$156 Cheap flight deals from Chicago (CHI) to Santee (CAE)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

This Weekend's Flight Deals from Chicago to Santee

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Dec 19 - Tue, Jan 6
ORD
O'Hare Intl.
CAE
Columbia Metropolitan
$304 Roundtrip, found 5 days ago
$304
Roundtrip
found 5 days ago
Select Delta flight, departing Fri, Dec 19 from O'Hare Intl. to Columbia Metropolitan, returning Tue, Jan 6, priced at $304 found 5 days ago
Sun, Dec 21 - Sun, Dec 28
MDW
Midway Intl.
CAE
Columbia Metropolitan
$857 Roundtrip, found 2 days ago
$857
Roundtrip
found 2 days ago
Select Delta flight, departing Sun, Dec 21 from Midway Intl. to Columbia Metropolitan, returning Sun, Dec 28, priced at $857 found 2 days ago

Airfares from $156 One Way, $209 Round Trip from Chicago to Santee

Prices starting at $209 for return flights and $156 for one-way flights to Santee were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Feb 11 - Sat, Feb 14
ORD
Chicago
CAE
Columbia
$209 Roundtrip, found 6 days ago
$209
Roundtrip
found 6 days ago
Select United flight, departing Wed, Feb 11 from Chicago to Columbia, returning Sat, Feb 14, priced at $209 found 6 days ago
Wed, Feb 11 - Sat, Feb 14
ORD
Chicago
CAE
Columbia
$219 Roundtrip, found 6 days ago
$219
Roundtrip
found 6 days ago
Select United flight, departing Wed, Feb 11 from Chicago to Columbia, returning Sat, Feb 14, priced at $219 found 6 days ago
Wed, Feb 11 - Sat, Feb 14
ORD
Chicago
CAE
Columbia
$229 Roundtrip, found 6 days ago
$229
Roundtrip
found 6 days ago
Select United flight, departing Wed, Feb 11 from Chicago to Columbia, returning Sat, Feb 14, priced at $229 found 6 days ago
Tue, Mar 10 - Sat, Mar 14
MDW
Chicago
CAE
Columbia
$229 Roundtrip, found 4 days ago
$229
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Mar 10 from Chicago to Columbia, returning Sat, Mar 14, priced at $229 found 4 days ago
Wed, Apr 8 - Tue, Apr 14
ORD
Chicago
CAE
Columbia
$229 Roundtrip, just found
$229
Roundtrip
just found
Select Delta flight, departing Wed, Apr 8 from Chicago to Columbia, returning Tue, Apr 14, priced at $229 just found

Santee economy flight packages

Price found within the past 48 hours. Click for updated prices.
Sleep Inn Columbia
2.5-star property

Sleep Inn Columbia

8.2/10 Very Good! (1,005 reviews)

Jan 15 - Jan 19

4 night stay

Chicago (ORD) to Columbia (CAE)

American Airlines • Non-stop • Coach

Columbia (CAE) to Chicago (ORD)

Spirit Airlines • Non-stop • Coach
Price was $462, price is now $369 per person
$369
per person
found 19 hours ago
The staff was great. Friendly and efficient.

Reviewed on Nov 19, 2025

Graduate by Hilton Columbia SC
4.0-star property

Graduate by Hilton Columbia SC

9.4/10 Exceptional! (1,003 reviews)

Jan 15 - Jan 19

4 night stay

Chicago (ORD) to Columbia (CAE)

American Airlines • Non-stop • Coach

Columbia (CAE) to Chicago (ORD)

Spirit Airlines • Non-stop • Coach
Price was $615, price is now $500 per person
$500
per person
found 19 hours ago
The Graduate Columbia is quaint, our GPS took us to the front of the building but the checkin desk is in the back so we thought we were walking into someone’s house! Obviously the entrance says Graduate so we knew we were in the right place. So the ground floor area is cute and cozy. The themed gamecock areas/rooms are fun and the convenience to USC is great, easy walk across the street. However, the rooms are pretty small and tight, the bathrooms even more so and the shower door is rusting, also the room/bathroom was not very clean. I had turned down housekeeping upon checkin, two nights, thought we would be in and out so much it would be easier and wouldn’t really need it. I wonder if the infrequent cleaning these days and then a rushed cleaning on room turnover is contributing to a less than thorough clean? Also the coffee in the room is instant? The latte from the bar downstairs was undrinkable, I threw it away. There is a cute coffee shop nearby on Gervais in an old funeral home that we got on our way out of town, highly recommend-knowledge coffee, also good breakfast sandwich. Overall it served its purpose for our college tour but if we came back I would look for somewhere else to stay.

Reviewed on Jul 29, 2025

Hilton Garden Inn Columbia Airport
3.0-star property

Hilton Garden Inn Columbia Airport

9/10 Wonderful! (1,003 reviews)

Jan 15 - Jan 19

4 night stay

Chicago (ORD) to Columbia (CAE)

American Airlines • Non-stop • Coach

Columbia (CAE) to Chicago (ORD)

Spirit Airlines • Non-stop • Coach
Price was $590, price is now $482 per person
$482
per person
found 19 hours ago
The hotel was super clean and the staff were all amazingly friendly snd helpful. Hotel was very quiet. Loved it!

Reviewed on Jul 6, 2025

Don't see what you're looking for?
See all available trips from Chicago to Santee
View all trips

More About Flying To Santee from Chicago

Route Information for Flights from Chicago to Santee

Origin Airport IATA Code
CHI
Destination Airport IATA Code
CAE
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Chicago to Santee

Orbitz can provide you with the greatest deals on a wide range of Chicago to Santee flights. Orbitz offers guaranteed low prices and offers you the convenience of cutting-edge mobile tools thus providing you with your best travel experience ever.

Mobile Apps for Chicago to Santee Flights

You can use our mobile app to find the cheapest prices for flights from Chicago to Santee. With this cutting-edge technology, you can check up on your flight’s status, gate number and luggage claim handling, and reserve exclusive deals on top hotels at short notice.

Loyalty Rewarded

For travelers who regularly book Chicago to Santee flights, our frequent flyer program offers even more low-cost air tickets. You will be able to store your miles in your personal Orbitz account and add them with ease to your future reservations.

Trouble-Free Traveling With Flight Alerts

Orbitz will not only provide you with the assistance that you require when purchasing flights from Chicago to Santee but will ensure that you remain fully updated on any flight delays, changes or disruptions by providing free alerts. Your Chicago to Santee flights alerts can be sent directly to your phone or email. You can also opt for these alerts to be sent to your family and friends so that everyone is kept informed of your travel plans.

 Budget Flying Made Simple

Finding cheap flights from Chicago to Santee is easy with Orbitz. You can pick and choose airlines for your international flights to create inexpensive yet convenient travel arrangements.

More Destinations

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.