$192 Cheap flight deals from Panama City (PTY) to Mexico City (MEX)

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This Weekend's Flight Deals from Panama City to Mexico City

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Aug 2 - Sat, Aug 9
PTY
Tocumen Intl.
MEX
Mexico City Intl.
$343 Roundtrip, found 1 day ago
$343
Roundtrip
found 1 day ago
Select Aeromexico flight, departing Sat, Aug 2 from Tocumen Intl. to Mexico City Intl., returning Sat, Aug 9, priced at $343 found 1 day ago

Airfares from $192 One Way, $342 Round Trip from Panama City to Mexico City

Prices starting at $342 for return flights and $192 for one-way flights to Mexico City were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Nov 23 - Mon, Dec 15
PTY
Panama City
MEX
Mexico City
$342 Roundtrip, found 2 hours ago
$342
Roundtrip
found 2 hours ago
Select Copa flight, departing Sun, Nov 23 from Panama City to Mexico City, returning Mon, Dec 15, priced at $342 found 2 hours ago
Sun, Aug 17 - Sun, Aug 24
PTY
Panama City
MEX
Mexico City
$343 Roundtrip, just found
$343
Roundtrip
just found
Select Aeromexico flight, departing Sun, Aug 17 from Panama City to Mexico City, returning Sun, Aug 24, priced at $343 just found
Wed, Aug 6 - Sun, Aug 17
PTY
Panama City
MEX
Mexico City
$345 Roundtrip, found 4 hours ago
$345
Roundtrip
found 4 hours ago
Select Aeromexico flight, departing Wed, Aug 6 from Panama City to Mexico City, returning Sun, Aug 17, priced at $345 found 4 hours ago
Thu, Sep 18 - Thu, Sep 25
PTY
Panama City
MEX
Mexico City
$363 Roundtrip, found 2 hours ago
$363
Roundtrip
found 2 hours ago
Select avianca flight, departing Thu, Sep 18 from Panama City to Mexico City, returning Thu, Sep 25, priced at $363 found 2 hours ago
Thu, Dec 4 - Sun, Dec 7
PTY
Panama City
MEX
Mexico City
$364 Roundtrip, just found
$364
Roundtrip
just found
Select Aeromexico flight, departing Thu, Dec 4 from Panama City to Mexico City, returning Sun, Dec 7, priced at $364 just found

Mexico City economy flight packages

Price found within the past 48 hours. Click for updated prices.
Zocalo Central & Rooftop Mexico City
4.0-star property

Zocalo Central & Rooftop Mexico City

9.8/10 Exceptional! (2,424 reviews)

Sep 4 - Sep 8

4 night stay

Panama City (PTY) to Mexico City (MEX)

Copa • Roundtrip • Coach
Save 100% on your flight
per person
found 1 day ago
The staff was wonderful! They were exceedingly kind and always helpful. We had a wonderful stay and we highly recommend this hotel.

Reviewed on Jul 4, 2025

Casa de la Luz Hotel Boutique
4.0-star property

Casa de la Luz Hotel Boutique

9.6/10 Exceptional! (369 reviews)

Sep 4 - Sep 8

4 night stay

Panama City (PTY) to Mexico City (MEX)

Copa • Roundtrip • Coach
Save 100% on your flight
per person
found 1 day ago
The hotel is a diamond within a scruffy neighborhood. A wonderful oasis within the historic core of Mexico City. It's sited on a quarter-block park which removes it a touch from the roar of traffic. Staff is fantastic and the included breakfast is unparalleled.

Reviewed on Feb 14, 2025

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More About Flying To Mexico City from Panama City

Route Information for Flights from Panama City to Mexico City

Origin Airport IATA Code
PTY
Destination Airport IATA Code
MEX
Distance
1498 mi
Direct Flight Airlines
Emirates, Copa Airlines, Aeromexico
Earliest Flight Arrival
5:10PM UTC
Latest Flight Arrival
6:00AM UTC

Panama City to Mexico City

Great Deals on Flights From Panama City to Mexico City

Spend more of your time and money at Mexico City instead of sitting at your computer, searching for discount Panama City to Mexico City flights. This is why Orbitz makes it easy for you to check out destinations, plan your trip, and book your air fare, hotel, car rental, and more in just one place. Our low price guarantee means that you get great deals on flights from Panama City to Mexico City.

Flights That Fit Your Budget

Traveling on a budget? Not to worry if you are using Orbitz. We monitor thousands of fares to make sure we show you the best air ticket prices available for your travel dates. Besides amazing prices on Panama City to Mexico City flights, we offer you great deals on hotels, vacation packages, and last-minute getaways for the perfect trip.

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Orbitz offers free mobile apps for iPad, iPhone, and Android-based devices, so even the busiest trip-planner can research and book flights from Panama City to Mexico City. Find cheap Panama City to Mexico City flights, research local festivities and attractions, and book reservations while sitting in the salon. Orbitz will also update you on flight delays with free alerts sent to your mobile phone or email address, so you’re never left in the dark.

Frequently asked questions

Are there non-stop flights from Panama City to Mexico City?
There most certainly is. Copa Airlines offers direct flights from PTY to MEX, which makes going from Panama City to Mexico City a cinch.
What is the shortest flight from Panama City to Mexico City?
The quickest flight time from Tocumen Intl. Airport (PTY) to MEX is around 3 hours and 47 minutes. Order a wine from the drink cart, write in your travel journal or make friends with your seat mate — you'll have the time on this medium-haul journey.
What airlines fly from Panama City to Mexico City most frequently?
Copa Airlines is the most frequent airline servicing the Panama City to Mexico City route. You can select from 152 flights every month with this carrier.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.