Cheap flights from TPA to TYS (Tampa Intl. to McGhee Tyson)

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Cheap Flights from TPA to TYS starting at $81 One Way, $216 Round Trip

Prices starting at $216 for return flights and $81 for one-way flights to McGhee Tyson were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Apr 26 - Thu, Apr 30
TPA
Tampa
TYS
Knoxville
$216 Roundtrip, found 6 days ago
$216
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Sun, Apr 26 from Tampa to Knoxville, returning Thu, Apr 30, priced at $216 found 6 days ago
Thu, Apr 2 - Mon, Apr 6
TPA
Tampa
TYS
Knoxville
$234 Roundtrip, found 6 days ago
$234
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Thu, Apr 2 from Tampa to Knoxville, returning Mon, Apr 6, priced at $234 found 6 days ago
Sun, Apr 26 - Thu, Apr 30
TPA
Tampa
TYS
Knoxville
$237 Roundtrip, found 6 days ago
$237
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Sun, Apr 26 from Tampa to Knoxville, returning Thu, Apr 30, priced at $237 found 6 days ago
Wed, Apr 8 - Sat, Apr 11
TPA
Tampa
TYS
Knoxville
$249 Roundtrip, found 5 days ago
$249
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Apr 8 from Tampa to Knoxville, returning Sat, Apr 11, priced at $249 found 5 days ago
Wed, Apr 8 - Sat, Apr 11
TPA
Tampa
TYS
Knoxville
$250 Roundtrip, found 5 days ago
$250
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Wed, Apr 8 from Tampa to Knoxville, returning Sat, Apr 11, priced at $250 found 5 days ago

Hotel Ideas near McGhee Tyson

Airport Hotels near McGhee Tyson

Hilton Knoxville Airport

Hilton Knoxville Airport

3.5 out of 5
2001 Alcoa Hwy Alcoa TN
$152 nightly
The price is $175 total per night from Mar 30 to Mar 31
$175 total
Mar 30 - Mar 31
Total with taxes and fees
Book a stay at this family-friendly hotel in Alcoa. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (1,002 reviews)
What’s not to like? Friendly and professional staff, comfortable and clean rooms and a great restaurant!

Reviewed on Mar 1, 2026

Hilton Knoxville Airport
La Quinta Inn & Suites by Wyndham Knoxville Airport

La Quinta Inn & Suites by Wyndham Knoxville Airport

3 out of 5
126 Cusick Road Alcoa TN
$85 nightly
The price is $100 total per night from Mar 8 to Mar 9
$100 total
Mar 8 - Mar 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,774 reviews)
Staff was great

Reviewed on Feb 28, 2026

La Quinta Inn & Suites by Wyndham Knoxville Airport
Tru by Hilton Alcoa Knoxville Airport

Tru by Hilton Alcoa Knoxville Airport

2.5 out of 5
125 FURROW WAY Alcoa TN
$83 nightly
The price is $98 total per night from Mar 8 to Mar 9
$98 total
Mar 8 - Mar 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (681 reviews)
The room was clean, which is my main concern. The refrigerator or something in the room was fairly loud (like a whine?), but I brought ear plugs thankfully.

Reviewed on Feb 23, 2026

Tru by Hilton Alcoa Knoxville Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Knoxville

Hilton Knoxville Airport

Hilton Knoxville Airport

3.5 out of 5
2001 Alcoa Hwy Alcoa TN
$152 nightly
The price is $175 total per night from Mar 30 to Mar 31
$175 total
Mar 30 - Mar 31
Total with taxes and fees
Book a stay at this family-friendly hotel in Alcoa. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (1,002 reviews)
What’s not to like? Friendly and professional staff, comfortable and clean rooms and a great restaurant!

Reviewed on Mar 1, 2026

Hilton Knoxville Airport
La Quinta Inn & Suites by Wyndham Knoxville Airport

La Quinta Inn & Suites by Wyndham Knoxville Airport

3 out of 5
126 Cusick Road Alcoa TN
$85 nightly
The price is $100 total per night from Mar 8 to Mar 9
$100 total
Mar 8 - Mar 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,774 reviews)
Staff was great

Reviewed on Feb 28, 2026

La Quinta Inn & Suites by Wyndham Knoxville Airport
Mainstay Suites Knoxville Airport

Mainstay Suites Knoxville Airport

2.5 out of 5
361 Fountain View Cir Alcoa TN
$76 nightly
The price is $90 total per night from Mar 3 to Mar 4
$90 total
Mar 3 - Mar 4
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
7.8/10 Good! (704 reviews)
Staff is wonderful

Reviewed on Feb 20, 2026

Mainstay Suites Knoxville Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Knoxville Hotels With Airport Transportation

La Quinta Inn & Suites by Wyndham Knoxville Airport

La Quinta Inn & Suites by Wyndham Knoxville Airport

3 out of 5
126 Cusick Road Alcoa TN
$85 nightly
The price is $100 total per night from Mar 8 to Mar 9
$100 total
Mar 8 - Mar 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,774 reviews)
Staff was great

Reviewed on Feb 28, 2026

La Quinta Inn & Suites by Wyndham Knoxville Airport
USA Inn

USA Inn

3 out of 5
Alcoa Hwy, 2962 Alcoa TN
$55 nightly
The price is $65 total per night from Mar 5 to Mar 6
$65 total
Mar 5 - Mar 6
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Meigs Falls and Fort Loudoun ...
5/10 (714 reviews)
Won’t be back

Reviewed on Oct 12, 2025

USA Inn
Best Western Knoxville Airport/Alcoa

Best Western Knoxville Airport/Alcoa

2.5 out of 5
162 Cusick Rd Alcoa TN
$69 nightly
The price is $82 total per night from Mar 22 to Mar 23
$82 total
Mar 22 - Mar 23
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (1,001 reviews)
Very clean room,staff very friendly.Located very close to airport

Reviewed on Feb 22, 2026

Best Western Knoxville Airport/Alcoa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Knoxville Hotels

USA Inn

USA Inn

3 out of 5
Alcoa Hwy, 2962 Alcoa TN
$55 nightly
The price is $65 total per night from Mar 5 to Mar 6
$65 total
Mar 5 - Mar 6
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Meigs Falls and Fort Loudoun ...
5/10 (714 reviews)
Won’t be back

Reviewed on Oct 12, 2025

USA Inn
Candlewood Suites Knoxville Airport-Alcoa by IHG

Candlewood Suites Knoxville Airport-Alcoa by IHG

2.5 out of 5
176 Cusick Road Alcoa TN
$80 nightly
The price is $95 total per night from Apr 1 to Apr 2
$95 total
Apr 1 - Apr 2
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free WiFi, an outdoor pool, and a free airport shuttle. Popular attractions Meigs Falls and Palace ...
8.4/10 Very Good! (624 reviews)
The hotel and room were very clean. Right across the highway from the airport and offers a free shuttle. There are no frills and most of the guests are long-term renters. Therefore, you will have a mixture of smells due to multiple units cooking. We stay for a conference that was located at the hotel ...

Reviewed on Mar 1, 2026

Candlewood Suites Knoxville Airport-Alcoa by IHG
Best Western Knoxville Airport/Alcoa

Best Western Knoxville Airport/Alcoa

2.5 out of 5
162 Cusick Rd Alcoa TN
$69 nightly
The price is $82 total per night from Mar 22 to Mar 23
$82 total
Mar 22 - Mar 23
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (1,001 reviews)
Very clean room,staff very friendly.Located very close to airport

Reviewed on Feb 22, 2026

Best Western Knoxville Airport/Alcoa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Knoxville

Comfort Suites Knoxville Airport

Comfort Suites Knoxville Airport

2.5 out of 5
140 Cusick Rd Alcoa TN
$77 nightly
The price is $91 total per night from Mar 8 to Mar 9
$91 total
Mar 8 - Mar 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Comfort Suites Knoxville Airport
Best Western Knoxville Airport/Alcoa

Best Western Knoxville Airport/Alcoa

2.5 out of 5
162 Cusick Rd Alcoa TN
$69 nightly
The price is $82 total per night from Mar 22 to Mar 23
$82 total
Mar 22 - Mar 23
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (1,001 reviews)
Very clean room,staff very friendly.Located very close to airport

Reviewed on Feb 22, 2026

Best Western Knoxville Airport/Alcoa
La Quinta Inn & Suites by Wyndham Knoxville Airport

La Quinta Inn & Suites by Wyndham Knoxville Airport

3 out of 5
126 Cusick Road Alcoa TN
$85 nightly
The price is $100 total per night from Mar 8 to Mar 9
$100 total
Mar 8 - Mar 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Alcoa. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,774 reviews)
Staff was great

Reviewed on Feb 28, 2026

La Quinta Inn & Suites by Wyndham Knoxville Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

TPA to TYS Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
TPA Address & GPS
Address:
5507 West Spruce Street
Tampa FL, 33607
United States
IATA Code:
TPA
Longitude:
-82.535415
Latitude:
27.979869
Time Zone:
America/New_York
TYS Address & GPS
Address:
2055 Alcoa Highway
Knoxville TN, 37701
United States
IATA Code:
TYS
Longitude:
-83.989729
Latitude:
35.80565
Time Zone:
America/New_York

Frequently asked questions

Are there non-stop flights from TPA to Knoxville Airport?
Unfortunately, you won't find any direct flights between these destinations. But American Airlines, Delta Air Lines and United Airlines can get you from TPA to McGhee Tyson Airport (TYS) with just one stopover.
What is the shortest flight from TPA to Knoxville Airport?
From Tampa, the thrilling sights and sounds of Knoxville are around 4 hours and 39 minutes away. Lock in your favorite seat, or maybe even upgrade to one with a bit more legroom, and fly to your destination in pure comfort.
How many hours flight from Tampa Intl. Airport (TPA) to Knoxville Airport?
From TPA to Knoxville Airport, you'll be cruising the skies for roughly 4 hours and 45 minutes. Settle in, order a glass of wine and put on your noise-canceling headphones. It's time to rewatch your favorite TV shows.
What airlines have the most flights from Tampa Intl. Airport (TPA) to Knoxville Airport?
If you want to book with an airline that advertises direct flights from TPA to McGhee Tyson Airport (TYS), you won't have much luck. You'll have to book a flight with at least one stopover to get to your destination.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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