Cheap flights from STL to TYS (Lambert-St. Louis Intl. to McGhee Tyson)

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Cheap Flights from STL to TYS starting at $137 One Way, $288 Round Trip

Prices starting at $288 for return flights and $137 for one-way flights to McGhee Tyson were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Sep 17 - Sun, Sep 20
STL
St. Louis
TYS
Knoxville
$288 Roundtrip, found 3 days ago
$288
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Thu, Sep 17 from St. Louis to Knoxville, returning Sun, Sep 20, priced at $288 found 3 days ago
Thu, Jun 25 - Tue, Jun 30
STL
St. Louis
TYS
Knoxville
$290 Roundtrip, found 21 hours ago
$290
Roundtrip
found 21 hours ago
Select Southwest Airlines flight, departing Thu, Jun 25 from St. Louis to Knoxville, returning Tue, Jun 30, priced at $290 found 21 hours ago
Thu, Sep 17 - Sun, Sep 20
STL
St. Louis
TYS
Knoxville
$293 Roundtrip, found 3 days ago
$293
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Thu, Sep 17 from St. Louis to Knoxville, returning Sun, Sep 20, priced at $293 found 3 days ago
Fri, May 29 - Sat, May 30
STL
St. Louis
TYS
Knoxville
$295 Roundtrip, found 1 day ago
$295
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, May 29 from St. Louis to Knoxville, returning Sat, May 30, priced at $295 found 1 day ago
Fri, May 29 - Sat, May 30
STL
St. Louis
TYS
Knoxville
$295 Roundtrip, found 1 day ago
$295
Roundtrip
found 1 day ago
Select United flight, departing Fri, May 29 from St. Louis to Knoxville, returning Sat, May 30, priced at $295 found 1 day ago

Hotel Ideas near McGhee Tyson

Airport Hotels near McGhee Tyson

La Quinta Inn & Suites by Wyndham Knoxville Airport

La Quinta Inn & Suites by Wyndham Knoxville Airport

3 out of 5
126 Cusick Road Alcoa TN
$74 nightly
The price is $88 total per night from May 17 to May 18
$88 total
May 17 - May 18
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,873 reviews)
I was very disappointed the elevator was not working. It was a planned close down but did not make it known in advance .

Reviewed on May 9, 2026

La Quinta Inn & Suites by Wyndham Knoxville Airport
Hilton Knoxville Airport

Hilton Knoxville Airport

3.5 out of 5
2001 Alcoa Hwy Alcoa TN
$144 nightly
The price is $165 total per night from May 24 to May 25
$165 total
May 24 - May 25
Total with taxes and fees
Book a stay at this family-friendly hotel in Alcoa. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (1,004 reviews)
Enjoyed having amenities and restaurant without leaving the property

Reviewed on May 5, 2026

Hilton Knoxville Airport
Best Western Knoxville Airport/Alcoa

Best Western Knoxville Airport/Alcoa

2.5 out of 5
162 Cusick Rd Alcoa TN
$70 nightly
The price is $83 total per night from May 25 to May 26
$83 total
May 25 - May 26
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (1,013 reviews)
Everything was great. We didn't eat breakfast there, because it wasn't a whole lot of great options I liked, but they did have options..

Reviewed on May 8, 2026

Best Western Knoxville Airport/Alcoa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Knoxville

La Quinta Inn & Suites by Wyndham Knoxville Airport

La Quinta Inn & Suites by Wyndham Knoxville Airport

3 out of 5
126 Cusick Road Alcoa TN
$74 nightly
The price is $88 total per night from May 17 to May 18
$88 total
May 17 - May 18
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,873 reviews)
I was very disappointed the elevator was not working. It was a planned close down but did not make it known in advance .

Reviewed on May 9, 2026

La Quinta Inn & Suites by Wyndham Knoxville Airport
Hilton Knoxville Airport

Hilton Knoxville Airport

3.5 out of 5
2001 Alcoa Hwy Alcoa TN
$144 nightly
The price is $165 total per night from May 24 to May 25
$165 total
May 24 - May 25
Total with taxes and fees
Book a stay at this family-friendly hotel in Alcoa. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (1,004 reviews)
Enjoyed having amenities and restaurant without leaving the property

Reviewed on May 5, 2026

Hilton Knoxville Airport
Mainstay Suites Knoxville Airport

Mainstay Suites Knoxville Airport

2.5 out of 5
361 Fountain View Cir Alcoa TN
$80 nightly
The price is $95 total per night from May 10 to May 11
$95 total
May 10 - May 11
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
7.8/10 Good! (733 reviews)
Great staff very friendly, rooms larger Then most.

Reviewed on May 9, 2026

Mainstay Suites Knoxville Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Knoxville Hotels With Airport Transportation

La Quinta Inn & Suites by Wyndham Knoxville Airport

La Quinta Inn & Suites by Wyndham Knoxville Airport

3 out of 5
126 Cusick Road Alcoa TN
$74 nightly
The price is $88 total per night from May 17 to May 18
$88 total
May 17 - May 18
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,873 reviews)
I was very disappointed the elevator was not working. It was a planned close down but did not make it known in advance .

Reviewed on May 9, 2026

La Quinta Inn & Suites by Wyndham Knoxville Airport
USA Inn

USA Inn

3 out of 5
Alcoa Hwy, 2962 Alcoa TN
$52 nightly
The price is $61 total per night from May 14 to May 15
$61 total
May 14 - May 15
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Meigs Falls and Fort Loudoun ...
5/10 (716 reviews)
Dirty

Reviewed on Apr 23, 2026

USA Inn
Best Western Knoxville Airport/Alcoa

Best Western Knoxville Airport/Alcoa

2.5 out of 5
162 Cusick Rd Alcoa TN
$70 nightly
The price is $83 total per night from May 25 to May 26
$83 total
May 25 - May 26
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (1,013 reviews)
Everything was great. We didn't eat breakfast there, because it wasn't a whole lot of great options I liked, but they did have options..

Reviewed on May 8, 2026

Best Western Knoxville Airport/Alcoa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Knoxville Hotels

USA Inn

USA Inn

3 out of 5
Alcoa Hwy, 2962 Alcoa TN
$52 nightly
The price is $61 total per night from May 14 to May 15
$61 total
May 14 - May 15
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Meigs Falls and Fort Loudoun ...
5/10 (716 reviews)
Dirty

Reviewed on Apr 23, 2026

USA Inn
Candlewood Suites Knoxville Airport-Alcoa by IHG

Candlewood Suites Knoxville Airport-Alcoa by IHG

2.5 out of 5
176 Cusick Road Alcoa TN
$67 nightly
The price is $80 total per night from May 24 to May 25
$80 total
May 24 - May 25
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free WiFi, an outdoor pool, and a free airport shuttle. Popular attractions Meigs Falls and Palace ...
8.4/10 Very Good! (650 reviews)
Staff was great. Park and fly option is great. My only complaint is that the tv is mounted in a weird way so only one of us could see the screen from the bed. The bathroom hand soap is mounted on a wall so you have to shut the door to use the sink. It was pretty noisy in the hallways in early evening. ...

Reviewed on May 5, 2026

Candlewood Suites Knoxville Airport-Alcoa by IHG
Best Western Knoxville Airport/Alcoa

Best Western Knoxville Airport/Alcoa

2.5 out of 5
162 Cusick Rd Alcoa TN
$70 nightly
The price is $83 total per night from May 25 to May 26
$83 total
May 25 - May 26
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (1,013 reviews)
Everything was great. We didn't eat breakfast there, because it wasn't a whole lot of great options I liked, but they did have options..

Reviewed on May 8, 2026

Best Western Knoxville Airport/Alcoa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Knoxville

Comfort Suites Knoxville Airport

Comfort Suites Knoxville Airport

2.5 out of 5
140 Cusick Rd Alcoa TN
$77 nightly
The price is $91 total per night from Jun 7 to Jun 8
$91 total
Jun 7 - Jun 8
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.8/10 Good! (793 reviews)
So glad we went with this hotel - great price and airport shuttle excellent - All of the staff were very helpful and kind - good clean safe choice near the airport.

Reviewed on May 7, 2026

Comfort Suites Knoxville Airport
Best Western Knoxville Airport/Alcoa

Best Western Knoxville Airport/Alcoa

2.5 out of 5
162 Cusick Rd Alcoa TN
$70 nightly
The price is $83 total per night from May 25 to May 26
$83 total
May 25 - May 26
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (1,013 reviews)
Everything was great. We didn't eat breakfast there, because it wasn't a whole lot of great options I liked, but they did have options..

Reviewed on May 8, 2026

Best Western Knoxville Airport/Alcoa
La Quinta Inn & Suites by Wyndham Knoxville Airport

La Quinta Inn & Suites by Wyndham Knoxville Airport

3 out of 5
126 Cusick Road Alcoa TN
$74 nightly
The price is $88 total per night from May 17 to May 18
$88 total
May 17 - May 18
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,873 reviews)
I was very disappointed the elevator was not working. It was a planned close down but did not make it known in advance .

Reviewed on May 9, 2026

La Quinta Inn & Suites by Wyndham Knoxville Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

STL to TYS Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
STL Address & GPS
Address:
10701 Lambert International Blvd.
Saint Louis MO, 63145
United States
IATA Code:
STL
Longitude:
-90.379002
Latitude:
38.748707
Time Zone:
America/Chicago
TYS Address & GPS
Address:
2055 Alcoa Highway
Knoxville TN, 37701
United States
IATA Code:
TYS
Longitude:
-83.989729
Latitude:
35.80565
Time Zone:
America/New_York

Frequently asked questions

Are there non-stop flights from St. Louis Lambert International Airport to McGhee Tyson Airport (TYS)?
As you can't fly direct from Lambert Field to McGhee Tyson Airport (TYS) at the moment, a flight with a single stopover is your best bet. American Airlines, Delta Air Lines and United Airlines are respected airlines that service this route.
What is the shortest flight from St. Louis Lambert International Airport to Knoxville Airport?
The quickest flight time from St. Louis to Knoxville is 4 hours and 1 minute. Grab your favorite tipple from the cabin crew, hone your travel itinerary or finish that podcast — you'll have plenty of time on this medium-haul journey.
How many hours flight from St. Louis Lambert International Airport to TYS?
From STL to TYS, you'll be in your plane seat for approximately 4 hours and 9 minutes. Get comfy, order a wine and put on your noise-canceling earphones. It's time for a binge-watching session.
What airlines have the most flights from St. Louis Lambert International Airport to Knoxville Airport?
At the moment, you can't fly direct between STL and TYS. However, you can find flights with one or more stops. It's not all bad — use the break to stretch your travel-weary legs or grab a nice coffee!

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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