
$80 Cheap flight deals from Des Moines (DSM) to Cleveland (HOU)
Earn rewards on top of your airline miles with Orbitz Rewards
Many airlines offer flexible change policies
Sign up to receive text alerts about your trip
This Weekend's Flight Deals from Des Moines to Cleveland
This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Airfares from $80 One Way, $149 Round Trip from Des Moines to Cleveland
Prices starting at $149 for return flights and $80 for one-way flights to Cleveland were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Cleveland economy flight packages

Holiday Inn Club Vacations Galveston Beach Resort by IHG
Mar 15 - Mar 20
Des Moines (DSM) to Houston (IAH)
Houston (IAH) to Des Moines (DSM)
Reviewed on Jan 16, 2026

Holiday Inn Club Vacations Galveston Seaside Resort by IHG
Mar 15 - Mar 20
Des Moines (DSM) to Houston (IAH)
Houston (IAH) to Des Moines (DSM)
Reviewed on Dec 9, 2025

The George Manor
Mar 19 - Mar 22
Des Moines (DSM) to Houston (IAH)
Reviewed on Nov 3, 2022
More About Flying To Cleveland from Des Moines
Route Information for Flights from Des Moines to Cleveland
Origin Airport IATA Code | DSM |
|---|---|
Destination Airport IATA Code | HOU |
Distance | |
Direct Flight Airlines | |
Earliest Flight Arrival | |
Latest Flight Arrival |
Des Moines to Cleveland
Rack up your savings with low-cost flights from Des Moines to Cleveland with Orbitz On-the-Go. Orbitz On-the-Go offers mobile-only deals and cutting edge mobile tools to help you find bargain flights from Des Moines to Cleveland.
Mobile-Only Deals on Des Moines to Cleveland flights
Find guaranteed low prices on Des Moines to Cleveland flights using Orbitz On-the-Go. You can book discount domestic flights from Des Moines to Cleveland, and international tickets on Des Moines to Cleveland flights using our mobile site and apps.
Free Alerts Are No Surprise
Not only will you find cheap tickets on flights from Des Moines to Cleveland, but Orbitz free alerts will keep you up to speed on flight status, plus gate and baggage claim details. Receive instant updates via your choice of email, voice or text. Orbitz keeps you easily on task and on budget.
Share Itineraries on Flights from Des Moines to Cleveland
Are you traveling for business, pleasure or a combination of both? Keep family, friends and business contacts posted on flight and gate info. Just use MyTrips for iPhone, Android and web phones like Blackberry and Windows.
Add Smiles to Your Miles with Sales and Deals on Des Moines to Cleveland Flights
Travel planning is easy when you store your frequent flyer and loyalty program information on your Orbitz account. Then snag a low-fare air ticket on Des Moines to Cleveland flights, and you’re done. No muss, no fuss. Your miles will fly by with Orbitz On-the-Go cutting edge mobile tools and guaranteed low prices.
Flights from Des Moines
- Des Moines to Chicago
- Des Moines to Los Angeles
- Des Moines to New York
- Des Moines to Orlando
- Des Moines to Paris
- Des Moines to Sacramento
- Des Moines to Bucharest
- Des Moines to Atlanta
- Des Moines to Beijing
- Des Moines to Charlotte
- Des Moines to Dallas
- Des Moines to Detroit
- Des Moines to Houston
- Des Moines to London
- Des Moines to New Orleans
- Des Moines to Phoenix
- Des Moines to San Francisco
- Des Moines to Seattle
- Des Moines to Toronto
- Des Moines to Washington
Des Moines Airports
More Destinations
- Flights from El Paso to The Woodlands
- Flights from Austin to The Woodlands
- Flights from Boston to The Woodlands
- Flights from Cleveland to The Woodlands
- Flights from Detroit to The Woodlands
- Flights from Los Angeles to The Woodlands
- Flights from New Orleans to The Woodlands
- Flights from Orlando to The Woodlands
- Flights from Portland to The Woodlands
- Flights from Raleigh to The Woodlands
- Flights from San Francisco to The Woodlands
- Flights from Seattle to The Woodlands
- Flights from St. Louis to The Woodlands
- Flights from Vancouver to The Woodlands
- Flights from Vienna to The Woodlands
- Flights from Paris to The Woodlands
- Flights from Sacramento to The Woodlands
- Flights from Palm Springs to The Woodlands
- Flights from Myrtle Beach to The Woodlands
- Flights from Fort Lauderdale to The Woodlands
- Flights from Newark to The Woodlands
- Flights from Midland to The Woodlands
- Flights from Buffalo to The Woodlands
- Flights from Springfield to The Woodlands
- Flights from Cedar Rapids - Iowa City to The Woodlands
- Flights from Tampa to The Woodlands
- Flights from Baton Rouge to The Woodlands
- Flights from Albany to The Woodlands
- Flights from Greenville - Spartanburg to The Woodlands
- Flights from Wichita to The Woodlands
- Flights from Austin to Kingwood
- Flights from Dallas to Kingwood
- Flights from Los Angeles to Kingwood
- Flights from Memphis to Kingwood
- Flights from Miami to Kingwood
- Flights from New York to Kingwood
- Flights from Charleston to Kingwood
- Flights from Omaha to Kingwood
- Flights from Fort Lauderdale to Kingwood
- Flights from Newark to Kingwood
- Flights from Daytona Beach to Kingwood
- Flights from Little Rock to Kingwood
- Flights from Norfolk - Virginia Beach to Kingwood
- Flights from Knoxville to Kingwood
- Flights from Mobile to Kingwood
- Flights from Colorado Springs to Kingwood
- Flights from Tampa to Kingwood
- Flights from Albuquerque (ABQ) to Houston (IAH)
- Flights from Austin (AUS) to Houston (IAH)
- Flights from Nashville (BNA) to Houston (IAH)
- Flights from Bogotá (BOG) to Houston (IAH)
- Flights from Baton Rouge (BTR) to Houston (IAH)
- Flights from Colorado Springs (COS) to Houston (IAH)
- Flights from Corpus Christi (CRP) to Houston (IAH)
- Flights from Cancun (CUN) to Houston (IAH)
- Flights from Denver (DEN) to Houston (IAH)
- Flights from Des Moines (DSM) to Houston (IAH)
- Flights from Guadalajara (GDL) to Houston (IAH)
- Flights from Hyderabad (HYD) to Houston (IAH)
- Flights from Seoul (ICN) to Houston (IAH)
- Flights from Indianapolis (IND) to Houston (IAH)
- Flights from Las Vegas (LAS) to Houston (IAH)
- Flights from London (LHR) to Houston (IAH)
- Flights from Little Rock (LIT) to Houston (IAH)
- Flights from Mexico City (MEX) to Houston (IAH)
- Flights from McAllen (MFE) to Houston (IAH)
- Flights from Portland (PDX) to Houston (IAH)
- Flights from Port of Spain (POS) to Houston (IAH)
- Flights from Panama City (PTY) to Houston (IAH)
- Flights from San Salvador (SAL) to Houston (IAH)
- Flights from San Antonio (SAT) to Houston (IAH)
- Flights from San José (SJO) to Houston (IAH)
- Flights from San Juan (SJU) to Houston (IAH)
- Flights from Salt Lake City (SLC) to Houston (IAH)
- Flights from Cairo to Humble
- Flights from London to Humble
- Flights from New Orleans to Humble
- Flights from Salt Lake City to Humble
- Flights from San Antonio to Humble
- Flights from Seattle to Humble
- Flights from Washington to Humble
- Flights from Paris to Humble
- Flights from Budapest to Humble
- Flights from Jacksonville to Humble
- Flights from Pittsburgh to Humble
- Flights from Fort Lauderdale to Humble
- Flights from Syracuse to Humble
- Flights from Little Rock to Humble
- Flights from Montgomery to Humble
- Flights from Boise to Humble
- Flights from Mumbai to Humble
- Flights from Hyderabad to Humble
- Flights from Atlanta to Houston
- Flights from Chicago to Houston
- Flights from Dallas to Houston
- Flights from New York to Houston
- Flights from Sacramento to Southeast Texas
- Flights from Delhi to Spring
- Flights from Moline to Spring
- Flights from Fort Lauderdale to Spring
Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.
