Cheap flights from TYS to COU (McGhee Tyson to Columbia Regional)

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Cheap Flights from TYS to COU starting at One Way, $473 Round Trip

Prices starting at $473 for return flights and for one-way flights to Columbia Regional were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Sep 16 - Tue, Sep 23
TYS
Knoxville
COU
Columbia
$473 Roundtrip, found 1 day ago
$473
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Sep 16 from Knoxville to Columbia, returning Tue, Sep 23, priced at $473 found 1 day ago
Tue, Sep 16 - Wed, Sep 24
TYS
Knoxville
COU
Columbia
$478 Roundtrip, found 1 day ago
$478
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Sep 16 from Knoxville to Columbia, returning Wed, Sep 24, priced at $478 found 1 day ago
Fri, Sep 19 - Sun, Sep 21
TYS
Knoxville
COU
Columbia
$495 Roundtrip, found 1 day ago
$495
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Sep 19 from Knoxville to Columbia, returning Sun, Sep 21, priced at $495 found 1 day ago
Sun, Sep 21 - Sat, Sep 27
TYS
Knoxville
COU
Columbia
$500 Roundtrip, found 1 day ago
$500
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sun, Sep 21 from Knoxville to Columbia, returning Sat, Sep 27, priced at $500 found 1 day ago
Wed, Sep 17 - Sun, Sep 21
TYS
Knoxville
COU
Columbia
$516 Roundtrip, found 1 day ago
$516
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Sep 17 from Knoxville to Columbia, returning Sun, Sep 21, priced at $516 found 1 day ago
Fri, Sep 19 - Sun, Sep 21
TYS
Knoxville
COU
Columbia
$549 Roundtrip, found 1 day ago
$549
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Sep 19 from Knoxville to Columbia, returning Sun, Sep 21, priced at $549 found 1 day ago
Fri, Sep 19 - Sun, Sep 21
TYS
Knoxville
COU
Columbia
$572 Roundtrip, found 1 day ago
$572
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Sep 19 from Knoxville to Columbia, returning Sun, Sep 21, priced at $572 found 1 day ago
Fri, Sep 19 - Sun, Sep 21
TYS
Knoxville
COU
Columbia
$575 Roundtrip, found 1 day ago
$575
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Sep 19 from Knoxville to Columbia, returning Sun, Sep 21, priced at $575 found 1 day ago
Fri, Sep 19 - Sun, Sep 21
TYS
Knoxville
COU
Columbia
$589 Roundtrip, found 1 day ago
$589
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Sep 19 from Knoxville to Columbia, returning Sun, Sep 21, priced at $589 found 1 day ago
Fri, Sep 19 - Sun, Sep 21
TYS
Knoxville
COU
Columbia
$597 Roundtrip, found 1 day ago
$597
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Sep 19 from Knoxville to Columbia, returning Sun, Sep 21, priced at $597 found 1 day ago

Hotel Ideas near Columbia Regional

Airport Hotels near Columbia Regional

3-bedroom Ranch Duplex in charming Columbia with WiFi, 6 miles to Mizzou Arena

3-bedroom Ranch Duplex in charming Columbia with WiFi, 6 miles to Mizzou Arena

Columbia
$295 nightly
The price is $302 total per night from Aug 5 to Aug 6
$302 total
Aug 5 - Aug 6
Total includes taxes and fees
Stay at this vacation home in Columbia. Enjoy free WiFi, laundry facilities, and patios. Popular attractions Gans Creek Conservation Area and Philips Lake are ...
8/10 Very Good! (3 reviews)
Great Columbia location
"We had a great weekend in Columbia the property was close to everything we needed. Would definitely recommend and stay again"

Reviewed on Jul 13, 2025

3-bedroom Ranch Duplex in charming Columbia with WiFi, 6 miles to Mizzou Arena
Cozy cabin getaway with hot-tub under stars!

Cozy cabin getaway with hot-tub under stars!

Ashland
$237 nightly
The price is $237 total per night from Jul 31 to Aug 1
$237 total
Jul 31 - Aug 1
Total includes taxes and fees
Stay at this cabin in Boone County. Enjoy laundry facilities, patios, and an in-room coffeemaker. Popular attractions Church Farm Conservation Area and Stanley ...
9.4/10 Exceptional! (17 reviews)
Secluded and quiet
"Absolutely worth the money, especially if you're looking for a peaceful escape from the city—that’s exactly what we wanted! The setting was relaxing and serene. The host was incredibly attentive and communicated well, making our stay even more enjoyable. While there's no Wi-Fi, cell service is available ..."

Reviewed on Mar 2, 2025

Cozy cabin getaway with hot-tub under stars!
TownePlace Suites by Marriott Columbia

TownePlace Suites by Marriott Columbia

3 out of 5
4400 Nocona Parkway, Columbia, MO
$105 nightly
The price is $119 total per night from Aug 10 to Aug 11
$119 total
Aug 10 - Aug 11
Total includes taxes and fees
Stay at this 3-star business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Popular attractions A. Perry Philips Park and Philips ...
9/10 Wonderful! (343 reviews)
"Very nice and very clean"

Reviewed on Jul 23, 2025

TownePlace Suites by Marriott Columbia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Columbia

Baymont by Wyndham Columbia, MO

Baymont by Wyndham Columbia, MO

2.5 out of 5
2500 I 70 Dr Sw, Columbia, MO
$61 nightly
The price is $69 total per night from Aug 24 to Aug 25
$69 total
Aug 24 - Aug 25
Total includes taxes and fees
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
7.8/10 Good! (388 reviews)
Comfortable stay but had to add an extra room
"Well, there was a total of 5 of us and when i put on the reservation there would be 3 adults in one 1 room and 2 in 1 room and they charged me extra for the 2nd room thinking we would be given an extra cot or pull out for the 3rd adult but the hotel didnt have anything that could accommodate us so ..."

Reviewed on Jul 27, 2025

Baymont by Wyndham Columbia, MO
Drury Plaza Hotel Columbia East

Drury Plaza Hotel Columbia East

3 out of 5
3100 Interstate 70 Dr. SE, Columbia, MO
$90 nightly
The price is $102 total per night from Aug 3 to Aug 4
$102 total
Aug 3 - Aug 4
Total includes taxes and fees
Stay at this 3-star business-friendly hotel in Columbia. Enjoy free breakfast, free parking, and a 24-hour fitness center. Our guests praise the breakfast and ...
9.6/10 Exceptional! (1,208 reviews)
"Great stay, friendly staff, clean room as were all public areas, great pool. Overall a great stay"

Reviewed on Jul 30, 2025

Drury Plaza Hotel Columbia East
Wingate by Wyndham - Columbia

Wingate by Wyndham - Columbia

3 out of 5
3101 Wingate Ct, Columbia, MO
$88 nightly
The price is $99 total per night from Aug 10 to Aug 11
$99 total
Aug 10 - Aug 11
Total includes taxes and fees
Stay at this 3-star business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,125 reviews)
"Great value for the price"

Reviewed on Jul 25, 2025

Wingate by Wyndham - Columbia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Columbia Hotels With Airport Transportation

Courtyard by Marriott Columbia Missouri

Courtyard by Marriott Columbia Missouri

3 out of 5
3301 LeMone Industrial Blvd, Columbia, MO
$101 nightly
The price is $114 total per night from Aug 10 to Aug 11
$114 total
Aug 10 - Aug 11
Total includes taxes and fees
Stay at this 3-star business-friendly hotel in Columbia. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Lazer Lanes and Walters-Boone ...
8.6/10 Excellent! (619 reviews)
"Took 10 minutes to get a beer because staff shortage."

Reviewed on Jul 26, 2025

Courtyard by Marriott Columbia Missouri
Stoney Creek Hotel Columbia

Stoney Creek Hotel Columbia

2.5 out of 5
2601 S Providence Rd, Columbia, MO
$114 nightly
The price is $129 total per night from Aug 4 to Aug 5
$129 total
Aug 4 - Aug 5
Total includes taxes and fees
Book a stay at this business-friendly hotel in Columbia. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the breakfast and the pool in ...
8.6/10 Excellent! (1,278 reviews)
"Fantastic hotel"

Reviewed on Jul 25, 2025

Stoney Creek Hotel Columbia
The Broadway Columbia - a DoubleTree by Hilton

The Broadway Columbia - a DoubleTree by Hilton

4 out of 5
1111 E Broadway, Columbia, MO
$143 nightly
The price is $162 total per night from Aug 18 to Aug 19
$162 total
Aug 18 - Aug 19
Total includes taxes and fees
Stay at this 4-star business-friendly hotel in Columbia. Enjoy free WiFi, 2 bars/lounges, and breakfast (surcharge). Our guests praise the helpful staff in our ...
9.2/10 Wonderful! (866 reviews)
"Very nice hotel. Beds are super comfy."

Reviewed on Jul 22, 2025

The Broadway Columbia - a DoubleTree by Hilton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Columbia Hotels

Baymont by Wyndham Kingdom City

Baymont by Wyndham Kingdom City

2 out of 5
5750 Jade Rd, Kingdom City, MO
$89 nightly
The price is $100 total per night from Jul 31 to Aug 1
$100 total
Jul 31 - Aug 1
Total includes taxes and fees
Book a stay at this business-friendly motel in Kingdom City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (65 reviews)
"The property is very nice freshly remodeled."

Reviewed on Jul 28, 2025

Baymont by Wyndham Kingdom City
Ramada by Wyndham Columbia

Ramada by Wyndham Columbia

2.5 out of 5
901 Conley Rd, Columbia, MO
$63 nightly
The price is $72 total per night from Aug 14 to Aug 15
$72 total
Aug 14 - Aug 15
Total includes taxes and fees
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,000 reviews)
Great place!
"Everything was great!!! Wewill stay here again!"

Reviewed on Jul 28, 2025

Ramada by Wyndham Columbia
Budget Inn

Budget Inn

2 out of 5
1309 Jefferson St, Jefferson City, MO
$65 nightly
The price is $75 total per night from Jul 31 to Aug 1
$75 total
Jul 31 - Aug 1
Total includes taxes and fees
Stay at this motel in Jefferson City. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Hickory Adams Park and McKay Park are located ...
5.8/10 (122 reviews)
The room was clean and quiet.
"I was very pleased with my stay at Budget Inn Jefferson City, MO. The room was clean and quiet. The bed was comfortable. I would stay at this hotel again. The people that are running the place are friendly, and efficient. I had to get back to my home or I would have stayed another day."

Reviewed on Apr 27, 2025

Budget Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Columbia

Wingate by Wyndham - Columbia

Wingate by Wyndham - Columbia

3 out of 5
3101 Wingate Ct, Columbia, MO
$88 nightly
The price is $99 total per night from Aug 10 to Aug 11
$99 total
Aug 10 - Aug 11
Total includes taxes and fees
Stay at this 3-star business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,125 reviews)
"Great value for the price"

Reviewed on Jul 25, 2025

Wingate by Wyndham - Columbia
Country Inn & Suites by Radisson, Columbia, MO

Country Inn & Suites by Radisson, Columbia, MO

2.5 out of 5
817 N Keene St, Columbia, MO
$83 nightly
The price is $93 total per night from Aug 17 to Aug 18
$93 total
Aug 17 - Aug 18
Total includes taxes and fees
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,552 reviews)
"Our room was clean and fresh and the bed was excellent for a good night’s rest. The breakfast area was nice and clean and we had a good a good selection for breakfast."

Reviewed on Jul 24, 2025

Country Inn & Suites by Radisson, Columbia, MO
Full House Just Steps Away from Missouri River, Katy Trail, Shopping & More!

Full House Just Steps Away from Missouri River, Katy Trail, Shopping & More!

Boonville
Book a stay at this family-friendly vacation home in Boonville. Enjoy free WiFi, a water park, and a garden. Popular attractions Isle of Capri Casino and Boonville ...
9.6/10 Exceptional! (98 reviews)

Families like: Waterpark, kitchen, sofa bed, games and toys

Travelers say...
"Perfect house and location. This is our second stay for a family reunion and we'll definitely be back!"

Reviewed on Jun 16, 2025

Get rates
Full House Just Steps Away from Missouri River, Katy Trail, Shopping & More!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

TYS to COU Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date

Frequently asked questions

What is the shortest flight from Knoxville Airport to Columbia Regional Airport (COU)?
The quickest you can fly from McGhee Tyson Airport (TYS) to Columbia Regional Airport is 3 hours and 44 minutes. Slip a few things into your carry-on to keep you out of mischief, like a fascinating read or a crossword puzzle.
How many hours flight from Knoxville Airport to Columbia Regional Airport?
On average, the flight from TYS to Columbia Regional Airport takes 3 hours and 52 minutes. If you'd like to be as comfortable as possible, contemplate upgrading your seat using air miles or cash.
What airlines have the most flights from Knoxville Airport to Columbia Regional Airport?
You'll have to make one or more stopovers if you're traveling from McGhee Tyson Airport (TYS) to COU. Unfortunately, you won't find any airlines that advertise nonstop flights on this route.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.