$146 Cheap flight deals from Panama City (PTY) to Medellín (MDE)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

This Weekend's Flight Deals from Panama City to Medellín

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Oct 3 - Wed, Oct 7
PTY
Tocumen Intl.
MDE
José María Córdova Intl.
$341 Roundtrip, found 3 hours ago
$341
Roundtrip
found 3 hours ago
Select avianca flight, departing Sat, Oct 3 from Tocumen Intl. to José María Córdova Intl., returning Wed, Oct 7, priced at $341 found 3 hours ago

Airfares from $146 One Way, $277 Round Trip from Panama City to Medellín

Prices starting at $277 for return flights and $146 for one-way flights to Medellín were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Apr 1 - Mon, Apr 5
PTY
Panama City
MDE
Medellín
$277 Roundtrip, found 4 hours ago
$277
Roundtrip
found 4 hours ago
Select Copa flight, departing Thu, Apr 1 from Panama City to Medellín, returning Mon, Apr 5, priced at $277 found 4 hours ago
Thu, Nov 5 - Tue, Nov 10
PTY
Panama City
MDE
Medellín
$286 Roundtrip, just found
$286
Roundtrip
just found
Select avianca flight, departing Thu, Nov 5 from Panama City to Medellín, returning Tue, Nov 10, priced at $286 just found
Thu, Apr 1 - Mon, Apr 5
PTY
Panama City
MDE
Medellín
$288 Roundtrip, found 4 hours ago
$288
Roundtrip
found 4 hours ago
Select Copa flight, departing Thu, Apr 1 from Panama City to Medellín, returning Mon, Apr 5, priced at $288 found 4 hours ago
Fri, Nov 6 - Tue, Nov 10
PTY
Panama City
MDE
Medellín
$297 Roundtrip, just found
$297
Roundtrip
just found
Select avianca flight, departing Fri, Nov 6 from Panama City to Medellín, returning Tue, Nov 10, priced at $297 just found
Thu, Apr 1 - Mon, Apr 5
PTY
Panama City
MDE
Medellín
$298 Roundtrip, found 4 hours ago
$298
Roundtrip
found 4 hours ago
Select Copa flight, departing Thu, Apr 1 from Panama City to Medellín, returning Mon, Apr 5, priced at $298 found 4 hours ago

Medellín economy flight packages

Price found within the past 48 hours. Click for updated prices.
Calle Flora Hotel by Jalo
4.0-star property

Calle Flora Hotel by Jalo

9/10 Wonderful! (1,422 reviews)

Oct 31 - Nov 5

5 night stay

Panama City (PTY) to Medellín (MDE)

Copa • Roundtrip • Coach
Price was $1,051, price is now $777 per person
$777
per person
found 1 day ago

Blues Suites Medellin
4.0-star property

Blues Suites Medellin

9/10 Wonderful! (1,328 reviews)

Oct 31 - Nov 5

5 night stay

Panama City (PTY) to Medellín (MDE)

Copa • Roundtrip • Coach
Price was $1,051, price is now $777 per person
$777
per person
found 1 day ago
Very helpful and polite they were always willing to help

Reviewed on Sep 29, 2026

Selvario 36 Hotel
4.0-star property

Selvario 36 Hotel

9.4/10 Exceptional! (833 reviews)

Oct 31 - Nov 5

5 night stay

Panama City (PTY) to Medellín (MDE)

Copa • Roundtrip • Coach
Price was $1,262, price is now $939 per person
$939
per person
found 1 day ago

Don't see what you're looking for?
See all available trips from Panama City to Medellín
View all trips

More About Flying To Medellín from Panama City

Route Information for Flights from Panama City to Medellín

Origin Airport IATA Code
PTY
Destination Airport IATA Code
MDE
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Panama City to Medellín

Planning a trip is rarely straight forward, especially when searching for cheap deals. At Orbitz.com, we make it easier than anywhere else by providing you with guaranteed low prices. So if you are looking for Panama City to Medellín flights at low cost, you will not be disappointed.

Cruising for a bargain deal

Regardless of your destination, we always provide you fantastic bargains for your trip, and that includes on hotels and even cruises. We offer budget air fares on flights from Panama City to Medellín so you can reach your destination with more money in your pocket to spend.

Cheap Panama City to Medellín flights that lead to rewards

Get rewarded for your cheap Panama City to Medellín flights by earning miles and points for your airline loyalty or frequent flyer program. Rack up the miles by flying cheaply with Orbitz so you can earn free flights and other savings with your favorite airlines. Just enter your frequent flyer number when booking your discount fare on flights from Panama City to Medellín on Orbtiz.com.

Quality combinations

If you require budget Panama City to Medellín flights and a bargain hotel to go with it, Orbitz will wow you with the great combinations we can offer. The quality is always high and always a superb value.

Even last minute bookings on our apps

You do not need to be tied to your desktop computer to make your booking. With our cutting-edge mobile tools, you can search for those low cost deals anywhere, anytime. Our app gives you the freedom to secure flights from Panama City to Medellín at the very last minute from your mobile device.

Frequently asked questions

Are there non-stop flights from Panama City to Medellin?
Get your passport ready, because Copa Airlines will take you straight from Panama City to Medellin. Book your fare now and enjoy a stress-free, nonstop flight.
What is the shortest flight from Panama City to Medellin?
If conditions are good and everything goes to plan, you could be landing at MDE from Panama Airport in just 1 hour and 12 minutes. With such a speedy flight time, think about taking hand luggage only.
What airlines fly from Panama City to Medellin most frequently?
If you're looking for the airline that offers the most flights from Panama City to Medellin, Copa Airlines is your best bet. This respected airline operates 152 flights along this route every month.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

More Destinations

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.