$178 Cheap flight deals from Boston (BOS) to Knoxville (DSM)

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This Weekend's Flight Deals from Boston to Knoxville

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Apr 12 - Fri, Apr 17
PVD
T.F. Green
DSM
Des Moines Intl.
$602 Roundtrip, found 5 days ago
$602
Roundtrip
found 5 days ago
Select United flight, departing Sun, Apr 12 from T.F. Green to Des Moines Intl., returning Fri, Apr 17, priced at $602 found 5 days ago
Sat, Apr 11 - Tue, Apr 14
BOS
Logan Intl.
DSM
Des Moines Intl.
$752 Roundtrip, found 6 days ago
$752
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, Apr 11 from Logan Intl. to Des Moines Intl., returning Tue, Apr 14, priced at $752 found 6 days ago

Airfares from $178 One Way, $351 Round Trip from Boston to Knoxville

Prices starting at $351 for return flights and $178 for one-way flights to Knoxville were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Aug 11 - Wed, Aug 26
BOS
Boston
DSM
Des Moines
$351 Roundtrip, found 20 hours ago
$351
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Tue, Aug 11 from Boston to Des Moines, returning Wed, Aug 26, priced at $351 found 20 hours ago
Tue, Aug 11 - Wed, Aug 26
PVD
Providence
DSM
Des Moines
$351 Roundtrip, found 20 hours ago
$351
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Tue, Aug 11 from Providence to Des Moines, returning Wed, Aug 26, priced at $351 found 20 hours ago
Tue, Aug 11 - Wed, Aug 26
BOS
Boston
DSM
Des Moines
$351 Roundtrip, found 20 hours ago
$351
Roundtrip
found 20 hours ago
Select United flight, departing Tue, Aug 11 from Boston to Des Moines, returning Wed, Aug 26, priced at $351 found 20 hours ago
Tue, Aug 11 - Wed, Aug 26
PVD
Providence
DSM
Des Moines
$351 Roundtrip, found 20 hours ago
$351
Roundtrip
found 20 hours ago
Select Southwest Airlines flight, departing Tue, Aug 11 from Providence to Des Moines, returning Wed, Aug 26, priced at $351 found 20 hours ago
Tue, Aug 11 - Wed, Aug 26
PVD
Providence
DSM
Des Moines
$356 Roundtrip, found 20 hours ago
$356
Roundtrip
found 20 hours ago
Select Southwest Airlines flight, departing Tue, Aug 11 from Providence to Des Moines, returning Wed, Aug 26, priced at $356 found 20 hours ago

Knoxville economy flight packages

Price found within the past 48 hours. Click for updated prices.
Holiday Inn Downtown - Mercy Area by IHG
3.0-star property

Holiday Inn Downtown - Mercy Area by IHG

7.8/10 Good! (1,005 reviews)

May 22 - May 26

4 night stay

Boston (BOS) to Des Moines (DSM)

American Airlines • Non-stop roundtrip • Coach
Price was $703, price is now $601 per person
$601
per person
found 7 hours ago
Stayed here for Paul McCartney concert. Parking lot was under construction so we had to park at the hospital. Lounge was never open even though they were full and would have had lots of customers. Staff seemed flustered by the crowd returning from the concert as elevators got seriously backed up. Needed more vans to accomodate crowd.

Reviewed on Oct 15, 2025

Hotel Fort Des Moines, Curio Collection by Hilton
4.5-star property

Hotel Fort Des Moines, Curio Collection by Hilton

9.6/10 Exceptional! (1,106 reviews)

May 22 - May 26

4 night stay

Boston (BOS) to Des Moines (DSM)

American Airlines • Non-stop roundtrip • Coach
Price was $909, price is now $733 per person
$733
per person
found 7 hours ago
Beautiful, comfortable room with nice, modern bathroom. Very friendly staff and exceptionally friendly wait staff and bartenders in the Proudfoot & Bird restaurant.

Reviewed on Nov 28, 2025

Hyatt Place West Des Moines Jordan Creek
3.0-star property

Hyatt Place West Des Moines Jordan Creek

9.2/10 Wonderful! (1,004 reviews)

May 22 - May 26

4 night stay

Boston (BOS) to Des Moines (DSM)

American Airlines • Non-stop roundtrip • Coach
Price was $836, price is now $691 per person
$691
per person
found 7 hours ago
This property was incredibly comfortable and convenient for visiting family in the area. I would absolutely stay here again. The pool was even awesome for adults.

Reviewed on Jul 7, 2025

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More About Flying To Knoxville from Boston

Route Information for Flights from Boston to Knoxville

Origin Airport IATA Code
BOS
Destination Airport IATA Code
DSM
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Boston to Knoxville

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.