
$170 Cheap flight deals from Buffalo (BUF) to Knoxville (TYS)
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Airfares from $170 One Way, $337 Round Trip from Buffalo to Knoxville
Prices starting at $337 for return flights and $170 for one-way flights to Knoxville were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Knoxville economy flight packages


The Ramsey Hotel & Convention Center
Dec 12 - Dec 14
Buffalo (BUF) to Knoxville (TYS)
Reviewed on Oct 5, 2025

Dolly's Lodge by Avantstay Sleeps 28 - Luxe Smokies Cabin Game Room, Hot Tub, Views, Near Attractions
Dec 12 - Dec 14
Buffalo (BUF) to Knoxville (TYS)
More About Flying To Knoxville from Buffalo
Route Information for Flights from Buffalo to Knoxville
Origin Airport IATA Code | BUF |
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Destination Airport IATA Code | TYS |
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Direct Flight Airlines | |
Earliest Flight Arrival | |
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Flying from Buffalo to Knoxville
Buffalo Niagara International Airport
With more than 100 flights taking off from its runways every day, the Buffalo Niagara International Airport is the most popular airport for people living in the area. Orbitz.com can help you find flights from Buffalo that leave any day and reach any destination of your choosing. The airport is less than 10 miles from the Buffalo city limits and around a 30-minute drive from downtown. Delta, jetBlue, United, and American Airlines are just a few of the carriers offering international and domestic flights from this airport.
Getting to the Airport
In addition to driving, the Buffalo Niagara International Airport offers several other transportation options. Taxis and limousines let you skip the long-term parking and get to the airport quickly. Renting a limo might cost more than $100, while a taxi ride can cost $20 or less. Several shuttles depart from local hotels, such as the Holiday Inn and the Hyatt Regency. Even if you do not stay at the hotel, some hotels will let you ride the shuttle for a small fee.
Parking Your Vehicle
The Buffalo Niagara International Airport has several long-term parking areas. The cost ranges from $10 to $13 per day, depending on the lot. The preferred long-term parking area charges $78 for one week, while the other lots charge $50-55 for a week of parking.
Restaurants at the Airport
If you have some free time available, you can have a drink or get a snack from one of the on-site restaurants before getting in the air. The Coffee Beanery, Lake Erie Grille, Jake's Bistro & News, and Blue Zone are a few of the more popular options. Orbitz.com can make planning your trip easier by helping you find great and inexpensive flights from Buffalo.
Knoxville Airport Information
Visitors coming to the Knoxville area usually fly into the McGhee Tyson Airport, just 14 miles south of the city. When you use Orbitz.com to book cheap flights to Knoxville, you will be able to choose from all of the major airlines that serve the airport, including Allegiant, American Airlines, Delta, Frontier, United and US Airways.
Ground Transportation in Knoxville
Knoxville doesn't offer much in the way of public transportation, but you will have your choice of shuttle vans, taxis and private car and limousine services to take you to your final destination. Orbitz.com can help you choose a rental car to get around while you are in the Knoxville area. You can also use Orbitz to book a hotel that offers free shuttle service to and from the airport.
Knoxville Area Weather Information
Knoxville winters can be chilly, with temperatures in the 20s, 30s and 40s, so make sure to pack a winter jacket or fleece to keep you warm. Summers are warm, with temperatures ranging from the high 60s to the high 80s. July usually sees the highest average rainfall, so be sure to pack a lightweight rain slicker or umbrella to keep you dry.
What to Do in Knoxville
Knoxville combines small-town Southern charm with the fun and activities you would expect to find in a big city. You can spend your time playing golf, visiting museums or touring some of the area's historical landmarks, but be sure not to miss the area's famous festivals and celebrations. Some of the city's most popular events include the Boomsday, Rossini and Dogwood Arts festivals and the Knoxville Brewers Jam. Enjoy your time in the city, and remember to use Orbitz.com the next time you want to book cheap flights to Knoxville.
Frequently asked questions
- Flights to Knoxville
- Flights from Buffalo
- Buffalo Airports
- Knoxville Airports
- Airlines Operating
- Flights To
Flights to Knoxville
- Chicago to Knoxville
- Dallas to Knoxville
- Orlando to Knoxville
- Houston to Knoxville
- New York to Knoxville
- Fort Lauderdale to Knoxville
- Detroit to Knoxville
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- New Orleans to Knoxville
- Washington to Knoxville
- Phoenix to Knoxville
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Flights from Buffalo
- Buffalo to Orlando
- Buffalo to New York
- Buffalo to Atlanta
- Buffalo to Houston
- Buffalo to Dallas
- Buffalo to Chicago
- Buffalo to Los Angeles
- Buffalo to Phoenix
- Buffalo to Washington
- Buffalo to Charlotte
- Buffalo to New Orleans
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- Buffalo to Detroit
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- Buffalo to London
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- Buffalo to Rome
- Buffalo to Paris
Buffalo Airports
Knoxville Airports
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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

