$291 Cheap flight deals from Denver (DEN) to Panama City (PTY)

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This Weekend's Flight Deals from Denver to Panama City

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Oct 18 - Sun, Oct 25
DEN
Denver Intl.
PTY
Tocumen Intl.
$696 Roundtrip, found 6 days ago
$696
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sun, Oct 18 from Denver Intl. to Tocumen Intl., returning Sun, Oct 25, priced at $696 found 6 days ago

Airfares from $291 One Way, $647 Round Trip from Denver to Panama City

Prices starting at $647 for return flights and $291 for one-way flights to Panama City were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Apr 15 - Tue, Apr 20
DEN
Denver
PTY
Panama City
$647 Roundtrip, found 8 hours ago
$647
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Thu, Apr 15 from Denver to Panama City, returning Tue, Apr 20, priced at $647 found 8 hours ago
Sat, Feb 6 - Fri, Feb 19
DEN
Denver
PTY
Panama City
$649 Roundtrip, found 4 hours ago
$649
Roundtrip
found 4 hours ago
Select Copa flight, departing Sat, Feb 6 from Denver to Panama City, returning Fri, Feb 19, priced at $649 found 4 hours ago
Thu, Apr 15 - Tue, Apr 20
DEN
Denver
PTY
Panama City
$652 Roundtrip, found 8 hours ago
$652
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Thu, Apr 15 from Denver to Panama City, returning Tue, Apr 20, priced at $652 found 8 hours ago
Thu, Mar 4 - Thu, Mar 25
COS
Colorado Springs
PTY
Panama City
$662 Roundtrip, found 3 days ago
$662
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Mar 4 from Colorado Springs to Panama City, returning Thu, Mar 25, priced at $662 found 3 days ago
Mon, Nov 2 - Wed, Nov 11
DEN
Denver
PTY
Panama City
$664 Roundtrip, found 5 hours ago
$664
Roundtrip
found 5 hours ago
Select Delta flight, departing Mon, Nov 2 from Denver to Panama City, returning Wed, Nov 11, priced at $664 found 5 hours ago

Panama City economy flight packages

Price found within the past 48 hours. Click for updated prices.
Riande Aeropuerto Hotel & Casino
4.0-star property

Riande Aeropuerto Hotel & Casino

8.6/10 Excellent! (1,819 reviews)

Dec 7 - Dec 13

6 night stay

Denver (DEN) to Panama City (PTY)

Copa • Roundtrip • Coach
Price was $1,471, price is now $956 per person
$956
per person
found 1 day ago
Solo pasamos un noche pero es un hotel excelente con un ambiente muy agradable muy acogedor, el traslado aeropuerto hotel aeropuerto es maravilloso y el desayuno Buenisimo … buenas instalaciones todo muy limpio y en buen estado.

Reviewed on Oct 13, 2026

Megapolis Hotel Panamá
4.5-star property

Megapolis Hotel Panamá

8.6/10 Excellent! (1,764 reviews)

Dec 7 - Dec 13

6 night stay

Denver (DEN) to Panama City (PTY)

Copa • Roundtrip • Coach
Price was $2,967, price is now $1,259 per person
$1,259
per person
found 1 day ago

Central Hotel Panama Casco Viejo
4.0-star property

Central Hotel Panama Casco Viejo

9/10 Wonderful! (1,006 reviews)

Dec 7 - Dec 13

6 night stay

Denver (DEN) to Panama City (PTY)

Copa • Roundtrip • Coach
Save 100% on your flight
Price was $2,628, price is now $1,317 per person
$1,317
per person
found 1 day ago
This is a charming, lovely old hotel. There was a musician playing morning and night near the lobby. The restaurants were good. The staff was very helpful and attentive. I will definitely go back!

Reviewed on Oct 14, 2026

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More About Flying To Panama City from Denver

Route Information for Flights from Denver to Panama City

Origin Airport IATA Code
DEN
Destination Airport IATA Code
PTY
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Denver to Panama City

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Easily Plan Your Vacation

Not only does Orbitz offer great prices on flights from Denver to Panama City, but you will also find fantastic deals on hotels, cruises, and vacation activities. Never miss out on that dream trip or waste hours waiting in long lines—you can buy tickets to attraction in advance with Orbitz to guarantee admission to your favorite places.

Best Deals At Your Fingertips

Orbitz combines low prices on Denver to Panama City flights with discounts on quality hotels. Using Orbitz’s Display Matrix, you can see all your options and savings easily. With our low price guarantee, you know you have the best deals at your fingertips.

Frequently asked questions

What is the shortest flight from Denver to Panama City?
The shortest flight time from Denver to Panama City is 6 hours and 28 minutes. Grab a refreshment from the cabin crew, perfect your travel itinerary or get to know your seat mate — you'll have enough time on this medium-haul trip.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.