$27 Cheap flight deals from Medellin (MDE) to Cali (CLO)

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This Weekend's Flight Deals from Medellin to Cali

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Jan 31 - Sun, Feb 1
MDE
José María Córdova Intl.
CLO
Alfonso Bonilla Aragon Intl.
$124 Roundtrip, found 13 hours ago
$124
Roundtrip
found 13 hours ago
Select Jetsmart SPA flight, departing Sat, Jan 31 from José María Córdova Intl. to Alfonso Bonilla Aragon Intl., returning Sun, Feb 1, priced at $124 found 13 hours ago

Airfares from $27 One Way, $54 Round Trip from Medellin to Cali

Prices starting at $54 for return flights and $27 for one-way flights to Cali were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Feb 7 - Wed, Feb 11
MDE
Medellin
CLO
Cali
$54 Roundtrip, found 3 days ago
$54
Roundtrip
found 3 days ago
Select Jetsmart SPA flight, departing Sat, Feb 7 from Medellin to Cali, returning Wed, Feb 11, priced at $54 found 3 days ago
Wed, Mar 18 - Tue, Mar 24
MDE
Medellin
CLO
Cali
$74 Roundtrip, found 1 day ago
$74
Roundtrip
found 1 day ago
Select Jetsmart SPA flight, departing Wed, Mar 18 from Medellin to Cali, returning Tue, Mar 24, priced at $74 found 1 day ago
Wed, Feb 25 - Wed, Mar 4
MDE
Medellin
CLO
Cali
$75 Roundtrip, found 2 hours ago
$75
Roundtrip
found 2 hours ago
Select Jetsmart SPA flight, departing Wed, Feb 25 from Medellin to Cali, returning Wed, Mar 4, priced at $75 found 2 hours ago
Fri, Mar 6 - Fri, Mar 20
MDE
Medellin
CLO
Cali
$76 Roundtrip, found 3 days ago
$76
Roundtrip
found 3 days ago
Select LATAM Airlines Group flight, departing Fri, Mar 6 from Medellin to Cali, returning Fri, Mar 20, priced at $76 found 3 days ago
Thu, Apr 9 - Wed, Apr 15
MDE
Medellin
CLO
Cali
$78 Roundtrip, found 5 days ago
$78
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Thu, Apr 9 from Medellin to Cali, returning Wed, Apr 15, priced at $78 found 5 days ago

Cali economy flight packages

Price found within the past 48 hours. Click for updated prices.
Basic Hotel Chipichape By Hoteles MS
3.0-star property

Basic Hotel Chipichape By Hoteles MS

7/10 Good! (2 reviews)

Mar 20 - Mar 23

3 night stay

Medellín (MDE) to Cali (CLO)

B & H Airlines • Roundtrip • Coach
Save 100% on your flight
Price was $254, price is now $142 per person
$142
per person
found 1 day ago
Hotel MS Ciudad Jardín Plus
3.5-star property

Hotel MS Ciudad Jardín Plus

8.2/10 Very Good! (321 reviews)

Mar 20 - Mar 23

3 night stay

Medellín (MDE) to Cali (CLO)

B & H Airlines • Roundtrip • Coach
Save 100% on your flight
Price was $308, price is now $172 per person
$172
per person
found 1 day ago
Very clean and friendly staff! Nice breakfast. The decoration was nice and the rooms are very comfortable.

Reviewed on Dec 7, 2018

Alko Hotel Casa Nispero
4.0-star property

Alko Hotel Casa Nispero

9.4/10 Exceptional! (193 reviews)

Mar 20 - Mar 23

3 night stay

Medellín (MDE) to Cali (CLO)

B & H Airlines • Roundtrip • Coach
Save 100% on your flight
Price was $360, price is now $210 per person
$210
per person
found 1 day ago
High attention to detail in all facets

Reviewed on Nov 8, 2025

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More About Flying To Cali from Medellin

Route Information for Flights from Medellin to Cali

Origin Airport IATA Code
MDE
Destination Airport IATA Code
CLO
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Medellin to Cali

Orbitz guarantees you low prices on flights from Medellin to Cali. In addition to low fares on Medellin to Cali flights, Orbitz offers fantastic savings on hotels, cruises, vacation packages, and more.

Earn Miles While Saving

Besides helping you fly for the lowest fares, Orbitz lets you earn miles for your frequent flyer program for certain flights from Medellin to Cali. If you are a member of the frequent flyer or loyalty program offered by the airline you booked through Orbitz or a partner airline’s, simply add your frequent flyer number to your Orbitz reservation to get credit for your Medellin to Cali flights.

Travel Planning Made Easy

We help take some of the anxiety out of your Medellin to Cali flights with free flight alerts. We will let you know of flight changes and delays to your flights from Medellin to Cali by email, voicemail, or text messages to your mobile phone. Alerts can also be sent to up to six other contacts to keep family and business teams informed.

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Orbitz lets you find the best deals on Medellin to Cali flights while on the go, with our easy-to-use Android and iPhone mobile apps. Easily check flight status, gate numbers, and other flight details all in one place with our app—which is great when you are in a hurry. You can use the apps to access great mobile deals on flights and amazing hotel rooms.

Frequently asked questions

Are there non-stop flights from Medellin to Cali?
There certainly are. As a matter of fact, there are 3 airlines that will take you nonstop from Medellin Airport to Cali (CLO-Alfonso Bonilla Aragon Intl.). Lock in your ticket with one of these well-known carriers:

  • LATAM Airlines
  • Viva Air Colombia
  • Avianca

What is the shortest flight from Medellin to Cali?
The trip from Medellin to Cali can be as fast as 1 hour. With an easy flight time like this, why not grab some friends and organize a spontaneous getaway?
What airlines fly from Medellin to Cali most frequently?
Consider booking a ticket with LATAM Airlines (LA), which flies frequently along this route. This airline offers 86 flights every month between MDE and Alfonso Bonilla Aragon Intl. Airport (CLO). Alternatively, reserve your favorite seat with Viva Air Colombia (VH). You'll have 69 monthly flights between Medellin and Cali to take your pick of with this airline.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

More Destinations

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.