Cheap flights from TPA to TYS (Tampa Intl. to McGhee Tyson)

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Cheap Flights from TPA to TYS starting at $109 One Way, $217 Round Trip

Prices starting at $217 for return flights and $109 for one-way flights to McGhee Tyson were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Dec 2 - Sat, Dec 5
TPA
Tampa
TYS
Knoxville
$217 Roundtrip, found 5 days ago
$217
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Dec 2 from Tampa to Knoxville, returning Sat, Dec 5, priced at $217 found 5 days ago
Wed, Dec 2 - Sat, Dec 5
TPA
Tampa
TYS
Knoxville
$217 Roundtrip, found 5 days ago
$217
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Wed, Dec 2 from Tampa to Knoxville, returning Sat, Dec 5, priced at $217 found 5 days ago
Wed, Dec 2 - Sat, Dec 5
TPA
Tampa
TYS
Knoxville
$227 Roundtrip, found 5 days ago
$227
Roundtrip
found 5 days ago
Select Delta flight, departing Wed, Dec 2 from Tampa to Knoxville, returning Sat, Dec 5, priced at $227 found 5 days ago

Hotel Ideas near McGhee Tyson

Airport Hotels near McGhee Tyson

La Quinta Inn & Suites by Wyndham Knoxville Airport

La Quinta Inn & Suites by Wyndham Knoxville Airport

3 out of 5
126 Cusick Road Alcoa TN
$80 nightly
The price is $95 total per night from Oct 26 to Oct 27
$95 total
Oct 26 - Oct 27
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
La Quinta Inn & Suites by Wyndham Knoxville Airport
Hilton Knoxville Airport

Hilton Knoxville Airport

3.5 out of 5
2001 Alcoa Hwy Alcoa TN
$144 nightly
The price is $165 total per night from Nov 1 to Nov 2
$165 total
Nov 1 - Nov 2
Total with taxes and fees
Book a stay at this family-friendly hotel in Alcoa. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
Hilton Knoxville Airport
Best Western Knoxville Airport/Alcoa

Best Western Knoxville Airport/Alcoa

2.5 out of 5
162 Cusick Rd Alcoa TN
$73 nightly
The price is $87 total per night from Oct 27 to Oct 28
$87 total
Oct 27 - Oct 28
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Best Western Knoxville Airport/Alcoa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Knoxville

La Quinta Inn & Suites by Wyndham Knoxville Airport

La Quinta Inn & Suites by Wyndham Knoxville Airport

3 out of 5
126 Cusick Road Alcoa TN
$80 nightly
The price is $95 total per night from Oct 26 to Oct 27
$95 total
Oct 26 - Oct 27
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
La Quinta Inn & Suites by Wyndham Knoxville Airport
Hilton Knoxville Airport

Hilton Knoxville Airport

3.5 out of 5
2001 Alcoa Hwy Alcoa TN
$144 nightly
The price is $165 total per night from Nov 1 to Nov 2
$165 total
Nov 1 - Nov 2
Total with taxes and fees
Book a stay at this family-friendly hotel in Alcoa. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
Hilton Knoxville Airport
Mainstay Suites Knoxville Airport

Mainstay Suites Knoxville Airport

2.5 out of 5
361 Fountain View Cir Alcoa TN
$85 nightly
The price is $100 total per night from Oct 8 to Oct 9
$100 total
Oct 8 - Oct 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
7.8/10 Good! (835 reviews)
"I have stayed at this property 3 times now for motorcycle events and always feel very safe inside and out as the parking lot is very well lit. It is always clean and the staff pleasant."

Reviewed on Oct 7, 2026

Mainstay Suites Knoxville Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Knoxville Hotels With Airport Transportation

La Quinta Inn & Suites by Wyndham Knoxville Airport

La Quinta Inn & Suites by Wyndham Knoxville Airport

3 out of 5
126 Cusick Road Alcoa TN
$80 nightly
The price is $95 total per night from Oct 26 to Oct 27
$95 total
Oct 26 - Oct 27
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
La Quinta Inn & Suites by Wyndham Knoxville Airport
USA Inn

USA Inn

3 out of 5
Alcoa Hwy, 2962 Alcoa TN
$50 nightly
The price is $59 total per night from Oct 8 to Oct 9
$59 total
Oct 8 - Oct 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Meigs Falls and Fort Loudoun ...
5/10 (725 reviews)
"The room was filthy. Dead bugs littered the floor. The sheets were threadbare and stained. The tub was so dirty it turned the water black the first time I ran it. The TV had no remote. The fridge hadn't been defrosted in so long it was sealed shut with a massive of ice, which also took up most of ..."

Reviewed on Oct 6, 2026

USA Inn
Best Western Knoxville Airport/Alcoa

Best Western Knoxville Airport/Alcoa

2.5 out of 5
162 Cusick Rd Alcoa TN
$73 nightly
The price is $87 total per night from Oct 27 to Oct 28
$87 total
Oct 27 - Oct 28
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Best Western Knoxville Airport/Alcoa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Knoxville Hotels

USA Inn

USA Inn

3 out of 5
Alcoa Hwy, 2962 Alcoa TN
$50 nightly
The price is $59 total per night from Oct 8 to Oct 9
$59 total
Oct 8 - Oct 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Meigs Falls and Fort Loudoun ...
5/10 (725 reviews)
"The room was filthy. Dead bugs littered the floor. The sheets were threadbare and stained. The tub was so dirty it turned the water black the first time I ran it. The TV had no remote. The fridge hadn't been defrosted in so long it was sealed shut with a massive of ice, which also took up most of ..."

Reviewed on Oct 6, 2026

USA Inn
Candlewood Suites Knoxville Airport-Alcoa by IHG

Candlewood Suites Knoxville Airport-Alcoa by IHG

2.5 out of 5
176 Cusick Road Alcoa TN
$76 nightly
The price is $90 total per night from Oct 18 to Oct 19
$90 total
Oct 18 - Oct 19
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free WiFi, an outdoor pool, and a free airport shuttle. Popular attractions Meigs Falls and Palace ...
8.4/10 Very Good! (724 reviews)
"Room was clean and updated. Transfers to and from airport very convenient and staff very friendly."

Reviewed on Oct 4, 2026

Candlewood Suites Knoxville Airport-Alcoa by IHG
Best Western Knoxville Airport/Alcoa

Best Western Knoxville Airport/Alcoa

2.5 out of 5
162 Cusick Rd Alcoa TN
$73 nightly
The price is $87 total per night from Oct 27 to Oct 28
$87 total
Oct 27 - Oct 28
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Best Western Knoxville Airport/Alcoa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Knoxville

Comfort Suites Knoxville Airport

Comfort Suites Knoxville Airport

2.5 out of 5
140 Cusick Rd Alcoa TN
$84 nightly
The price is $100 total per night from Oct 27 to Oct 28
$100 total
Oct 27 - Oct 28
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.8/10 Good! (830 reviews)
"Good hotel. No issues. Would stay there again."

Reviewed on Oct 5, 2026

Comfort Suites Knoxville Airport
Best Western Knoxville Airport/Alcoa

Best Western Knoxville Airport/Alcoa

2.5 out of 5
162 Cusick Rd Alcoa TN
$73 nightly
The price is $87 total per night from Oct 27 to Oct 28
$87 total
Oct 27 - Oct 28
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Best Western Knoxville Airport/Alcoa
La Quinta Inn & Suites by Wyndham Knoxville Airport

La Quinta Inn & Suites by Wyndham Knoxville Airport

3 out of 5
126 Cusick Road Alcoa TN
$80 nightly
The price is $95 total per night from Oct 26 to Oct 27
$95 total
Oct 26 - Oct 27
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
La Quinta Inn & Suites by Wyndham Knoxville Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

TPA to TYS Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
TPA Address & GPS
Address:
5507 West Spruce Street
Tampa FL, 33607
United States
IATA Code:
TPA
Longitude:
-82.535415
Latitude:
27.979869
Time Zone:
America/New_York
TYS Address & GPS
Address:
2055 Alcoa Highway
Knoxville TN, 37701
United States
IATA Code:
TYS
Longitude:
-83.989729
Latitude:
35.80565
Time Zone:
America/New_York

Frequently asked questions

Are there non-stop flights from TPA to Knoxville Airport?
Unfortunately, you won't find any direct flights between these destinations. But American Airlines, Delta Air Lines and United Airlines can get you from TPA to McGhee Tyson Airport (TYS) with just one stopover.
What is the shortest flight from TPA to Knoxville Airport?
From Tampa, the thrilling sights and sounds of Knoxville are around 4 hours and 39 minutes away. Lock in your favorite seat, or maybe even upgrade to one with a bit more legroom, and fly to your destination in pure comfort.
How many hours flight from Tampa Intl. Airport (TPA) to Knoxville Airport?
From TPA to Knoxville Airport, you'll be cruising the skies for roughly 4 hours and 45 minutes. Settle in, order a glass of wine and put on your noise-canceling headphones. It's time to rewatch your favorite TV shows.
What airlines have the most flights from Tampa Intl. Airport (TPA) to Knoxville Airport?
If you want to book with an airline that advertises direct flights from TPA to McGhee Tyson Airport (TYS), you won't have much luck. You'll have to book a flight with at least one stopover to get to your destination.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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