Cheap flights from RSW to DSM (Southwest Florida Intl. to Des Moines Intl.)

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Cheap Flights from RSW to DSM starting at $128 One Way, $256 Round Trip

Prices starting at $256 for return flights and $128 for one-way flights to Des Moines Intl. were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Sep 21 - Fri, Sep 27
RSW
Fort Myers
DSM
Des Moines
$256 Roundtrip, found 12 hours ago
$256
Roundtrip
found 12 hours ago
Select Delta flight, departing Sat, Sep 21 from Fort Myers to Des Moines, returning Fri, Sep 27, priced at $256 found 12 hours ago
Tue, Jul 23 - Wed, Aug 7
RSW
Fort Myers
DSM
Des Moines
$281 Roundtrip, found 1 day ago
$281
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Jul 23 from Fort Myers to Des Moines, returning Wed, Aug 7, priced at $281 found 1 day ago
Wed, Jul 31 - Tue, Aug 6
RSW
Fort Myers
DSM
Des Moines
$286 Roundtrip, found 6 days ago
$286
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, Jul 31 from Fort Myers to Des Moines, returning Tue, Aug 6, priced at $286 found 6 days ago
Wed, Jul 31 - Tue, Aug 6
RSW
Fort Myers
DSM
Des Moines
$290 Roundtrip, found 6 days ago
$290
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, Jul 31 from Fort Myers to Des Moines, returning Tue, Aug 6, priced at $290 found 6 days ago
Thu, Aug 15 - Sun, Aug 18
RSW
Fort Myers
DSM
Des Moines
$292 Roundtrip, found 16 hours ago
$292
Roundtrip
found 16 hours ago
Select United flight, departing Thu, Aug 15 from Fort Myers to Des Moines, returning Sun, Aug 18, priced at $292 found 16 hours ago

Hotel Ideas near Des Moines Intl.

Airport Hotels near Des Moines Intl.

Days Inn & Suites by Wyndham Des Moines Airport
Days Inn & Suites by Wyndham Des Moines Airport
2 out of 5
1901 Hackley Ave, Des Moines, IA
The price is $70 per night from May 26 to May 27
$70
per night
May 26 - May 27
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.2/10 Very Good! (1,153 reviews)
Early DSM flight
"Overnight stay due to an early AM flight from DSM. Convenient, quiet and clean. Could not ask for more!"

Reviewed on May 22, 2024

Days Inn & Suites by Wyndham Des Moines Airport
Hampton Inn Des Moines-Airport
Hampton Inn Des Moines-Airport
2.5 out of 5
5001 Fleur Dr, Des Moines, IA
The price is $114 per night from May 29 to May 30
$114
per night
May 29 - May 30
Stay at this hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
8.4/10 Very Good! (1,002 reviews)
"Very nice staff! Room comfy and nice. Sink has cracks but no leaks. Some of lobby furniture outdated and worn. Nice food area but only had coffee as we left before 6 AM."

Reviewed on May 22, 2024

Hampton Inn Des Moines-Airport
AmericInn by Wyndham Des Moines Airport
AmericInn by Wyndham Des Moines Airport
2.5 out of 5
1920 Hackley Ave, Des Moines, IA
The price is $74 per night from Jun 2 to Jun 3
$74
per night
Jun 2 - Jun 3
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.6/10 Good! (895 reviews)
"Very nice staff and clean room"

Reviewed on May 21, 2024

AmericInn by Wyndham Des Moines Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Des Moines

Quality Inn & Suites Des Moines - Merle Hay Road
Quality Inn & Suites Des Moines - Merle Hay Road
2.5 out of 5
4995 Merle Hay Rd, Des Moines, IA
The price is $67 per night from May 26 to May 27
$67
per night
May 26 - May 27
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.6/10 Good! (593 reviews)
"Pool was nice. No internal Lock on the door cigarette burns on the sheets"

Reviewed on May 20, 2024

Quality Inn & Suites Des Moines - Merle Hay Road
Stoney Creek Hotel Des Moines - Johnston
Stoney Creek Hotel Des Moines - Johnston
2.5 out of 5
5291 Stoney Creek Court, Johnston, IA
The price is $99 per night from May 27 to May 28
$99
per night
May 27 - May 28
Book a stay at this business-friendly hotel in Johnston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,165 reviews)
"The "cabin" feel was unique and cute. The staff from everyone at the front desk to house keeping was so pleasant! We've already recommended others to go here."

Reviewed on May 20, 2024

Stoney Creek Hotel Des Moines - Johnston
Surety Hotel
Surety Hotel
4 out of 5
206 6th Ave., Des Moines, IA
The price is $127 per night from Jun 12 to Jun 13
$127
per night
Jun 12 - Jun 13
Stay at this 4-star hotel in Des Moines. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the restaurant and the bar in our reviews. ...
9.2/10 Wonderful! (674 reviews)
"Lobby and rooms are beautiful, restaurant is very good, there is a very cute courtyard as well. The beds are very comfortable, the service is great and there is coffee in the lobby."

Reviewed on May 19, 2024

Surety Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Des Moines Hotels With Airport Transportation

Days Inn & Suites by Wyndham Des Moines Airport
Days Inn & Suites by Wyndham Des Moines Airport
2 out of 5
1901 Hackley Ave, Des Moines, IA
The price is $70 per night from May 26 to May 27
$70
per night
May 26 - May 27
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.2/10 Very Good! (1,153 reviews)
Early DSM flight
"Overnight stay due to an early AM flight from DSM. Convenient, quiet and clean. Could not ask for more!"

Reviewed on May 22, 2024

Days Inn & Suites by Wyndham Des Moines Airport
Quality Inn & Suites Des Moines Airport
Quality Inn & Suites Des Moines Airport
2.5 out of 5
5231 Fleur Dr, Des Moines, IA
The price is $76 per night from May 29 to May 30
$76
per night
May 29 - May 30
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7/10 Good! (777 reviews)
"Was there on a Mission journey had a good stay! Great staff!"

Reviewed on May 20, 2024

Quality Inn & Suites Des Moines Airport
Hampton Inn Des Moines-Airport
Hampton Inn Des Moines-Airport
2.5 out of 5
5001 Fleur Dr, Des Moines, IA
The price is $114 per night from May 29 to May 30
$114
per night
May 29 - May 30
Stay at this hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
8.4/10 Very Good! (1,002 reviews)
"Very nice staff! Room comfy and nice. Sink has cracks but no leaks. Some of lobby furniture outdated and worn. Nice food area but only had coffee as we left before 6 AM."

Reviewed on May 22, 2024

Hampton Inn Des Moines-Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Des Moines Hotels

Motel 6 West Des Moines, IA
Motel 6 West Des Moines, IA
2 out of 5
7655 Office Plaza Dr N, West Des Moines, IA
The price is $60 per night from May 26 to May 27
$60
per night
May 26 - May 27
Stay at this motel in West Des Moines. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our ...
6.8/10 (1,006 reviews)
"Staff was very helpful and prompt."

Reviewed on May 18, 2024

Motel 6 West Des Moines, IA
Sterling Hotel and Suites
Sterling Hotel and Suites
2 out of 5
11428 Forest Ave, Clive, IA
Book a stay at this business-friendly hotel in Clive. Enjoy free WiFi, free parking, and a business center. Popular attractions Jordan Creek Town Center and ...
7.2/10 Good! (1,000 reviews)
"The the hotel we stayed out my phone got stolen and my meds and the room person was just about to get my ring before we left we will never go back to the same hotel it cost me $400 when we got home just to get a new phone"

Reviewed on Aug 23, 2022

Get rates
Sterling Hotel and Suites
Cozy Rest Motel
Cozy Rest Motel
2 out of 5
2316 Southeast 14th Street, Des Moines, IA
The price is $67 per night from May 27 to May 28
$67
per night
May 27 - May 28
Stay at this motel in Des Moines. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.6/10 Good! (550 reviews)
"A place for travelers who do not need a lot of amenities. Simple room with a fine shower, small tv, and a comfortable bed. Faced east but the heavy drapes kept the sun out and the light did not wake me up. I had a problem with the WiFi connection as I was in a building separate from the office and ..."

Reviewed on May 20, 2024

Cozy Rest Motel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Des Moines

Ramada Tropics Resort & Conf Center by Wyndham Des Moines
Ramada Tropics Resort & Conf Center by Wyndham Des Moines
3 out of 5
5000 Merle Hay Rd, Urbandale, IA
The price is $80 per night from May 27 to May 28
$80
per night
May 27 - May 28
Book a stay at this family-friendly hotel in Urbandale. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
6.4/10 (1,000 reviews)

Families like: Indoor pools, waterpark, game room, extra beds/cribs

Travelers say...
"Carpets need to replaced! Sheets are a little small for the bed they wouldn’t stay on the bed! The food in the bar was excellent! Not a lot of choices for Breakfast but the Breakfast pizza was very good! Overall a Good place to stay! The pool was fun and the staff were very nice! We will stay here ..."

Reviewed on May 16, 2024

Ramada Tropics Resort & Conf Center by Wyndham Des Moines
Wildwood Lodge
Wildwood Lodge
3 out of 5
11431 Forest Ave, Clive, IA
The price is $119 per night from May 26 to May 27
$119
per night
May 26 - May 27
Stay at this 3-star hotel in Clive. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. Popular attractions ...
9.4/10 Exceptional! (1,363 reviews)

Families like: Indoor pools, free breakfast for the whole family, laundry

Perfect Overnighter
"My overnight impromptu stay was better than expected. I was in town for a baseball tournament and decided to get a room last minute vs driving home 2hrs just to get back on the road at 6am to drive another 2hrs. Especially after sitting in 85° heat all day. The folks at the check-in were courteous ..."

Reviewed on May 19, 2024

Wildwood Lodge
Sterling Hotel and Suites
Sterling Hotel and Suites
2 out of 5
11428 Forest Ave, Clive, IA
Book a stay at this business-friendly hotel in Clive. Enjoy free WiFi, free parking, and a business center. Popular attractions Jordan Creek Town Center and ...
7.2/10 Good! (1,000 reviews)

Families like: Outdoor pools, kitchen, laundry

Travelers say...
"The the hotel we stayed out my phone got stolen and my meds and the room person was just about to get my ring before we left we will never go back to the same hotel it cost me $400 when we got home just to get a new phone"

Reviewed on Aug 23, 2022

Get rates
Sterling Hotel and Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Map To Nearby Hotels

RSW to DSM Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
RSW Address & GPS
Address:
11000 Terminal Access Road
Fort Myers FL,
United States
IATA Code:
RSW
Longitude:
-81.755263
Latitude:
26.527887
Time Zone:
America/New_York
DSM Address & GPS
Address:
5800 Fleur Drive, Suite 201
Des Moines IA, 50321-2854
United States
IATA Code:
DSM
Longitude:
-93.648087
Latitude:
41.532434
Time Zone:
America/Chicago

Frequently asked questions

Am I able to catch a flight from Fort Myers, FL Airport (RSW-Southwest Florida Intl.) to Des Moines, IA Airport (DSM-Des Moines Intl.) now?
Go right to our Covid-19 Travel Advisor for the most up-to-date information on travel restrictions and quarantine when flying from Fort Myers, FL Airport (RSW-Southwest Florida Intl.) to Des Moines, IA Airport (DSM-Des Moines Intl.).
Are there non-stop flights from Southwest Florida Intl. Airport to Des Moines Intl. Airport (DSM)?
You’ll need to switch planes if you’re wanting to travel from Fort Myers, FL Airport (RSW-Southwest Florida Intl.) to Des Moines Intl. Airport. Several airlines offer services on this route with only one stopover, including American Airlines, Delta and United Airlines.
What is the shortest flight from Fort Myers, FL Airport (RSW-Southwest Florida Intl.) to Des Moines Intl. Airport?
Traveling from Fort Myers, FL Airport (RSW-Southwest Florida Intl.) to DSM takes at least 4 hours and 34 minutes. Enjoy a wine and watch a flick or two — this is a great opportunity to sit back and unwind.
How many hours flight from Southwest Florida Intl. Airport (RSW) to DSM?
Typically, the journey from Southwest Florida Intl. Airport to Des Moines, IA Airport (DSM-Des Moines Intl.) takes 4 hours and 40 minutes. If you want to be as comfy as possible, try upgrading your seat using miles or cash.
If I am not able to travel due to COVID-19, can I cancel my flight to Des Moines, IA Airport (DSM-Des Moines Intl.)?
We get that traveling right now has its challenges, so it’s good to know that many reservations booked through us are able to be cancelled or changed. If your travel plans to Des Moines, IA Airport (DSM-Des Moines Intl.) have been affected by COVID-19, a lot of airlines are making things easier by offering credits to use at a later date. Just sign in to your account and you’ll quickly see what options are available. Our Customer Service Portal is the place to go for more information.
Are there flights to Des Moines, IA Airport (DSM-Des Moines Intl.) with flexible change policies?
In most cases you’ll have the option to reschedule your flight to Des Moines, IA Airport (DSM-Des Moines Intl.) without a change fee. All you have to do then is pay the difference between the old flight and the new one. Look for the “no change fees” filter and book with confidence.
What airlines have the most flights from Southwest Florida Intl. Airport (RSW) to Des Moines, IA Airport (DSM-Des Moines Intl.)?
There are no airlines flying direct from Fort Myers, FL Airport (RSW-Southwest Florida Intl.) to Des Moines, IA Airport (DSM-Des Moines Intl.). Do your research and secure a multi or single-stop plane ticket.

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.