$104 Cheap flight deals from St. Louis (STL) to Panama City (PNS)

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This Weekend's Flight Deals from St. Louis to Panama City

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Dec 13 - Tue, Dec 16
STL
Lambert-St. Louis Intl.
PNS
Pensacola Intl.
$351 Roundtrip, found 2 days ago
$351
Roundtrip
found 2 days ago
Select Delta flight, departing Sat, Dec 13 from Lambert-St. Louis Intl. to Pensacola Intl., returning Tue, Dec 16, priced at $351 found 2 days ago
Fri, Dec 12 - Tue, Dec 16
STL
Lambert-St. Louis Intl.
VPS
Northwest Florida Regional
$509 Roundtrip, found 4 days ago
$509
Roundtrip
found 4 days ago
Select Delta flight, departing Fri, Dec 12 from Lambert-St. Louis Intl. to Northwest Florida Regional, returning Tue, Dec 16, priced at $509 found 4 days ago

Airfares from $104 One Way, $177 Round Trip from St. Louis to Panama City

Prices starting at $177 for return flights and $104 for one-way flights to Panama City were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Jan 14 - Tue, Jan 20
STL
St. Louis
VPS
Fort Walton Beach
$177 Roundtrip, found 3 days ago
$177
Roundtrip
found 3 days ago
Select Delta flight, departing Wed, Jan 14 from St. Louis to Fort Walton Beach, returning Tue, Jan 20, priced at $177 found 3 days ago
Tue, Jan 13 - Tue, Jan 20
STL
St. Louis
VPS
Fort Walton Beach
$181 Roundtrip, found 3 days ago
$181
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, Jan 13 from St. Louis to Fort Walton Beach, returning Tue, Jan 20, priced at $181 found 3 days ago
Wed, Jan 14 - Thu, Jan 15
STL
St. Louis
VPS
Fort Walton Beach
$192 Roundtrip, found 3 days ago
$192
Roundtrip
found 3 days ago
Select Delta flight, departing Wed, Jan 14 from St. Louis to Fort Walton Beach, returning Thu, Jan 15, priced at $192 found 3 days ago
Tue, Jan 13 - Thu, Jan 15
STL
St. Louis
VPS
Fort Walton Beach
$196 Roundtrip, found 3 days ago
$196
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, Jan 13 from St. Louis to Fort Walton Beach, returning Thu, Jan 15, priced at $196 found 3 days ago
Fri, Feb 20 - Mon, Feb 23
STL
St. Louis
PNS
Pensacola
$207 Roundtrip, found 6 days ago
$207
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Fri, Feb 20 from St. Louis to Pensacola, returning Mon, Feb 23, priced at $207 found 6 days ago

Panama City economy flight packages

Price found within the past 48 hours. Click for updated prices.
OYO Hotel Pensacola I-10 & Hwy 29
2.0-star property

OYO Hotel Pensacola I-10 & Hwy 29

4.2/10 (698 reviews)

Jan 23 - Jan 28

5 night stay

St. Louis (STL) to Pensacola (PNS)

Delta • Non-stop • Coach

Pensacola (PNS) to St. Louis (STL)

Southwest Airlines • Non-stop • Coach
Price was $528, price is now $418 per person
$418
per person
found 22 hours ago
You get what you pay for

Reviewed on Jun 29, 2023

The Henderson Beach Resort & Spa
5.0-star property

The Henderson Beach Resort & Spa

9.2/10 Wonderful! (1,000 reviews)

Jan 15 - Jan 18

3 night stay

St. Louis (STL) to Fort Walton Beach (VPS)

Delta • Non-stop • Coach

Fort Walton Beach (VPS) to St. Louis (STL)

Southwest Airlines • Non-stop • Coach
Price was $806, price is now $583 per person
$583
per person
found 1 day ago
⸻ We expected the hotel to be more family-friendly. The kids club was always closed and it was impossible to reach anyone there. There weren’t many kids’ menu options and not a lot of activities for children. On the positive side, the hotel is very beautiful, clean, and the staff is friendly. However, the price feels very high compared to the overall value received.

Reviewed on Sep 1, 2025

The Pearl Hotel
4.0-star property

The Pearl Hotel

9.4/10 Exceptional! (188 reviews)

Jan 15 - Jan 18

3 night stay

St. Louis (STL) to Panama City (ECP)

United • Non-stop • Coach

Panama City (ECP) to St. Louis (STL)

American Airlines • Non-stop • Coach
Save 100% on your flight
Price was $1,497, price is now $1,167 per person
$1,167
per person
found 16 hours ago
The elevator was broken for the elderly to get to rroftt

Reviewed on Jun 9, 2024

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More About Flying To Panama City from St. Louis

Route Information for Flights from St. Louis to Panama City

Origin Airport IATA Code
STL
Destination Airport IATA Code
PNS
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

St. Louis to Panama City

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Frequently asked questions

Are there non-stop flights from St. Louis to Panama City?
Dust off your trusty passport, because Southwest Airlines will fly you straight from St. Louis to Panama City. Book your plane ticket now and enjoy a trouble-free, nonstop flight.
What is the shortest flight from St. Louis to Panama City?
The trip from St. Louis to Panama City can be as quick as 2 hours and 20 minutes. With a short and sweet flight time like this, why not book an impromptu getaway?
What airlines fly from St. Louis to Panama City most frequently?
If you're looking for the airline with the most flights from St. Louis to Panama City, Southwest Airlines is the top pick. This well-known airline operates 39 flights along this route per month.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.