$167 Cheap flight deals from Guayaquil (GYE) to Panama City (PTY)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

This Weekend's Flight Deals from Guayaquil to Panama City

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Sep 6 - Wed, Sep 9
GYE
Jose Joaquin de Olmedo Intl.
PTY
Tocumen Intl.
$486 Roundtrip, found 3 days ago
$486
Roundtrip
found 3 days ago
Select avianca flight, departing Sun, Sep 6 from Jose Joaquin de Olmedo Intl. to Tocumen Intl., returning Wed, Sep 9, priced at $486 found 3 days ago

Airfares from $167 One Way, $339 Round Trip from Guayaquil to Panama City

Prices starting at $339 for return flights and $167 for one-way flights to Panama City were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Oct 28 - Sat, Oct 31
GYE
Guayaquil
PTY
Panama City
$339 Roundtrip, found 3 days ago
$339
Roundtrip
found 3 days ago
Select Copa flight, departing Wed, Oct 28 from Guayaquil to Panama City, returning Sat, Oct 31, priced at $339 found 3 days ago
Wed, Oct 28 - Sat, Oct 31
GYE
Guayaquil
PTY
Panama City
$351 Roundtrip, found 3 days ago
$351
Roundtrip
found 3 days ago
Select Copa flight, departing Wed, Oct 28 from Guayaquil to Panama City, returning Sat, Oct 31, priced at $351 found 3 days ago
Sat, Oct 24 - Sat, Oct 31
GYE
Guayaquil
PTY
Panama City
$352 Roundtrip, found 18 hours ago
$352
Roundtrip
found 18 hours ago
Select Copa flight, departing Sat, Oct 24 from Guayaquil to Panama City, returning Sat, Oct 31, priced at $352 found 18 hours ago
Wed, Oct 28 - Sat, Oct 31
GYE
Guayaquil
PTY
Panama City
$363 Roundtrip, found 3 days ago
$363
Roundtrip
found 3 days ago
Select Copa flight, departing Wed, Oct 28 from Guayaquil to Panama City, returning Sat, Oct 31, priced at $363 found 3 days ago
Sat, Oct 24 - Sat, Oct 31
GYE
Guayaquil
PTY
Panama City
$364 Roundtrip, found 18 hours ago
$364
Roundtrip
found 18 hours ago
Select Copa flight, departing Sat, Oct 24 from Guayaquil to Panama City, returning Sat, Oct 31, priced at $364 found 18 hours ago

Panama City economy flight packages

Price found within the past 48 hours. Click for updated prices.
Decapolis Hotel Panama City
4.0-star property

Decapolis Hotel Panama City

8.6/10 Excellent! (1,716 reviews)

Oct 7 - Oct 13

6 night stay

Guayaquil (GYE) to Panama City (PTY)

Copa • Roundtrip • Coach
Save 100% on your flight
Price was $1,149, price is now $657 per person
$657
per person
found 1 day ago
Na

Reviewed on Sep 1, 2026

Central Hotel Panama Casco Viejo
4.0-star property

Central Hotel Panama Casco Viejo

9.2/10 Wonderful! (1,001 reviews)

Oct 7 - Oct 13

6 night stay

Guayaquil (GYE) to Panama City (PTY)

Copa • Roundtrip • Coach
Price was $1,988, price is now $809 per person
$809
per person
found 1 day ago
The hotel is in a really good location, is fairly clean, the breakfast buffet is really nice and the rooms are fairly clean and comfortable. However; I felt a bit disappointed that the hotel management wants to just focus on making money. I stayed here for a entire week and I told them that on my last day, my flight is later in the evening and if they could allow me to check out a bit later in the afternoon. They flat out refused and asked for $100 to let me check out at 4 pm. That tells me that it wasn't a availability issue because they were willing to let me stay till 4 pm for a extra $100. This is bad business. If I stayed for just a couple of days, that would have been a different story. I stayed at this hotel for a full week and paid around $1000 for my stay - showing some courtesy to the hotel guests and allowing them to checkout a bit later goes a long way to build goodwill and earn more business.

Reviewed on Sep 1, 2026

Megapolis Hotel Panamá
4.5-star property

Megapolis Hotel Panamá

8.4/10 Very Good! (1,671 reviews)

Oct 7 - Oct 13

6 night stay

Guayaquil (GYE) to Panama City (PTY)

Copa • Roundtrip • Coach
Price was $1,938, price is now $838 per person
$838
per person
found 1 day ago
Our stay was very comfortable at the Megapolis. We were 2 adults and 2 children in a deluxe room with 2 beds. There was a mini fridge with refreshments and snacks upon arrival and water was replenished everyday.. The buffet breakfast selection was vast and the sky walk connecting to the mall was very convenient but there were stairs so going with a stroller was difficult. The hotel decor was very impressive however some of the furniture appeared to be in disrepair and the hallway carpets on our floor needed to be vacuumed as there was visible dirt, even right outside our door, for the duration of our stay. Overall I would definitely stay here again.

Reviewed on Sep 1, 2026

Don't see what you're looking for?
See all available trips from Guayaquil to Panama City
View all trips

More About Flying To Panama City from Guayaquil

Route Information for Flights from Guayaquil to Panama City

Origin Airport IATA Code
GYE
Destination Airport IATA Code
PTY
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Guayaquil to Panama City

Smart business means on-the-spot travel planning at budget prices. Orbitz On-the-Go can help by using cutting-edge mobile tools and guaranteed low prices. Orbitz On-the-Go is your go-to for bargain flights from Guayaquil to Panama City, and discount Guayaquil to Panama City flights.

Business Development

Boosting sales with multiple presentations within a day or week? Then easily book cheap domestic flights from Guayaquil to Panama City. Are you expanding into emerging markets? Find low-fare deals on international Guayaquil to Panama City flights. Orbitz On-the-Go mobile apps keep it simple.

Continuing Education

Successful business people know that keeping your edge in business means staying in training. Find a low-cost air ticket for your next workshop with Orbitz flights from Guayaquil to Panama City. Move to the head of the seminar with Orbitz On-the-Go’s guaranteed low prices on Guayaquil to Panama City flights.

Budget Planning

Orbitz allows you to focus on the income, while we reduce your expenses with guaranteed low prices. Your bottom line is bound to improve with our bargain flights from Guayaquil to Panama City and discount Guayaquil to Panama City flights. Watch your business thrive.

Time Management

Time is money, and Orbitz On-the-Go saves both. Our cutting-edge mobile tools make business travel planning quick and easy, even for same-day reservations. It’s not unusual for our clients to save big on same-day tickets for Guayaquil to {destination.name} flights. Free alerts keep you on time with flight, gate and baggage updates, plus other time-saving features.

Frequently asked questions

Are there non-stop flights from Guayaquil to Panama City?
Work out your ideal travel dates, because there is. You can fly from Airport of Guayaquil to Panama City (PTY-Tocumen Intl.) in one simple journey with Copa Airlines.
What is the shortest flight from Guayaquil to Panama City?
Leave that movie marathon for some other time, because the journey from Guayaquil to Panama City can take as little as 2 hours and 6 minutes.
What airlines fly from Guayaquil to Panama City most frequently?
Copa Airlines has the most flights along this route. This popular airline operates 152 flights from Guayaquil to Panama City each month.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

More Destinations

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.