Cheap flights from LEX to FLO (Blue Grass to Florence Regional)

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Cheap Flights from LEX to FLO starting at $335 One Way, $619 Round Trip

Prices starting at $619 for return flights and $335 for one-way flights to Florence Regional were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Apr 3 - Sun, Apr 5
LEX
Lexington
FLO
Florence
$619 Roundtrip, found 1 day ago
$619
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Apr 3 from Lexington to Florence, returning Sun, Apr 5, priced at $619 found 1 day ago
Fri, Apr 3 - Sun, Apr 5
LEX
Lexington
FLO
Florence
$639 Roundtrip, found 1 day ago
$639
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Apr 3 from Lexington to Florence, returning Sun, Apr 5, priced at $639 found 1 day ago
Wed, Apr 1 - Fri, Apr 3
LEX
Lexington
FLO
Florence
$672 Roundtrip, found 1 day ago
$672
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Apr 1 from Lexington to Florence, returning Fri, Apr 3, priced at $672 found 1 day ago
Fri, Apr 3 - Sun, Apr 5
LEX
Lexington
FLO
Florence
$719 Roundtrip, found 1 day ago
$719
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Apr 3 from Lexington to Florence, returning Sun, Apr 5, priced at $719 found 1 day ago
Fri, Apr 3 - Sun, Apr 5
LEX
Lexington
FLO
Florence
$721 Roundtrip, found 1 day ago
$721
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Apr 3 from Lexington to Florence, returning Sun, Apr 5, priced at $721 found 1 day ago

Hotel Ideas near Florence Regional

Airport Hotels near Florence Regional

Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence Florence SC
$122 nightly
The price is $137 total per night from Apr 12 to Apr 13
$137 total
Apr 12 - Apr 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
9/10 Wonderful! (1,005 reviews)
Everything was great except the staff at the bar. The first girl didn’t know how to use a bottle opener to open a beer. I asked the second girl to put in a grilled cheese right away so I can bring it up to my 1 year old baby. It took about an hour to get this grilled cheese and it came out with the ...

Reviewed on Mar 27, 2026

Hyatt Place Florence Downtown
Hotel Florence, Tapestry Collection by Hilton

Hotel Florence, Tapestry Collection by Hilton

3 out of 5
126 W Evans St Florence SC
$130 nightly
The price is $146 total per night from Apr 12 to Apr 13
$146 total
Apr 12 - Apr 13
Total with taxes and fees
Book a stay at this spa hotel in Florence. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (624 reviews)
Not used

Reviewed on Mar 30, 2026

Hotel Florence, Tapestry Collection by Hilton
Rodeway Inn Florence Downtown

Rodeway Inn Florence Downtown

2 out of 5
415 S. IRBY ST Florence SC
$57 nightly
The price is $63 total per night from Apr 29 to Apr 30
$63 total
Apr 29 - Apr 30
Total with taxes and fees
Stay at this hotel in Florence. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Drs Bruce and Lee Foundation Library and Florence ...
4.6/10 (4 reviews)
Looks like the owners are doing a lot of work on the property however, cleanliness is doable but not done. Our room was supposed to have 2 beds in it but the first room we got looked like someone was still in it. Unmade bed, clothes on chair and a huge fan in the middle of the room. Second room, ...

Reviewed on Mar 11, 2026

Rodeway Inn Florence Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Florence

Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
$60 nightly
The price is $68 total per night from Apr 26 to Apr 27
$68 total
Apr 26 - Apr 27
Total with taxes and fees
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,599 reviews)
Nice sized clean room that looks updated. Need was extremely comfortable! Plenty of towels and more available if needed. Staff very friendly. Breakfast was well stocked. Area was within several restaurants. Felt completely safe in the area and in our room. We were very pleased with this stay! Just ...

Reviewed on Mar 31, 2026

Howard Johnson by Wyndham Florence
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

2.5 out of 5
527 Woody Jones Blvd Florence SC
$101 nightly
The price is $114 total per night from Apr 26 to Apr 27
$114 total
Apr 26 - Apr 27
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,244 reviews)
Good breakfast

Reviewed on Mar 30, 2026

Comfort Inn & Suites Florence Center Area
Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence Florence SC
$122 nightly
The price is $137 total per night from Apr 12 to Apr 13
$137 total
Apr 12 - Apr 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
9/10 Wonderful! (1,005 reviews)
Everything was great except the staff at the bar. The first girl didn’t know how to use a bottle opener to open a beer. I asked the second girl to put in a grilled cheese right away so I can bring it up to my 1 year old baby. It took about an hour to get this grilled cheese and it came out with the ...

Reviewed on Mar 27, 2026

Hyatt Place Florence Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Florence Hotels

Red Roof Inn Florence - Civic Center

Red Roof Inn Florence - Civic Center

2 out of 5
2690 David H McLeod Boulevard Florence SC
$61 nightly
The price is $68 total per night from Apr 4 to Apr 5
$68 total
Apr 4 - Apr 5
Total with taxes and fees
Stay at this hotel in Florence. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
6.8/10 (1,002 reviews)
The staff was friendly. The property was in very nice condition. Neighborhood was safe.

Reviewed on Mar 30, 2026

Red Roof Inn Florence - Civic Center
Budget Inn Timmonsville

Budget Inn Timmonsville

2 out of 5
2200 Cale Yarborough Highway Timmonsville SC
$61 nightly
The price is $68 total per night from Apr 1 to Apr 2
$68 total
Apr 1 - Apr 2
Total with taxes and fees
Stay at this motel in Timmonsville. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attraction Florence Motor Speedway is located nearby.
7/10 Good! (331 reviews)
Check in was easy. Parking was easy. The room was clean. For a $72 room, I didn't mind that the microwave or fridge had cosmetic issues (I didn't need to use them). I work in hotels and found that everything was standard for a roadside motel. The one issue I had was my tub didn't have a drain. Not ...

Reviewed on Mar 23, 2026

Budget Inn Timmonsville
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
$66 nightly
The price is $74 total per night from Apr 7 to Apr 8
$74 total
Apr 7 - Apr 8
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7/10 Good! (1,000 reviews)
The hotel was in a great location. It was near the mall and close by some restaurants. The hotel itself was very clean and the staff was very welcoming they had breakfast every morning to where you could fix whatever you wanted.

Reviewed on Mar 31, 2026

Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Florence

Home2 Suites by Hilton Florence, SC

Home2 Suites by Hilton Florence, SC

3 out of 5
900 Woody Jones Blvd Florence SC
$131 nightly
The price is $147 total per night from Apr 5 to Apr 6
$147 total
Apr 5 - Apr 6
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,003 reviews)
The heavy blinds we couldn’t put down so had the lights from outside shining in room

Reviewed on Mar 28, 2026

Home2 Suites by Hilton Florence, SC
Spark by Hilton Florence North I-95, SC

Spark by Hilton Florence North I-95, SC

2.5 out of 5
1739 Mandeville Rd Florence SC
$93 nightly
The price is $104 total per night from Apr 7 to Apr 8
$104 total
Apr 7 - Apr 8
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (60 reviews)
Hotel was OK. Breakfast was slim. Very small selection, everything was fresh. Bed was comfy.

Reviewed on Mar 30, 2026

Spark by Hilton Florence North I-95, SC
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
$66 nightly
The price is $74 total per night from Apr 7 to Apr 8
$74 total
Apr 7 - Apr 8
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7/10 Good! (1,000 reviews)
The hotel was in a great location. It was near the mall and close by some restaurants. The hotel itself was very clean and the staff was very welcoming they had breakfast every morning to where you could fix whatever you wanted.

Reviewed on Mar 31, 2026

Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

LEX to FLO Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date

Frequently asked questions

What is the shortest flight from Blue Grass Airport to Florence Regional Airport?
If the weather is good and everything goes to plan, you could be landing at Florence Regional Airport (FLO) from Blue Grass Airport (LEX) in only 2 hours and 18 minutes. With such a brief flight time, contemplate traveling with carry-on luggage only.
How many hours flight from Blue Grass Airport (LEX) to Florence Regional Airport?
The general flight time from LEX to FLO is a short and sweet 2 hours and 36 minutes. So, pack your gear and hop on a flight. There's nothing more exciting than an impromptu vacation.
What airlines have the most flights from Blue Grass Airport (LEX) to Florence Regional Airport?
Pick up a souvenir, have a coffee, chat with a stranger ... Airport stopovers don't have to be something to dread! If you're traveling from Blue Grass Airport (LEX) to FLO, you can't fly direct. Plan for at least one stopover somewhere.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

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