Cheap flights from LGA to FLO (LaGuardia to Florence Regional)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

Cheap Flights from LGA to FLO starting at $239 One Way, $294 Round Trip

Prices starting at $294 for return flights and $239 for one-way flights to Florence Regional were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, May 9 - Wed, May 13
LGA
New York
FLO
Florence
$294 Roundtrip, found 4 days ago
$294
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, May 9 from New York to Florence, returning Wed, May 13, priced at $294 found 4 days ago
Sat, May 9 - Wed, May 13
LGA
New York
FLO
Florence
$374 Roundtrip, found 4 days ago
$374
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, May 9 from New York to Florence, returning Wed, May 13, priced at $374 found 4 days ago
Sat, May 9 - Wed, May 13
LGA
New York
FLO
Florence
$441 Roundtrip, found 4 days ago
$441
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, May 9 from New York to Florence, returning Wed, May 13, priced at $441 found 4 days ago
Sat, May 9 - Wed, May 13
LGA
New York
FLO
Florence
$454 Roundtrip, found 4 days ago
$454
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, May 9 from New York to Florence, returning Wed, May 13, priced at $454 found 4 days ago
Sat, May 9 - Wed, May 13
LGA
New York
FLO
Florence
$492 Roundtrip, found 4 days ago
$492
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, May 9 from New York to Florence, returning Wed, May 13, priced at $492 found 4 days ago

Hotel Ideas near Florence Regional

Airport Hotels near Florence Regional

Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence Florence SC
$122 nightly
The price is $137 total per night from Apr 26 to Apr 27
$137 total
Apr 26 - Apr 27
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
9/10 Wonderful! (1,009 reviews)
Clean room great service

Reviewed on Apr 6, 2026

Hyatt Place Florence Downtown
Hotel Florence, Tapestry Collection by Hilton

Hotel Florence, Tapestry Collection by Hilton

3 out of 5
126 W Evans St Florence SC
$130 nightly
The price is $146 total per night from Apr 26 to Apr 27
$146 total
Apr 26 - Apr 27
Total with taxes and fees
Book a stay at this spa hotel in Florence. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (625 reviews)
I called ahead to request a pack and play for our small child in our suite for when we arrived since it was going to be late, they said no problem. We asked the front desk if the pack and play is in the room already, they said yes. We got in the room.. and the pack and play was not there. The TV ...

Reviewed on Apr 4, 2026

Hotel Florence, Tapestry Collection by Hilton
Rodeway Inn Florence Downtown

Rodeway Inn Florence Downtown

2 out of 5
415 S. IRBY ST Florence SC
$57 nightly
The price is $63 total per night from May 6 to May 7
$63 total
May 6 - May 7
Total with taxes and fees
Stay at this hotel in Florence. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Drs Bruce and Lee Foundation Library and Florence ...
4.6/10 (4 reviews)
Looks like the owners are doing a lot of work on the property however, cleanliness is doable but not done. Our room was supposed to have 2 beds in it but the first room we got looked like someone was still in it. Unmade bed, clothes on chair and a huge fan in the middle of the room. Second room, ...

Reviewed on Mar 11, 2026

Rodeway Inn Florence Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Florence

Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
$67 nightly
The price is $75 total per night from Apr 8 to Apr 9
$75 total
Apr 8 - Apr 9
Total with taxes and fees
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,607 reviews)
It was reasonably priced but not quite as clean as I would have liked. We have stayed here before and it seems to have gone a little down hill.

Reviewed on Apr 7, 2026

Howard Johnson by Wyndham Florence
Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road Florence SC
$89 nightly
The price is $100 total per night from Apr 26 to Apr 27
$100 total
Apr 26 - Apr 27
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (2,242 reviews)
Room has moisture , property was not expected as per price and photos

Reviewed on Apr 7, 2026

Park Inn by Radisson Florence, SC
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

2.5 out of 5
527 Woody Jones Blvd Florence SC
$98 nightly
The price is $109 total per night from May 3 to May 4
$109 total
May 3 - May 4
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,251 reviews)
Pet friendly room should probably not have carpet as it had a slight odor. Nothing terrible but definitely noticeable.

Reviewed on Apr 7, 2026

Comfort Inn & Suites Florence Center Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Florence Hotels

Red Roof Inn Florence - Civic Center

Red Roof Inn Florence - Civic Center

2 out of 5
2690 David H McLeod Boulevard Florence SC
$56 nightly
The price is $63 total per night from May 3 to May 4
$63 total
May 3 - May 4
Total with taxes and fees
Stay at this hotel in Florence. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
Red Roof Inn Florence - Civic Center
Budget Inn Timmonsville

Budget Inn Timmonsville

2 out of 5
2200 Cale Yarborough Highway Timmonsville SC
$61 nightly
The price is $68 total per night from Apr 8 to Apr 9
$68 total
Apr 8 - Apr 9
Total with taxes and fees
Stay at this motel in Timmonsville. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attraction Florence Motor Speedway is located nearby.
7/10 Good! (333 reviews)
Clean room. Nothing bad and nothing special. It was a good peaceful stay.

Reviewed on Apr 2, 2026

Budget Inn Timmonsville
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
$66 nightly
The price is $74 total per night from Apr 15 to Apr 16
$74 total
Apr 15 - Apr 16
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7/10 Good! (1,003 reviews)
Booked 2 rooms on my way down to FL from VA and they were both dirty- the beds, the floors & the bathroom. We ended up having to book there again on the way back, hoping for a better outcome but the rooms were filthy again. Was also overcharged when booked at front desk vs. booking online. If it ...

Reviewed on Apr 6, 2026

Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Florence

Home2 Suites by Hilton Florence, SC

Home2 Suites by Hilton Florence, SC

3 out of 5
900 Woody Jones Blvd Florence SC
$129 nightly
The price is $144 total per night from Apr 26 to Apr 27
$144 total
Apr 26 - Apr 27
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,005 reviews)
Roaches, poor pool condition. Booked for five people and only 4 pillows available. After asking if we can get one more, we we're told that we don't offer extra pillows.

Reviewed on Apr 7, 2026

Home2 Suites by Hilton Florence, SC
Spark by Hilton Florence North I-95, SC

Spark by Hilton Florence North I-95, SC

2.5 out of 5
1739 Mandeville Rd Florence SC
$93 nightly
The price is $104 total per night from Apr 27 to Apr 28
$104 total
Apr 27 - Apr 28
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (63 reviews)
We only stayed one night and didn't get to try the pool or anything. Breakfast was great though

Reviewed on Apr 6, 2026

Spark by Hilton Florence North I-95, SC
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
$66 nightly
The price is $74 total per night from Apr 15 to Apr 16
$74 total
Apr 15 - Apr 16
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7/10 Good! (1,003 reviews)
Booked 2 rooms on my way down to FL from VA and they were both dirty- the beds, the floors & the bathroom. We ended up having to book there again on the way back, hoping for a better outcome but the rooms were filthy again. Was also overcharged when booked at front desk vs. booking online. If it ...

Reviewed on Apr 6, 2026

Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

LGA to FLO Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date

Frequently asked questions

What is the shortest flight from LaGuardia Airport (LGA) to Florence Regional Airport?
The quickest flight from LaGuardia Airport (LGA) to FLO is 3 hours and 1 minute. Grab your favorite tipple from the drink cart, get stuck into your travel journal or read a few magazines — you'll have plenty of time on this medium-haul journey.
How many hours flight from LaGuardia Airport (LGA) to FLO?
The journey from LaGuardia Airport (LGA) to FLO takes an average of 3 hours and 18 minutes. A few good movies, a gripping novel and a decent snooze will help make time fly by.
What airlines have the most flights from LaGuardia Airport to FLO?
You won't find any airlines that fly direct between LaGuardia Airport (LGA) and FLO. Be organized and secure a multi-stop or one-stop plane ticket.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

More to Explore