There are no direct flights from Des Moines, IA (DSM-Des Moines Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.), so your next best option is to pick a carrier that offers a stopover. Collect a few more air miles with American Airlines, United Airlines or Delta Air Lines.
The journey from DSM to ECP can be as fast as 2 hours and 40 minutes. With an easy flight time like this, why not organize an impulsive getaway?
|Origin Airport IATA Code||DSM|
|Destination Airport IATA Code||PNS|
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^Savings based on all package bookings with Flight + Hotel made on Orbitz.com from January 1, 2019 to December 31, 2019 as compared to the price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages.