Cheap flights from CLE to FLO (Hopkins Intl. to Florence Regional)

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Cheap Flights from CLE to FLO starting at One Way, $487 Round Trip

Prices starting at $487 for return flights and for one-way flights to Florence Regional were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, May 7 - Mon, May 12
CLE
Cleveland
FLO
Florence
$487 Roundtrip, found 1 day ago
$487
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, May 7 from Cleveland to Florence, returning Mon, May 12, priced at $487 found 1 day ago
Sat, May 10 - Tue, May 13
CLE
Cleveland
FLO
Florence
$518 Roundtrip, found 1 day ago
$518
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, May 10 from Cleveland to Florence, returning Tue, May 13, priced at $518 found 1 day ago
Tue, May 6 - Sat, May 10
CLE
Cleveland
FLO
Florence
$519 Roundtrip, found 1 day ago
$519
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, May 6 from Cleveland to Florence, returning Sat, May 10, priced at $519 found 1 day ago
Thu, May 8 - Mon, May 12
CLE
Cleveland
FLO
Florence
$527 Roundtrip, found 1 day ago
$527
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, May 8 from Cleveland to Florence, returning Mon, May 12, priced at $527 found 1 day ago
Mon, May 5 - Sat, May 10
CLE
Cleveland
FLO
Florence
$535 Roundtrip, found 1 day ago
$535
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, May 5 from Cleveland to Florence, returning Sat, May 10, priced at $535 found 1 day ago
Fri, May 9 - Sat, May 10
CLE
Cleveland
FLO
Florence
$542 Roundtrip, found 1 day ago
$542
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, May 9 from Cleveland to Florence, returning Sat, May 10, priced at $542 found 1 day ago
Mon, May 5 - Sun, May 11
CLE
Cleveland
FLO
Florence
$559 Roundtrip, found 1 day ago
$559
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, May 5 from Cleveland to Florence, returning Sun, May 11, priced at $559 found 1 day ago
Fri, May 9 - Sun, May 11
CLE
Cleveland
FLO
Florence
$566 Roundtrip, found 1 day ago
$566
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, May 9 from Cleveland to Florence, returning Sun, May 11, priced at $566 found 1 day ago
Sun, May 4 - Sun, May 11
CLE
Cleveland
FLO
Florence
$567 Roundtrip, found 1 day ago
$567
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sun, May 4 from Cleveland to Florence, returning Sun, May 11, priced at $567 found 1 day ago
Wed, May 7 - Mon, May 12
CLE
Cleveland
FLO
Florence
$617 Roundtrip, found 1 day ago
$617
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, May 7 from Cleveland to Florence, returning Mon, May 12, priced at $617 found 1 day ago

Hotel Ideas near Florence Regional

Airport Hotels near Florence Regional

Hyatt Place Florence Downtown
Hyatt Place Florence Downtown
3 out of 5
100 East Evans Street Florence, Florence, SC
The price is $133 per night from May 11 to May 12
$133
includes taxes & fees
$119 per night
May 11 - May 12
Stay at this 3-star business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (1,000 reviews)
"Just a super simple but super well done hotel"

Reviewed on Apr 23, 2025

Hyatt Place Florence Downtown
Charming 3-bedroom home in Florence nea downtown, McLeod and MUSC hospitals.
Charming 3-bedroom home in Florence nea downtown, McLeod and MUSC hospitals.
Florence
Stay at this vacation home in Florence. Enjoy free WiFi, patios, and cable/satellite TV service. Popular attractions Florence Museum and South Park are located ...
10/10 Exceptional! (2 reviews)
Clean, easy stay in Florence
"Our host David is wonderful and he accommodated us over the holidays with some short notice. The property is very clean and well kept. Check in and out was easy. There are plenty of towels and the kitchen has everything you’d need for a comfortable stay. I appreciated how easy it was to communicate ..."

Reviewed on Dec 26, 2024

Get rates
Charming 3-bedroom home in Florence nea downtown, McLeod and MUSC hospitals.
Hotel Florence, Tapestry Collection by Hilton
Hotel Florence, Tapestry Collection by Hilton
3 out of 5
126 W Evans St, Florence, SC
The price is $154 per night from May 11 to May 12
$154
includes taxes & fees
$138 per night
May 11 - May 12
Stay at this 3-star spa hotel in Florence. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (565 reviews)
"I loved the restoration and history. Downtown Florence is quaint and well-kept. The room was comfortable and the staff welcoming. The food in the restaurant is very good."

Reviewed on Apr 27, 2025

Hotel Florence, Tapestry Collection by Hilton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Florence

Quality Inn & Suites Florence Civic Center
Quality Inn & Suites Florence Civic Center
2.5 out of 5
150 Dunbarton Dr, Florence, SC
The price is $93 per night from Jun 1 to Jun 2
$93
includes taxes & fees
$83 per night
Jun 1 - Jun 2
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,202 reviews)
"Very comfortable bed"

Reviewed on Apr 22, 2025

Quality Inn & Suites Florence Civic Center
Park Inn by Radisson Florence, SC
Park Inn by Radisson Florence, SC
2.5 out of 5
1729 Mandeville Road, Florence, SC
The price is $94 per night from May 26 to May 27
$94
includes taxes & fees
$84 per night
May 26 - May 27
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (2,037 reviews)
"Nice rooms , good price , great breakfast"

Reviewed on Apr 26, 2025

Park Inn by Radisson Florence, SC
Howard Johnson by Wyndham Florence
Howard Johnson by Wyndham Florence
2 out of 5
2038 W Lucas Street, I-95 Exit 164, Florence, SC
The price is $73 per night from May 4 to May 5
$73
includes taxes & fees
$66 per night
May 4 - May 5
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,195 reviews)
"The property was conveniently located to 95 for an overnight stay"

Reviewed on May 1, 2025

Howard Johnson by Wyndham Florence
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Florence Hotels

Red Roof Inn Florence - Civic Center
Red Roof Inn Florence - Civic Center
2 out of 5
2690 David H McLeod Boulevard, Florence, SC
The price is $71 per night from May 6 to May 7
$71
includes taxes & fees
$64 per night
May 6 - May 7
Stay at this hotel in Florence. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
6.6/10 (1,001 reviews)
"Nice stay thanks"

Reviewed on Apr 30, 2025

Red Roof Inn Florence - Civic Center
Budget Inn Timmonsville
Budget Inn Timmonsville
2 out of 5
2200 Cale Yarborough Highway, Timmonsville, SC
The price is $68 per night from May 4 to May 5
$68
includes taxes & fees
$61 per night
May 4 - May 5
Stay at this motel in Timmonsville. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attraction Florence Motor Speedway is located nearby.
7/10 Good! (302 reviews)
"Place was older, but clean and staff was very helpful :)"

Reviewed on Apr 14, 2025

Budget Inn Timmonsville
Days Inn by Wyndham Florence Near Civic Center
Days Inn by Wyndham Florence Near Civic Center
2.5 out of 5
140 Dunbarton Dr, Florence, SC
The price is $71 per night from May 4 to May 5
$71
includes taxes & fees
$64 per night
May 4 - May 5
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.6/10 (1,000 reviews)
"Clean amd quiet. The breakfast was not so good"

Reviewed on Apr 11, 2025

Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Florence

Home2 Suites by Hilton Florence, SC
Home2 Suites by Hilton Florence, SC
3 out of 5
900 Woody Jones Blvd, Florence, SC
The price is $148 per night from May 4 to May 5
$148
includes taxes & fees
$133 per night
May 4 - May 5
Stay at this 3-star business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,001 reviews)
"Very nice and quiet"

Reviewed on Apr 30, 2025

Home2 Suites by Hilton Florence, SC
Baymont Inn & Suites Florence by Wyndham
Baymont Inn & Suites Florence by Wyndham
2.5 out of 5
1826 W Lucas Street, Florence, SC
Book a stay at this business-friendly hotel in Florence. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Beaver Creek Golf Club and Palmetto ...
5.6/10 (1,000 reviews)
"Still in Renovation mode"

Reviewed on Sep 3, 2024

Get rates
Baymont Inn & Suites Florence by Wyndham
Country Inn & Suites by Radisson, Florence, SC
Country Inn & Suites by Radisson, Florence, SC
2.5 out of 5
1739 Mandeville Rd, Florence, SC
The price is $125 per night from Jun 1 to Jun 2
$125
includes taxes & fees
$111 per night
Jun 1 - Jun 2
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.4/10 Good! (1,001 reviews)
Double Dip
"I was charged twice for my room on my card, once by Hotels.com and again by the hotel. So desk service not so good! Ok to Good on the rest of the stay."

Reviewed on Apr 8, 2025

Country Inn & Suites by Radisson, Florence, SC
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

CLE to FLO Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
CLE Address & GPS
Address:
5300 Riverside Drive
Cleveland OH, 44135-3193
United States
IATA Code:
CLE
Longitude:
-81.83821
Latitude:
41.410856
Time Zone:
America/New_York
FLO Address & GPS
Address:
2100 Terminal Drive
Florence SC, 29501
United States
IATA Code:
FLO
Longitude:
-79.724444
Latitude:
34.188889
Time Zone:
America/New_York

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.