in a tipple and watch a flick or two — it's a golden opportunity to sit back and chill out.
How many hours flight from Manchester Airport to SFO?
Make yourself comfortable, because the average plane trip from Manchester Airport to SFO is 8 hours and 28 minutes. Enjoy some wine with your meal, finally finish that book ... You'll have enough time to kick back and enjoy the ride.
What airlines have the most flights from Manchester Airport to San Francisco Airport?
Pick up a souvenir, grab a glazed doughnut, strike up a conversation with a stranger ... Airport stopovers don't have to be a drag! If you're planning to head between Manchester and San Francisco, you won't find any direct flights. Be prepared to make at least one stop somewhere.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.