$174 Cheap flight deals from Guayaquil (GYE) to Panama City (PTY)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

This Weekend's Flight Deals from Guayaquil to Panama City

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Jan 25 - Thu, Jan 29
GYE
Jose Joaquin de Olmedo Intl.
PTY
Tocumen Intl.
$357 Roundtrip, found 3 hours ago
$357
Roundtrip
found 3 hours ago
Select avianca flight, departing Sun, Jan 25 from Jose Joaquin de Olmedo Intl. to Tocumen Intl., returning Thu, Jan 29, priced at $357 found 3 hours ago

Airfares from $174 One Way, $283 Round Trip from Guayaquil to Panama City

Prices starting at $283 for return flights and $174 for one-way flights to Panama City were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Apr 24 - Mon, Apr 27
GYE
Guayaquil
PTY
Panama City
$283 Roundtrip, found 17 hours ago
$283
Roundtrip
found 17 hours ago
Select Copa flight, departing Fri, Apr 24 from Guayaquil to Panama City, returning Mon, Apr 27, priced at $283 found 17 hours ago
Thu, Jan 29 - Tue, Feb 3
GYE
Guayaquil
PTY
Panama City
$284 Roundtrip, found 1 day ago
$284
Roundtrip
found 1 day ago
Select Copa flight, departing Thu, Jan 29 from Guayaquil to Panama City, returning Tue, Feb 3, priced at $284 found 1 day ago
Fri, Apr 24 - Mon, Apr 27
GYE
Guayaquil
PTY
Panama City
$295 Roundtrip, found 17 hours ago
$295
Roundtrip
found 17 hours ago
Select Copa flight, departing Fri, Apr 24 from Guayaquil to Panama City, returning Mon, Apr 27, priced at $295 found 17 hours ago
Thu, Jan 29 - Tue, Feb 3
GYE
Guayaquil
PTY
Panama City
$296 Roundtrip, found 1 day ago
$296
Roundtrip
found 1 day ago
Select Copa flight, departing Thu, Jan 29 from Guayaquil to Panama City, returning Tue, Feb 3, priced at $296 found 1 day ago
Fri, Apr 24 - Mon, Apr 27
GYE
Guayaquil
PTY
Panama City
$307 Roundtrip, found 17 hours ago
$307
Roundtrip
found 17 hours ago
Select Copa flight, departing Fri, Apr 24 from Guayaquil to Panama City, returning Mon, Apr 27, priced at $307 found 17 hours ago

Panama City economy flight packages

Price found within the past 48 hours. Click for updated prices.
Mahogany Suites
2.0-star property

Mahogany Suites

10/10 Exceptional! (1 review)

Feb 25 - Mar 2

5 night stay

Guayaquil (GYE) to Panama City (PTY)

Copa • Roundtrip • Coach
Price was $1,042, price is now $411 per person
$411
per person
found 21 hours ago
Central Hotel Panama Casco Viejo
4.0-star property

Central Hotel Panama Casco Viejo

9/10 Wonderful! (1,002 reviews)

Feb 25 - Mar 2

5 night stay

Guayaquil (GYE) to Panama City (PTY)

Copa • Roundtrip • Coach
Save 100% on your flight
Price was $1,838, price is now $969 per person
$969
per person
found 21 hours ago
Kimberly at the Front Desk was wonderful!

Reviewed on Jun 8, 2025

Megapolis Hotel Panamá
4.5-star property

Megapolis Hotel Panamá

8.4/10 Very Good! (1,204 reviews)

Mar 9 - Mar 14

5 night stay

Guayaquil (GYE) to Panama City (PTY)

Copa • Roundtrip • Coach
Save 100% on your flight
Price was $1,280, price is now $762 per person
$762
per person
found 23 hours ago
Room was very clean, breakfast was great.Easy check in.

Reviewed on Nov 16, 2025

Don't see what you're looking for?
See all available trips from Guayaquil to Panama City
View all trips

More About Flying To Panama City from Guayaquil

Route Information for Flights from Guayaquil to Panama City

Origin Airport IATA Code
GYE
Destination Airport IATA Code
PTY
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Guayaquil to Panama City

Orbitz is the best place to find guaranteed low prices on Guayaquil to Panama City flights. Because of our cutting-edge mobile tools and low fares on domestic and international flights, Orbitz is the best starting point for travelers.

Find Cheap Guayaquil to Panama City Flights

Orbitz offers free mobile apps for iPhone and Android devices—a great way to find fantastic deals on flights from Guayaquil to Panama City. Not only that, but you can check the status of your flight or even book low cost hotel rooms with the apps or on m.orbitz.com.

Get Miles and Points for Your Flight

Simply enter your frequent flyer information while booking to get miles or points for qualifying Guayaquil to Panama City flights. This information can all be saved in your Orbitz account, which means it will not have to be entered each time you take advantage of a great air fare deal.

Flight Alerts Take Away the Stress

Orbitz does not want travelers to worry on their flights from Guayaquil to Panama City. We keep you updated on any flight changes for Guayaquil to Panama City flights with alerts sent directly to your email or a mobile device. These alerts can also be sent to friends and family.

Discount Travel Planning Made Simple

You will have no problems finding budget flights from Guayaquil to Panama City on Orbitz.com. If your travel plans are flexible, you can search for fares three days before and after a specific date to find the best price.

Frequently asked questions

Are there non-stop flights from Guayaquil to Panama City?
Work out your ideal travel dates, because there is. You can fly from Airport of Guayaquil to Panama City (PTY-Tocumen Intl.) in one simple journey with Copa Airlines.
What is the shortest flight from Guayaquil to Panama City?
Leave that movie marathon for some other time, because the journey from Guayaquil to Panama City can take as little as 2 hours and 6 minutes.
What airlines fly from Guayaquil to Panama City most frequently?
Copa Airlines has the most flights along this route. This popular airline operates 152 flights from Guayaquil to Panama City each month.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

More Destinations

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.