$117 Cheap flight deals from St. Louis (STL) to Panama City (PNS)

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This Weekend's Flight Deals from St. Louis to Panama City

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Oct 18 - Thu, Oct 23
STL
Lambert-St. Louis Intl.
PNS
Pensacola Intl.
$322 Roundtrip, found 6 days ago
$322
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Sat, Oct 18 from Lambert-St. Louis Intl. to Pensacola Intl., returning Thu, Oct 23, priced at $322 found 6 days ago
Fri, Oct 17 - Fri, Oct 31
STL
Lambert-St. Louis Intl.
ECP
Northwest Florida Beaches Intl.
$378 Roundtrip, found 4 days ago
$378
Roundtrip
found 4 days ago
Select Delta flight, departing Fri, Oct 17 from Lambert-St. Louis Intl. to Northwest Florida Beaches Intl., returning Fri, Oct 31, priced at $378 found 4 days ago
Sun, Oct 19 - Mon, Oct 27
STL
Lambert-St. Louis Intl.
VPS
Northwest Florida Regional
$482 Roundtrip, found 1 day ago
$482
Roundtrip
found 1 day ago
Select Delta flight, departing Sun, Oct 19 from Lambert-St. Louis Intl. to Northwest Florida Regional, returning Mon, Oct 27, priced at $482 found 1 day ago

Airfares from $117 One Way, $204 Round Trip from St. Louis to Panama City

Prices starting at $204 for return flights and $117 for one-way flights to Panama City were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Nov 6 - Mon, Nov 17
STL
St. Louis
PNS
Pensacola
$204 Roundtrip, found 20 hours ago
$204
Roundtrip
found 20 hours ago
Select Frontier Airlines flight, departing Thu, Nov 6 from St. Louis to Pensacola, returning Mon, Nov 17, priced at $204 found 20 hours ago
Fri, Nov 14 - Wed, Dec 3
STL
St. Louis
ECP
Panama City
$207 Roundtrip, found 4 days ago
$207
Roundtrip
found 4 days ago
Select Delta flight, departing Fri, Nov 14 from St. Louis to Panama City, returning Wed, Dec 3, priced at $207 found 4 days ago
Wed, Dec 3 - Sun, Dec 14
STL
St. Louis
ECP
Panama City
$210 Roundtrip, found 4 days ago
$210
Roundtrip
found 4 days ago
Select Delta flight, departing Wed, Dec 3 from St. Louis to Panama City, returning Sun, Dec 14, priced at $210 found 4 days ago
Mon, Nov 3 - Tue, Nov 18
STL
St. Louis
ECP
Panama City
$217 Roundtrip, found 4 days ago
$217
Roundtrip
found 4 days ago
Select Delta flight, departing Mon, Nov 3 from St. Louis to Panama City, returning Tue, Nov 18, priced at $217 found 4 days ago
Sun, Nov 2 - Tue, Nov 18
STL
St. Louis
ECP
Panama City
$220 Roundtrip, found 4 days ago
$220
Roundtrip
found 4 days ago
Select Delta flight, departing Sun, Nov 2 from St. Louis to Panama City, returning Tue, Nov 18, priced at $220 found 4 days ago

Panama City economy flight packages

Price found within the past 48 hours. Click for updated prices.
Destin Studio With Resort Amenities and Private Beach Access
3.5-star property

Destin Studio With Resort Amenities and Private Beach Access

No reviews

Nov 23 - Nov 28

5 night stay

St. Louis (STL) to Fort Walton Beach (VPS)

Delta • Non-stop roundtrip • Coach
Price was $1,042, price is now $919 per person
$919
per person
found 1 day ago
The Henderson Beach Resort & Spa
5.0-star property

The Henderson Beach Resort & Spa

9.2/10 Wonderful! (1,005 reviews)

Nov 23 - Nov 28

5 night stay

St. Louis (STL) to Fort Walton Beach (VPS)

Delta • Non-stop roundtrip • Coach
Save 100% on your flight
Price was $1,386, price is now $948 per person
$948
per person
found 1 day ago
⸻ We expected the hotel to be more family-friendly. The kids club was always closed and it was impossible to reach anyone there. There weren’t many kids’ menu options and not a lot of activities for children. On the positive side, the hotel is very beautiful, clean, and the staff is friendly. However, the price feels very high compared to the overall value received.

Reviewed on Sep 1, 2025

Destin Beach House - Happy Harbor House
4.0-star property

Destin Beach House - Happy Harbor House

8/10 Very Good! (1 review)

Nov 23 - Nov 28

5 night stay

St. Louis (STL) to Fort Walton Beach (VPS)

Delta • Non-stop roundtrip • Coach
Price was $2,847, price is now $2,490 per person
$2,490
per person
found 1 day ago
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More About Flying To Panama City from St. Louis

Route Information for Flights from St. Louis to Panama City

Origin Airport IATA Code
STL
Destination Airport IATA Code
PNS
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

St. Louis to Panama City

Whether you want to book cheap flights from St. Louis to Panama City or are looking for the perfect package holiday, Orbitz is your one-stop source. Taking the stress and expense out of travel, Orbitz helps you find the best fares for St. Louis to Panama City flights.

Make the Most of Your Vacation

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Book your flights from St. Louis to Panama City wherever you are with the Orbitz app for Android and iPhone. Or simply use m.orbitz.com on your mobile browser to search and book the St. Louis to Panama City flights that you want. And if you’re running late, you check your flight status and baggage claim information on your mobile device too too.

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With Orbitz’s free alerts service, you will stay informed of flight or services disruptions to your St. Louis to Panama City flights. The alerts can be sent straight to your mobile phone or email.

Frequently asked questions

Are there non-stop flights from St. Louis to Panama City?
Dust off your trusty passport, because Southwest Airlines will fly you straight from St. Louis to Panama City. Book your plane ticket now and enjoy a trouble-free, nonstop flight.
What is the shortest flight from St. Louis to Panama City?
The trip from St. Louis to Panama City can be as quick as 2 hours and 20 minutes. With a short and sweet flight time like this, why not book an impromptu getaway?
What airlines fly from St. Louis to Panama City most frequently?
If you're looking for the airline with the most flights from St. Louis to Panama City, Southwest Airlines is the top pick. This well-known airline operates 39 flights along this route per month.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

More Destinations

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.