$288 Cheap flight deals from San Antonio (SAT) to Medellín (MDE)

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This Weekend's Flight Deals from San Antonio to Medellín

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Jul 25 - Tue, Aug 11
SAT
San Antonio Intl.
MDE
José María Córdova Intl.
$577 Roundtrip, found 4 days ago
$577
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Jul 25 from San Antonio Intl. to José María Córdova Intl., returning Tue, Aug 11, priced at $577 found 4 days ago

Airfares from $288 One Way, $514 Round Trip from San Antonio to Medellín

Prices starting at $514 for return flights and $288 for one-way flights to Medellín were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Aug 10 - Sat, Aug 22
SAT
San Antonio
MDE
Medellín
$514 Roundtrip, found 3 days ago
$514
Roundtrip
found 3 days ago
Select American Airlines flight, departing Mon, Aug 10 from San Antonio to Medellín, returning Sat, Aug 22, priced at $514 found 3 days ago
Mon, Aug 10 - Fri, Aug 21
SAT
San Antonio
MDE
Medellín
$543 Roundtrip, found 2 days ago
$543
Roundtrip
found 2 days ago
Select American Airlines flight, departing Mon, Aug 10 from San Antonio to Medellín, returning Fri, Aug 21, priced at $543 found 2 days ago
Fri, Sep 18 - Mon, Sep 21
SAT
San Antonio
MDE
Medellín
$560 Roundtrip, found 2 hours ago
$560
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Fri, Sep 18 from San Antonio to Medellín, returning Mon, Sep 21, priced at $560 found 2 hours ago
Mon, Aug 10 - Sat, Aug 22
SAT
San Antonio
MDE
Medellín
$563 Roundtrip, found 3 days ago
$563
Roundtrip
found 3 days ago
Select American Airlines flight, departing Mon, Aug 10 from San Antonio to Medellín, returning Sat, Aug 22, priced at $563 found 3 days ago
Fri, Sep 18 - Mon, Sep 21
SAT
San Antonio
MDE
Medellín
$571 Roundtrip, found 2 hours ago
$571
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Fri, Sep 18 from San Antonio to Medellín, returning Mon, Sep 21, priced at $571 found 2 hours ago

Medellín economy flight packages

Price found within the past 48 hours. Click for updated prices.
Hotel Helene
3.5-star property

Hotel Helene

8.8/10 Excellent! (258 reviews)

Aug 31 - Sep 6

6 night stay

San Antonio (SAT) to Medellín (MDE)

American Airlines • Non-stop roundtrip • Coach
Price was $1,157, price is now $776 per person
$776
per person
found 1 day ago
Really nice but funny toilets

Reviewed on Jul 16, 2026

Devú
5.0-star property

Devú

10/10 Exceptional! (14 reviews)

Aug 31 - Sep 6

6 night stay

San Antonio (SAT) to Medellín (MDE)

American Airlines • Non-stop roundtrip • Coach
Save 100% on your flight
Price was $1,904, price is now $1,186 per person
$1,186
per person
found 1 day ago
We really enjoyed our stay at Devu Hotel — it’s a fantastic hotel apartment. The facility is clean, the location is excellent, and the service is superb, meeting all of our expectations. The location couldn’t be more convenient, close to everywhere we needed to go. The apartment itself was clean, well-maintained, and comfortable throughout our stay. What really stood out was the service. The customer service was phenomenal across the board — from the front desk to housekeeping. Most importantly, the manager, Mateo, went above and beyond, providing excellent service and making our stay extremely comfortable. We will definitely be back soon and highly recommend Devu Hotel to anyone looking for a great stay!

Reviewed on Jul 13, 2026

Blues Suites Medellin
4.0-star property

Blues Suites Medellin

9/10 Wonderful! (1,275 reviews)

Aug 31 - Sep 6

6 night stay

San Antonio (SAT) to Medellín (MDE)

American Airlines • Non-stop roundtrip • Coach
Price was $1,362, price is now $939 per person
$939
per person
found 1 day ago
Personal amable. Buena localidad. Muy limpio todo.

Reviewed on Jul 19, 2026

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More About Flying To Medellín from San Antonio

Route Information for Flights from San Antonio to Medellín

Origin Airport IATA Code
SAT
Destination Airport IATA Code
MDE
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

San Antonio to Medellín

Whether you want to book cheap flights from San Antonio to Medellín or are looking for the perfect package holiday, Orbitz is your one-stop source. Taking the stress and expense out of travel, Orbitz helps you find the best fares for San Antonio to Medellín flights.

Make the Most of Your Vacation

Not only does Orbitz have cheap deals for San Antonio to Medellín flights, we can also help you plan your vacation in advance. Why wait in lengthy lines for tickets to shows, amusement parks, and other attractions when you could be making the most of your holiday? Add activities to your flight booking for fewer hassles once you arrive in Medellín.

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Book your flights from San Antonio to Medellín wherever you are with the Orbitz app for Android and iPhone. Or simply use m.orbitz.com on your mobile browser to search and book the San Antonio to Medellín flights that you want. And if you’re running late, you check your flight status and baggage claim information on your mobile device too too.

Craft Your Perfect Vacation

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Keep Informed With Orbitz

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Frequently asked questions

What is the shortest flight from San Antonio to Medellin?
The quickest flight time from San Antonio to Medellin is around 6 hours and 9 minutes. Grab a wine from the cabin crew, work on your travel itinerary or get to know your neighbors — you'll have enough time on this medium-haul journey.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.