$202 Cheap flight deals from Panama City (PTY) to Mexico City (MEX)

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This Weekend's Flight Deals from Panama City to Mexico City

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Jun 28 - Wed, Jul 30
PTY
Tocumen Intl.
MEX
Mexico City Intl.
$362 Roundtrip, found 5 days ago
$362
Roundtrip
found 5 days ago
Select avianca flight, departing Sat, Jun 28 from Tocumen Intl. to Mexico City Intl., returning Wed, Jul 30, priced at $362 found 5 days ago

Airfares from $202 One Way, $341 Round Trip from Panama City to Mexico City

Prices starting at $341 for return flights and $202 for one-way flights to Mexico City were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Jul 5 - Sun, Jul 6
PTY
Panama City
MEX
Mexico City
$341 Roundtrip, found 10 hours ago
$341
Roundtrip
found 10 hours ago
Select Copa flight, departing Sat, Jul 5 from Panama City to Mexico City, returning Sun, Jul 6, priced at $341 found 10 hours ago
Wed, Oct 22 - Fri, Oct 24
PTY
Panama City
MEX
Mexico City
$342 Roundtrip, just found
$342
Roundtrip
just found
Select Aeromexico flight, departing Wed, Oct 22 from Panama City to Mexico City, returning Fri, Oct 24, priced at $342 just found
Sat, Jul 5 - Sun, Jul 6
PTY
Panama City
MEX
Mexico City
$352 Roundtrip, found 10 hours ago
$352
Roundtrip
found 10 hours ago
Select Copa flight, departing Sat, Jul 5 from Panama City to Mexico City, returning Sun, Jul 6, priced at $352 found 10 hours ago
Sat, Jul 5 - Sun, Jul 6
PTY
Panama City
MEX
Mexico City
$362 Roundtrip, found 10 hours ago
$362
Roundtrip
found 10 hours ago
Select Copa flight, departing Sat, Jul 5 from Panama City to Mexico City, returning Sun, Jul 6, priced at $362 found 10 hours ago
Fri, Jun 27 - Sun, Jun 29
PTY
Panama City
MEX
Mexico City
$363 Roundtrip, found 4 hours ago
$363
Roundtrip
found 4 hours ago
Select Aeromexico flight, departing Fri, Jun 27 from Panama City to Mexico City, returning Sun, Jun 29, priced at $363 found 4 hours ago

Mexico City economy flight packages

Price found within the past 48 hours. Click for updated prices.
Hotel & Suites PF
3.5-star property

Hotel & Suites PF

8.6/10 Excellent! (1,899 reviews)

Jul 23 - Jul 30

7 night stay

Panama City (PTY) to Mexico City (MEX)

Aeromexico • Roundtrip • Coach
Save 100% on your flight
per person
found 1 day ago
Great location to many restaurants and proximity in town. Nice staff, very friendly Cleaning staff very sweet. Unfortunately no washcloths or hand towels provided. A/C had issues would shut off for hours at a time, happened on 3 different days that I was there.

Reviewed on May 19, 2025

Casa Decu
4.0-star property

Casa Decu

9.4/10 Exceptional! (715 reviews)

Jul 23 - Jul 30

7 night stay

Panama City (PTY) to Mexico City (MEX)

Aeromexico • Roundtrip • Coach
Save 100% on your flight
per person
found 1 day ago
Great boutique hotel located in a cute neighborhood in La Condensa. Staff hospitality was amazing with provided great restaurant recommendation and quick response. Accessible to cute cafes and delicious restaurants…all within walking distance. I would definitely recommend this hotel.

Reviewed on Sep 10, 2023

Gran Hotel Ciudad de Mexico Zocalo View
4.5-star property

Gran Hotel Ciudad de Mexico Zocalo View

9.8/10 Exceptional! (1,000 reviews)

Jul 23 - Jul 30

7 night stay

Panama City (PTY) to Mexico City (MEX)

Aeromexico • Roundtrip • Coach
Save 100% on your flight
per person
found 1 day ago
The property itself is simply beautful! We loved coming "home" to it each evening. Special recognition to Diego, he was always so helpful and peasant.

Reviewed on Aug 26, 2024

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More About Flying To Mexico City from Panama City

Route Information for Flights from Panama City to Mexico City

Origin Airport IATA Code
PTY
Destination Airport IATA Code
MEX
Distance
1498 mi
Direct Flight Airlines
Emirates, Copa Airlines, Aeromexico
Earliest Flight Arrival
5:10PM UTC
Latest Flight Arrival
6:00AM UTC

Panama City to Mexico City

When you’re ready to take your next trip, get the most affordable prices on flights from Panama City to Mexico City with Orbitz! The guaranteed low prices and cutting-edge mobile tools on Orbits make it easy for you to plan your next great vacation.

Keep Up With Sudden Flight Changes

As any traveler knows, air travel can suddenly be temporarily halted due to service disruptions. Along with offering the best fares for flights from Panama City to Mexico City, Orbitz also offers free mobile phone and email alerts that help you keep up with sudden changes to your flight plans. Choose from email, text, or voice message alerts.

Get Great Prices for Panama City to Mexico City Flights

Orbitz features both an Android app and an iPhone app to give you the lowest prices for Panama City to Mexico City flights. Use these mobile apps to get updates on your flight, the details of your itinerary, and to learn about available hotel deals in the area.

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Frequently asked questions

Are there non-stop flights from Panama City to Mexico City?
There most certainly is. Copa Airlines offers direct flights from PTY to MEX, which makes going from Panama City to Mexico City a cinch.
What is the shortest flight from Panama City to Mexico City?
The quickest flight time from Tocumen Intl. Airport (PTY) to MEX is around 3 hours and 47 minutes. Order a wine from the drink cart, write in your travel journal or make friends with your seat mate --- you'll have the time on this medium-haul journey.
What airlines fly from Panama City to Mexico City most frequently?
Copa Airlines is the most frequent airline servicing the Panama City to Mexico City route. You can select from 152 flights every month with this carrier.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.