$260 Cheap flight deals from St. Louis (STL) to Panama City (PTY)

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This Weekend's Flight Deals from St. Louis to Panama City

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Jul 4 - Sat, Jul 11
STL
Lambert-St. Louis Intl.
PTY
Tocumen Intl.
$709 Roundtrip, found 1 day ago
$709
Roundtrip
found 1 day ago
Select Air Canada flight, departing Sat, Jul 4 from Lambert-St. Louis Intl. to Tocumen Intl., returning Sat, Jul 11, priced at $709 found 1 day ago

Airfares from $260 One Way, $589 Round Trip from St. Louis to Panama City

Prices starting at $589 for return flights and $260 for one-way flights to Panama City were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Dec 7 - Tue, Dec 22
STL
St. Louis
PTY
Panama City
$589 Roundtrip, found 1 day ago
$589
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Dec 7 from St. Louis to Panama City, returning Tue, Dec 22, priced at $589 found 1 day ago
Sat, Aug 1 - Thu, Aug 13
STL
St. Louis
PTY
Panama City
$606 Roundtrip, found 2 days ago
$606
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Aug 1 from St. Louis to Panama City, returning Thu, Aug 13, priced at $606 found 2 days ago
Mon, Dec 7 - Tue, Dec 22
STL
St. Louis
PTY
Panama City
$615 Roundtrip, found 1 day ago
$615
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Dec 7 from St. Louis to Panama City, returning Tue, Dec 22, priced at $615 found 1 day ago
Fri, Apr 9 - Sat, Apr 17
STL
St. Louis
PTY
Panama City
$619 Roundtrip, found 4 days ago
$619
Roundtrip
found 4 days ago
Select United flight, departing Fri, Apr 9 from St. Louis to Panama City, returning Sat, Apr 17, priced at $619 found 4 days ago
Sat, Aug 1 - Thu, Aug 13
STL
St. Louis
PTY
Panama City
$619 Roundtrip, found 2 days ago
$619
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Aug 1 from St. Louis to Panama City, returning Thu, Aug 13, priced at $619 found 2 days ago

Panama City economy flight packages

Price found within the past 48 hours. Click for updated prices.
Riande Aeropuerto Hotel & Casino
4.0-star property

Riande Aeropuerto Hotel & Casino

8.4/10 Very Good! (1,813 reviews)

Aug 5 - Aug 9

4 night stay

St. Louis (STL) to Panama City (PTY)

United • Non-stop roundtrip • Coach
Price was $1,120, price is now $823 per person
$823
per person
found 1 day ago
This hotel is very old, no amenities and very noisy. Noise from street, pool filter and they have put refrigerator between beds next to your head. We ask the staff to give us the quite room, but she gave us a very noisy one. The breakfast was trible at 8 am they were out of eggs and coffee. When they bring some coffee and eggs after while coffee taste trible.

Reviewed on Jul 1, 2026

Megapolis Hotel Panamá
4.5-star property

Megapolis Hotel Panamá

8.4/10 Very Good! (1,570 reviews)

Aug 5 - Aug 9

4 night stay

St. Louis (STL) to Panama City (PTY)

United • Non-stop roundtrip • Coach
Price was $1,293, price is now $873 per person
$873
per person
found 1 day ago
The whole staff was extremely helpful.

Reviewed on Jul 1, 2026

Hotel Riu Plaza Panama
5.0-star property

Hotel Riu Plaza Panama

9/10 Wonderful! (5,643 reviews)

Aug 5 - Aug 9

4 night stay

St. Louis (STL) to Panama City (PTY)

United • Non-stop roundtrip • Coach
Price was $1,131, price is now $856 per person
$856
per person
found 1 day ago
For the most part my stay was good. Friendly and helpful staff. I did have to call maintenance twice for toilet issues though, but each time someone came rather quickly and public relations called to follow up - I thought that was nice.

Reviewed on Jul 1, 2026

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More About Flying To Panama City from St. Louis

Route Information for Flights from St. Louis to Panama City

Origin Airport IATA Code
STL
Destination Airport IATA Code
PTY
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

St. Louis to Panama City

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Frequently asked questions

What is the shortest flight from St. Louis to Panama City?
Getting from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Panama City (PTY-Tocumen Intl.) will take you at least 5 hours and 30 minutes. Enjoy a wine and watch a show or two — here's your chance to sit back and chill out.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.