$172 Cheap flight deals from Medellín (MDE) to Panama City (PTY)

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This Weekend's Flight Deals from Medellín to Panama City

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Aug 9 - Mon, Aug 10
MDE
José María Córdova Intl.
PTY
Tocumen Intl.
$328 Roundtrip, found 2 days ago
$328
Roundtrip
found 2 days ago
Select avianca flight, departing Sun, Aug 9 from José María Córdova Intl. to Tocumen Intl., returning Mon, Aug 10, priced at $328 found 2 days ago

Airfares from $172 One Way, $289 Round Trip from Medellín to Panama City

Prices starting at $289 for return flights and $172 for one-way flights to Panama City were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Aug 20 - Tue, Aug 25
MDE
Medellín
PTY
Panama City
$289 Roundtrip, found 1 day ago
$289
Roundtrip
found 1 day ago
Select Copa flight, departing Thu, Aug 20 from Medellín to Panama City, returning Tue, Aug 25, priced at $289 found 1 day ago
Thu, May 27 - Mon, May 31
MDE
Medellín
PTY
Panama City
$290 Roundtrip, found 1 day ago
$290
Roundtrip
found 1 day ago
Select Copa flight, departing Thu, May 27 from Medellín to Panama City, returning Mon, May 31, priced at $290 found 1 day ago
Fri, Aug 21 - Wed, Aug 26
MDE
Medellín
PTY
Panama City
$300 Roundtrip, found 1 day ago
$300
Roundtrip
found 1 day ago
Select Copa flight, departing Fri, Aug 21 from Medellín to Panama City, returning Wed, Aug 26, priced at $300 found 1 day ago
Thu, May 27 - Mon, May 31
MDE
Medellín
PTY
Panama City
$301 Roundtrip, found 1 day ago
$301
Roundtrip
found 1 day ago
Select Copa flight, departing Thu, May 27 from Medellín to Panama City, returning Mon, May 31, priced at $301 found 1 day ago
Mon, Aug 24 - Wed, Aug 26
MDE
Medellín
PTY
Panama City
$311 Roundtrip, found 1 day ago
$311
Roundtrip
found 1 day ago
Select Copa flight, departing Mon, Aug 24 from Medellín to Panama City, returning Wed, Aug 26, priced at $311 found 1 day ago

Panama City economy flight packages

Price found within the past 48 hours. Click for updated prices.
Riande Aeropuerto Hotel & Casino
4.0-star property

Riande Aeropuerto Hotel & Casino

8.4/10 Very Good! (1,816 reviews)

Oct 3 - Oct 5

2 night stay

Medellín (MDE) to Panama City (PTY)

Copa • Roundtrip • Coach
Price was $543, price is now $376 per person
$376
per person
found 1 day ago
there was only one bar and no entertainment at all one restaurant well

Reviewed on Aug 6, 2026

Central Hotel Panama Casco Viejo
4.0-star property

Central Hotel Panama Casco Viejo

9.2/10 Wonderful! (1,000 reviews)

Oct 3 - Oct 5

2 night stay

Medellín (MDE) to Panama City (PTY)

Copa • Roundtrip • Coach
Save 100% on your flight
Price was $770, price is now $416 per person
$416
per person
found 1 day ago
The hotel is as the name indicated, in the center of old town. The location is fantastic. Very convenient. However, as some of the reviews had mentioned, they have live music in the lobby all day until 11pm. I was aware of this and requested that they give us a quiet room. However, we were given a room with windows facing the atrium and were subjected to the music all day. It was not too loud but was quite annoying if you want quietness. Add to this, it was on the 4th floor and next to one of the restaurant/bar and there were noises coming from it until late. The room was 426 so to other travelers, avoid this room. The bathroom shower was poorly designed and the floor was flooded after every shower. We had to use tons to towels to mop up the water. Not sure why we were given such a lousy room even though the hotel didn’t seem fully booked. The only reason I didn’t request for another room because my husband has unpacked all his stuffs and didn’t want to move. Are Expedia customers treated worse or something? The positives: the room was reasonably spacious. Beddings were comfortable. Roof top pool was nice although it is rather of small and it could use some fixing up. The staff was courteous and breakfast was decent. Had it not for the noisy room, it would have been a nice stay. For this reason, I don’t think we’ll stay here again in the future since noisy room is a deal breaker for me.

Reviewed on Aug 6, 2026

Megapolis Hotel Panamá
4.5-star property

Megapolis Hotel Panamá

8.4/10 Very Good! (1,621 reviews)

Oct 3 - Oct 5

2 night stay

Medellín (MDE) to Panama City (PTY)

Copa • Roundtrip • Coach
Save 100% on your flight
Price was $802, price is now $434 per person
$434
per person
found 1 day ago

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More About Flying To Panama City from Medellín

Route Information for Flights from Medellín to Panama City

Origin Airport IATA Code
MDE
Destination Airport IATA Code
PTY
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Medellín to Panama City

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Frequently asked questions

Are there non-stop flights from Medellin to Panama City?
Yes, you can jet from MDE to Panama City (PTY-Tocumen Intl.) with Copa Airlines, the only airline offering nonstop services on this route.
What is the shortest flight from Medellin to Panama City?
Leave that movie marathon for the hotel room, because the flight from Medellin to Panama City can take as little as 1 hour and 9 minutes.
What airlines fly from Medellin to Panama City most frequently?
If you're looking for the airline that offers the most flights from Medellin to Panama City, Copa Airlines is your best bet. This trusted airline operates 152 flights along this route per month.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.