Cheap flights from BUF to FLO (Buffalo Niagara Intl. to Florence Regional)

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Cheap Flights from BUF to FLO starting at $411 One Way, $583 Round Trip

Prices starting at $583 for return flights and $411 for one-way flights to Florence Regional were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Dec 19 - Mon, Dec 22
BUF
Buffalo
FLO
Florence
$583 Roundtrip, found 6 days ago
$583
Roundtrip
found 6 days ago
Select American Airlines flight, departing Fri, Dec 19 from Buffalo to Florence, returning Mon, Dec 22, priced at $583 found 6 days ago
Fri, Dec 19 - Mon, Dec 22
BUF
Buffalo
FLO
Florence
$586 Roundtrip, found 6 days ago
$586
Roundtrip
found 6 days ago
Select American Airlines flight, departing Fri, Dec 19 from Buffalo to Florence, returning Mon, Dec 22, priced at $586 found 6 days ago
Fri, Dec 19 - Mon, Dec 22
BUF
Buffalo
FLO
Florence
$686 Roundtrip, found 6 days ago
$686
Roundtrip
found 6 days ago
Select American Airlines flight, departing Fri, Dec 19 from Buffalo to Florence, returning Mon, Dec 22, priced at $686 found 6 days ago
Fri, Dec 19 - Mon, Dec 22
BUF
Buffalo
FLO
Florence
$689 Roundtrip, found 6 days ago
$689
Roundtrip
found 6 days ago
Select American Airlines flight, departing Fri, Dec 19 from Buffalo to Florence, returning Mon, Dec 22, priced at $689 found 6 days ago
Fri, Dec 19 - Mon, Dec 22
BUF
Buffalo
FLO
Florence
$709 Roundtrip, found 6 days ago
$709
Roundtrip
found 6 days ago
Select American Airlines flight, departing Fri, Dec 19 from Buffalo to Florence, returning Mon, Dec 22, priced at $709 found 6 days ago
Fri, Dec 19 - Mon, Dec 22
BUF
Buffalo
FLO
Florence
$712 Roundtrip, found 6 days ago
$712
Roundtrip
found 6 days ago
Select American Airlines flight, departing Fri, Dec 19 from Buffalo to Florence, returning Mon, Dec 22, priced at $712 found 6 days ago

Hotel Ideas near Florence Regional

Airport Hotels near Florence Regional

Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence Florence SC
$100 nightly
The price is $112 total per night from Dec 22 to Dec 23
$112 total
Dec 22 - Dec 23
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
8.8/10 Excellent! (1,006 reviews)
I wish Hyatt Place would upgrade the scramble egg on the menu. The powdered eggs are not very good. It's not the staff's fault. I'm sure it is a corporate decision. Step up the breakfast menu.

Reviewed on Dec 13, 2025

Hyatt Place Florence Downtown
Hotel Florence, Tapestry Collection by Hilton

Hotel Florence, Tapestry Collection by Hilton

3 out of 5
126 W Evans St Florence SC
$130 nightly
The price is $146 total per night from Dec 28 to Dec 29
$146 total
Dec 28 - Dec 29
Total with taxes and fees
Book a stay at this spa hotel in Florence. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (603 reviews)
Room spotless. Staff courteous. 👍

Reviewed on Dec 14, 2025

Hotel Florence, Tapestry Collection by Hilton
Walking distance from one of South Carolina's top Medical centers.

Walking distance from one of South Carolina's top Medical centers.

Florence SC
$210 nightly
The price is $235 total per night from Dec 17 to Dec 18
$235 total
Dec 17 - Dec 18
Total with taxes and fees
Stay at this vacation home in Florence. Enjoy free WiFi, a garden, and laundry facilities. Popular attractions Old Greenwood Athletic Park and Drs Bruce and ...
9.8/10 Exceptional! (41 reviews)
Everything was great!

Reviewed on Nov 10, 2025

Walking distance from one of South Carolina's top Medical centers.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Florence

Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
$62 nightly
The price is $70 total per night from Dec 17 to Dec 18
$70 total
Dec 17 - Dec 18
Total with taxes and fees
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,493 reviews)
Rooms were spacious and clean. Usual continental breakfast with waffles.

Reviewed on Dec 13, 2025

Howard Johnson by Wyndham Florence
Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road Florence SC
$85 nightly
The price is $95 total per night from Dec 23 to Dec 24
$95 total
Dec 23 - Dec 24
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
8.8/10 Excellent! (2,195 reviews)
Clean new good hotel

Reviewed on Dec 15, 2025

Park Inn by Radisson Florence, SC
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

2.5 out of 5
527 Woody Jones Blvd Florence SC
$97 nightly
The price is $109 total per night from Dec 30 to Dec 31
$109 total
Dec 30 - Dec 31
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,169 reviews)
It was clean and quiet. I found the bed too hard.

Reviewed on Dec 15, 2025

Comfort Inn & Suites Florence Center Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Florence Hotels

Red Roof Inn Florence - Civic Center

Red Roof Inn Florence - Civic Center

2 out of 5
2690 David H McLeod Boulevard Florence SC
$56 nightly
The price is $63 total per night from Dec 21 to Dec 22
$63 total
Dec 21 - Dec 22
Total with taxes and fees
Stay at this hotel in Florence. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
6.6/10 (1,000 reviews)
room was decent

Reviewed on Nov 23, 2025

Red Roof Inn Florence - Civic Center
Budget Inn Timmonsville

Budget Inn Timmonsville

2 out of 5
2200 Cale Yarborough Highway Timmonsville SC
$61 nightly
The price is $68 total per night from Dec 17 to Dec 18
$68 total
Dec 17 - Dec 18
Total with taxes and fees
Stay at this motel in Timmonsville. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attraction Florence Motor Speedway is located nearby.
7/10 Good! (320 reviews)
very clean

Reviewed on Oct 16, 2025

Budget Inn Timmonsville
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
$62 nightly
The price is $69 total per night from Dec 17 to Dec 18
$69 total
Dec 17 - Dec 18
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.8/10 (1,002 reviews)
Everything was good except tv issues

Reviewed on Dec 10, 2025

Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Florence

Home2 Suites by Hilton Florence, SC

Home2 Suites by Hilton Florence, SC

3 out of 5
900 Woody Jones Blvd Florence SC
$103 nightly
The price is $116 total per night from Dec 23 to Dec 24
$116 total
Dec 23 - Dec 24
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,001 reviews)
Very clean room, bed was very comfortable and the room had a great kitchenette. I would defy stay here again.

Reviewed on Dec 13, 2025

Home2 Suites by Hilton Florence, SC
Spark by Hilton Florence North I-95, SC

Spark by Hilton Florence North I-95, SC

2.5 out of 5
1739 Mandeville Rd Florence SC
$95 nightly
The price is $106 total per night from Dec 22 to Dec 23
$106 total
Dec 22 - Dec 23
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.8/10 Good! (22 reviews)
Friendly staff and clean environment

Reviewed on Dec 9, 2025

Spark by Hilton Florence North I-95, SC
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
$62 nightly
The price is $69 total per night from Dec 17 to Dec 18
$69 total
Dec 17 - Dec 18
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.8/10 (1,002 reviews)
Everything was good except tv issues

Reviewed on Dec 10, 2025

Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

BUF to FLO Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date

Frequently asked questions

What is the shortest flight from Buffalo Niagara Intl. Airport (BUF) to FLO?
It can take merely 2 hours and 59 minutes to fly from Buffalo Niagara International Airport to Florence Regional Airport (FLO). Take a seat and enjoy the service, because you'll be touching down in next to no time.
How many hours flight from Buffalo Niagara International Airport to FLO?
Get comfortable, because a typical plane ride from Buffalo Niagara Intl. Airport (BUF) to FLO is 3 hours and 6 minutes. Enjoy some wine with your meal, get stuck into that book ... There's plenty of time to relax and unwind.
What airlines have the most flights from Buffalo Niagara International Airport to Florence Regional Airport?
If you're hoping to book with an airline that offers direct flights from Buffalo Niagara Intl. Airport (BUF) to FLO, good luck with that. You'll have to book a flight with at least one stopover to get to Florence.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.