$152 Cheap flight deals from Panama City (PTY) to Medellin (MDE)

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This Weekend's Flight Deals from Panama City to Medellin

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Jan 3 - Tue, Feb 3
PTY
Tocumen Intl.
MDE
José María Córdova Intl.
$348 Roundtrip, found 1 day ago
$348
Roundtrip
found 1 day ago
Select avianca flight, departing Sat, Jan 3 from Tocumen Intl. to José María Córdova Intl., returning Tue, Feb 3, priced at $348 found 1 day ago

Airfares from $152 One Way, $286 Round Trip from Panama City to Medellin

Prices starting at $286 for return flights and $152 for one-way flights to Medellin were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Jan 15 - Tue, Jan 20
PTY
Panama City
MDE
Medellin
$286 Roundtrip, found 12 hours ago
$286
Roundtrip
found 12 hours ago
Select Copa flight, departing Thu, Jan 15 from Panama City to Medellin, returning Tue, Jan 20, priced at $286 found 12 hours ago
Thu, Jan 15 - Tue, Jan 20
PTY
Panama City
MDE
Medellin
$297 Roundtrip, found 12 hours ago
$297
Roundtrip
found 12 hours ago
Select Copa flight, departing Thu, Jan 15 from Panama City to Medellin, returning Tue, Jan 20, priced at $297 found 12 hours ago
Mon, Mar 30 - Thu, Apr 2
PTY
Panama City
MDE
Medellin
$298 Roundtrip, found 1 day ago
$298
Roundtrip
found 1 day ago
Select Copa flight, departing Mon, Mar 30 from Panama City to Medellin, returning Thu, Apr 2, priced at $298 found 1 day ago
Thu, Jan 15 - Tue, Jan 20
PTY
Panama City
MDE
Medellin
$303 Roundtrip, found 12 hours ago
$303
Roundtrip
found 12 hours ago
Select Copa flight, departing Thu, Jan 15 from Panama City to Medellin, returning Tue, Jan 20, priced at $303 found 12 hours ago
Thu, Jan 15 - Tue, Jan 20
PTY
Panama City
MDE
Medellin
$314 Roundtrip, found 12 hours ago
$314
Roundtrip
found 12 hours ago
Select Copa flight, departing Thu, Jan 15 from Panama City to Medellin, returning Tue, Jan 20, priced at $314 found 12 hours ago

Medellin economy flight packages

Price found within the past 48 hours. Click for updated prices.
Aparta Suites Torre Poblado
3.0-star property

Aparta Suites Torre Poblado

8.8/10 Excellent! (863 reviews)

Feb 13 - Feb 17

4 night stay

Panama City (PTY) to Medellín (MDE)

Copa • Roundtrip • Coach
Price was $739, price is now $504 per person
$504
per person
found 1 day ago
Central location. Close to food and entertainment

Reviewed on Jun 12, 2023

Blues Suites Medellin
4.0-star property

Blues Suites Medellin

9/10 Wonderful! (981 reviews)

Feb 13 - Feb 17

4 night stay

Panama City (PTY) to Medellín (MDE)

Copa • Roundtrip • Coach
Price was $730, price is now $517 per person
$517
per person
found 1 day ago
Perfect location, excellent staff! Will definitely stay again here!

Reviewed on Sep 20, 2025

The Charlee Hotel
5.0-star property

The Charlee Hotel

8.8/10 Excellent! (1,002 reviews)

Feb 13 - Feb 18

5 night stay

Panama City (PTY) to Medellín (MDE)

Copa • Coach

Medellín (MDE) to Panama City (PTY)

Avianca • Coach
Price was $1,301, price is now $933 per person
$933
per person
found 1 day ago
The staff was amazing and made me feel as if I were regular and it was my 1st stay at this specific hotel

Reviewed on Nov 3, 2025

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More About Flying To Medellin from Panama City

Route Information for Flights from Panama City to Medellin

Origin Airport IATA Code
PTY
Destination Airport IATA Code
MDE
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Panama City to Medellin

Great Deals on Flights From Panama City to Medellin

Spend more of your time and money at Medellin instead of sitting at your computer, searching for discount Panama City to Medellin flights. This is why Orbitz makes it easy for you to check out destinations, plan your trip, and book your air fare, hotel, car rental, and more in just one place. Our low price guarantee means that you get great deals on flights from Panama City to Medellin.

Flights That Fit Your Budget

Traveling on a budget? Not to worry if you are using Orbitz. We monitor thousands of fares to make sure we show you the best air ticket prices available for your travel dates. Besides amazing prices on Panama City to Medellin flights, we offer you great deals on hotels, vacation packages, and last-minute getaways for the perfect trip.

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Orbitz offers free mobile apps for iPad, iPhone, and Android-based devices, so even the busiest trip-planner can research and book flights from Panama City to Medellin. Find cheap Panama City to Medellin flights, research local festivities and attractions, and book reservations while sitting in the salon. Orbitz will also update you on flight delays with free alerts sent to your mobile phone or email address, so you’re never left in the dark.

Frequently asked questions

Are there non-stop flights from Panama City to Medellin?
Get your passport ready, because Copa Airlines will take you straight from Panama City to Medellin. Book your fare now and enjoy a stress-free, nonstop flight.
What is the shortest flight from Panama City to Medellin?
If conditions are good and everything goes to plan, you could be landing at MDE from Panama Airport in just 1 hour and 12 minutes. With such a speedy flight time, think about taking hand luggage only.
What airlines fly from Panama City to Medellin most frequently?
If you're looking for the airline that offers the most flights from Panama City to Medellin, Copa Airlines is your best bet. This respected airline operates 152 flights along this route every month.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.