$174 Cheap flight deals from Medellín (MDE) to Panama City (PTY)

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This Weekend's Flight Deals from Medellín to Panama City

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Sep 25 - Mon, Sep 28
MDE
José María Córdova Intl.
PTY
Tocumen Intl.
$356 Roundtrip, found 1 day ago
$356
Roundtrip
found 1 day ago
Select avianca flight, departing Fri, Sep 25 from José María Córdova Intl. to Tocumen Intl., returning Mon, Sep 28, priced at $356 found 1 day ago

Airfares from $174 One Way, $290 Round Trip from Medellín to Panama City

Prices starting at $290 for return flights and $174 for one-way flights to Panama City were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Oct 21 - Sun, Oct 25
MDE
Medellín
PTY
Panama City
$290 Roundtrip, found 2 days ago
$290
Roundtrip
found 2 days ago
Select Copa flight, departing Wed, Oct 21 from Medellín to Panama City, returning Sun, Oct 25, priced at $290 found 2 days ago
Wed, Oct 21 - Sun, Oct 25
MDE
Medellín
PTY
Panama City
$301 Roundtrip, found 2 days ago
$301
Roundtrip
found 2 days ago
Select Copa flight, departing Wed, Oct 21 from Medellín to Panama City, returning Sun, Oct 25, priced at $301 found 2 days ago
Mon, Sep 28 - Fri, Oct 2
MDE
Medellín
PTY
Panama City
$302 Roundtrip, found 3 days ago
$302
Roundtrip
found 3 days ago
Select Copa flight, departing Mon, Sep 28 from Medellín to Panama City, returning Fri, Oct 2, priced at $302 found 3 days ago
Mon, Sep 28 - Fri, Oct 2
MDE
Medellín
PTY
Panama City
$313 Roundtrip, found 3 days ago
$313
Roundtrip
found 3 days ago
Select Copa flight, departing Mon, Sep 28 from Medellín to Panama City, returning Fri, Oct 2, priced at $313 found 3 days ago
Wed, Oct 21 - Sun, Oct 25
MDE
Medellín
PTY
Panama City
$344 Roundtrip, found 2 days ago
$344
Roundtrip
found 2 days ago
Select Copa flight, departing Wed, Oct 21 from Medellín to Panama City, returning Sun, Oct 25, priced at $344 found 2 days ago

Panama City economy flight packages

Price found within the past 48 hours. Click for updated prices.
Riande Aeropuerto Hotel & Casino
4.0-star property

Riande Aeropuerto Hotel & Casino

8.6/10 Excellent! (1,811 reviews)

Oct 24 - Oct 27

3 night stay

Medellín (MDE) to Panama City (PTY)

Copa • Roundtrip • Coach
Price was $655, price is now $429 per person
$429
per person
found 1 day ago
Clean room and

Reviewed on Sep 21, 2026

Megapolis Hotel Panamá
4.5-star property

Megapolis Hotel Panamá

8.4/10 Very Good! (1,693 reviews)

Oct 24 - Oct 27

3 night stay

Medellín (MDE) to Panama City (PTY)

Copa • Roundtrip • Coach
Save 100% on your flight
Price was $1,050, price is now $504 per person
$504
per person
found 1 day ago
The pool Is on maintenance, my room had 2 water bottles one was open already I called so they could change it but it never happened. Also the toilet had a stain it look like not watched properly.

Reviewed on Sep 20, 2026

Decapolis Hotel Panama City
4.0-star property

Decapolis Hotel Panama City

8.6/10 Excellent! (1,708 reviews)

Oct 24 - Oct 27

3 night stay

Medellín (MDE) to Panama City (PTY)

Copa • Roundtrip • Coach
Price was $648, price is now $436 per person
$436
per person
found 1 day ago

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More About Flying To Panama City from Medellín

Route Information for Flights from Medellín to Panama City

Origin Airport IATA Code
MDE
Destination Airport IATA Code
PTY
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Medellín to Panama City

The best fares for Medellín to Panama City flights are always found on Orbitz. With superior discounts and the latest innovations in mobile access, your ideal trip starts with Orbitz.

The Easy Way to Plan Travel Cheaply

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Our iPhone and Android mobile apps can be used to compare and book flights from Medellín to Panama City. These apps are perfect for checking the status of flights, gate and baggage claims details, car rental rates, and for receiving alerts on special savings that are exclusive to mobile users. Mobile app users can even score great rates when booking hotel rooms. You can compare hotels, virtually view photo galleries, and check out user reviews using the app, as well as find out which ones are closest to you.

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Frequently asked questions

Are there non-stop flights from Medellin to Panama City?
Yes, you can jet from MDE to Panama City (PTY-Tocumen Intl.) with Copa Airlines, the only airline offering nonstop services on this route.
What is the shortest flight from Medellin to Panama City?
Leave that movie marathon for the hotel room, because the flight from Medellin to Panama City can take as little as 1 hour and 9 minutes.
What airlines fly from Medellin to Panama City most frequently?
If you're looking for the airline that offers the most flights from Medellin to Panama City, Copa Airlines is your best bet. This trusted airline operates 152 flights along this route per month.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.