Cheap flights from MSP to FLO (Minneapolis - St. Paul Intl. to Florence Regional)

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Cheap Flights from MSP to FLO starting at $378 One Way, $384 Round Trip

Prices starting at $384 for return flights and $378 for one-way flights to Florence Regional were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Feb 20 - Sat, Feb 28
MSP
Minneapolis
FLO
Florence
$384 Roundtrip, found 2 days ago
$384
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, Feb 20 from Minneapolis to Florence, returning Sat, Feb 28, priced at $384 found 2 days ago
Fri, Feb 20 - Sat, Feb 28
MSP
Minneapolis
FLO
Florence
$389 Roundtrip, found 2 days ago
$389
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, Feb 20 from Minneapolis to Florence, returning Sat, Feb 28, priced at $389 found 2 days ago
Sat, Feb 21 - Sat, Feb 28
MSP
Minneapolis
FLO
Florence
$449 Roundtrip, found 2 days ago
$449
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Feb 21 from Minneapolis to Florence, returning Sat, Feb 28, priced at $449 found 2 days ago
Wed, Feb 18 - Sat, Feb 28
MSP
Minneapolis
FLO
Florence
$455 Roundtrip, found 2 days ago
$455
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Feb 18 from Minneapolis to Florence, returning Sat, Feb 28, priced at $455 found 2 days ago
Fri, Feb 20 - Sat, Feb 28
MSP
Minneapolis
FLO
Florence
$458 Roundtrip, found 2 days ago
$458
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, Feb 20 from Minneapolis to Florence, returning Sat, Feb 28, priced at $458 found 2 days ago

Hotel Ideas near Florence Regional

Airport Hotels near Florence Regional

Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence Florence SC
$100 nightly
The price is $112 total per night from Feb 9 to Feb 10
$112 total
Feb 9 - Feb 10
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
8.8/10 Excellent! (1,002 reviews)
Clean and spacious room.

Reviewed on Jan 27, 2026

Hyatt Place Florence Downtown
Hotel Florence, Tapestry Collection by Hilton

Hotel Florence, Tapestry Collection by Hilton

3 out of 5
126 W Evans St Florence SC
$130 nightly
The price is $146 total per night from Feb 8 to Feb 9
$146 total
Feb 8 - Feb 9
Total with taxes and fees
Book a stay at this spa hotel in Florence. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (615 reviews)
Didn't stay long enough to try any of the amenities that they offer.

Reviewed on Jan 11, 2026

Hotel Florence, Tapestry Collection by Hilton
Walking distance from one of South Carolina's top Medical centers.

Walking distance from one of South Carolina's top Medical centers.

Florence SC
$209 nightly
The price is $234 total per night from Feb 3 to Feb 4
$234 total
Feb 3 - Feb 4
Total with taxes and fees
Stay at this vacation home in Florence. Enjoy free WiFi, a garden, and laundry facilities. Popular attractions Old Greenwood Athletic Park and Drs Bruce and ...
9.8/10 Exceptional! (41 reviews)
Everything was great!

Reviewed on Nov 10, 2025

Walking distance from one of South Carolina's top Medical centers.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Florence

Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road Florence SC
$85 nightly
The price is $95 total per night from Feb 8 to Feb 9
$95 total
Feb 8 - Feb 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
8.8/10 Excellent! (2,244 reviews)
Front desk person was was friendly & helpful. Room was clean bed was comfy. Recommend if your in the area.

Reviewed on Jan 31, 2026

Park Inn by Radisson Florence, SC
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
$70 nightly
The price is $79 total per night from Feb 2 to Feb 3
$79 total
Feb 2 - Feb 3
Total with taxes and fees
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,560 reviews)
The staff were very friendly and gave great recommendations for dinner.

Reviewed on Jan 29, 2026

Howard Johnson by Wyndham Florence
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

2.5 out of 5
527 Woody Jones Blvd Florence SC
$99 nightly
The price is $110 total per night from Feb 8 to Feb 9
$110 total
Feb 8 - Feb 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,199 reviews)
Yes

Reviewed on Jan 24, 2026

Comfort Inn & Suites Florence Center Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Florence Hotels

Red Roof Inn Florence - Civic Center

Red Roof Inn Florence - Civic Center

2 out of 5
2690 David H McLeod Boulevard Florence SC
$56 nightly
The price is $63 total per night from Feb 5 to Feb 6
$63 total
Feb 5 - Feb 6
Total with taxes and fees
Stay at this hotel in Florence. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
6.6/10 (1,002 reviews)
Room was good. No microwave tho. Staff was very courteous and helpful

Reviewed on Jan 9, 2026

Red Roof Inn Florence - Civic Center
Budget Inn Timmonsville

Budget Inn Timmonsville

2 out of 5
2200 Cale Yarborough Highway Timmonsville SC
$61 nightly
The price is $68 total per night from Feb 2 to Feb 3
$68 total
Feb 2 - Feb 3
Total with taxes and fees
Stay at this motel in Timmonsville. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attraction Florence Motor Speedway is located nearby.
7/10 Good! (325 reviews)
Clean room, great for price, stayed with spouse, 2 children and two pets. You can hear cars pulling in and out of this location. There was a homeless guy asking for money but you can encounter that anywhere. No bugs, no concerns. :)

Reviewed on Dec 29, 2025

Budget Inn Timmonsville
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
$66 nightly
The price is $74 total per night from Feb 4 to Feb 5
$74 total
Feb 4 - Feb 5
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.8/10 (1,002 reviews)
Love this room dearly

Reviewed on Jan 30, 2026

Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Florence

Home2 Suites by Hilton Florence, SC

Home2 Suites by Hilton Florence, SC

3 out of 5
900 Woody Jones Blvd Florence SC
$106 nightly
The price is $118 total per night from Feb 22 to Feb 23
$118 total
Feb 22 - Feb 23
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,007 reviews)
Yes very clean and friendly!

Reviewed on Jan 20, 2026

Home2 Suites by Hilton Florence, SC
Spark by Hilton Florence North I-95, SC

Spark by Hilton Florence North I-95, SC

2.5 out of 5
1739 Mandeville Rd Florence SC
$101 nightly
The price is $113 total per night from Feb 8 to Feb 9
$113 total
Feb 8 - Feb 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.8/10 Good! (46 reviews)
Wonderful staff and very clean room and facilities ,

Reviewed on Jan 24, 2026

Spark by Hilton Florence North I-95, SC
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
$66 nightly
The price is $74 total per night from Feb 4 to Feb 5
$74 total
Feb 4 - Feb 5
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.8/10 (1,002 reviews)
Love this room dearly

Reviewed on Jan 30, 2026

Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

MSP to FLO Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date

Frequently asked questions

What is the shortest flight from Wold–Chamberlain Field to Florence Regional Airport?
The fastest flight from Wold–Chamberlain Field to FLO is 3 hours and 33 minutes. Pack a few things in your carry-on to help pass the time, like a gripping read or a portable board game.
How many hours flight from Minneapolis - St. Paul Intl. Airport (MSP) to FLO?
On average, it takes 3 hours and 47 minutes to journey from Wold–Chamberlain Field to Florence Regional Airport (FLO). You'll be in the sky for a good amount of time, so bring plenty of entertainment, like an engrossing book or some crossword puzzles.
What airlines have the most flights from MSP to Florence Regional Airport?
If you're wanting to find an airline that flies direct from MSP to Florence Regional Airport, you're out of luck. You'll have to book a flight with at least one stopover to get to Florence.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.