Cheap flights from LGA to FLO (LaGuardia to Florence Regional)

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Cheap Flights from LGA to FLO starting at $295 One Way, $368 Round Trip

Prices starting at $368 for return flights and $295 for one-way flights to Florence Regional were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Oct 7 - Sat, Oct 10
LGA
New York
FLO
Florence
$368 Roundtrip, found 16 hours ago
$368
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Wed, Oct 7 from New York to Florence, returning Sat, Oct 10, priced at $368 found 16 hours ago
Wed, Oct 7 - Sat, Oct 10
LGA
New York
FLO
Florence
$423 Roundtrip, found 3 days ago
$423
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Oct 7 from New York to Florence, returning Sat, Oct 10, priced at $423 found 3 days ago
Thu, Oct 8 - Sat, Oct 10
LGA
New York
FLO
Florence
$426 Roundtrip, found 3 days ago
$426
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Oct 8 from New York to Florence, returning Sat, Oct 10, priced at $426 found 3 days ago
Wed, Oct 7 - Sat, Oct 10
LGA
New York
FLO
Florence
$449 Roundtrip, found 16 hours ago
$449
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Wed, Oct 7 from New York to Florence, returning Sat, Oct 10, priced at $449 found 16 hours ago
Thu, Oct 8 - Sat, Oct 10
LGA
New York
FLO
Florence
$481 Roundtrip, found 3 days ago
$481
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Oct 8 from New York to Florence, returning Sat, Oct 10, priced at $481 found 3 days ago

Hotel Ideas near Florence Regional

Airport Hotels near Florence Regional

Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence Florence SC
$114 nightly
The price is $128 total per night from Sep 7 to Sep 8
$128 total
Sep 7 - Sep 8
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
Hyatt Place Florence Downtown
Hotel Florence, Tapestry Collection by Hilton

Hotel Florence, Tapestry Collection by Hilton

3 out of 5
126 W Evans St Florence SC
$139 nightly
The price is $155 total per night from Sep 11 to Sep 12
$155 total
Sep 11 - Sep 12
Total with taxes and fees
Book a stay at this spa hotel in Florence. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (652 reviews)
"Very nice"

Reviewed on Aug 26, 2026

Hotel Florence, Tapestry Collection by Hilton
Cozy & Inviting

Cozy & Inviting

Florence SC
Stay at this apartment in Florence. Enjoy air conditioning. Popular attractions Florence County Museum and FMU Performing Arts Center are located nearby.
Get rates
Cozy & Inviting
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Florence

Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

2.5 out of 5
150 Dunbarton Dr Florence SC
$88 nightly
The price is $98 total per night from Sep 28 to Sep 29
$98 total
Sep 28 - Sep 29
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Quality Inn & Suites Florence Civic Center
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
$65 nightly
The price is $72 total per night from Sep 1 to Sep 2
$72 total
Sep 1 - Sep 2
Total with taxes and fees
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Howard Johnson by Wyndham Florence
Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road Florence SC
$80 nightly
The price is $89 total per night from Sep 7 to Sep 8
$89 total
Sep 7 - Sep 8
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (2,409 reviews)
"It was comfortable and clean We enjoyed our stay"

Reviewed on Aug 29, 2026

Park Inn by Radisson Florence, SC
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Florence Hotels

Red Roof Inn Florence - Civic Center

Red Roof Inn Florence - Civic Center

2 out of 5
2690 David H McLeod Boulevard Florence SC
$56 nightly
The price is $63 total per night from Sep 9 to Sep 10
$63 total
Sep 9 - Sep 10
Total with taxes and fees
Stay at this hotel in Florence. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
6.8/10 (1,002 reviews)
"very clean"

Reviewed on Aug 18, 2026

Red Roof Inn Florence - Civic Center
Budget Inn Timmonsville

Budget Inn Timmonsville

2 out of 5
2200 Cale Yarborough Highway Timmonsville SC
$61 nightly
The price is $68 total per night from Aug 31 to Sep 1
$68 total
Aug 31 - Sep 1
Total with taxes and fees
Stay at this motel in Timmonsville. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attraction Florence Motor Speedway is located nearby.
Budget Inn Timmonsville
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
$64 nightly
The price is $72 total per night from Sep 13 to Sep 14
$72 total
Sep 13 - Sep 14
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Florence

Home2 Suites by Hilton Florence, SC

Home2 Suites by Hilton Florence, SC

3 out of 5
900 Woody Jones Blvd Florence SC
$105 nightly
The price is $118 total per night from Sep 27 to Sep 28
$118 total
Sep 27 - Sep 28
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Home2 Suites by Hilton Florence, SC
Spark by Hilton Florence North I-95, SC

Spark by Hilton Florence North I-95, SC

2.5 out of 5
1739 Mandeville Rd Florence SC
$97 nightly
The price is $109 total per night from Sep 13 to Sep 14
$109 total
Sep 13 - Sep 14
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Spark by Hilton Florence North I-95, SC
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
$64 nightly
The price is $72 total per night from Sep 13 to Sep 14
$72 total
Sep 13 - Sep 14
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

LGA to FLO Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date

Frequently asked questions

What is the shortest flight from LaGuardia Airport (LGA) to Florence Regional Airport?
The quickest flight from LaGuardia Airport (LGA) to FLO is 3 hours and 1 minute. Grab your favorite tipple from the drink cart, get stuck into your travel journal or read a few magazines — you'll have plenty of time on this medium-haul journey.
How many hours flight from LaGuardia Airport (LGA) to FLO?
The journey from LaGuardia Airport (LGA) to FLO takes an average of 3 hours and 18 minutes. A few good movies, a gripping novel and a decent snooze will help make time fly by.
What airlines have the most flights from LaGuardia Airport to FLO?
You won't find any airlines that fly direct between LaGuardia Airport (LGA) and FLO. Be organized and secure a multi-stop or one-stop plane ticket.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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