Cheap flights from STL to TYS (Lambert-St. Louis Intl. to McGhee Tyson)

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Cheap Flights from STL to TYS starting at $120 One Way, $264 Round Trip

Prices starting at $264 for return flights and $120 for one-way flights to McGhee Tyson were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Mar 24 - Wed, Apr 1
STL
St. Louis
TYS
Knoxville
$264 Roundtrip, found 4 days ago
$264
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Mar 24 from St. Louis to Knoxville, returning Wed, Apr 1, priced at $264 found 4 days ago
Tue, Mar 24 - Sat, Apr 4
STL
St. Louis
TYS
Knoxville
$265 Roundtrip, found 4 days ago
$265
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Mar 24 from St. Louis to Knoxville, returning Sat, Apr 4, priced at $265 found 4 days ago
Thu, May 28 - Mon, Jun 1
STL
St. Louis
TYS
Knoxville
$279 Roundtrip, found 4 days ago
$279
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Thu, May 28 from St. Louis to Knoxville, returning Mon, Jun 1, priced at $279 found 4 days ago
Thu, May 28 - Sun, May 31
STL
St. Louis
TYS
Knoxville
$283 Roundtrip, found 4 days ago
$283
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Thu, May 28 from St. Louis to Knoxville, returning Sun, May 31, priced at $283 found 4 days ago
Thu, May 28 - Mon, Jun 1
STL
St. Louis
TYS
Knoxville
$284 Roundtrip, found 4 days ago
$284
Roundtrip
found 4 days ago
Select Delta flight, departing Thu, May 28 from St. Louis to Knoxville, returning Mon, Jun 1, priced at $284 found 4 days ago

Hotel Ideas near McGhee Tyson

Airport Hotels near McGhee Tyson

Hilton Knoxville Airport

Hilton Knoxville Airport

3.5 out of 5
2001 Alcoa Hwy Alcoa TN
$121 nightly
The price is $139 total per night from Feb 28 to Mar 1
$139 total
Feb 28 - Mar 1
Total with taxes and fees
Book a stay at this family-friendly hotel in Alcoa. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
9/10 Wonderful! (1,003 reviews)
Room was great, front desk personnel are fantastic. Wish they offered park and fly, very inconvenient and expensive moving car to airport parking lot

Reviewed on Feb 1, 2026

Hilton Knoxville Airport
La Quinta Inn & Suites by Wyndham Knoxville Airport

La Quinta Inn & Suites by Wyndham Knoxville Airport

3 out of 5
126 Cusick Road Alcoa TN
$76 nightly
The price is $90 total per night from Feb 15 to Feb 16
$90 total
Feb 15 - Feb 16
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,739 reviews)
Check in and check out was super easy and fast, the room was clean, beds were comfy, and staff were pleasant. Breakfast was also good!

Reviewed on Feb 2, 2026

La Quinta Inn & Suites by Wyndham Knoxville Airport
Best Western Knoxville Airport/Alcoa

Best Western Knoxville Airport/Alcoa

2.5 out of 5
162 Cusick Rd Alcoa TN
$69 nightly
The price is $82 total per night from Feb 17 to Feb 18
$82 total
Feb 17 - Feb 18
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (1,003 reviews)
Front desk was helpful

Reviewed on Feb 1, 2026

Best Western Knoxville Airport/Alcoa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Knoxville

Hilton Knoxville Airport

Hilton Knoxville Airport

3.5 out of 5
2001 Alcoa Hwy Alcoa TN
$121 nightly
The price is $139 total per night from Feb 28 to Mar 1
$139 total
Feb 28 - Mar 1
Total with taxes and fees
Book a stay at this family-friendly hotel in Alcoa. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
9/10 Wonderful! (1,003 reviews)
Room was great, front desk personnel are fantastic. Wish they offered park and fly, very inconvenient and expensive moving car to airport parking lot

Reviewed on Feb 1, 2026

Hilton Knoxville Airport
La Quinta Inn & Suites by Wyndham Knoxville Airport

La Quinta Inn & Suites by Wyndham Knoxville Airport

3 out of 5
126 Cusick Road Alcoa TN
$76 nightly
The price is $90 total per night from Feb 15 to Feb 16
$90 total
Feb 15 - Feb 16
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,739 reviews)
Check in and check out was super easy and fast, the room was clean, beds were comfy, and staff were pleasant. Breakfast was also good!

Reviewed on Feb 2, 2026

La Quinta Inn & Suites by Wyndham Knoxville Airport
Mainstay Suites Knoxville Airport

Mainstay Suites Knoxville Airport

2.5 out of 5
361 Fountain View Cir Alcoa TN
$76 nightly
The price is $90 total per night from Feb 8 to Feb 9
$90 total
Feb 8 - Feb 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
7.6/10 Good! (697 reviews)
Service and amenities were great!

Reviewed on Feb 5, 2026

Mainstay Suites Knoxville Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Knoxville Hotels With Airport Transportation

La Quinta Inn & Suites by Wyndham Knoxville Airport

La Quinta Inn & Suites by Wyndham Knoxville Airport

3 out of 5
126 Cusick Road Alcoa TN
$76 nightly
The price is $90 total per night from Feb 15 to Feb 16
$90 total
Feb 15 - Feb 16
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,739 reviews)
Check in and check out was super easy and fast, the room was clean, beds were comfy, and staff were pleasant. Breakfast was also good!

Reviewed on Feb 2, 2026

La Quinta Inn & Suites by Wyndham Knoxville Airport
USA Inn

USA Inn

3 out of 5
Alcoa Hwy, 2962 Alcoa TN
$55 nightly
The price is $66 total per night from Feb 8 to Feb 9
$66 total
Feb 8 - Feb 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Meigs Falls and Fort Loudoun ...
5/10 (714 reviews)
Many. Bugs. Full size mattresses on cots. We need a room we missed a flight. We needed some space to sleep, we got it. Minus the sleep.

Reviewed on Sep 16, 2025

USA Inn
Best Western Knoxville Airport/Alcoa

Best Western Knoxville Airport/Alcoa

2.5 out of 5
162 Cusick Rd Alcoa TN
$69 nightly
The price is $82 total per night from Feb 17 to Feb 18
$82 total
Feb 17 - Feb 18
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (1,003 reviews)
Front desk was helpful

Reviewed on Feb 1, 2026

Best Western Knoxville Airport/Alcoa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Knoxville Hotels

USA Inn

USA Inn

3 out of 5
Alcoa Hwy, 2962 Alcoa TN
$55 nightly
The price is $66 total per night from Feb 8 to Feb 9
$66 total
Feb 8 - Feb 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Meigs Falls and Fort Loudoun ...
5/10 (714 reviews)
Many. Bugs. Full size mattresses on cots. We need a room we missed a flight. We needed some space to sleep, we got it. Minus the sleep.

Reviewed on Sep 16, 2025

USA Inn
Candlewood Suites Knoxville Airport-Alcoa by IHG

Candlewood Suites Knoxville Airport-Alcoa by IHG

2.5 out of 5
176 Cusick Road Alcoa TN
$71 nightly
The price is $84 total per night from Feb 22 to Feb 23
$84 total
Feb 22 - Feb 23
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free WiFi, an outdoor pool, and a free airport shuttle. Popular attractions Meigs Falls and Palace ...
8.4/10 Very Good! (618 reviews)
We stayed one night to catch an early morning flight out of McGhee Tyson airport. It was literally 2 mins from the airport. Super nice staff, easy checkin and checkout process. The room was very clean, the hotel was very quiet and the bed was very comfortable. Would definitely stay there again.

Reviewed on Feb 1, 2026

Candlewood Suites Knoxville Airport-Alcoa by IHG
Best Western Knoxville Airport/Alcoa

Best Western Knoxville Airport/Alcoa

2.5 out of 5
162 Cusick Rd Alcoa TN
$69 nightly
The price is $82 total per night from Feb 17 to Feb 18
$82 total
Feb 17 - Feb 18
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (1,003 reviews)
Front desk was helpful

Reviewed on Feb 1, 2026

Best Western Knoxville Airport/Alcoa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Knoxville

Comfort Suites Knoxville Airport

Comfort Suites Knoxville Airport

2.5 out of 5
140 Cusick Rd Alcoa TN
$72 nightly
The price is $86 total per night from Feb 13 to Feb 14
$86 total
Feb 13 - Feb 14
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.6/10 Good! (763 reviews)
Staff was great

Reviewed on Feb 2, 2026

Comfort Suites Knoxville Airport
Best Western Knoxville Airport/Alcoa

Best Western Knoxville Airport/Alcoa

2.5 out of 5
162 Cusick Rd Alcoa TN
$69 nightly
The price is $82 total per night from Feb 17 to Feb 18
$82 total
Feb 17 - Feb 18
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (1,003 reviews)
Front desk was helpful

Reviewed on Feb 1, 2026

Best Western Knoxville Airport/Alcoa
La Quinta Inn & Suites by Wyndham Knoxville Airport

La Quinta Inn & Suites by Wyndham Knoxville Airport

3 out of 5
126 Cusick Road Alcoa TN
$76 nightly
The price is $90 total per night from Feb 15 to Feb 16
$90 total
Feb 15 - Feb 16
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,739 reviews)
Check in and check out was super easy and fast, the room was clean, beds were comfy, and staff were pleasant. Breakfast was also good!

Reviewed on Feb 2, 2026

La Quinta Inn & Suites by Wyndham Knoxville Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

STL to TYS Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
STL Address & GPS
Address:
10701 Lambert International Blvd.
Saint Louis MO, 63145
United States
IATA Code:
STL
Longitude:
-90.379002
Latitude:
38.748707
Time Zone:
America/Chicago
TYS Address & GPS
Address:
2055 Alcoa Highway
Knoxville TN, 37701
United States
IATA Code:
TYS
Longitude:
-83.989729
Latitude:
35.80565
Time Zone:
America/New_York

Frequently asked questions

Are there non-stop flights from St. Louis Lambert International Airport to McGhee Tyson Airport (TYS)?
As you can't fly direct from Lambert Field to McGhee Tyson Airport (TYS) at the moment, a flight with a single stopover is your best bet. American Airlines, Delta Air Lines and United Airlines are respected airlines that service this route.
What is the shortest flight from St. Louis Lambert International Airport to Knoxville Airport?
The quickest flight time from St. Louis to Knoxville is 4 hours and 1 minute. Grab your favorite tipple from the cabin crew, hone your travel itinerary or finish that podcast — you'll have plenty of time on this medium-haul journey.
How many hours flight from St. Louis Lambert International Airport to TYS?
From STL to TYS, you'll be in your plane seat for approximately 4 hours and 9 minutes. Get comfy, order a wine and put on your noise-canceling earphones. It's time for a binge-watching session.
What airlines have the most flights from St. Louis Lambert International Airport to Knoxville Airport?
At the moment, you can't fly direct between STL and TYS. However, you can find flights with one or more stops. It's not all bad — use the break to stretch your travel-weary legs or grab a nice coffee!

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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