$165 Cheap flight deals from Medellin (MDE) to Panama City (PTY)

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This Weekend's Flight Deals from Medellin to Panama City

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Dec 26 - Sat, Jan 10
MDE
José María Córdova Intl.
PTY
Tocumen Intl.
$343 Roundtrip, found 6 days ago
$343
Roundtrip
found 6 days ago
Select avianca flight, departing Fri, Dec 26 from José María Córdova Intl. to Tocumen Intl., returning Sat, Jan 10, priced at $343 found 6 days ago

Airfares from $165 One Way, $287 Round Trip from Medellin to Panama City

Prices starting at $287 for return flights and $165 for one-way flights to Panama City were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Mar 27 - Sat, Mar 28
MDE
Medellin
PTY
Panama City
$287 Roundtrip, found 3 days ago
$287
Roundtrip
found 3 days ago
Select Copa flight, departing Fri, Mar 27 from Medellin to Panama City, returning Sat, Mar 28, priced at $287 found 3 days ago
Mon, Feb 2 - Tue, Feb 3
MDE
Medellin
PTY
Panama City
$295 Roundtrip, found 21 hours ago
$295
Roundtrip
found 21 hours ago
Select Copa flight, departing Mon, Feb 2 from Medellin to Panama City, returning Tue, Feb 3, priced at $295 found 21 hours ago
Fri, Mar 27 - Sat, Mar 28
MDE
Medellin
PTY
Panama City
$297 Roundtrip, found 3 days ago
$297
Roundtrip
found 3 days ago
Select Copa flight, departing Fri, Mar 27 from Medellin to Panama City, returning Sat, Mar 28, priced at $297 found 3 days ago
Mon, Feb 2 - Tue, Feb 3
MDE
Medellin
PTY
Panama City
$302 Roundtrip, found 21 hours ago
$302
Roundtrip
found 21 hours ago
Select Copa flight, departing Mon, Feb 2 from Medellin to Panama City, returning Tue, Feb 3, priced at $302 found 21 hours ago
Mon, Feb 2 - Tue, Feb 3
MDE
Medellin
PTY
Panama City
$305 Roundtrip, found 21 hours ago
$305
Roundtrip
found 21 hours ago
Select Copa flight, departing Mon, Feb 2 from Medellin to Panama City, returning Tue, Feb 3, priced at $305 found 21 hours ago

Panama City economy flight packages

Price found within the past 48 hours. Click for updated prices.
Hotel Riu Plaza Panama
5.0-star property

Hotel Riu Plaza Panama

9/10 Wonderful! (4,515 reviews)

Jan 23 - Jan 27

4 night stay

Medellín (MDE) to Panama City (PTY)

Copa • Roundtrip • Coach
Price was $735, price is now $483 per person
$483
per person
found 15 hours ago
OK, but a request for housekeeping services after checking failed. They never showed up! And food at the poolside restaurant wasn't that good. Otherwise Hotel was fine and his staff very friendly and helpful.

Reviewed on Dec 12, 2025

Megapolis Hotel Panamá
4.5-star property

Megapolis Hotel Panamá

8.4/10 Very Good! (1,204 reviews)

Jan 23 - Jan 27

4 night stay

Medellín (MDE) to Panama City (PTY)

Copa • Roundtrip • Coach
Save 100% on your flight
Price was $1,082, price is now $710 per person
$710
per person
found 15 hours ago
Room was very clean, breakfast was great.Easy check in.

Reviewed on Nov 16, 2025

Las Americas Golden Tower Panama
4.0-star property

Las Americas Golden Tower Panama

9/10 Wonderful! (1,005 reviews)

Jan 23 - Jan 27

4 night stay

Medellín (MDE) to Panama City (PTY)

Copa • Roundtrip • Coach
Price was $727, price is now $549 per person
$549
per person
found 15 hours ago
Everything very nice

Reviewed on May 1, 2023

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More About Flying To Panama City from Medellin

Route Information for Flights from Medellin to Panama City

Origin Airport IATA Code
MDE
Destination Airport IATA Code
PTY
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Medellin to Panama City

For the best travel experience from Medellin to Panama City domestic and international travelers everywhere choose Orbitz for guaranteed low prices and cutting-edge mobile tools.

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Frequently asked questions

Are there non-stop flights from Medellin to Panama City?
Yes, you can jet from MDE to Panama City (PTY-Tocumen Intl.) with Copa Airlines, the only airline offering nonstop services on this route.
What is the shortest flight from Medellin to Panama City?
Leave that movie marathon for the hotel room, because the flight from Medellin to Panama City can take as little as 1 hour and 9 minutes.
What airlines fly from Medellin to Panama City most frequently?
If you're looking for the airline that offers the most flights from Medellin to Panama City, Copa Airlines is your best bet. This trusted airline operates 152 flights along this route per month.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.