$124 Cheap flight deals from Panama City (PNS) to Knoxville (TYS)

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This Weekend's Flight Deals from Panama City to Knoxville

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Jul 10 - Sat, Jul 11
ECP
Northwest Florida Beaches Intl.
TYS
McGhee Tyson
$639 Roundtrip, found 2 days ago
$639
Roundtrip
found 2 days ago
Select Delta flight, departing Fri, Jul 10 from Northwest Florida Beaches Intl. to McGhee Tyson, returning Sat, Jul 11, priced at $639 found 2 days ago

Airfares from $124 One Way, $237 Round Trip from Panama City to Knoxville

Prices starting at $237 for return flights and $124 for one-way flights to Knoxville were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Jul 28 - Wed, Jul 29
PNS
Pensacola
TYS
Knoxville
$237 Roundtrip, found 6 days ago
$237
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Jul 28 from Pensacola to Knoxville, returning Wed, Jul 29, priced at $237 found 6 days ago
Tue, Jul 28 - Wed, Jul 29
PNS
Pensacola
TYS
Knoxville
$237 Roundtrip, found 6 days ago
$237
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Jul 28 from Pensacola to Knoxville, returning Wed, Jul 29, priced at $237 found 6 days ago
Tue, Jul 28 - Wed, Jul 29
PNS
Pensacola
TYS
Knoxville
$239 Roundtrip, found 6 days ago
$239
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Jul 28 from Pensacola to Knoxville, returning Wed, Jul 29, priced at $239 found 6 days ago
Tue, Jul 28 - Wed, Jul 29
PNS
Pensacola
TYS
Knoxville
$274 Roundtrip, found 6 days ago
$274
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Jul 28 from Pensacola to Knoxville, returning Wed, Jul 29, priced at $274 found 6 days ago
Tue, Jul 28 - Wed, Jul 29
PNS
Pensacola
TYS
Knoxville
$276 Roundtrip, found 6 days ago
$276
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Jul 28 from Pensacola to Knoxville, returning Wed, Jul 29, priced at $276 found 6 days ago

Knoxville economy flight packages

Price found within the past 48 hours. Click for updated prices.
Hilton Knoxville
3.5-star property

Hilton Knoxville

8.6/10 Excellent! (2,048 reviews)

Aug 7 - Aug 9

2 night stay

Pensacola (PNS) to Knoxville (TYS)

American Airlines • Non-stop roundtrip • Coach
Price was $632, price is now $582 per person
$582
per person
found 3 hours ago
The team here is very great. I always enjoy my stays here. I’ll only stay at this location if I’m in Knoxville

Reviewed on Jul 6, 2026

The Oliver Hotel
3.5-star property

The Oliver Hotel

9.8/10 Exceptional! (814 reviews)

Aug 7 - Aug 9

2 night stay

Pensacola (PNS) to Knoxville (TYS)

American Airlines • Non-stop roundtrip • Coach
Price was $710, price is now $601 per person
$601
per person
found 3 hours ago
My husband and I can in for a little anniversary celebration and truly enjoyed our stay. The rooms were cozy clean and exceptional. The staff was very friendly and helpful with things we were asking about nearby. You definitely need to check out the speakeasy as well during your stay. 10 out of 10.

Reviewed on Jul 4, 2026

Hampton Inn & Suites Knoxville-Downtown
2.5-star property

Hampton Inn & Suites Knoxville-Downtown

8.8/10 Excellent! (1,003 reviews)

Aug 7 - Aug 9

2 night stay

Pensacola (PNS) to Knoxville (TYS)

American Airlines • Non-stop roundtrip • Coach
Price was $650, price is now $599 per person
$599
per person
found 3 hours ago
Great amenities. Friendly staff who went above and beyond. Shower was amazing!

Reviewed on Jun 30, 2026

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More About Flying To Knoxville from Panama City

Route Information for Flights from Panama City to Knoxville

Origin Airport IATA Code
PNS
Destination Airport IATA Code
TYS
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Panama City to Knoxville

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Orbitz provides the cheapest fares from Panama City to Knoxville. When reserving your flight you can mix and match a range of low cost airlines for you departing and returning domestic or international flights. This way you can travel on a budget while selecting the flights that suit your schedule.

Modern Tools for Fast-Paced Travel

Orbitz makes use of the latest technology to ensure that you are always kept up-to-date on the status of your Panama City to Knoxville flights. Through easy-to-use mobile Android and iPhone apps you can book low cost flights from Panama City to Knoxville and choose a range of cheap hotels to stay in.

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Once you have booked your flights from Panama City to Knoxville on Orbitz you will always be kept informed of any changes to your flight. When you opt into Orbitz’s free email and SMS alerts on your Panama City to Knoxville flights you can ask Orbitz to send the flight details to up to 6 other contacts, so keeping your family and business team informed is a cinch.

Frequent Flyer Program

For loyal Orbitz customers who fly from Panama City to Knoxville the chance to join our frequent flyer program is an added bonus. Simply log-on to your online account and input your frequent flyer number for future flights.

Frequently asked questions

Are there non-stop flights from Panama City to Knoxville?
Allegiant Air will fly you nonstop from Northwest Florida Regional Airport (VPS) to McGhee Tyson Airport (TYS), which means you won't have to stress about swapping planes or missing your connection on this route.
What is the shortest flight from Panama City to Knoxville?
If conditions are good and there are no delays, you could be stepping off the plane at TYS from Pensacola Airport in only 1 hour and 58 minutes. With such a brief flight time, think about bringing hand luggage only.
What airlines fly from Panama City to Knoxville most frequently?
Allegiant Air is the most frequent flyer along this route. This top-rated carrier operates 8 flights from Destin–Fort Walton Beach Airport to Knoxville Airport every month.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

More Destinations

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.