Important: This destination may have COVID-19 travel restrictions in place, including specific restrictions for lodging. Check any national, local, and health advisories for this destination before you book.

Cheap Flight Deals From Des Moines (DSM) to Panama City (PNS) Starting at $89

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This Weekend's Flight Deals from Des Moines to Panama City

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Airfares from $89 One Way, $174 Round Trip from Des Moines to Panama City

Prices starting at $174 for return flights and $89 for one-way flights to Panama City were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Panama City economy flight packages

Grand Panama Beach Resort by Emerald View Resorts
Shores of Panama by Emerald View Resorts
Emerald Beach Resort by Resort Collection
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More About Flying To Panama City from Des Moines

Des Moines to Panama City

If you feel you cannot afford the costs involved to your dream trip to a local or international destination happen, think again! Orbitz gives you incredible deals on flights from Des Moines to Panama City. Now you can book guaranteed low fares for Des Moines to Panama City flights and plan your trip with confidence.

Great deals on flights from Des Moines to Panama City

Cheap airfares on Des Moines to Panama City flights allow you to stick to your budget and still have a great trip. We give you guaranteed low prices and make it easy to research and book discount flights using our website. Additionally, you can add your frequent flyer numbers to your Orbitz account profile, and this information will automatically be included on all your future reservations for qualified flights from Des Moines to Panama City.

Cutting-edge mobile tools make travel easy

Now you can access your flight details on-the-go using your Android and iPhone phones and tablets. Book flights from Des Moines to Panama City directly from your mobile phone or easily check your flight status and baggage claim details or book exclusive mobile hotel deals.

Des Moines to Panama City flights at discounted rates

Finding flights at the right prices can be difficult if you are not sure where to look. Don’t ruin your trip by spending more on your flights than your budget allows. Orbitz gives you guaranteed low fares on Des Moines to Panama City flights and amazing discount offers on car rentals, hotels, and even fun activities in your destination. Your dream trip is more affordable than ever with Orbitz.

Flights from Des Moines to Panama City - Frequently Asked Questions

Am I able to catch a flight from Des Moines to Panama City now?

The Covid-19 Travel Advisor can help you with queries about quarantine requirements and travel restrictions when taking a plane flight from Des Moines to Panama City.

What is the shortest flight from Des Moines to Panama City?

The quickest flight from Des Moines Intl. Airport (DSM) to PNS is 3 hours and 11 minutes. Pack a few things in your carry-on to help pass the time, like the latest edition of your favorite magazine or a sketch pad.

If I am not able to travel due to COVID-19, can I cancel my flight to Panama City?

We get that traveling right now has its challenges, so it's good to know that many reservations booked through us are able to be cancelled or changed. If your travel plans to Panama City have been affected by COVID-19, a lot of airlines are making things easier by offering credits to use at a later date. Just sign in to your account and you'll quickly see what options are available. Our Customer Service Portal is the place to go for more information.

Are there flights to Panama City with flexible change policies?

In most cases you'll have the option to reschedule your flight to Panama City without a change fee. All you have to do then is pay the difference between the old flight and the new one. Look for the "no change fees" filter and book with confidence.

What is the cheapest day of the week to fly?

Consider flying out early in the week to save on your airfare. Orbitz data from 2020 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.

What is the cheapest month to fly?

We won't keep you guessing, according to Orbitz data the cheapest month to fly is August. Perfect for those who need a weekend getaway, or just a break from it all before the weather changes. Be aware that the most expensive time to fly is the height of summer, with ticket prices peaking in the month of June.

How can I save money on flights?

To really save big on your next vacation, think outside the box. Select two different airlines or fare types for your return trip and you'll generally get a much better deal. Those who tried this on Orbitz in 2020 saved up to 45% on their airfares. Get mixing and matching today!

*According to flight demand on Orbitz.com from January to December 2020. Savings are subject to change based on departure location, date and destination.

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.