Cheap flights from MLI to SNA (Quad City Intl. to John Wayne)

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Cheap Flights from MLI to SNA starting at $335 One Way, $376 Round Trip

Prices starting at $376 for return flights and $335 for one-way flights to John Wayne were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, May 5 - Tue, May 12
MLI
Moline
SNA
Orange County
$376 Roundtrip, found 2 days ago
$376
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, May 5 from Moline to Orange County, returning Tue, May 12, priced at $376 found 2 days ago
Tue, May 5 - Tue, May 12
MLI
Moline
SNA
Orange County
$376 Roundtrip, found 2 days ago
$376
Roundtrip
found 2 days ago
Select United flight, departing Tue, May 5 from Moline to Orange County, returning Tue, May 12, priced at $376 found 2 days ago
Tue, May 5 - Tue, May 12
MLI
Moline
SNA
Orange County
$381 Roundtrip, found 2 days ago
$381
Roundtrip
found 2 days ago
Select United flight, departing Tue, May 5 from Moline to Orange County, returning Tue, May 12, priced at $381 found 2 days ago
Tue, May 5 - Tue, May 12
MLI
Moline
SNA
Orange County
$393 Roundtrip, found 2 days ago
$393
Roundtrip
found 2 days ago
Select United flight, departing Tue, May 5 from Moline to Orange County, returning Tue, May 12, priced at $393 found 2 days ago
Tue, May 5 - Tue, May 12
MLI
Moline
SNA
Orange County
$399 Roundtrip, found 2 days ago
$399
Roundtrip
found 2 days ago
Select United flight, departing Tue, May 5 from Moline to Orange County, returning Tue, May 12, priced at $399 found 2 days ago

Hotel Ideas near John Wayne

Airport Hotels near John Wayne

Ayres Hotel Costa Mesa/Newport Beach

Ayres Hotel Costa Mesa/Newport Beach

4 out of 5
325 Bristol Street Costa Mesa CA
$139 nightly
The price is $155 total per night from Apr 5 to Apr 6
$155 total
Apr 5 - Apr 6
Total with taxes and fees
Book a stay at this business-friendly hotel in Costa Mesa. Enjoy free WiFi, 2 outdoor pools, and a free airport shuttle. Our guests praise the breakfast and ...
9/10 Wonderful! (3,171 reviews)
Clean hotel. Friendly staff. Great food at the restaurant. Shuttle to and from airport great!

Reviewed on Apr 4, 2026

Ayres Hotel Costa Mesa/Newport Beach
Embassy Suites by Hilton Santa Ana Orange County Airport

Embassy Suites by Hilton Santa Ana Orange County Airport

3.5 out of 5
1325 East Dyer Road Santa Ana CA
$122 nightly
The price is $138 total per night from Apr 12 to Apr 13
$138 total
Apr 12 - Apr 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free breakfast, a free airport shuttle, and room service. Our guests praise the breakfast and ...
6.2/10 (1,959 reviews)
One side of the elevators didn’t work and the fire alarm went off at 4am! It was very clean.

Reviewed on Apr 4, 2026

Embassy Suites by Hilton Santa Ana Orange County Airport
MainStay Suites John Wayne Airport by Choice Hotels

MainStay Suites John Wayne Airport by Choice Hotels

2.5 out of 5
2701 Hotel Terrace Santa Ana CA
$93 nightly
The price is $105 total per night from Apr 12 to Apr 13
$105 total
Apr 12 - Apr 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (1,759 reviews)
The breakfast wasn’t good. Not a lot of options and few things to choose from

Reviewed on Apr 4, 2026

MainStay Suites John Wayne Airport by Choice Hotels
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Orange County

Embassy Suites by Hilton Santa Ana Orange County Airport

Embassy Suites by Hilton Santa Ana Orange County Airport

3.5 out of 5
1325 East Dyer Road Santa Ana CA
$122 nightly
The price is $138 total per night from Apr 12 to Apr 13
$138 total
Apr 12 - Apr 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free breakfast, a free airport shuttle, and room service. Our guests praise the breakfast and ...
6.2/10 (1,959 reviews)
One side of the elevators didn’t work and the fire alarm went off at 4am! It was very clean.

Reviewed on Apr 4, 2026

Embassy Suites by Hilton Santa Ana Orange County Airport
MainStay Suites John Wayne Airport by Choice Hotels

MainStay Suites John Wayne Airport by Choice Hotels

2.5 out of 5
2701 Hotel Terrace Santa Ana CA
$93 nightly
The price is $105 total per night from Apr 12 to Apr 13
$105 total
Apr 12 - Apr 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (1,759 reviews)
The breakfast wasn’t good. Not a lot of options and few things to choose from

Reviewed on Apr 4, 2026

MainStay Suites John Wayne Airport by Choice Hotels
Hilton Anaheim

Hilton Anaheim

4 out of 5
777 W Convention Way Anaheim CA
$165 nightly
The price is $193 total per night from Apr 12 to Apr 13
$193 total
Apr 12 - Apr 13
Total with taxes and fees
Book a stay at this family-friendly hotel in Anaheim. Enjoy 4 restaurants, 2 hot tubs, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (1,188 reviews)
Clean room and great amenities

Reviewed on Apr 4, 2026

Hilton Anaheim
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Orange County Hotels With Airport Transportation

MainStay Suites John Wayne Airport by Choice Hotels

MainStay Suites John Wayne Airport by Choice Hotels

2.5 out of 5
2701 Hotel Terrace Santa Ana CA
$93 nightly
The price is $105 total per night from Apr 12 to Apr 13
$105 total
Apr 12 - Apr 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (1,759 reviews)
The breakfast wasn’t good. Not a lot of options and few things to choose from

Reviewed on Apr 4, 2026

MainStay Suites John Wayne Airport by Choice Hotels
Best Western Plus Orange County Airport North

Best Western Plus Orange County Airport North

2.5 out of 5
2700 Hotel Terrace Dr. Santa Ana CA
$113 nightly
The price is $128 total per night from Apr 5 to Apr 6
$128 total
Apr 5 - Apr 6
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,783 reviews)
Ok

Reviewed on Apr 4, 2026

Best Western Plus Orange County Airport North
Hotel Zessa Orange County Airport, a DoubleTree by Hilton

Hotel Zessa Orange County Airport, a DoubleTree by Hilton

4 out of 5
201 E MacArthur Blvd Santa Ana CA
$126 nightly
The price is $143 total per night from Apr 12 to Apr 13
$143 total
Apr 12 - Apr 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
9/10 Wonderful! (688 reviews)
Although we only stayed for the night, it was what we needed. Very Clean, and staff very friendly.

Reviewed on Apr 3, 2026

Hotel Zessa Orange County Airport, a DoubleTree by Hilton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Orange County Hotels

Motel 6 Santa Ana, CA

Motel 6 Santa Ana, CA

2 out of 5
1623 East 1st Street Santa Ana CA
$83 nightly
The price is $93 total per night from Apr 5 to Apr 6
$93 total
Apr 5 - Apr 6
Total with taxes and fees
Stay at this motel in Santa Ana. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.4/10 Good! (1,002 reviews)
.

Reviewed on Mar 26, 2026

Motel 6 Santa Ana, CA
West Coast Inn - Near Gem Theatre

West Coast Inn - Near Gem Theatre

2 out of 5
Santa Ana CA
$86 nightly
The price is $95 total per night from May 1 to May 2
$95 total
May 1 - May 2
Total with taxes and fees
Stay at this vacation home in Santa Ana. Enjoy free WiFi, free parking, and room service. Popular attractions Anaheim Convention Center and Disney California ...
7/10 Good! (317 reviews)
Spent too much money for a jacuzzi room. Jacuzzi broken, no television, chick on drugs knocking on my window all night, what a treat.

Reviewed on Mar 21, 2026

West Coast Inn - Near Gem Theatre
Best Western Plus Orange County Airport North

Best Western Plus Orange County Airport North

2.5 out of 5
2700 Hotel Terrace Dr. Santa Ana CA
$113 nightly
The price is $128 total per night from Apr 5 to Apr 6
$128 total
Apr 5 - Apr 6
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,783 reviews)
Ok

Reviewed on Apr 4, 2026

Best Western Plus Orange County Airport North
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Orange County

Embassy Suites by Hilton Santa Ana Orange County Airport

Embassy Suites by Hilton Santa Ana Orange County Airport

3.5 out of 5
1325 East Dyer Road Santa Ana CA
$122 nightly
The price is $138 total per night from Apr 12 to Apr 13
$138 total
Apr 12 - Apr 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free breakfast, a free airport shuttle, and room service. Our guests praise the breakfast and ...
6.2/10 (1,959 reviews)
One side of the elevators didn’t work and the fire alarm went off at 4am! It was very clean.

Reviewed on Apr 4, 2026

Embassy Suites by Hilton Santa Ana Orange County Airport
MainStay Suites John Wayne Airport by Choice Hotels

MainStay Suites John Wayne Airport by Choice Hotels

2.5 out of 5
2701 Hotel Terrace Santa Ana CA
$93 nightly
The price is $105 total per night from Apr 12 to Apr 13
$105 total
Apr 12 - Apr 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (1,759 reviews)
The breakfast wasn’t good. Not a lot of options and few things to choose from

Reviewed on Apr 4, 2026

MainStay Suites John Wayne Airport by Choice Hotels
Best Western Plus Orange County Airport North

Best Western Plus Orange County Airport North

2.5 out of 5
2700 Hotel Terrace Dr. Santa Ana CA
$113 nightly
The price is $128 total per night from Apr 5 to Apr 6
$128 total
Apr 5 - Apr 6
Total with taxes and fees
Book a stay at this business-friendly hotel in Santa Ana. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,783 reviews)
Ok

Reviewed on Apr 4, 2026

Best Western Plus Orange County Airport North
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

MLI to SNA Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
MLI Address & GPS
Address:
2200 69th Ave.
Moline IL, 61265
United States
IATA Code:
MLI
Longitude:
-90.506111
Latitude:
41.453897
Time Zone:
America/Chicago
SNA Address & GPS
Address:
18601 Airport Way
Santa Ana CA, 92707
United States
IATA Code:
SNA
Longitude:
-117.860538
Latitude:
33.680201
Time Zone:
America/Los_Angeles

Frequently asked questions

Are there non-stop flights from Quad City Intl. Airport (MLI) to John Wayne Airport (SNA)?
Traveling from Quad City Intl. Airport to John Wayne Airport means you'll need to swap planes. But hey — that's OK. American Airlines, United Airlines and Delta Air Lines offer flights with a single stopover.
What is the shortest flight from Quad City Intl. Airport (MLI) to John Wayne Airport?
From Moline, the thrilling sights and sounds of Santa Ana are 6 hours and 9 minutes away. Book your favorite seat, or maybe even upgrade to one with extra legroom, and get to your destination in pure comfort.
How many hours flight from Quad City Intl. Airport (MLI) to John Wayne Airport?
From Quad City Intl. Airport to John Wayne Airport, you'll be cruising the skies for approximately 6 hours and 15 minutes. Get comfy, order a glass of bubbly and put on your noise-canceling earphones. It's time to binge-watch some awesome TV shows.
What airlines have the most flights from Quad City Intl. Airport to SNA?
Unfortunately there are no airlines that fly direct between MLI and John Wayne Airport. Plan ahead and secure a multi-stop or one-stop plane ticket.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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