Cheap flights from LGA to FLO (LaGuardia to Florence Regional)

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Cheap Flights from LGA to FLO starting at $252 One Way, $423 Round Trip

Prices starting at $423 for return flights and $252 for one-way flights to Florence Regional were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Aug 22 - Sun, Aug 24
LGA
New York
FLO
Florence
$423 Roundtrip, found 3 days ago
$423
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Aug 22 from New York to Florence, returning Sun, Aug 24, priced at $423 found 3 days ago
Thu, Aug 14 - Sat, Aug 16
LGA
New York
FLO
Florence
$433 Roundtrip, found 1 day ago
$433
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Aug 14 from New York to Florence, returning Sat, Aug 16, priced at $433 found 1 day ago
Fri, Aug 22 - Sun, Aug 24
LGA
New York
FLO
Florence
$446 Roundtrip, found 3 days ago
$446
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Aug 22 from New York to Florence, returning Sun, Aug 24, priced at $446 found 3 days ago
Fri, Aug 22 - Mon, Sep 1
LGA
New York
FLO
Florence
$460 Roundtrip, found 3 days ago
$460
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Aug 22 from New York to Florence, returning Mon, Sep 1, priced at $460 found 3 days ago
Fri, Aug 22 - Sun, Aug 24
LGA
New York
FLO
Florence
$476 Roundtrip, found 3 days ago
$476
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Aug 22 from New York to Florence, returning Sun, Aug 24, priced at $476 found 3 days ago

Hotel Ideas near Florence Regional

Airport Hotels near Florence Regional

Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence, Florence, SC
$109 nightly
The price is $122 total per night from Aug 21 to Aug 22
$122 total
Aug 21 - Aug 22
Total includes taxes and fees
Stay at this 3-star business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
8.8/10 Excellent! (1,011 reviews)
Would stay again
"Check in was fast and easy. The Hotel Lobby was clean and had a lounge and bar inside. We did not use the pool but there is one on the premises. The rooms were clean and well maintained. Bathroom was clean and fully stocked. Only thing I did not like was the parking. You have to drive down an alley ..."

Reviewed on Jul 21, 2025

Hyatt Place Florence Downtown
Hotel Florence, Tapestry Collection by Hilton

Hotel Florence, Tapestry Collection by Hilton

3 out of 5
126 W Evans St, Florence, SC
$124 nightly
The price is $139 total per night from Aug 10 to Aug 11
$139 total
Aug 10 - Aug 11
Total includes taxes and fees
Stay at this 3-star spa hotel in Florence. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (577 reviews)
"Loved the staircase"

Reviewed on Jul 26, 2025

Hotel Florence, Tapestry Collection by Hilton
Charming and Cozy 4BR 2BA House with Parking, Minutes from I-95 and Buc-ees

Charming and Cozy 4BR 2BA House with Parking, Minutes from I-95 and Buc-ees

Florence
Stay at this vacation home in Florence. Enjoy free WiFi, laundry facilities, and patios. Popular attractions Old Greenwood Athletic Park and Greenwood Baseball ...
9.6/10 Exceptional! (5 reviews)
House
"The neighborhood was good. House was very clean and , way better in person than the"

Reviewed on Apr 23, 2025

Get rates
Charming and Cozy 4BR 2BA House with Parking, Minutes from I-95 and Buc-ees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Florence

Comfort Inn & Suites

Comfort Inn & Suites

2.5 out of 5
527 Woody Jones Blvd, Florence, SC
$108 nightly
The price is $121 total per night from Aug 24 to Aug 25
$121 total
Aug 24 - Aug 25
Total includes taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,045 reviews)
Nice
"Great hotel."

Reviewed on Jul 26, 2025

Comfort Inn & Suites
Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road, Florence, SC
$94 nightly
The price is $105 total per night from Aug 17 to Aug 18
$105 total
Aug 17 - Aug 18
Total includes taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (2,115 reviews)
"Clean and quiet. Clean bathroom and clean general areas."

Reviewed on Jul 27, 2025

Park Inn by Radisson Florence, SC
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street, I-95 Exit 164, Florence, SC
$70 nightly
The price is $79 total per night from Jul 29 to Jul 30
$79 total
Jul 29 - Jul 30
Total includes taxes and fees
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,324 reviews)
"clean and safe"

Reviewed on Jul 27, 2025

Howard Johnson by Wyndham Florence
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Florence Hotels

Red Roof Inn Florence - Civic Center

Red Roof Inn Florence - Civic Center

2 out of 5
2690 David H McLeod Boulevard, Florence, SC
$56 nightly
The price is $63 total per night from Aug 3 to Aug 4
$63 total
Aug 3 - Aug 4
Total includes taxes and fees
Stay at this hotel in Florence. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
6.6/10 (1,009 reviews)
"Ok place for a nights sleep when weary from the road."

Reviewed on Jul 24, 2025

Red Roof Inn Florence - Civic Center
Budget Inn Timmonsville

Budget Inn Timmonsville

2 out of 5
2200 Cale Yarborough Highway, Timmonsville, SC
$61 nightly
The price is $68 total per night from Jul 29 to Jul 30
$68 total
Jul 29 - Jul 30
Total includes taxes and fees
Stay at this motel in Timmonsville. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attraction Florence Motor Speedway is located nearby.
7/10 Good! (311 reviews)
"Was perfect for a middle of the night stop due to pouring rain."

Reviewed on Jul 20, 2025

Budget Inn Timmonsville
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr, Florence, SC
$57 nightly
The price is $64 total per night from Jul 31 to Aug 1
$64 total
Jul 31 - Aug 1
Total includes taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.6/10 (1,014 reviews)
"I would reserve again, but my wife has her own opinion."

Reviewed on Jul 20, 2025

Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Florence

Home2 Suites by Hilton Florence, SC

Home2 Suites by Hilton Florence, SC

3 out of 5
900 Woody Jones Blvd, Florence, SC
$110 nightly
The price is $123 total per night from Aug 5 to Aug 6
$123 total
Aug 5 - Aug 6
Total includes taxes and fees
Stay at this 3-star business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,000 reviews)
Nice stay!
"Nice, clean, comfortable, convenient and staff was friendly. Breakfast was ok. Wish they had scrambled eggs and bacon."

Reviewed on Jul 15, 2025

Home2 Suites by Hilton Florence, SC
Baymont Inn & Suites Florence by Wyndham

Baymont Inn & Suites Florence by Wyndham

2.5 out of 5
1826 W Lucas Street, Florence, SC
Book a stay at this business-friendly hotel in Florence. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Dr. Eddie Floyd Tennis Center ...
"Still in Renovation mode"

Reviewed on Sep 3, 2024

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Baymont Inn & Suites Florence by Wyndham
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr, Florence, SC
$57 nightly
The price is $64 total per night from Jul 31 to Aug 1
$64 total
Jul 31 - Aug 1
Total includes taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.6/10 (1,014 reviews)
"I would reserve again, but my wife has her own opinion."

Reviewed on Jul 20, 2025

Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

LGA to FLO Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date

Frequently asked questions

What is the shortest flight from LaGuardia Airport (LGA) to Florence Regional Airport?
The quickest flight from LaGuardia Airport (LGA) to FLO is 3 hours and 1 minute. Grab your favorite tipple from the drink cart, get stuck into your travel journal or read a few magazines — you'll have plenty of time on this medium-haul journey.
How many hours flight from LaGuardia Airport (LGA) to FLO?
The journey from LaGuardia Airport (LGA) to FLO takes an average of 3 hours and 18 minutes. A few good movies, a gripping novel and a decent snooze will help make time fly by.
What airlines have the most flights from LaGuardia Airport to FLO?
You won't find any airlines that fly direct between LaGuardia Airport (LGA) and FLO. Be organized and secure a multi-stop or one-stop plane ticket.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.