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Fares from $82 One Way, $156 Round Trip from Des Moines to Panama City

Prices starting at $156 for return flights and $82 for one-way flights to Panama City were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

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More About Flying To Panama City from Des Moines

Flights from Des Moines to Panama City - Frequently Asked Questions

Are there non-stop flights from Des Moines to Panama City?

There are no direct flights from Des Moines, IA (DSM-Des Moines Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.), so your next best option is to pick a carrier that offers a stopover. Collect a few more air miles with American Airlines, United Airlines or Delta Air Lines.

What is the shortest flight from Des Moines to Panama City?

The journey from DSM to ECP can be as fast as 2 hours and 40 minutes. With an easy flight time like this, why not organize an impulsive getaway?

Route Information for Flights from Des Moines to Panama City

Origin Airport IATA CodeDSM
Destination Airport IATA CodePNS
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Des Moines to Panama City

Planning a trip is rarely straight forward, especially when searching for cheap deals. At, we make it easier than anywhere else by providing you with guaranteed low prices. So if you are looking for Des Moines to Panama City flights at low cost, you will not be disappointed.

Cruising for a bargain deal

Regardless of your destination, we always provide you fantastic bargains for your trip, and that includes on hotels and even cruises. We offer budget air fares on flights from Des Moines to Panama City so you can reach your destination with more money in your pocket to spend.

Cheap Des Moines to Panama City flights that lead to rewards

Get rewarded for your cheap Des Moines to Panama City flights by earning miles and points for your airline loyalty or frequent flyer program. Rack up the miles by flying cheaply with Orbitz so you can earn free flights and other savings with your favorite airlines. Just enter your frequent flyer number when booking your discount fare on flights from Des Moines to Panama City on

Quality combinations

If you require budget Des Moines to Panama City flights and a bargain hotel to go with it, Orbitz will wow you with the great combinations we can offer. The quality is always high and always a superb value.

Even last minute bookings on our apps

You do not need to be tied to your desktop computer to make your booking. With our cutting-edge mobile tools, you can search for those low cost deals anywhere, anytime. Our app gives you the freedom to secure flights from Des Moines to Panama City at the very last minute from your mobile device.

^Savings based on all package bookings with Flight + Hotel made on from January 1, 2019 to December 31, 2019 as compared to the price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages.